Cross_talk_ID	m6A_Regulator_ID	m6A_Target_ID	Epigenetic_Regulation_Type_all	Epigenetic_Regulator_ID	Regulated_Target_ID	Downstream Gene ID	m6A_Methylation_Regulation	Cross_talk_Relationship_1	Cross_talk_Relationship_2	Cross_talk_Relationship_3	Cross_talk_Relationship_4	Crosstalk_Mechanism	Cross_talk_Summary	Disease_ID	PMID	Drug_ID
M6ACROT05001	REG00008	.	Non-coding RNA	EPIREG00201	EPITAR00232	.	.	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hsa-miR-27a exerts a protective effect on SNFH by negatively regulating YTHDF2 expression, leading to a reduction in m6A methylation in BMSCs."	M6ADIS0114	38711079	.
M6ACROT05002	REG00002	M6ATAR01280	Non-coding RNA	EPIREG00202	EPITAR00233	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	SNHG12 reduced the overall survival of GC patients and promoted GC tumorigenesis by activating the AKT/GSK-3beta pathway and binding with the RNA binding protein ELAVL1 (also known as HuR) and stabilizing 14-3-3 protein zeta/delta (YWHAZ) expression.	M6ADIS0057	34195070	.
M6ACROT05003	REG00002	M6ATAR00211	Non-coding RNA	EPIREG00203	EPITAR00233	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"VPS9D1-AS1 silencing suppressed HCC tumor growth in vivo. Mechanistically, VPS9D1-AS1 was able to bind to ELAVL1 and thereby influence the stability and expression of the Cyclin-dependent kinase 4 (CDK4) mRNA, thus impacting HCC cell proliferation. The VPS9D1-AS1/HuR/CDK4 signaling axis regulates HCC tumor cell oncogenic activity, highlighting this pathway as a promising therapeutic target."	M6ADIS0006	34558987	.
M6ACROT05004	REG00012	M6ATAR00341	Non-coding RNA	EPIREG00204	EPITAR00234	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	Epigenetic silencing of LncRNA LINC00261 promotes Myc proto-oncogene protein (MYC)-mediated aerobic glycolysis by regulating miR-222-3p/HIPK2/ERK axis and sequestering IGF2BP1. LINC00261 decreased c-myc mRNA stability by sequestering IGF2BP1	M6ADIS0061	33122827	.
M6ACROT05005	REG00012	M6ATAR01258	Non-coding RNA	EPIREG00205	EPITAR00234	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	LINC01426 contributes to clear cell renal cell carcinoma progression by modulating C-terminal-binding protein 1 (CTBP1)/miR-423-5p/FOXM1 axis via interacting with IGF2BP1	M6ADIS0343	32583425	.
M6ACROT05006	REG00014	M6ATAR00671	Non-coding RNA	EPIREG00206	EPITAR00235	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	LINC00467 promotes cell proliferation and metastasis by binding with IGF2BP3 to enhance the mRNA stability of TNF receptor-associated factor 5 (TRAF5) in hepatocellular carcinoma	M6ADIS0006	31656043	.
M6ACROT05007	REG00014	M6ATAR01679	Non-coding RNA	EPIREG00207	EPITAR00235	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	IGF2BP3 interacted with RMRP and E3 ubiquitin-protein ligase ZNRF3 (ZNRF3) mRNA. IGF2BP3 knockdown weakened the interaction of Argonaute 2 (Ago2) and ZNRF3. RMRP reduced ZNRF3 expression and mRNA stability by IGF2BP3. A positive feedback loop of lncRNA-RMRP/ZNRF3 axis and Wnt/beta-catenin signaling regulates the progression and temozolomide resistance in glioma.	M6ADIS0001	34657141	M6ADRUG0010
M6ACROT05008	REG00012	M6ATAR00341	Non-coding RNA	EPIREG00208	EPITAR00234	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	Long noncoding RNA NBAT1 suppresses hepatocellular carcinoma progression via competitively associating with IGF2BP1 and decreasing Myc proto-oncogene protein (MYC) expression	M6ADIS0006	33387362	.
M6ACROT05009	REG00004	M6ATAR01164	Non-coding RNA	EPIREG00209	EPITAR00212	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"H19 stabilized and upregulated the expression of RAF proto-oncogene serine/threonine-protein kinase (RAF1) by facilitated the interaction between HNRNPA2B1 and Raf-1 mRNA, resulting in activation of Raf-ERK signaling.Long non-coding RNA H19 promotes colorectal cancer metastasis via binding to hnRNPA2B1"	M6ADIS0059	32698890	.
M6ACROT05010	REG00003	M6ATAR00303	Non-coding RNA	EPIREG00210	EPITAR00236	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Knockdown of LINC00662 represses Adenylate kinase 4, mitochondrial (AK4) and attenuates radioresistance of oral squamous cell carcinoma.LINC00662 modulated the radiosensitivity of OSCC cells via HNRNPC-modulated AK4."	M6ADIS0055	32549791	.
M6ACROT05011	REG00014	M6ATAR00308	Non-coding RNA	EPIREG00211	EPITAR00235	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"Downregulation of LncRNA DARS1-AS1 Inhibits the Tumorigenesis of Cervical Cancer via Inhibition of IGF2BP3, In contrast to the mRNA-decay-promoting function of YTH domain-containing family protein 2, IGF2BPs promote the stability and storage of their target mRNAs (for example, MYC) in an m6A-dependent manner under normal and stress conditions and therefore affect gene expression output. Four representative high confidence targets, including MYC, FSCN1, Thymidine kinase, cytosolic (TK1), and MARCKSL1, exhibit strong binding with IGF2BPs around their m6A motifs in control cells. Knocking down of each individual IGF2BPs in Hela (cervical cancer) and HepG2 (liver cancer) cells significantly repressed MYC expression."	M6ADIS0008	33658798; 29476152	.
M6ACROT05012	REG00014	M6ATAR00341	Non-coding RNA	EPIREG00211	EPITAR00235	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"Downregulation of LncRNA DARS1-AS1 Inhibits the Tumorigenesis of Cervical Cancer via Inhibition of IGF2BP3, In contrast to the mRNA-decay-promoting function of YTH domain-containing family protein 2, IGF2BPs promote the stability and storage of their target mRNAs (for example, MYC) in an m6A-dependent manner under normal and stress conditions and therefore affect gene expression output. Four representative high confidence targets, including Myc proto-oncogene protein (MYC), FSCN1, TK1, and MARCKSL1, exhibit strong binding with IGF2BPs around their m6A motifs in control cells. Knocking down of each individual IGF2BPs in Hela (cervical cancer) and HepG2 (liver cancer) cells significantly repressed MYC expression."	M6ADIS0008	33658798; 29476152	.
M6ACROT05013	REG00014	M6ATAR00261	Non-coding RNA	EPIREG00211	EPITAR00235	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"Downregulation of LncRNA DARS1-AS1 Inhibits the Tumorigenesis of Cervical Cancer via Inhibition of IGF2BP3, In contrast to the mRNA-decay-promoting function of YTH domain-containing family protein 2, IGF2BPs promote the stability and storage of their target mRNAs (for example, MYC) in an m6A-dependent manner under normal and stress conditions and therefore affect gene expression output. Four representative high confidence targets, including MYC, Fascin (FSCN1), TK1, and MARCKSL1, exhibit strong binding with IGF2BPs around their m6A motifs in control cells. Knocking down of each individual IGF2BPs in Hela (cervical cancer) and HepG2 (liver cancer) cells significantly repressed MYC expression."	M6ADIS0008	33658798; 29476152	.
M6ACROT05014	REG00014	M6ATAR00337	Non-coding RNA	EPIREG00211	EPITAR00235	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"Downregulation of LncRNA DARS1-AS1 Inhibits the Tumorigenesis of Cervical Cancer via Inhibition of IGF2BP3, In contrast to the mRNA-decay-promoting function of YTH domain-containing family protein 2, IGF2BPs promote the stability and storage of their target mRNAs (for example, MYC) in an m6A-dependent manner under normal and stress conditions and therefore affect gene expression output. Four representative high confidence targets, including MYC, FSCN1, TK1, and MARCKS-related protein (MARCKSL1), exhibit strong binding with IGF2BPs around their m6A motifs in control cells. Knocking down of each individual IGF2BPs in Hela (cervical cancer) and HepG2 (liver cancer) cells significantly repressed MYC expression."	M6ADIS0008	33658798; 29476152	.
M6ACROT05015	REG00014	M6ATAR00078	Non-coding RNA	EPIREG00211	EPITAR00235	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"Downregulation of LncRNA DARS1-AS1 Inhibits the Tumorigenesis of Cervical Cancer via Inhibition of IGF2BP3,KCNMB2 antisense RNA 1 (KCNMB2-AS1) and IGF2BP3 formed a positive regulatory circuit that enlarged the tumorigenic effect of KCNMB2-AS1 in cervical cancer."	M6ADIS0008	33658798; 33028109	.
M6ACROT05016	REG00014	M6ATAR00533	Non-coding RNA	EPIREG00211	EPITAR00235	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"Downregulation of LncRNA DARS1-AS1 Inhibits the Tumorigenesis of Cervical Cancer via Inhibition of IGF2BP3, METTL3 interacts with IGF2BP3 to promote the mRNA stability of Apoptotic chromatin condensation inducer in the nucleus (ACIN1), the overexpression of which induces the aggressiveness of CC cells."	M6ADIS0008	33658798; 35255776	.
M6ACROT05017	REG00014	M6ATAR01533	Non-coding RNA	EPIREG00211	EPITAR00235	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"Downregulation of LncRNA DARS1-AS1 Inhibits the Tumorigenesis of Cervical Cancer via Inhibition of IGF2BP3, IGF2BP3-mediated regulation of Glutaminase kidney isoform, mitochondrial (GLS) and GLUD1 gene expression promotes treg-induced immune escape in human cervical cancer"	M6ADIS0008	33658798; 38058838	.
M6ACROT05018	REG00014	M6ATAR01016	Non-coding RNA	EPIREG00211	EPITAR00235	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"Downregulation of LncRNA DARS1-AS1 Inhibits the Tumorigenesis of Cervical Cancer via Inhibition of IGF2BP3, IGF2BP3-mediated regulation of GLS and Glutamate dehydrogenase 1, mitochondrial (GLUD1) gene expression promotes treg-induced immune escape in human cervical cancer"	M6ADIS0008	33658798; 38058838	.
M6ACROT05019	REG00014	M6ATAR00388	Non-coding RNA	EPIREG00211	EPITAR00235	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"Downregulation of LncRNA DARS1-AS1 Inhibits the Tumorigenesis of Cervical Cancer via Inhibition of IGF2BP3, Mechanistically, IGF2BP3 regulated Stearoyl-CoA desaturase (SCD) mRNA m6A modifications via IGF2BP3-METTL14 complex, thereby enhanced CC proliferation, metastasis, and lipid metabolism. "	M6ADIS0008	33658798; 38355626	.
M6ACROT05020	REG00004	M6ATAR01247	Non-coding RNA	EPIREG00212	EPITAR00237	.	Up regulation	m6A	Indirect	Enhancement	ncRNA	m6A regulators indirectly modulate the functionality of ncRNAs through downstream signaling pathways	"Integrative Analysis of NSCLC Identifies Long intergenic non-protein coding RNA 1234 (LINC01234) as an Oncogenic lncRNA that Interacts with HNRNPA2B1 and Regulates miR-106b Biogenesis. hsa-miR-106b-5p enhanced NSCLC cell growth by downregulating Cryptochrome circadian regulator 2 (CRY2), thereby increasing c-Myc expression."	M6ADIS0007	32246902	.
M6ACROT05021	REG00013	M6ATAR01620	Non-coding RNA	EPIREG00213	EPITAR00028	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	LINC01305 promotes metastasis and proliferation of esophageal squamous cell carcinoma through interacting with IGF2BP2 and IGF2BP3 to stabilize 5-hydroxytryptamine receptor 3A (HTR3A) mRNA	M6ADIS0056	34022433	.
M6ACROT05022	REG00014	M6ATAR01620	Non-coding RNA	EPIREG00213	EPITAR00235	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	LINC01305 promotes metastasis and proliferation of esophageal squamous cell carcinoma through interacting with IGF2BP2 and IGF2BP3 to stabilize 5-hydroxytryptamine receptor 3A (HTR3A) mRNA	M6ADIS0056	34022433	.
M6ACROT05023	REG00002	M6ATAR00453	Non-coding RNA	EPIREG00214	EPITAR00233	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Zinc finger E-box-binding homeobox 1 (ZEB1) induced-upregulation of ZEB1-AS1 maintained the stability of ZEB1 mRNA by binding with ELAVL1, which formed a feedback loop to facilitate TNBC progression. These findings might provide a new target for TNBC treatment."	M6ADIS0184	31922280	.
M6ACROT05024	REG00003	.	Non-coding RNA	EPIREG00215	EPITAR00236	.	.	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	MALAT1 interacts with HNRNPC in cell cycle regulation	.	23973260	.
M6ACROT05025	REG00022	M6ATAR01681	Non-coding RNA	EPIREG00216	EPITAR00238	.	Down regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	METTL3 mediates m6A modification of lncRNA CRNDE to promote Ubiquitin-like-conjugating enzyme ATG10 (ATG10) expression and improve brain ischemia/reperfusion injury through YTHDC1	M6ADIS0091	39407279	.
M6ACROT05026	REG00007	M6ATAR00675	Non-coding RNA	EPIREG00217	EPITAR00028	.	.	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"LINC00035 (ABHD11-AS1) is methylated by METTL3 and subsequently recognized by Insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2), thereby affecting CRC development through enhancing FOXM1 stability."	M6ADIS0059	38838765	.
M6ACROT05027	REG00013	M6ATAR00258	Non-coding RNA	EPIREG00217	EPITAR00028	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	ABHD11-AS1 interacts with IGF2BP2 and affects CRC development through enhancing Forkhead box protein M1 (FOXM1) stability	M6ADIS0059	38838765	.
M6ACROT05028	REG00007	M6ATAR01682	Non-coding RNA	EPIREG00218	EPITAR00027	.	Down regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Overexpressing miRNAs significantly increased the amount of mRNAs associated with METTL3, whereas downregulating miRNA abundance by antagomirs significantly reduced METTL3 binding on mRNAs (i.e., Integral membrane protein DGCR2/IDD (DGCR2) and TUBB4B, targeted by hsa-miR-423-3p and miR-1226-3p, respectively) in HeLa cells "	.	25683224	.
M6ACROT05029	REG00007	M6ATAR01683	Non-coding RNA	EPIREG00219	EPITAR00027	.	Down regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Overexpressing miRNAs significantly increased the amount of mRNAs associated with METTL3, whereas downregulating miRNA abundance by antagomirs significantly reduced METTL3 binding on mRNAs (i.e., DGCR2 and Tubulin beta-4B chain (TUBB4B), targeted by miR-423-3p and hsa-miR-1226-3p, respectively) in HeLa cells "	.	25683224	.
M6ACROT05030	REG00007	M6ATAR01684	Non-coding RNA	EPIREG00220	EPITAR00027	.	Down regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Consistently, the amounts of METTL3-crosslinked total RNAs and mRNAs (i.e., Transcription factor 4 (TCF4) and RPS13) targeted by designed miRNAs (hsa-miR-330-5p and miR-1981-5p)."	.	25683224	.
M6ACROT05031	REG00007	M6ATAR01685	Non-coding RNA	EPIREG00221	EPITAR00027	.	Down regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Consistently, the amounts of METTL3-crosslinked total RNAs and mRNAs (i.e., TCF4 and Small ribosomal subunit protein uS15 (RPS13)) targeted by designed miRNAs (i.e., miR-330-5p and mmu-miR-1981-5p)."	.	25683224	.
M6ACROT05032	REG00007	M6ATAR00237	Non-coding RNA	EPIREG00222	EPITAR00027	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hsa-miR-33a suppresses proliferation of NSCLC cells via targeting METTL3 mRNA.miR-33a was able to depress the expression of Epidermal growth factor receptor (EGFR), TAZ, MAPKAPK2 and DNMT3A at the level of protein"	M6ADIS0007	27856248	.
M6ACROT05033	REG00007	M6ATAR01160	Non-coding RNA	EPIREG00222	EPITAR00027	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hsa-miR-33a suppresses proliferation of NSCLC cells via targeting METTL3 mRNA.miR-33a was able to depress the expression of EGFR, Tafazzin (TAFAZZIN), MAPKAPK2 and DNMT3A at the level of protein"	M6ADIS0007	27856248	.
M6ACROT05034	REG00007	M6ATAR01159	Non-coding RNA	EPIREG00222	EPITAR00027	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hsa-miR-33a suppresses proliferation of NSCLC cells via targeting METTL3 mRNA.miR-33a was able to depress the expression of EGFR, TAZ, MAP kinase-activated protein kinase 2 (MAPKAPK2) and DNMT3A at the level of protein"	M6ADIS0007	27856248	.
M6ACROT05035	REG00007	M6ATAR01491	Non-coding RNA	EPIREG00222	EPITAR00027	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hsa-miR-33a suppresses proliferation of NSCLC cells via targeting METTL3 mRNA.miR-33a was able to depress the expression of EGFR, TAZ, MAPKAPK2 and Cysteine methyltransferase DNMT3A (DNMT3A) at the level of protein"	M6ADIS0007	27856248	.
M6ACROT05036	REG00007	M6ATAR00319	Non-coding RNA	EPIREG00223	EPITAR00027	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"Ragulator complex protein LAMTOR5 (LAMTOR5/HBXIP) up-regulates METTL3 by suppressing MIRLET7G, in which METTL3 increased HBXIP expression forming a positive feedback loop of HBXIP/let-7g/METTL3/HBXIP, leading to accelerated cell proliferation in breast cancer."	M6ADIS0065	29174803	.
M6ACROT05037	REG00008	M6ATAR00237	Non-coding RNA	EPIREG00224	EPITAR00232	.	Down regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	MIR145 modulates m6A levels by targeting the 3'-UTR of YTHDF2 mRNA in HCC cells.YTHDF2 acts as a tumor suppressor to repress cell proliferation and growth via destabilizing the Epidermal growth factor receptor (EGFR) mRNA in HCC.	M6ADIS0006	28104805; 30423408	.
M6ACROT05038	REG00008	M6ATAR00022	Non-coding RNA	EPIREG00224	EPITAR00232	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"MIR145 modulates m6A levels by targeting the 3'-UTR of YTHDF2 mRNA in HCC cells.YTHDF2 promotes the CSC liver phenotype and cancer metastasis by modulating the m6A methylation of POU domain, class 5, transcription factor 1 (POU5F1) mRNA. YTHDF2 expression is positively correlated with OCT4 expression and m6A levels in the 5'-UTR of OCT4 mRNA in clinical hepatocellular carcinoma specimens."	M6ADIS0006	28104805; 32366907	.
M6ACROT05039	REG00008	M6ATAR00293	Non-coding RNA	EPIREG00224	EPITAR00232	.	Down regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	MIR145 modulates m6A levels by targeting the 3'-UTR of YTHDF2 mRNA in HCC cells.YTHDF2 processed the decay of m6A-containing Interleukin-11 (IL11) and serpin family E member 2 (SERPINE2) mRNAs. YTHDF2 transcription succumbed to hypoxia-inducible factor-2-alpha (HIF-2-alpha). Administration of a HIF-2-alpha antagonist (PT2385) restored YTHDF2-programed epigenetic machinery and repressed liver cancer.	M6ADIS0006	28104805; 31735169	.
M6ACROT05040	REG00008	M6ATAR00266	Non-coding RNA	EPIREG00224	EPITAR00232	.	Down regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	MIR145 modulates m6A levels by targeting the 3'-UTR of YTHDF2 mRNA in HCC cells.YTHDF2 processed the decay of m6A-containing interleukin 11 (IL11) and Glia-derived nexin (SERPINE2) mRNAs. YTHDF2 transcription succumbed to hypoxia-inducible factor-2-alpha (HIF-2-alpha). Administration of a HIF-2-alpha antagonist (PT2385) restored YTHDF2-programed epigenetic machinery and repressed liver cancer.	M6ADIS0006	28104805; 31735169	.
M6ACROT05041	REG00008	M6ATAR00494	Non-coding RNA	EPIREG00224	EPITAR00232	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"MIR145 modulates m6A levels by targeting the 3'-UTR of YTHDF2 mRNA in HCC cells.YTHDF2 expression was associated positively with Splicing factor 3A subunit 3 (SF3A3) expression, which implied that they cooperate in LIHC progression. "	M6ADIS0006	28104805; 33344502	.
M6ACROT05042	REG00008	M6ATAR00511	Non-coding RNA	EPIREG00224	EPITAR00232	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	MIR145 modulates m6A levels by targeting the 3'-UTR of YTHDF2 mRNA in HCC cells.PA2G4 plays a pro-metastatic role by increasing Tyrosine-protein kinase Fyn (FYN) expression through binding with YTHDF2 in HCC. PA2G4 becomes a reliable prognostic marker or therapeutic target for HCC patients.	M6ADIS0006	28104805; 35526051	.
M6ACROT05043	REG00008	M6ATAR00512	Non-coding RNA	EPIREG00224	EPITAR00232	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	MIR145 modulates m6A levels by targeting the 3'-UTR of YTHDF2 mRNA in HCC cells.Proliferation-associated protein 2G4 (PA2G4) plays a pro-metastatic role by increasing FYN expression through binding with YTHDF2 in HCC. PA2G4 becomes a reliable prognostic marker or therapeutic target for HCC patients.	M6ADIS0006	28104805; 35526051	.
M6ACROT05044	REG00008	M6ATAR00659	Non-coding RNA	EPIREG00224	EPITAR00232	.	Down regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"MIR145 modulates m6A levels by targeting the 3'-UTR of YTHDF2 mRNA in HCC cells.Long intergenic non-protein coding RNA 1273 (LINC01273) was modified with m6A, METTL3 increased LINC01273 m6A modification, followed by LINC01273 decay in the presence of YTHDF2, a m6A 'reader'. And LINC01273 plays a key role in sorafenib resistant HCC cells."	M6ADIS0006	28104805; 35037556	.
M6ACROT05045	REG00008	M6ATAR00269	Non-coding RNA	EPIREG00224	EPITAR00232	.	Down regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"MIR145 modulates m6A levels by targeting the 3'-UTR of YTHDF2 mRNA in HCC cells.FTO decreased m6A modification on mRNAs of glycolysis associated genes including Glucose transporter type 1 (GLUT1), PKM2, and c-Myc which alleviated the YTH N6-methyladenosine RNA binding protein 2 (YTHDF2)-mediated mRNA degradation. Therefore, the upregulated expression of FTO-IT1 leaded to overexpression of GLUT1, PKM2, and c-Myc by which enhanced glycolysis of HCC."	M6ADIS0006	28104805; 37840133	.
M6ACROT05046	REG00008	M6ATAR00312	Non-coding RNA	EPIREG00224	EPITAR00232	.	Down regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"MIR145 modulates m6A levels by targeting the 3'-UTR of YTHDF2 mRNA in HCC cells.FTO decreased m6A modification on mRNAs of glycolysis associated genes including GLUT1, Pyruvate kinase PKM (PKM2/PKM), and c-Myc which alleviated the YTH N6-methyladenosine RNA binding protein 2 (YTHDF2)-mediated mRNA degradation. Therefore, the upregulated expression of FTO-IT1 leaded to overexpression of GLUT1, PKM2, and c-Myc by which enhanced glycolysis of HCC."	M6ADIS0006	28104805; 37840133	.
M6ACROT05047	REG00008	M6ATAR00341	Non-coding RNA	EPIREG00224	EPITAR00232	.	Down regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"MIR145 modulates m6A levels by targeting the 3'-UTR of YTHDF2 mRNA in HCC cells.FTO decreased m6A modification on mRNAs of glycolysis associated genes including GLUT1, PKM2, and Myc proto-oncogene protein (MYC) which alleviated the YTH N6-methyladenosine RNA binding protein 2 (YTHDF2)-mediated mRNA degradation. Therefore, the upregulated expression of FTO-IT1 leaded to overexpression of GLUT1, PKM2, and c-Myc by which enhanced glycolysis of HCC."	M6ADIS0006	28104805; 37840133	.
M6ACROT05048	REG00009	.	Non-coding RNA	EPIREG00225	EPITAR00239	.	.	ncRNA	Indirect	Inhibition	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"Overexpression of MIR29A in GSCs inhibited expression of WTAP and suppressed both phosphoinositide 3-kinase/AKT and extracellular signal-related kinase pathways by downregulating QKI, KH domain containing RNA binding (QKI), thereby inhibiting cell proliferation, migration, and invasion but promoting apoptosis. "	M6ADIS0001	28212562	.
M6ACROT05049	REG00005	M6ATAR00148	Non-coding RNA	EPIREG00226	EPITAR00183	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"GAS5-AS1 interacted with the tumor suppressor Growth arrest specific 5 (GAS5), and increased its stability by interacting with RNA demethylase ALKBH5 and decreasing GAS5 N6-methyladenosine (m6A) modification. Moreover, it was shown that m6A-mediated GAS5 RNA degradation relied on the m6A reader protein YTHDF2-dependent pathway. Our findings reveal an important mechanism of epigenetic alteration in CC carcinogenesis and metastasis."	M6ADIS0008	31497208	.
M6ACROT05050	REG00008	M6ATAR00148	Non-coding RNA	EPIREG00226	EPITAR00183	.	Down regulation	ncRNA	Indirect	Inhibition	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"GAS5-AS1 interacted with the tumor suppressor Growth arrest specific 5 (GAS5), and increased its stability by interacting with RNA demethylase RNA demethylase ALKBH5 (ALKBH5) and decreasing GAS5 N6-methyladenosine (m6A) modification. Moreover, it was shown that m6A-mediated GAS5 RNA degradation relied on the m6A reader protein YTHDF2-dependent pathway. Our findings reveal an important mechanism of epigenetic alteration in CC carcinogenesis and metastasis."	M6ADIS0008	31497208	.
M6ACROT05051	REG00007	M6ATAR00795	Non-coding RNA	EPIREG00227	EPITAR00027	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"In summary, impaired autophagic degradation of lncRNA ARHGAP5-AS1 in chemoresistant cancer cells promoted chemoresistance. It can activate the transcription of ARHGAP5 in the nucleus and stimulate m6A modification of Rho GTPase activating protein 5 (ARHGAP5) mRNA to stabilize ARHGAP5 mRNA in the cytoplasm by recruiting METTL3."	M6ADIS0057	31097692	M6ADRUG0047
M6ACROT05052	REG00007	M6ATAR00222	Non-coding RNA	EPIREG00228	EPITAR00027	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	Cross talk between RNA N6-methyladenosine methyltransferase-like 3 and MIR186 regulates hepatoblastoma progression through Wnt/beta-catenin signalling pathway.METTL3 was identified to be a direct target of microRNA-186 (miR-186).METTL3 is significantly up-regulated in Hepatoblastoma(HB) and promotes HB development.m6A mRNA methylation contributes significantly to regulate the Wnt/beta-catenin pathway. Reduced m6A methylation can lead to a decrease in expression and stability of the Catenin beta-1 (CTNNB1/Beta-catenin).	M6ADIS0006	31967701; 31870368	.
M6ACROT05053	REG00007	M6ATAR00134	Non-coding RNA	EPIREG00228	EPITAR00027	.	Down regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	Cross talk between RNA N6-methyladenosine methyltransferase-like 3 and MIR186 regulates hepatoblastoma progression through Wnt/beta-catenin signalling pathway. METTL3 was identified to be a direct target of microRNA-186 (miR-186). microRNA 186 (MIR186)/METTL3 axis contributed to the progression of Hepatoblastoma via the Wnt/beta-catenin signalling pathway. 	M6ADIS0006	31967701	.
M6ACROT05054	REG00007	M6ATAR00484	Non-coding RNA	EPIREG00228	EPITAR00027	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	Cross talk between RNA N6-methyladenosine methyltransferase-like 3 and MIR186 regulates hepatoblastoma progression through Wnt/beta-catenin signalling pathway.METTL3 was identified to be a direct target of microRNA-186 (miR-186).METTL3-mediated Cystine/glutamate transporter (SLC7A11) m6A modification enhances hepatoblastoma ferroptosis resistance. The METTL3/IGF2BP1/m6A modification promotes SLC7A11 mRNA stability and upregulates its expression by inhibiting the deadenylation process.	M6ADIS0006	31967701; 35522946	.
M6ACROT05055	REG00013	M6ATAR00341	Non-coding RNA	EPIREG00229	EPITAR00028	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	LncRNA LINC00920 stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer.LINRIS is an independent prognostic biomarker for CRC. The LINRIS-IGF2BP2-Myc proto-oncogene protein (MYC) axis promotes the progression of CRC and is a promising therapeutic target.	M6ADIS0059	31791342	.
M6ACROT05056	REG00005	M6ATAR00258	Non-coding RNA	EPIREG00230	EPITAR00183	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"FOXM1-AS enhances the binding of ALKBH5 to Forkhead box protein M1 (FOXM1) pre-mRNA, thereby facilitating the tumorigenicity of glioblastoma stem-like cells."	M6ADIS0001	28344040	.
M6ACROT05057	REG00015	M6ATAR00265	Non-coding RNA	EPIREG00231	EPITAR00240	.	Down regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"GATA3-AS1 enhances the interaction between VIRMA and Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) pre-mRNA, thereby accelerating the progression of hepatocellular carcinoma."	M6ADIS0006	31856849	.
M6ACROT05058	REG00012	M6ATAR00341	Non-coding RNA	EPIREG00232	EPITAR00234	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"LINC00266-1 binds to IGF2BP1 and strengthens m6A recognition by IGF2BP1 on RNAs, such as Myc proto-oncogene protein (MYC) mRNA, to increase the mRNA stability and expression of c-Myc, thereby promoting tumorigenesis."	.	32245947	.
M6ACROT05059	REG00005	M6ATAR01689	Non-coding RNA	EPIREG00233	EPITAR00183	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Overexpressed Circ_STAG1 captured ALKBH5 and decreased the translocation of ALKBH5 into the nucleus, leading to increased m6A methylation of fatty acid amide hydrolase (Fatty-acid amide hydrolase 1 (FAAH)) messenger RNA and degradation of FAAH in astrocytes with subsequent attenuation of depressive-like behaviors and astrocyte loss induced by corticosterone in vitro."	M6ADIS0370	32387133	.
M6ACROT05060	.	M6ATAR00451	Non-coding RNA	EPIREG00234	EPITAR00167	.	.	m6A	Direct	Enhancement	ncRNA	m6A modification regulates the functionality of ncRNAs through by altering the methylation levels of shared targets	m6A modification in the Transcriptional coactivator YAP1 (YAP1) 3'UTR induced the interaction of hsa-miR-382-5p and led to the inhibition of YAP. circRNA_104075 stimulates YAP-dependent tumorigenesis through the regulation of HNF4a and may serve as a diagnostic marker in hepatocellular carcinoma	M6ADIS0006	30361504	.
M6ACROT05061	REG00008	M6ATAR01691	Non-coding RNA	EPIREG00235	EPITAR00232	.	Down regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	hsa-miR-615-3p inhibited Fibulin-1 (FBLN1) and osteogenic differentiation of umbilical cord mesenchymal stem cells by associated with YTHDF2 in a m6A-miRNA interaction manner	M6ADIS0223	38353178	.
M6ACROT05062	REG00005	M6ATAR01692	Non-coding RNA	EPIREG00236	EPITAR00242	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Knockdown of ALKBH5 resulted in a significant increase in the m6A modification level of lnc-Lnc-AK311120, accompanied by a downregulation in the expression level of AK311120. AK311120 interacted with the RNA-binding proteins DExH-Box helicase 9 (DHX9) and YTH N6-methyladenosine RNA binding protein C2 (YTHDC2) to form a ternary complex, while mitogen-activated protein kinase kinase 7 (MAP2K7) served as the shared downstream target gene of DHX9 and YTHDC2."	.	39311450	.
M6ACROT05063	REG00023	M6ATAR01693	Non-coding RNA	EPIREG00236	EPITAR00242	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Lnc-AK311120 interacted with the RNA-binding proteins DExH-Box helicase 9 (DHX9) and YTHDC2 to form a ternary complex, while Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7) served as the shared downstream target gene of DHX9 and YTHDC2."	.	39311450	.
M6ACROT05064	REG00013	M6ATAR00356	Non-coding RNA	EPIREG00237	EPITAR00028	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"AIRN exerts anti-fibrotic effects by directly binding to IGF2BP2 and further prevents its ubiquitination-dependent degradation. Moreover, we revealed that Airn/IGF2BP2 protected Cellular tumor antigen p53 (TP53/p53) mRNA from degradation in m6A manner, leading to CF cell cycle arrest and reduced cardiac fibrosis. "	M6ADIS0375	36384975	.
M6ACROT05065	REG00007	M6ATAR01287	Non-coding RNA	EPIREG00238	EPITAR00243	.	.	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3-mediated m6A modification of OIP5 antisense RNA 1 (OIP5-AS1) reduced DDX5 ubiquitination and enhanced DDX5 stability by binding to Tripartite motif containing 5 (TRIM5), thereby promoting BC cell proliferation, migration and PTX resistance, and inhibiting apoptosis."	M6ADIS0057	39209141	.
M6ACROT05066	REG00013	M6ATAR01695	Non-coding RNA	EPIREG00239	EPITAR00028	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"rtcisE2F functions as a scaffold of N-methyladenosine (m6A) reader IGF2BP2 and Transcription factor E2F6 (E2F6)/E2F3 mRNA. rtcisE2F promotes the association of E2F6/E2F3 mRNAs with IGF2BP2, and inhibits their association with another m6A reader, YTHDF2. IGF2BP2 inhibits E2F6/E2F3 mRNA decay, whereas YTHDF2 promotes E2F6/E2F3 mRNA decay. "	M6ADIS0006	35266112	.
M6ACROT05067	REG00013	M6ATAR00235	Non-coding RNA	EPIREG00239	EPITAR00028	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"rtcisE2F functions as a scaffold of N-methyladenosine (m6A) reader IGF2BP2 and E2F6/Transcription factor E2F3 (E2F3) mRNA. rtcisE2F promotes the association of E2F6/E2F3 mRNAs with IGF2BP2, and inhibits their association with another m6A reader, YTHDF2. IGF2BP2 inhibits E2F6/E2F3 mRNA decay, whereas YTHDF2 promotes E2F6/E2F3 mRNA decay. "	M6ADIS0006	35266112	.
M6ACROT05068	REG00008	M6ATAR01695	Non-coding RNA	EPIREG00239	EPITAR00028	.	Down regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"rtcisE2F functions as a scaffold of N-methyladenosine (m6A) reader Insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2) and Transcription factor E2F6 (E2F6)/E2F3 mRNA. rtcisE2F promotes the association of E2F6/E2F3 mRNAs with IGF2BP2, and inhibits their association with another m6A reader, YTHDF2. IGF2BP2 inhibits E2F6/E2F3 mRNA decay, whereas YTHDF2 promotes E2F6/E2F3 mRNA decay. "	M6ADIS0006	35266112	.
M6ACROT05069	REG00008	M6ATAR00235	Non-coding RNA	EPIREG00239	EPITAR00028	.	Down regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"rtcisE2F functions as a scaffold of N-methyladenosine (m6A) reader Insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2) and E2F6/Transcription factor E2F3 (E2F3) mRNA. rtcisE2F promotes the association of E2F6/E2F3 mRNAs with IGF2BP2, and inhibits their association with another m6A reader, YTHDF2. IGF2BP2 inhibits E2F6/E2F3 mRNA decay, whereas YTHDF2 promotes E2F6/E2F3 mRNA decay. "	M6ADIS0006	35266112	.
M6ACROT05070	REG00013	M6ATAR01696	Non-coding RNA	EPIREG00240	EPITAR00028	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	PURPL maintains tumorigenicity by enhancing N6-methyladenosine reader IGF2BP2 dependent stabilization of Homeobox protein MSX-1 (MSX1) and JARID2: implication in colorectal cancer	M6ADIS0059	35173309	.
M6ACROT05071	REG00013	M6ATAR01697	Non-coding RNA	EPIREG00240	EPITAR00028	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	PURPL maintains tumorigenicity by enhancing N6-methyladenosine reader IGF2BP2 dependent stabilization of MSX1 and Protein Jumonji (JARID2): implication in colorectal cancer	M6ADIS0059	35173309	.
M6ACROT05072	REG00001	M6ATAR00348	Non-coding RNA	EPIREG00241	EPITAR00179	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"lncRNA UCA1 inhibits oxidative stress and ferroptosis, thereby preventing cardiomyocyte aging. This protective effect is likely mediated by increasing the expression of demethylase FTO and reducing m6A modification, which promotes the expression of Nuclear factor erythroid 2-related factor 2 (NFE2L2)."	M6ADIS0274	39538055	.
M6ACROT05073	REG00007	M6ATAR00379	Non-coding RNA	EPIREG00242	EPITAR00027	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	Transcriptome sequencing analysis reveals hsa-miR-30c-5p promotes ferroptosis in cervical cancer and inhibits growth and metastasis of cervical cancer xenografts by targeting the METTL3/GTPase KRas (KRAS) axis	M6ADIS0008	38286198	.
M6ACROT05074	REG00003	M6ATAR00179	Non-coding RNA	EPIREG00243	EPITAR00236	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	Analysis and validation of m6A regulatory network: a novel circBACH2/hsa-miR-944/HNRNPC axis in breast cancer progression.HNRNPC promotes collagen fiber alignment and immune evasion in breast cancer via activation of the VIRMA-mediated Transcription factor AP-2-alpha (TFAP2A)/DDR1 axis	M6ADIS0065	34952600; 37528369	.
M6ACROT05075	REG00003	M6ATAR01333	Non-coding RNA	EPIREG00243	EPITAR00236	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"Analysis and validation of m6A regulatory network: a novel circBACH2/hsa-miR-944/HNRNPC axis in breast cancer progression.HNRNPC was highly expressed in breast cancer, and played a crucial role in cell growth, especially in the luminal subtype. HNRNPC could combine and stabilize Methylosome protein WDR77 (WDR77) mRNA. WDR77 successively drove the G1/S phase transition in the cell cycle and promoted cell proliferation. Notably, this regulation axis was closely tied to the m6A modification status of WDR77 mRNA. Overall, a critical regulatory mechanism was identified, as well as promising targets for potential treatment strategies for luminal breast cancer."	M6ADIS0065	34952600; 38353359	.
M6ACROT05076	REG00003	M6ATAR00179	Non-coding RNA	EPIREG00244	EPITAR00244	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	Analysis and validation of m6A regulatory network: a novel Circ_BACH2/hsa-miR-944/HNRNPC axis in breast cancer progression.HNRNPC promotes collagen fiber alignment and immune evasion in breast cancer via activation of the VIRMA-mediated Transcription factor AP-2-alpha (TFAP2A)/DDR1 axis	M6ADIS0065	34952600; 37528369	.
M6ACROT05077	REG00003	M6ATAR01333	Non-coding RNA	EPIREG00244	EPITAR00244	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"Analysis and validation of m6A regulatory network: a novel Circ_BACH2/hsa-miR-944/HNRNPC axis in breast cancer progression.HNRNPC was highly expressed in breast cancer, and played a crucial role in cell growth, especially in the luminal subtype. HNRNPC could combine and stabilize Methylosome protein WDR77 (WDR77) mRNA. WDR77 successively drove the G1/S phase transition in the cell cycle and promoted cell proliferation. Notably, this regulation axis was closely tied to the m6A modification status of WDR77 mRNA. Overall, a critical regulatory mechanism was identified, as well as promising targets for potential treatment strategies for luminal breast cancer."	M6ADIS0065	34952600; 38353359	.
M6ACROT05078	REG00002	M6ATAR01699	Non-coding RNA	EPIREG00245	EPITAR00233	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"m6A-Mediated Biogenesis of Circ_DDIT4 Inhibits Prostate Cancer Progression by Sequestrating ELAVL1/HuR.By competitively binding to ELAV-like RNA binding protein 1 (ELAVL1/HuR) through its 3'-UTR, circDDIT4 acts as a protein sponge to decrease the expression of prostate cancer-overexpressed Anoctamin-7 (ANO7). "	M6ADIS0068	37647111	.
M6ACROT05079	REG00026	.	Non-coding RNA	EPIREG00246	EPITAR00245	.	.	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	Downregulation of ZC3H13 by hsa-miR-362-3p/miR-425-5p is associated with a poor prognosis and adverse outcomes in hepatocellular carcinoma	M6ADIS0006	35278064	.
M6ACROT05080	REG00026	.	Non-coding RNA	EPIREG00247	EPITAR00245	.	.	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	Downregulation of ZC3H13 by miR-362-3p/hsa-miR-425-5p is associated with a poor prognosis and adverse outcomes in hepatocellular carcinoma	M6ADIS0006	35278064	.
M6ACROT05081	.	M6ATAR01700	Non-coding RNA	EPIREG00248	EPITAR00246	.	.	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	LncRNA BCAN antisense RNA 1 (BCAN-AS1) stabilizes c-Myc via N6-methyladenosine-mediated binding with Smad nuclear interacting protein 1 (SNIP1) to promote pancreatic cancer.	M6ADIS0061	37726400	.
M6ACROT05082	REG00048	M6ATAR01701	Non-coding RNA	EPIREG00249	EPITAR00247	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	m6A-Induced lncRNA MEG3 Promotes Cerebral Ischemia-Reperfusion Injury Via Modulating Oxidative Stress and Mitochondrial Dysfunction by hnRNPA1/NAD-dependent protein deacetylase sirtuin-2 (SIRT2) Axis	M6ADIS0185	38358439	.
M6ACROT05083	REG00004	M6ATAR00497	Non-coding RNA	EPIREG00250	EPITAR00212	.	Down regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	DRAIC mediates HNRNPA2B1 stability and m6A-modified Insulin-like growth factor 1 receptor (IGF1R) instability to inhibit tumor progression	.	38811846	.
M6ACROT05084	REG00029	M6ATAR01702	Non-coding RNA	EPIREG00251	EPITAR00187	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	FAS-AS1 maintained the stability of Disintegrin and metalloproteinase domain-containing protein 8 (ADAM8) mRNA by recruiting FMR1. METTL14 knockdown repressed FAS-AS1 expression in an m6A-dependent manner. METTL14-mediated lncRNA-FAS-AS1 promotes osteoarthritis progression by up-regulating ADAM8	M6ADIS0110	39221886	.
M6ACROT05085	REG00048	M6ATAR01306	Non-coding RNA	EPIREG00252	EPITAR00247	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	Exosomal Monocarboxylate transporter 1 (SLC16A1)-AS1-induced M2 macrophages polarization facilitates hepatocellular carcinoma progression.the HCC exosomal SLC16A1-AS1 enhanced mRNA stabilization of SLC16A1 in macrophage by promoting the interaction between 3' untranslated regions (3'UTR) of SLC16A1 mRNA and hnRNPA1.	M6ADIS0006	39247822	.
M6ACROT05086	REG00007	M6ATAR01703	Non-coding RNA	EPIREG00253	EPITAR00027	.	Down regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N6-methyladenosine methylation of Protein mono-ADP-ribosyltransferase PARP10 (PARP10) mRNA	M6ADIS0100	33020597	.
M6ACROT05087	REG00024	M6ATAR01704	Non-coding RNA	EPIREG00254	EPITAR00248	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"m6A-modified lincRNA DUBR is required for neuronal development by stabilizing YTHDF1 and facilitating mRNA translation.Dubr interacts with m6A-binding proteins, the YTHDF1/3 complex, through its m6A motifs to protect YTHDF1/3 from degradation via the proteasome pathway. Furthermore, Microtubule-associated protein tau (TAU) and Calmodulin are regulated by YTHDF1/3 and m6A-modified Dubr."	.	36417851	.
M6ACROT05088	REG00025	M6ATAR01704	Non-coding RNA	EPIREG00254	EPITAR00249	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"m6A-modified lincRNA DUBR is required for neuronal development by stabilizing YTHDF1/YTHDF3 and facilitating mRNA translation.Dubr interacts with m6A-binding proteins, the YTHDF1/3 complex, through its m6A motifs to protect YTHDF1/3 from degradation via the proteasome pathway. Furthermore, Microtubule-associated protein tau (TAU) and Calmodulin are regulated by YTHDF1/3 and m6A-modified Dubr."	.	36417851	.
M6ACROT05089	REG00024	M6ATAR01705	Non-coding RNA	EPIREG00254	EPITAR00248	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"m6A-modified lincRNA DUBR is required for neuronal development by stabilizing YTHDF1 and facilitating mRNA translation.Dubr interacts with m6A-binding proteins, the YTHDF1/3 complex, through its m6A motifs to protect YTHDF1/3 from degradation via the proteasome pathway. Furthermore, Tau and Calmodulin-1 (CALM1) are regulated by YTHDF1/3 and m6A-modified Dubr."	.	36417851	.
M6ACROT05090	REG00025	M6ATAR01705	Non-coding RNA	EPIREG00254	EPITAR00249	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"m6A-modified lincRNA DUBR is required for neuronal development by stabilizing YTHDF1/YTHDF3 and facilitating mRNA translation.Dubr interacts with m6A-binding proteins, the YTHDF1/3 complex, through its m6A motifs to protect YTHDF1/3 from degradation via the proteasome pathway. Furthermore, Tau and Calmodulin-1 (CALM1) are regulated by YTHDF1/3 and m6A-modified Dubr."	.	36417851	.
M6ACROT05091	REG00013	M6ATAR00451	Non-coding RNA	EPIREG00255	EPITAR00027	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"Triple negative breast cancer cell derived piR 31115 promotes the proliferation and migration of endothelial cells via Methyltransferase-like protein 3 (METTL3) mediated m6A modification of Transcriptional coactivator YAP1 (YAP1).Concurrently, the IGF2BP2 plays a crucial role in stabilizing YAP1 protein expression."	M6ADIS0184	39820521	.
M6ACROT05092	REG00007	M6ATAR00451	Non-coding RNA	EPIREG00255	EPITAR00027	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	Triple negative breast cancer cell derived piR 31115 promotes the proliferation and migration of endothelial cells via METTL3 mediated m6A modification of Transcriptional coactivator YAP1 (YAP1)	M6ADIS0184	39820521	.
M6ACROT05093	REG00015	M6ATAR01706	Non-coding RNA	EPIREG00256	EPITAR00250	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"Long intergenic non-protein coding RNA 667 (LINC00667) positively regulated the VIRMA via sponging hsa-miR-556-5p, forming a KIAA1429/m6A/LINC00667/miR-556-5p feedback loop. Collectively, the central findings of our study suggest that KIAA1429-induced LINC00667 exerted its functions as an oncogene in BC progression through m6A-dependent feedback loop.N6-methyladenine- induced LINC00667 promoted breast cancer progression through m6A/KIAA1429 positive feedback loop"	M6ADIS0065	31717552	.
M6ACROT05094	REG00015	M6ATAR01706	Non-coding RNA	EPIREG00257	EPITAR00240	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"Long intergenic non-protein coding RNA 667 (LINC00667) positively regulated the VIRMA via sponging hsa-miR-556-5p, forming a KIAA1429/m6A/LINC00667/miR-556-5p feedback loop. Collectively, the central findings of our study suggest that KIAA1429-induced LINC00667 exerted its functions as an oncogene in BC progression through m6A-dependent feedback loop.N6-methyladenine- induced LINC00667 promoted breast cancer progression through m6A/KIAA1429 positive feedback loop"	M6ADIS0065	31717552	.
M6ACROT05095	REG00007	M6ATAR01707	Non-coding RNA	EPIREG00258	EPITAR00027	.	Down regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"Mechanistically, exosomal lncRNA PAET promoted methyltransferase-like 3 (METTL3) accumulation by increasing its stability, which stimulated N6-methyladenosine (m6A) modification of Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1), and COX4I1 levels were decreased in a mechanism dependent on the m6A ""reader"" YTH domain family 3 (YTHDF3)."	M6ADIS0164	38134679	.
M6ACROT05096	REG00025	M6ATAR01707	Non-coding RNA	EPIREG00258	EPITAR00027	.	Down regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"Mechanistically, exosomal lncRNA PAET promoted methyltransferase-like 3 (Methyltransferase-like protein 3 (METTL3)) accumulation by increasing its stability, which stimulated N6-methyladenosine (m6A) modification of Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1), and COX4I1 levels were decreased in a mechanism dependent on the m6A ""reader"" YTH domain family 3 (YTHDF3)."	M6ADIS0164	38134679	.
M6ACROT05097	REG00005	M6ATAR00404	Non-coding RNA	EPIREG00259	EPITAR00148	.	Up regulation	ncRNA	Indirect	Inhibition	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"Inhibition of MIR155 promoted the expression of Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A) and attenuated the m6A modification of Transcription factor SOX-2 (SOX2) mRNA by regulating ALKBH5, thereby promoting the expression of SOX2 and activating the downstream EGFR/MEK/ERK signaling pathway to promote wound healing in an in vitro DFU model."	M6ADIS0340	39509294	.
M6ACROT05098	REG00013	M6ATAR00206	Non-coding RNA	EPIREG00260	EPITAR00028	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	m6A Modification of Long Non-Coding RNA HNF1A-AS1 Facilitates Cell Cycle Progression in Colorectal Cancer via IGF2BP2-Mediated G1/S-specific cyclin-D1 (CCND1) mRNA Stabilization	M6ADIS0059	36230970	.
M6ACROT05099	REG00001	M6ATAR01060	Non-coding RNA	EPIREG00261	EPITAR00179	.	Down regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"BMSC-derived exosomal KLF4 promoted lncRNA-ZFAS1 expression to repress Dynamin-1-like protein (DRP1) m6A modification by targeting FTO, thus reducing mitochondrial dysfunction and alleviating neuronal injury in ischemic stroke."	M6ADIS0091	37002530	.
M6ACROT05100	REG00015	M6ATAR01708	Non-coding RNA	EPIREG00262	EPITAR00240	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"VIRMA-mediated m6A modification up-regulated lncRNA endogenous Bornavirus like nucleoprotein 3, pseudogene (EBLN3P) expression, and lncRNA EBLN3P increased KIAA1429 expression by competitively binding to hsa-miR-153-3p, thus reducing ferroptosis and increasing the radioresistance of CRC."	M6ADIS0059	38843497	.
M6ACROT05101	REG00015	M6ATAR01708	Non-coding RNA	EPIREG00263	EPITAR00252	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"VIRMA-mediated m6A modification up-regulated lncRNA endogenous Bornavirus like nucleoprotein 3, pseudogene (EBLN3P) expression, and lncRNA EBLN3P increased KIAA1429 expression by competitively binding to hsa-miR-153-3p, thus reducing ferroptosis and increasing the radioresistance of CRC."	M6ADIS0059	38843497	.
M6ACROT05102	REG00003	M6ATAR01709	Non-coding RNA	EPIREG00264	EPITAR00236	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"NAP1L6P activates MMP pathway by stabilizing the m6A-modified Nucleosome assembly protein 1-like 2 (NAP1L2) to promote malignant progression in prostate cancer. lncNAP1L6 recruited HNRNPC to m6A-modified NAP1L2, leading to stabilization of NAP1L2 mRNA."	M6ADIS0068	36195720	.
M6ACROT05103	REG00007	M6ATAR00341	Non-coding RNA	EPIREG00265	EPITAR00027	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	Tumor-suppressive MEG3 induces hsa-miR-493-5p expression to reduce arabinocytosine chemoresistance of acute myeloid leukemia cells by downregulating the METTL3/Myc proto-oncogene protein (MYC) axis	M6ADIS0046	35761379	.
M6ACROT05104	REG00007	M6ATAR00341	Non-coding RNA	EPIREG00249	EPITAR00253	.	Up regulation	ncRNA	Indirect	Inhibition	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	Tumor-suppressive MEG3 induces hsa-miR-493-5p expression to reduce arabinocytosine chemoresistance of acute myeloid leukemia cells by downregulating the METTL3/Myc proto-oncogene protein (MYC) axis	M6ADIS0046	35761379	.
M6ACROT05105	REG00005	M6ATAR00156	Non-coding RNA	EPIREG00209	EPITAR00254	.	Up regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	ALKBH5 regulated STAT3 expression by mediating its m6A modification and long noncoding RNA H19 imprinted maternally expressed transcript (H19)/hsa-miR-124-3p. ALKBH5 also alleviated the H/Post injury induced by the low expression of STAT3 in senescent cardiomyocytes.	M6ADIS0091	36609501	.
M6ACROT05106	REG00022	M6ATAR01710	Non-coding RNA	EPIREG00266	EPITAR00238	.	Down regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"piR-26441 inhibits mitochondrial oxidative phosphorylation and tumorigenesis in ovarian cancer through m6A modification by interacting with YTHDC1.piR-26441 could inhibit OC cell growth via the YTHDC1/Elongation factor Ts, mitochondrial (TSFM) signaling axis, underscoring its significant importance in the context of OC, as well as offering potential as a therapeutic target."	M6ADIS0066	39827178	.
M6ACROT05107	REG00053	M6ATAR00341	Non-coding RNA	EPIREG00267	EPITAR00255	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"LINC00942 up-regulated the MSI2 expression by preventing its interaction with SCFbeta-TRCPE3 ubiquitin ligase, eventually inhibiting ubiquitination. Then, LNC942 stabilized Myc proto-oncogene protein (MYC) mRNA in an N6-methyladenosine (m6A)-dependent manner. As a potential m6A recognition protein, MSI2 stabilized c-Myc mRNA with m6A modifications. Moreover, inhibition of the LNC942-MSI2-c-Myc axis was found to restore chemosensitivity both in vitro and in vivo.LNC942 was found to be up-regulated in chemoresistant GC cells"	M6ADIS0057	35073459	M6ADRUG0047
M6ACROT05108	REG00047	M6ATAR00348	Non-coding RNA	EPIREG00268	EPITAR00256	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Mechanistically, SNAI3-AS1 competitively binds to SND1 and perturbs the m6A-dependent recognition of Nuclear factor erythroid 2-related factor 2 (NFE2L2) mRNA 3'UTR by SND1, thereby reducing the mRNA stability of Nrf2. Epigenetically silenced lncRNA SNAI3-AS1 promotes ferroptosis in glioma via perturbing the m6A-dependent recognition of Nrf2 mRNA mediated by SND1"	M6ADIS0001	37202791	.
M6ACROT05109	REG00013	M6ATAR01711	Non-coding RNA	EPIREG00269	EPITAR00028	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"The LCLAT1-IGF2BP2-Cell division control protein 6 homolog (CDC6) axis appears to play a vital role in promoting the growth and migration of lung cancer cells, and is a potential therapeutic target for lung cancer."	M6ADIS0007	36257938	.
M6ACROT05110	REG00005	M6ATAR01712	Non-coding RNA	EPIREG00270	EPITAR00183	.	Down regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	A positive feedback loop between ALKBH5 and hsa-miR-193a-3p promotes growth and metastasis in esophageal squamous cell carcinoma.	M6ADIS0056	33231844	.
M6ACROT05111	REG00007	M6ATAR00297	Non-coding RNA	EPIREG00271	EPITAR00257	.	Up regulation	ncRNA	Indirect	Inhibition	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	hsa-miR-502-3p targeted YTHDF3 to regulate the translation of Integrin alpha-6 (ITGA6) and targeted Ragulator complex protein LAMTOR5 (LAMTOR5/HBXIP) to inhibit the m6A modification of ITGA6 through methyltransferase-like 3 (METTL3). Long noncoding RNA SNHG3 interacts with microRNA-502-3p to mediate ITGA6 expression in liver hepatocellular carcinoma. SNHG3 controls the YTHDF3/ITGA6 and HBXIP/METTL3/ITGA6 pathways by repressing miR-502-3p expression to sustain the self-renewal properties of CSC in LIHC.	M6ADIS0006	38680094	.
M6ACROT05112	REG00007	M6ATAR00297	Non-coding RNA	EPIREG00272	EPITAR00258	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	hsa-miR-502-3p targeted YTHDF3 to regulate the translation of Integrin alpha-6 (ITGA6) and targeted HBXIP to inhibit the m6A modification of ITGA6 through methyltransferase-like 3 (METTL3). Long noncoding RNA SNHG3 interacts with microRNA-502-3p to mediate ITGA6 expression in liver hepatocellular carcinoma. SNHG3 controls the YTHDF3/ITGA6 and HBXIP/METTL3/ITGA6 pathways by repressing miR-502-3p expression to sustain the self-renewal properties of CSC in LIHC.	M6ADIS0006	38680094	.
M6ACROT05113	REG00025	M6ATAR00297	Non-coding RNA	EPIREG00271	EPITAR00249	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	hsa-miR-502-3p targeted YTHDF3 to regulate the translation of Integrin alpha-6 (ITGA6) and targeted HBXIP to inhibit the m6A modification of ITGA6 through methyltransferase-like 3 (METTL3). Long noncoding RNA SNHG3 interacts with microRNA-502-3p to mediate ITGA6 expression in liver hepatocellular carcinoma. SNHG3 controls the YTHDF3/ITGA6 and HBXIP/METTL3/ITGA6 pathways by repressing miR-502-3p expression to sustain the self-renewal properties of CSC in LIHC.	M6ADIS0006	38680094	.
M6ACROT05114	REG00025	M6ATAR00297	Non-coding RNA	EPIREG00272	EPITAR00258	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	hsa-miR-502-3p targeted YTHDF3 to regulate the translation of Integrin alpha-6 (ITGA6) and targeted HBXIP to inhibit the m6A modification of ITGA6 through methyltransferase-like 3 (METTL3). Long noncoding RNA SNHG3 interacts with microRNA-502-3p to mediate ITGA6 expression in liver hepatocellular carcinoma. SNHG3 controls the YTHDF3/ITGA6 and HBXIP/METTL3/ITGA6 pathways by repressing miR-502-3p expression to sustain the self-renewal properties of CSC in LIHC.	M6ADIS0006	38680094	.
M6ACROT05115	REG00024	M6ATAR00341	Non-coding RNA	EPIREG00273	EPITAR00248	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Mechanistically, m6A methyltransferase METTL3 enhanced the stability of DLGAP1-AS2 via m6A site binding. Moreover, DLGAP1-AS2 interacted with YTHDF1 to enhance the stability of Myc proto-oncogene protein (MYC) mRNA through DLGAP1-AS2/YTHDF1/m6A/c-Myc mRNA"	M6ADIS0007	35972892	.
M6ACROT05116	REG00024	M6ATAR00283	Non-coding RNA	EPIREG00274	EPITAR00248	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"HCP5 was able to directly interact with YTHDF1, a N6-methyladenosine (m6A) reader, enhancing the binding of YTHDF1 to m6A-modified Hexokinase-2 (HK2) mRNA, leading to increasing HK2 stability, thereby promoting the Warburg effect (aerobic glycolysis) of ESCC cells"	M6ADIS0056	35389828	.
M6ACROT05117	REG00024	M6ATAR01713	Non-coding RNA	EPIREG00209	EPITAR00248	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	H19 recruited N6 -methyladenosine (m6A) reader YTHDF1 to promote Scavenger receptor class B member 1 (SCARB1) translation and facilitate angiogenesis in gastric cancer	M6ADIS0057	37279381	.
M6ACROT05118	REG00045	M6ATAR01714	Non-coding RNA	EPIREG00275	EPITAR00259	.	Down regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	m6A transferase METTL3 regulates endothelial-mesenchymal transition in diabetic retinopathy via lncRNA SNHG7/KHSRP/Myocardin-related transcription factor A (MKL1) axis	M6ADIS0015	36174881	.
M6ACROT05119	REG00001	M6ATAR01715	Non-coding RNA	EPIREG00276	EPITAR00179	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"Circ_GPR137B, co-localized with hsa-miR-4739 in the cytoplasm, acted as a sponge for miR-4739 to upregulate its target FTO, which mediated m6A demethylation of circGPR137B and promoted its expression. Thus, a feedback loop comprising circGPR137B/miR-4739/FTO axis was formed. FTO suppressed cell growth and indicated favorable survival in patients with HCC."	M6ADIS0006	35858900	.
M6ACROT05120	REG00001	M6ATAR01715	Non-coding RNA	EPIREG00277	EPITAR00260	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"Circ_GPR137B, co-localized with hsa-miR-4739 in the cytoplasm, acted as a sponge for miR-4739 to upregulate its target FTO, which mediated m6A demethylation of circGPR137B and promoted its expression. Thus, a feedback loop comprising circGPR137B/miR-4739/FTO axis was formed. FTO suppressed cell growth and indicated favorable survival in patients with HCC."	M6ADIS0006	35858900	.
M6ACROT05121	REG00006	M6ATAR00922	Non-coding RNA	EPIREG00278	EPITAR00195	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"Exosomes derived from M1 macrophages transferred hsa-miR-628-5p to HCC cells to inhibit human methyltransferase-like 14 (METTL14) expression. METTL14 promoted Circ_FUT8 m6A modification and facilitated its nuclear export to the cytoplasm, where M1 macrophages regulated the circFUT8/miR-552-3p/CHMP4B pathway, thereby suppressing HCC progression."	M6ADIS0006	36474147	.
M6ACROT05122	REG00004	M6ATAR01716	Non-coding RNA	EPIREG00279	EPITAR00212	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"SNHG7 was upregulated significantly by c-Jun/c-Fos in Regulation of nuclear pre-mRNA domain-containing protein 1B (RPRD1B)-overexpressing cells. NEAT1, in turn, increased the stability of the RPRD1B mRNA by recruiting the m6A ""reader"" protein HNRNPA2B1 and reduced the degradation of the RPRD1B protein by inhibiting TRIM25-mediated ubiquitination. "	M6ADIS0057	36171622	.
M6ACROT05123	REG00006	M6ATAR00274	Non-coding RNA	EPIREG00241	EPITAR00195	.	Down regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	LncRNA UCA1 promotes keratinocyte-driven inflammation via suppressing METTL14 and activating the Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A)/NF-kappaB axis in psoriasis	M6ADIS0172	37076497	.
M6ACROT05124	REG00022	M6ATAR01717	Non-coding RNA	EPIREG00280	EPITAR00238	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	MIR22HG facilitates ferritinophagy-mediated ferroptosis in sepsis by recruiting the m6A reader YTHDC1 and enhancing Angiopoietin-related protein 4 (ANGPTL4) mRNA stability	.	38842666	.
M6ACROT05125	REG00001	M6ATAR01718	Non-coding RNA	EPIREG00281	EPITAR00179	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"Ang II induced downregulation of Circ_CELF1 expression, while circCELF1 enhanced the expression of Dickkopf-related protein 2 (DKK2) by adsorbing miR-636. circCELF1 also reduced DKK2 m6A level by upregulating FTO expression, thereby inhibiting the binding of miR-636 to DKK2 and promoting DKK2 expression."	M6ADIS0142	35132536	.
M6ACROT05126	REG00014	M6ATAR01719	Non-coding RNA	EPIREG00282	EPITAR00261	.	Up regulation	ncRNA	Indirect	Inhibition	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"LINC01089 interacted with Heterogeneous nuclear ribonucleoprotein M (HNRNPM) and led to hnRNPM-mediated skipping of Protein diaphanous homolog 3 (DIAPH3) exon 3. Knockdown of LINC01089 increased the inclusion of DIAPH3 exon 3, which contains an important m6A-modification site that is recognized by IGF2BP3 to increase DIAPH3 mRNA stability. Thus, LINC01089 loss increased DIAPH3 protein levels, which suppressed the ERK/Elk1/Snail axis and inhibited EMT of HCC cells."	M6ADIS0006	37756562	.
M6ACROT05127	REG00001	M6ATAR00341	Non-coding RNA	EPIREG00283	EPITAR00179	.	Down regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	hsa-let-7b-5p Inhibits Proliferation of Human Leukemia THP-1 Cells via FTO/m6A/Myc proto-oncogene protein (MYC) Signaling Pathway	M6ADIS0046	33283713	.
M6ACROT05128	REG00054	M6ATAR00216	Non-coding RNA	EPIREG00284	EPITAR00075	.	.	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"Mechanically, hsa-miR-204 reduced METTL7A expression to Cell death activator CIDE-3 (CIDEC) m6A methylation, thus suppressing OS and mitochondrial dysfunction."	M6ADIS0117	38334961	.
M6ACROT05129	REG00004	M6ATAR00010	Non-coding RNA	EPIREG00285	EPITAR00212	.	Down regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Mechanically, PCAT6 functions as a scaffold between interferon-stimulated gene 15 (ISG15) and heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), leading to ISGylation of hnRNPA2B1, thus protecting hnRNPA2B1 from ubiquitination-mediated proteasomal degradation.HNRNPA2B1 is a reader of the N(6)-methyladenosine mark in primary-miRNAs and promotes DROSHA processing to precursor-miRNAs. HNRNPA2B1 downregulated hsa-miR-29a-3p, miR-29b-3p, and miR-222 and upregulated miR-1266-5p, miR-1268a, miR-671-3p. Transient overexpression of HNRNPA2/B1 reduced breast cancer cellMCF-7 sensitivity to 4-hydroxytamoxifen and fulvestrant, suggesting a role for HNRNPA2/B1 in endocrine-resistance."	M6ADIS0065	38626369; 31263129	M6ADRUG0028
M6ACROT05130	REG00004	M6ATAR00011	Non-coding RNA	EPIREG00285	EPITAR00212	.	Down regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Mechanically, PCAT6 functions as a scaffold between interferon-stimulated gene 15 (ISG15) and heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), leading to ISGylation of hnRNPA2B1, thus protecting hnRNPA2B1 from ubiquitination-mediated proteasomal degradation.HNRNPA2B1 is a reader of the N(6)-methyladenosine mark in primary-miRNAs and promotes DROSHA processing to precursor-miRNAs. HNRNPA2B1 downregulated hsa-miR-29a-3p, hsa-miR-29b-3p, and miR-222 and upregulated miR-1266-5p, miR-1268a, miR-671-3p. Transient overexpression of HNRNPA2/B1 reduced breast cancer cellMCF-7 sensitivity to 4-hydroxytamoxifen and fulvestrant, suggesting a role for HNRNPA2/B1 in endocrine-resistance."	M6ADIS0065	38626369; 31263129	M6ADRUG0028
M6ACROT05131	REG00004	M6ATAR00129	Non-coding RNA	EPIREG00285	EPITAR00212	.	Down regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Mechanically, PCAT6 functions as a scaffold between interferon-stimulated gene 15 (ISG15) and heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), leading to ISGylation of hnRNPA2B1, thus protecting hnRNPA2B1 from ubiquitination-mediated proteasomal degradation.HNRNPA2B1 is a reader of the N(6)-methyladenosine mark in primary-miRNAs and promotes DROSHA processing to precursor-miRNAs. HNRNPA2B1 downregulated hsa-miR-29a-3p, miR-29b-3p, and microRNA 222 (MIR222) and upregulated miR-1266-5p, miR-1268a, miR-671-3p. Transient overexpression of HNRNPA2/B1 reduced breast cancer cellMCF-7 sensitivity to 4-hydroxytamoxifen and fulvestrant, suggesting a role for HNRNPA2/B1 in endocrine-resistance."	M6ADIS0065	38626369; 31263129	M6ADRUG0028
M6ACROT05132	REG00004	M6ATAR00012	Non-coding RNA	EPIREG00285	EPITAR00212	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Mechanically, PCAT6 functions as a scaffold between interferon-stimulated gene 15 (ISG15) and heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), leading to ISGylation of hnRNPA2B1, thus protecting hnRNPA2B1 from ubiquitination-mediated proteasomal degradation.HNRNPA2B1 is a reader of the N(6)-methyladenosine mark in primary-miRNAs and promotes DROSHA processing to precursor-miRNAs. HNRNPA2B1 downregulated hsa-miR-29a-3p, miR-29b-3p, and miR-222 and upregulated hsa-miR-1266-5p, miR-1268a, miR-671-3p. Transient overexpression of HNRNPA2/B1 reduced breast cancer cellMCF-7 sensitivity to 4-hydroxytamoxifen and fulvestrant, suggesting a role for HNRNPA2/B1 in endocrine-resistance."	M6ADIS0065	38626369; 31263129	M6ADRUG0028
M6ACROT05133	REG00004	M6ATAR00013	Non-coding RNA	EPIREG00285	EPITAR00212	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Mechanically, PCAT6 functions as a scaffold between interferon-stimulated gene 15 (ISG15) and heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), leading to ISGylation of hnRNPA2B1, thus protecting hnRNPA2B1 from ubiquitination-mediated proteasomal degradation.HNRNPA2B1 is a reader of the N(6)-methyladenosine mark in primary-miRNAs and promotes DROSHA processing to precursor-miRNAs. HNRNPA2B1 downregulated hsa-miR-29a-3p, miR-29b-3p, and miR-222 and upregulated miR-1266-5p, hsa-miR-1268a, miR-671-3p. Transient overexpression of HNRNPA2/B1 reduced breast cancer cellMCF-7 sensitivity to 4-hydroxytamoxifen and fulvestrant, suggesting a role for HNRNPA2/B1 in endocrine-resistance."	M6ADIS0065	38626369; 31263129	M6ADRUG0028
M6ACROT05134	REG00004	M6ATAR00014	Non-coding RNA	EPIREG00285	EPITAR00212	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Mechanically, PCAT6 functions as a scaffold between interferon-stimulated gene 15 (ISG15) and heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), leading to ISGylation of hnRNPA2B1, thus protecting hnRNPA2B1 from ubiquitination-mediated proteasomal degradation.HNRNPA2B1 is a reader of the N(6)-methyladenosine mark in primary-miRNAs and promotes DROSHA processing to precursor-miRNAs. HNRNPA2B1 downregulated hsa-miR-29a-3p, miR-29b-3p, and miR-222 and upregulated miR-1266-5p, miR-1268a, hsa-miR-671-3p. Transient overexpression of HNRNPA2/B1 reduced breast cancer cellMCF-7 sensitivity to 4-hydroxytamoxifen and fulvestrant, suggesting a role for HNRNPA2/B1 in endocrine-resistance."	M6ADIS0065	38626369; 31263129	M6ADRUG0028
M6ACROT05135	REG00004	M6ATAR00385	Non-coding RNA	EPIREG00285	EPITAR00212	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Mechanically, PCAT6 functions as a scaffold between interferon-stimulated gene 15 (ISG15) and heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), leading to ISGylation of hnRNPA2B1, thus protecting hnRNPA2B1 from ubiquitination-mediated proteasomal degradation.HNRNPA2B1 is a reader of the N(6)-methyladenosine mark in primary-miRNAs and promotes Ribonuclease 3 (DROSHA) processing to precursor-miRNAs. HNRNPA2B1 downregulated hsa-miR-29a-3p, miR-29b-3p, and miR-222 and upregulated miR-1266-5p, miR-1268a, miR-671-3p. Transient overexpression of HNRNPA2/B1 reduced breast cancer cellMCF-7 sensitivity to 4-hydroxytamoxifen and fulvestrant, suggesting a role for HNRNPA2/B1 in endocrine-resistance."	M6ADIS0065	38626369; 31263129	M6ADRUG0039
M6ACROT05136	REG00004	M6ATAR00010	Non-coding RNA	EPIREG00285	EPITAR00212	.	Down regulation	ncRNA	Direct	Enhancement	m6A	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Mechanically, PCAT6 functions as a scaffold between interferon-stimulated gene 15 (ISG15) and heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), leading to ISGylation of hnRNPA2B1, thus protecting hnRNPA2B1 from ubiquitination-mediated proteasomal degradation.HNRNPA2B1 is a reader of the N(6)-methyladenosine mark in primary-miRNAs and promotes DROSHA processing to precursor-miRNAs. HNRNPA2B1 downregulated hsa-miR-29a-3p, miR-29b-3p, and miR-222 and upregulated miR-1266-5p, miR-1268a, miR-671-3p. Transient overexpression of HNRNPA2/B1 reduced breast cancer cellMCF-7 sensitivity to 4-hydroxytamoxifen and fulvestrant, suggesting a role for HNRNPA2/B1 in endocrine-resistance."	M6ADIS0006	38486042	M6ADRUG0032
M6ACROT05137	REG00004	M6ATAR00011	Non-coding RNA	EPIREG00285	EPITAR00212	.	Down regulation	ncRNA	Direct	Enhancement	m6A	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Mechanically, PCAT6 functions as a scaffold between interferon-stimulated gene 15 (ISG15) and heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), leading to ISGylation of hnRNPA2B1, thus protecting hnRNPA2B1 from ubiquitination-mediated proteasomal degradation.HNRNPA2B1 is a reader of the N(6)-methyladenosine mark in primary-miRNAs and promotes DROSHA processing to precursor-miRNAs. HNRNPA2B1 downregulated hsa-miR-29a-3p, hsa-miR-29b-3p, and miR-222 and upregulated miR-1266-5p, miR-1268a, miR-671-3p. Transient overexpression of HNRNPA2/B1 reduced breast cancer cellMCF-7 sensitivity to 4-hydroxytamoxifen and fulvestrant, suggesting a role for HNRNPA2/B1 in endocrine-resistance."	M6ADIS0006	38486042	M6ADRUG0032
M6ACROT05138	REG00004	M6ATAR00129	Non-coding RNA	EPIREG00285	EPITAR00212	.	Down regulation	ncRNA	Direct	Enhancement	m6A	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Mechanically, PCAT6 functions as a scaffold between interferon-stimulated gene 15 (ISG15) and heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), leading to ISGylation of hnRNPA2B1, thus protecting hnRNPA2B1 from ubiquitination-mediated proteasomal degradation.HNRNPA2B1 is a reader of the N(6)-methyladenosine mark in primary-miRNAs and promotes DROSHA processing to precursor-miRNAs. HNRNPA2B1 downregulated hsa-miR-29a-3p, miR-29b-3p, and microRNA 222 (MIR222) and upregulated miR-1266-5p, miR-1268a, miR-671-3p. Transient overexpression of HNRNPA2/B1 reduced breast cancer cellMCF-7 sensitivity to 4-hydroxytamoxifen and fulvestrant, suggesting a role for HNRNPA2/B1 in endocrine-resistance."	M6ADIS0065	33420414	M6ADRUG0034
M6ACROT05139	REG00004	M6ATAR00012	Non-coding RNA	EPIREG00285	EPITAR00212	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Mechanically, PCAT6 functions as a scaffold between interferon-stimulated gene 15 (ISG15) and heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), leading to ISGylation of hnRNPA2B1, thus protecting hnRNPA2B1 from ubiquitination-mediated proteasomal degradation.HNRNPA2B1 is a reader of the N(6)-methyladenosine mark in primary-miRNAs and promotes DROSHA processing to precursor-miRNAs. HNRNPA2B1 downregulated hsa-miR-29a-3p, miR-29b-3p, and miR-222 and upregulated hsa-miR-1266-5p, miR-1268a, miR-671-3p. Transient overexpression of HNRNPA2/B1 reduced breast cancer cellMCF-7 sensitivity to 4-hydroxytamoxifen and fulvestrant, suggesting a role for HNRNPA2/B1 in endocrine-resistance."	M6ADIS0065	38626369; 31263129	M6ADRUG0039
M6ACROT05140	REG00004	M6ATAR00013	Non-coding RNA	EPIREG00285	EPITAR00212	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Mechanically, PCAT6 functions as a scaffold between interferon-stimulated gene 15 (ISG15) and heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), leading to ISGylation of hnRNPA2B1, thus protecting hnRNPA2B1 from ubiquitination-mediated proteasomal degradation.HNRNPA2B1 is a reader of the N(6)-methyladenosine mark in primary-miRNAs and promotes DROSHA processing to precursor-miRNAs. HNRNPA2B1 downregulated hsa-miR-29a-3p, miR-29b-3p, and miR-222 and upregulated miR-1266-5p, hsa-miR-1268a, miR-671-3p. Transient overexpression of HNRNPA2/B1 reduced breast cancer cellMCF-7 sensitivity to 4-hydroxytamoxifen and fulvestrant, suggesting a role for HNRNPA2/B1 in endocrine-resistance."	M6ADIS0065	38626369; 31263129	M6ADRUG0039
M6ACROT05141	REG00004	M6ATAR00014	Non-coding RNA	EPIREG00285	EPITAR00212	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Mechanically, PCAT6 functions as a scaffold between interferon-stimulated gene 15 (ISG15) and heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), leading to ISGylation of hnRNPA2B1, thus protecting hnRNPA2B1 from ubiquitination-mediated proteasomal degradation.HNRNPA2B1 is a reader of the N(6)-methyladenosine mark in primary-miRNAs and promotes DROSHA processing to precursor-miRNAs. HNRNPA2B1 downregulated hsa-miR-29a-3p, miR-29b-3p, and miR-222 and upregulated miR-1266-5p, miR-1268a, hsa-miR-671-3p. Transient overexpression of HNRNPA2/B1 reduced breast cancer cellMCF-7 sensitivity to 4-hydroxytamoxifen and fulvestrant, suggesting a role for HNRNPA2/B1 in endocrine-resistance."	M6ADIS0065	38626369; 31263129	M6ADRUG0039
M6ACROT05142	REG00004	M6ATAR00385	Non-coding RNA	EPIREG00285	EPITAR00212	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Mechanically, PCAT6 functions as a scaffold between interferon-stimulated gene 15 (ISG15) and heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), leading to ISGylation of hnRNPA2B1, thus protecting hnRNPA2B1 from ubiquitination-mediated proteasomal degradation.HNRNPA2B1 is a reader of the N(6)-methyladenosine mark in primary-miRNAs and promotes Ribonuclease 3 (DROSHA) processing to precursor-miRNAs. HNRNPA2B1 downregulated hsa-miR-29a-3p, miR-29b-3p, and miR-222 and upregulated miR-1266-5p, miR-1268a, miR-671-3p. Transient overexpression of HNRNPA2/B1 reduced breast cancer cellMCF-7 sensitivity to 4-hydroxytamoxifen and fulvestrant, suggesting a role for HNRNPA2/B1 in endocrine-resistance."	M6ADIS0065	38626369; 31263129	M6ADRUG0028
M6ACROT05143	REG00004	M6ATAR00175	Non-coding RNA	EPIREG00285	EPITAR00212	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Mechanically, PCAT6 functions as a scaffold between interferon-stimulated gene 15 (ISG15) and heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), leading to ISGylation of hnRNPA2B1, thus protecting hnRNPA2B1 from ubiquitination-mediated proteasomal degradation.In breast cancer, modest stable overexpression of A2B1 in MCF-7 cells (MCF-7-A2B1 cells) resulted in tamoxifen and fulvestrant - resistance whereas knockdown of A2B1 in LCC9 and LY2 cells restored tamoxifen and fulvestrant, endocrine-sensitivity. MCF-7-A2B1 cells have increased ER-alpha and reduced miR-222-3p that targets ER-alpha. MCF-7-A2B1 have activated RAC-alpha serine/threonine-protein kinase (RAC-alpha serine/threonine-protein kinase (AKT1)1) and MAPK that depend on A2B1 expression and are growth inhibited by inhibitors of these pathways."	M6ADIS0065	38626369; 34273466	M6ADRUG0039
M6ACROT05144	REG00004	M6ATAR00327	Non-coding RNA	EPIREG00285	EPITAR00212	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Mechanically, PCAT6 functions as a scaffold between interferon-stimulated gene 15 (ISG15) and heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), leading to ISGylation of hnRNPA2B1, thus protecting hnRNPA2B1 from ubiquitination-mediated proteasomal degradation.In breast cancer, modest stable overexpression of A2B1 in MCF-7 cells (MCF-7-A2B1 cells) resulted in tamoxifen and fulvestrant - resistance whereas knockdown of A2B1 in LCC9 and LY2 cells restored tamoxifen and fulvestrant, endocrine-sensitivity. MCF-7-A2B1 cells have increased ER-alpha and reduced miR-222-3p that targets ER-alpha. MCF-7-A2B1 have activated RAC-alpha serine/threonine-protein kinase (AKT1) and Mitogen-activated protein kinase 1 (MAPK/ERK2/MAPK1) that depend on A2B1 expression and are growth inhibited by inhibitors of these pathways."	M6ADIS0065	38626369; 34273466	M6ADRUG0039
M6ACROT05145	REG00004	M6ATAR00175	Non-coding RNA	EPIREG00285	EPITAR00212	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Mechanically, PCAT6 functions as a scaffold between interferon-stimulated gene 15 (ISG15) and heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), leading to ISGylation of hnRNPA2B1, thus protecting hnRNPA2B1 from ubiquitination-mediated proteasomal degradation.In breast cancer, modest stable overexpression of A2B1 in MCF-7 cells (MCF-7-A2B1 cells) resulted in tamoxifen and fulvestrant - resistance whereas knockdown of A2B1 in LCC9 and LY2 cells restored tamoxifen and fulvestrant, endocrine-sensitivity. MCF-7-A2B1 cells have increased ER-alpha and reduced miR-222-3p that targets ER-alpha. MCF-7-A2B1 have activated RAC-alpha serine/threonine-protein kinase (RAC-alpha serine/threonine-protein kinase (AKT1)1) and MAPK that depend on A2B1 expression and are growth inhibited by inhibitors of these pathways."	M6ADIS0065	38626369; 34273466	M6ADRUG0028
M6ACROT05146	REG00004	M6ATAR00327	Non-coding RNA	EPIREG00285	EPITAR00212	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Mechanically, PCAT6 functions as a scaffold between interferon-stimulated gene 15 (ISG15) and heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), leading to ISGylation of hnRNPA2B1, thus protecting hnRNPA2B1 from ubiquitination-mediated proteasomal degradation.In breast cancer, modest stable overexpression of A2B1 in MCF-7 cells (MCF-7-A2B1 cells) resulted in tamoxifen and fulvestrant - resistance whereas knockdown of A2B1 in LCC9 and LY2 cells restored tamoxifen and fulvestrant, endocrine-sensitivity. MCF-7-A2B1 cells have increased ER-alpha and reduced miR-222-3p that targets ER-alpha. MCF-7-A2B1 have activated RAC-alpha serine/threonine-protein kinase (AKT1) and Mitogen-activated protein kinase 1 (MAPK/ERK2/MAPK1) that depend on A2B1 expression and are growth inhibited by inhibitors of these pathways."	M6ADIS0065	38626369; 34273466	M6ADRUG0028
M6ACROT05147	REG00004	M6ATAR00888	Non-coding RNA	EPIREG00285	EPITAR00212	.	Down regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Mechanically, PCAT6 functions as a scaffold between interferon-stimulated gene 15 (ISG15) and heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), leading to ISGylation of hnRNPA2B1, thus protecting hnRNPA2B1 from ubiquitination-mediated proteasomal degradation.Overexpression of Cysteine protease ATG4B (ATG4B) rescued the malignancy driven by HNRNPA2B1 in breast cancer cells and increased the olaparib sensitivity. Our study revealed that the m6A reader HNRNPA2B1 mediated proliferation and autophagy in breast cancer cell lines by facilitating ATG4B mRNA decay and targeting HNRNPA2B1/m6A/ATG4B might enhance the olaparib sensitivity of breast cancer cells."	M6ADIS0065	38626369; 36693492	M6ADRUG0097
M6ACROT05148	REG00006	M6ATAR00393	Non-coding RNA	EPIREG00286	EPITAR00195	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	hsa-miR-103-3p targets the m6 A methyltransferase METTL14 to inhibit osteoblastic bone formation.METTL14 alleviates the development of osteoporosis in ovariectomized mice by upregulating m6A level of NAD-dependent protein deacetylase sirtuin-1 (SIRT1) mRNA	M6ADIS0115	33440070; 36584783	.
M6ACROT05149	REG00006	M6ATAR00278	Non-coding RNA	EPIREG00286	EPITAR00195	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	hsa-miR-103-3p targets the m6 A methyltransferase METTL14 to inhibit osteoblastic bone formation.METTL14 plays a protective role against OP by promoting the Hepatocyte nuclear factor 1-alpha (HNF1A/TCF1)/RUNX2 axis.	M6ADIS0115	33440070; 36401086	.
M6ACROT05150	REG00006	M6ATAR01414	Non-coding RNA	EPIREG00286	EPITAR00195	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	hsa-miR-103-3p targets the m6 A methyltransferase METTL14 to inhibit osteoblastic bone formation.METTL14 represses osteoclast formation to ameliorate osteoporosis via enhancing Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4) mRNA stability	M6ADIS0115	33440070; 37195267	.
M6ACROT05151	REG00006	M6ATAR01077	Non-coding RNA	EPIREG00286	EPITAR00195	.	.	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hsa-miR-103-3p targets the m6 A methyltransferase METTL14 to inhibit osteoblastic bone formation.METTL14 released by exosomes can increase the m6A methylation level of Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) to inhibit osteoclasts, help postmenopausal osteoporosis patients preserve bone mass, and avoid triggering osteonecrosis of the jaw, thus becoming a new bioactive molecule for the treatment of osteoporosis."	M6ADIS0115	33440070; 37957146	.
M6ACROT05152	REG00006	M6ATAR01352	Non-coding RNA	EPIREG00286	EPITAR00195	.	.	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hsa-miR-103-3p targets the m6 A methyltransferase METTL14 to inhibit osteoblastic bone formation. METTL14 promotes Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3) expression via YTHDF1, leading to the modulation of various parameters in the H2O2-induced model. Similar positive effects of METTL14 on osteogenesis were observed in an ovariectomized mouse osteoporosis model. DISCUSSION METTL14 could serve as a potential therapeutic approach for enhancing osteoporosis treatment."	M6ADIS0115	33440070; 39737912	.
M6ACROT05153	REG00006	M6ATAR01359	Non-coding RNA	EPIREG00286	EPITAR00195	.	.	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hsa-miR-103-3p targets the m6 A methyltransferase METTL14 to inhibit osteoblastic bone formation.METTL14 knockdown overturned the promotive effects of ICA on Protein disulfide-isomerase (P4HB) m6A level and BMSC osteogenic differentiation. To sum up, ICA elevated the METTL14-mediated m6A modification of P4HB to facilitate BMSC osteogenic differentiation."	M6ADIS0115	33440070; 38906316	M6ADRUG0143
M6ACROT05154	REG00005	M6ATAR00393	Non-coding RNA	EPIREG00270	EPITAR00183	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"Suxiao Jiuxin Pill alleviates myocardial ischemia/reperfusion-induced autophagy via miR-193a-3p/ALKBH5 pathway.there was an enriched m6A motif in the 3'-UTR of NAD-dependent protein deacetylase sirtuin-1 (SIRT1) genome, and ALKBH5 overexpression promoted the stability of SIRT1 mRNA."	M6ADIS0159	38301300; 37193033	M6ADRUG0192
M6ACROT05155	REG00009	M6ATAR00401	Non-coding RNA	EPIREG00287	EPITAR00269	.	Up regulation	ncRNA	Indirect	Inhibition	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"The encoded micropeptide AC115619-22aa inhibited the progression of HCC by binding to WTAP and impeding the assembly of the N6-methyladenosine (m6A) methyltransferase complex, which regulates the expression of tumor-associated genes, such as Suppressor of cytokine signaling 2 (SOCS2) and ATG14. Hypoxia-Responsive lncRNA AC115619 Encodes a Micropeptide That Suppresses m6A Modifications and Hepatocellular Carcinoma Progression"	M6ADIS0006	37326474	.
M6ACROT05156	REG00009	M6ATAR00194	Non-coding RNA	EPIREG00287	EPITAR00269	.	Up regulation	ncRNA	Indirect	Inhibition	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"The encoded micropeptide AC115619-22aa inhibited the progression of HCC by binding to WTAP and impeding the assembly of the N6-methyladenosine (m6A) methyltransferase complex, which regulates the expression of tumor-associated genes, such as SOCS2 and Beclin 1-associated autophagy-related key regulator (ATG14). Hypoxia-Responsive lncRNA AC115619 Encodes a Micropeptide That Suppresses m6A Modifications and Hepatocellular Carcinoma Progression"	M6ADIS0006	37326474	.
M6ACROT05157	REG00009	M6ATAR01241	Non-coding RNA	EPIREG00288	EPITAR00262	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"piR-27222 could deubiquitinate and stabilize Eukaryotic translation initiation factor 4B (EIF4B) by directly binding to eIF4B and reducing its interaction with PARK2. The enhanced expression of eIF4B, in turn, promoted the expression of WTAP, leading to increased m6A modification in the Caspase-8 (CASP8) transcript."	M6ADIS0007	39106633	.
M6ACROT05158	REG00013	M6ATAR00283	Non-coding RNA	EPIREG00289	EPITAR00028	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"lncRNA MIR4458HG modulates hepatocellular carcinoma progression by activating m6A-dependent glycolysis and promoting the polarization of tumor-associated macrophages.Mechanistically, miR4458HG bound IGF2BP2 (a key RNA m6A reader) and facilitated IGF2BP2-mediated target mRNA stability, including Hexokinase-2 (HK2) and SLC2A1 (GLUT1), and consequently altered HCC glycolysis and tumor cell physiology"	M6ADIS0006	36933158	.
M6ACROT05159	REG00013	M6ATAR00269	Non-coding RNA	EPIREG00289	EPITAR00028	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"lncRNA MIR4458HG modulates hepatocellular carcinoma progression by activating m6A-dependent glycolysis and promoting the polarization of tumor-associated macrophages.Mechanistically, miR4458HG bound IGF2BP2 (a key RNA m6A reader) and facilitated IGF2BP2-mediated target mRNA stability, including HK2 and Glucose transporter type 1 (GLUT1) (GLUT1), and consequently altered HCC glycolysis and tumor cell physiology"	M6ADIS0006	36933158	.
M6ACROT05160	REG00006	M6ATAR01728	Non-coding RNA	EPIREG00290	EPITAR00195	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Lnc-Gm10532 increased Mitochondrial fission 1 protein (FIS1) expression and mitochondrial fission by recruiting the m6A writer methyltransferase-like 14 (METTL14) and enhancing m6A modification of Fis1 mRNA. Moreover, lnc-Gm10532 was also required for chronic Cd-induced mitochondrial dysfunction and memory deficits in a rodent model. Therefore, data of this study reveal a new epigenetic mechanism of chronic Cd neurotoxicity."	M6ADIS0342	36336035	.
M6ACROT05161	REG00007	M6ATAR00605	Non-coding RNA	EPIREG00291	EPITAR00027	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hucMSCs-EVs inhibited the secretion of pro-inflammatory factors and the degradation of cartilage ECM after lowering the m6A level of NACHT, LRR and PYD domains-containing protein 3 (NLRP3) mRNA with hsa-miR-1208 targeting combined with METTL3, thereby alleviating OA progression in mice and providing a novel therapy for clinical OA treatment."	M6ADIS0110	35842714	.
M6ACROT05162	REG00007	M6ATAR00433	Non-coding RNA	EPIREG00292	EPITAR00027	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	LINC01410 accelerates the invasion of trophoblast cells by modulating METTL3/Tumor necrosis factor receptor superfamily member 6 (FAS).	M6ADIS0311	39115693	.
M6ACROT05163	REG00001	M6ATAR00341	Non-coding RNA	EPIREG00293	EPITAR00263	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"LINC00858 modulated Myc proto-oncogene protein (MYC) m6A modification via FTO by recruiting Zinc finger protein 184 (ZNF184), thus facilitating ESCC progression."	M6ADIS0056	36868327	.
M6ACROT05164	REG00007	M6ATAR01729	Non-coding RNA	EPIREG00291	EPITAR00027	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hsa-miR-1208 downregulated the m6A methylation level of Nuclear pore complex protein Nup214 (NUP214) mRNA by negatively regulating the expression of METTL3, thereby NUP214 expression and TGF-beta pathway activity were suppressed."	M6ADIS0001	37580442	.
M6ACROT05165	REG00026	M6ATAR01730	Non-coding RNA	EPIREG00294	EPITAR00245	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"Hypoxic GSC-induced neuron activation promotes GBM progression by polarizing microglia via the exosomal hsa-miR-200c-3p/ZC3H13/Dual specificity protein phosphatase 9 (DUSP9)/p-ERK pathway. Levetiracetam, an antiepileptic drug, blocks the abnormal activation of neurons in GBM and impairs activity-dependent GBM progression."	M6ADIS0001	37855702	M6ADRUG0193
M6ACROT05166	REG00006	.	Non-coding RNA	EPIREG00295	EPITAR00195	.	.	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	The regulatory role of Lnc-SMAD7 in controlling METTL14 gene expression underscores its significance in mediating m6A modifications to regulate lipid synthesis in mammary epithelial cell	.	38320638	.
M6ACROT05167	REG00007	M6ATAR00944	Non-coding RNA	EPIREG00296	EPITAR00027	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	METTL3/Long intergenic non-protein coding RNA 662 (LINC00662)/hsa-miR-186-5p feedback loop regulates docetaxel resistance in triple negative breast cancer 	M6ADIS0184	36202872	M6ADRUG0194
M6ACROT05168	REG00007	M6ATAR00944	Non-coding RNA	EPIREG00210	EPITAR00264	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	METTL3/Long intergenic non-protein coding RNA 662 (LINC00662)/hsa-miR-186-5p feedback loop regulates docetaxel resistance in triple negative breast cancer 	M6ADIS0184	36202872	M6ADRUG0194
M6ACROT05169	REG00007	M6ATAR01731	Non-coding RNA	EPIREG00265	EPITAR00027	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"the METTL3/Paired box protein Pax-8 (PAX8)/YTHDC1 axis has been revealed to play a pivotal role in repressing tumour occurrence, and is antagonized by hsa-miR-493-5p."	M6ADIS0073	38993572	M6ADRUG0195
M6ACROT05170	REG00022	M6ATAR01731	Non-coding RNA	EPIREG00265	EPITAR00027	.	Up regulation	ncRNA	Indirect	Inhibition	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"the Methyltransferase-like protein 3 (METTL3)/Paired box protein Pax-8 (PAX8)/YTHDC1 axis has been revealed to play a pivotal role in repressing tumour occurrence, and is antagonized by hsa-miR-493-5p."	M6ADIS0073	38993572	M6ADRUG0195
M6ACROT05171	REG00001	M6ATAR01308	Non-coding RNA	EPIREG00297	EPITAR00265	.	Down regulation	m6A	Direct	Enhancement	ncRNA	m6A modification regulates the functionality of ncRNAs through by altering the methylation levels of shared targets	"Mechanistically, the risk allele of rs67734009 increased Estrogen receptor (ESR1) expression via hsa-miR-3492 binding and m6A modification which is regulated by FTO. "	M6ADIS0059	39111169	.
M6ACROT05172	REG00012	M6ATAR00341	Non-coding RNA	EPIREG00298	EPITAR00234	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"LncRNA FARP1 served as scaffold to facilitate the formation of the IGF2 mRNA binding protein 1 (IGF2BP1)-Myc proto-oncogene protein (MYC) complex, which led to the activation of the downstream tumor-promoting c-Myc-associated signal pathways."	M6ADIS0046	38048862	M6ADRUG0165
M6ACROT05173	REG00006	M6ATAR00223	Non-coding RNA	EPIREG00299	EPITAR00195	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	The facilitation of Circ_METTL14(11)/METTL14/C-X-C chemokine receptor type 4 (CXCR4) on TNF-alpha-induced endothelial inflammation of HUVECs was verified.	M6ADIS0125	37972448	.
M6ACROT05174	REG00006	M6ATAR01625	Non-coding RNA	EPIREG00300	EPITAR00195	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"METTL14 overexpression prohibits BCa cell migration, invasion in vitro and tumor metastasis in vivo. METTL14 stabilizes Ubiquitin carboxyl-terminal hydrolase 38 (USP38) mRNA by inducing N6-methyladenosine (m6A) modification and enhances USP38 mRNA stability in YTHDF2-dependent manner. METTL14 represses BCa cell migration, invasion and EMT via USP38. Additionally, hsa-miR-3165 inhibits METTL14 expression to promote BCa progression."	M6ADIS0070	36288387	.
M6ACROT05175	REG00008	M6ATAR01625	Non-coding RNA	EPIREG00300	EPITAR00195	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"Methyltransferase-like protein 14 (METTL14) overexpression prohibits BCa cell migration, invasion in vitro and tumor metastasis in vivo. METTL14 stabilizes Ubiquitin carboxyl-terminal hydrolase 38 (USP38) mRNA by inducing N6-methyladenosine (m6A) modification and enhances USP38 mRNA stability in YTHDF2-dependent manner. METTL14 represses BCa cell migration, invasion and EMT via USP38. Additionally, hsa-miR-3165 inhibits METTL14 expression to promote BCa progression."	M6ADIS0070	36288387	.
M6ACROT05176	REG00013	M6ATAR01732	Non-coding RNA	EPIREG00301	EPITAR00028	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"By competitively binding to IGF2BP2, Circ_CDK1 blocked the m6A modification of Serine/threonine-protein phosphatase CPPED1 (CPPED1) in IGF2BP2-dependent manner. Moreover, the circCDK1-mediated decrease of CPPED1 activated the PI3K/AKT signal pathway to facilitate progression of LSCC."	M6ADIS0027	37543219	.
M6ACROT05177	REG00007	M6ATAR01733	Non-coding RNA	EPIREG00302	EPITAR00027	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	H2AZ2P1 might be a biomarker that alters m6A modification by regulating the m6A methylases METTL3/14 and FTO and then mediating the downstream target Intraflagellar transport protein 80 homolog (IFT80) to promote HNSCC progression.	M6ADIS0055	35403343	.
M6ACROT05178	REG00006	M6ATAR01733	Non-coding RNA	EPIREG00302	EPITAR00195	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	H2AZ2P1 might be a biomarker that alters m6A modification by regulating the m6A methylases METTL3/METTL14 and FTO and then mediating the downstream target Intraflagellar transport protein 80 homolog (IFT80) to promote HNSCC progression.	M6ADIS0055	35403343	.
M6ACROT05179	REG00001	M6ATAR01733	Non-coding RNA	EPIREG00302	EPITAR00179	.	Down regulation	ncRNA	Indirect	Inhibition	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	H2AZ2P1 might be a biomarker that alters m6A modification by regulating the m6A methylases METTL3/14 and FTO and then mediating the downstream target Intraflagellar transport protein 80 homolog (IFT80) to promote HNSCC progression.	M6ADIS0055	35403343	.
M6ACROT05180	REG00007	M6ATAR00294	Non-coding RNA	EPIREG00303	EPITAR00027	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"Lnc-HZ06 promotes STAT4-mediated Interleukin-1 beta (IL1B) mRNA transcription, enhances IL1B mRNA stability by promoting the formation of METTL3/HuR/IL1B mRNA ternary complex, and finally up-regulates IL1B expression levels."	M6ADIS0361	38991640	M6ADRUG0182
M6ACROT05181	REG00001	M6ATAR00341	Non-coding RNA	EPIREG00304	EPITAR00179	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	Exos-mediated hsa_circ_0001739/lncRNA AC159540.1 competitively inhibited hsa-miR-218-5p to elevate FTO and Myc proto-oncogene protein (MYC). Tumor cell-derived exosomes mediating hsa_circ_0001739/lncRNA AC159540.1 facilitate liver metastasis in colorectal cancer	M6ADIS0059	37957486	.
M6ACROT05182	REG00001	M6ATAR00341	Non-coding RNA	EPIREG00305	EPITAR00266	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	Exos-mediated hsa_Circ_ZNF277/lncRNA AC159540.1 competitively inhibited hsa-miR-218-5p to elevate FTO and Myc proto-oncogene protein (MYC). Tumor cell-derived exosomes mediating hsa_circ_0001739/lncRNA AC159540.1 facilitate liver metastasis in colorectal cancer	M6ADIS0059	37957486	.
M6ACROT05183	REG00001	M6ATAR00341	Non-coding RNA	EPIREG00306	EPITAR00266	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	Exos-mediated hsa_circ_0001739/lncRNA AC159540.1 competitively inhibited hsa-miR-218-5p to elevate FTO and Myc proto-oncogene protein (MYC). Tumor cell-derived exosomes mediating hsa_circ_0001739/lncRNA AC159540.1 facilitate liver metastasis in colorectal cancer	M6ADIS0059	37957486	.
M6ACROT05184	REG00007	M6ATAR00823	Non-coding RNA	EPIREG00307	EPITAR00027	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"AI662270 promotes CCN family member 2 (CTGF) expression at the posttranscriptional stage by recruiting METTL3 to the CTGF promoter and depositing m6A modifications on the nascent mRNA, thereby, uncovering a novel regulatory mechanism of CTGF in the pathogenesis of kidney fibrosis."	M6ADIS0117	37389924	.
M6ACROT05185	REG00006	M6ATAR00823	Non-coding RNA	EPIREG00307	EPITAR00195	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"AI662270 promotes CCN family member 2 (CTGF) expression at the posttranscriptional stage by recruiting PTM (METTL14, WTAP, METTL3 and KIAA1429) to the CTGF promoter and depositing m6A modifications on the nascent mRNA, thereby, uncovering a novel regulatory mechanism of CTGF in the pathogenesis of kidney fibrosis."	M6ADIS0117	37389924	.
M6ACROT05186	REG00009	M6ATAR00823	Non-coding RNA	EPIREG00307	EPITAR00269	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"AI662270 promotes CCN family member 2 (CTGF) expression at the posttranscriptional stage by recruiting PTM (METTL14, WTAP, METTL3 and KIAA1429) to the CTGF promoter and depositing m6A modifications on the nascent mRNA, thereby, uncovering a novel regulatory mechanism of CTGF in the pathogenesis of kidney fibrosis."	M6ADIS0117	37389924	.
M6ACROT05187	REG00015	M6ATAR00823	Non-coding RNA	EPIREG00307	EPITAR00240	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"AI662270 promotes CCN family member 2 (CTGF) expression at the posttranscriptional stage by recruiting PTM (METTL14, WTAP, METTL3 and VIRMA) to the CTGF promoter and depositing m6A modifications on the nascent mRNA, thereby, uncovering a novel regulatory mechanism of CTGF in the pathogenesis of kidney fibrosis."	M6ADIS0117	37389924	.
M6ACROT05188	REG00007	M6ATAR01559	Non-coding RNA	EPIREG00308	EPITAR00027	.	.	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	METBIL as a novel molecular regulator in ischemia-induced cardiac fibrosis via METTL3-mediated m6A modification of Collagen alpha-2(I) chain (COL1A2).	M6ADIS0375	36753405	.
M6ACROT05189	REG00007	M6ATAR00745	Non-coding RNA	EPIREG00308	EPITAR00027	.	.	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	METBIL as a novel molecular regulator in ischemia-induced cardiac fibrosis via METTL3-mediated m6A modification of Metalloproteinase inhibitor 1 (TIMP-1).	M6ADIS0375	36753405	.
M6ACROT05190	REG00013	M6ATAR00451	Non-coding RNA	EPIREG00309	EPITAR00028	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Mechanically, exosomal Circ_PACRGL bound to IGF2BP2 to improve the stability of Transcriptional coactivator YAP1 (YAP1) mRNA and regulate Hippo signaling in polarized THP-1 cells. TMS inhibited NSCLC growth via suppressing Hippo signaling and M2 polarization in vivo."	M6ADIS0007	38394728	M6ADRUG0198
M6ACROT05191	REG00024	M6ATAR01734	Non-coding RNA	EPIREG00310	EPITAR00248	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"Mechanistically, hsa-miR-381 inhibited Interleukin-18 (IL18) translation in LMECs by inhibiting YTHDF1 expression via binding to its 3'-UTR. As expected, YTHDF1 overexpression in LMECs abolished the effects of miR-381-overexpressed exosomes on LMECs injury and Treg cell differentiation."	.	39357613	.
M6ACROT05192	REG00012	M6ATAR01735	Non-coding RNA	EPIREG00311	EPITAR00234	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Mechanistically, LOC101928222 synergized with IGF2BP1 to stabilize Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMGCS2) mRNA through an m6A-dependent pathway, leading to increased cholesterol synthesis and, ultimately, the promotion of CRC development."	M6ADIS0059	38965575	.
M6ACROT05193	REG00006	M6ATAR00217	Non-coding RNA	EPIREG00312	EPITAR00195	.	Down regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"METTL14 was a directed target gene of piR-14633. Knockdown of METTL14 with siRNA attenuated proliferation, migration and invasion of CC cells. piRNA-14633 increased Cytochrome P450 1B1 (CYP1B1) expression, while silencing of METTL14 impaired its expression. "	M6ADIS0008	35093098	.
M6ACROT05194	REG00006	M6ATAR00547	Non-coding RNA	EPIREG00313	EPITAR00195	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"MiR-200 family (miR-200b/miR-200c) and hsa-miR-141 reduced Pancreas/duodenum homeobox protein 1 (Pdx1) via targeting METTL14, which should also be a crucial contributor to beta-cell dysfunction and apoptosis in the pancreas of BPF-exposed mice."	.	36924560	M6ADRUG0199
M6ACROT05195	REG00006	M6ATAR00547	Non-coding RNA	EPIREG00314	EPITAR00195	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"MiR-200 family (hsa-miR-200b/miR-200c) and miR-141 reduced Pancreas/duodenum homeobox protein 1 (Pdx1) via targeting METTL14, which should also be a crucial contributor to beta-cell dysfunction and apoptosis in the pancreas of BPF-exposed mice."	.	36924560	M6ADRUG0199
M6ACROT05196	REG00006	M6ATAR00547	Non-coding RNA	EPIREG00315	EPITAR00195	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"MiR-200 family (miR-200b/hsa-miR-200c) and miR-141 reduced Pancreas/duodenum homeobox protein 1 (Pdx1) via targeting METTL14, which should also be a crucial contributor to beta-cell dysfunction and apoptosis in the pancreas of BPF-exposed mice."	.	36924560	M6ADRUG0199
M6ACROT05197	REG00013	M6ATAR01736	Non-coding RNA	EPIREG00316	EPITAR00028	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"SNHG5 enhanced Zinc finger protein 281 (ZNF281) mRNA stability by binding with the m6A reader IGF2BP2. Enhanced ZNF281 transcriptionally regulated CCL2 and CCL5 expression to activate P38 MAPK signaling in endothelial cells. High CCL2 and CCL5 expression was associated with tumor metastasis and poor prognosis in BC patients. The inhibitors RS102895, marasviroc and cenicriviroc inhibited angiogenesis and vascular permeability in the PMN by blocking the binding of CCL2/CCR2 and CCL5/CCR5. The lncSNHG5-ZNF281-CCL2/CCL5 signaling axis plays an essential role in inducing premetastatic niche formation to promote BC metastasis."	M6ADIS0065	36438499	M6ADRUG0202
M6ACROT05198	REG00013	M6ATAR00833	Non-coding RNA	EPIREG00317	EPITAR00028	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Circ_EZH2 interacts with m6A reader IGF2BP2 and blocks its ubiquitination-dependent degradation. Meanwhile, circEZH2 could serve as a sponge of miR-133b, resulting in the upregulation of IGF2BP2. Particularly, circEZH2/IGF2BP2 enhances the stability of Cyclic AMP-responsive element-binding protein 1 (CREB1) mRNA, thus aggravating CRC progression."	M6ADIS0059	35773744	.
M6ACROT05199	REG00013	M6ATAR00833	Non-coding RNA	EPIREG00318	EPITAR00028	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"circEZH2 interacts with m6A reader IGF2BP2 and blocks its ubiquitination-dependent degradation. Meanwhile, circEZH2 could serve as a sponge of hsa-miR-133b, resulting in the upregulation of IGF2BP2. Particularly, circEZH2/IGF2BP2 enhances the stability of Cyclic AMP-responsive element-binding protein 1 (CREB1) mRNA, thus aggravating CRC progression."	M6ADIS0059	35773744	.
M6ACROT05200	REG00013	M6ATAR00833	Non-coding RNA	EPIREG00317	EPITAR00267	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"Circ_EZH2 interacts with m6A reader IGF2BP2 and blocks its ubiquitination-dependent degradation. Meanwhile, circEZH2 could serve as a sponge of hsa-miR-133b, resulting in the upregulation of IGF2BP2. Particularly, circEZH2/IGF2BP2 enhances the stability of Cyclic AMP-responsive element-binding protein 1 (CREB1) mRNA, thus aggravating CRC progression."	M6ADIS0059	35773744	.
M6ACROT05201	REG00001	M6ATAR00399	Non-coding RNA	EPIREG00319	EPITAR00179	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hypoxia-driven E26 transformation-specific sequence-1 (ETS1), as an upstream modulatory mechanism, was essential for the downregulation of GATA6-AS1 in PDAC cells. GATA6-AS1 inhibited the expression of fat mass and obesity-associated protein (FTO), an N6-methyladenosine (m6A) eraser, and repressed Zinc finger protein SNAI1 (SNAI1) mRNA stability in an m6A-dependent manner."	M6ADIS0061	38057853	.
M6ACROT05202	REG00006	M6ATAR01486	Non-coding RNA	EPIREG00320	EPITAR00195	.	.	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	Exosomal hsa-miR-130a-3p confers cisplatin resistance in esophageal cancer by regulating ferroptosis via the suppression of METTL14-mediated m6A RNA methylation of Ferroptosis suppressor protein 1 (AIFM2)	M6ADIS0056	39689599	M6ADRUG0047
M6ACROT05203	REG00020	M6ATAR00433	Non-coding RNA	EPIREG00321	EPITAR00226	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"m6A RIP-seq analysis revealed that FTO-IT1 knockout increased mRNA m6A methylation of a subset of p53 transcriptional target genes (e.g., Tumor necrosis factor receptor superfamily member 6 (FAS), TP53INP1, and SESN2) and induced PCa cell cycle arrest and apoptosis. FTO-IT1 directly binds RBM15 and inhibits RBM15 binding, m6A methylation, and stability of p53 target mRNAs."	.	37478845	.
M6ACROT05204	REG00020	M6ATAR01737	Non-coding RNA	EPIREG00321	EPITAR00226	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"m6A RIP-seq analysis revealed that FTO-IT1 knockout increased mRNA m6A methylation of a subset of p53 transcriptional target genes (e.g., FAS, Tumor protein p53-inducible nuclear protein 1 (TP53INP1), and SESN2) and induced PCa cell cycle arrest and apoptosis. FTO-IT1 directly binds RBM15 and inhibits RBM15 binding, m6A methylation, and stability of p53 target mRNAs."	.	37478845	.
M6ACROT05205	REG00020	M6ATAR01738	Non-coding RNA	EPIREG00321	EPITAR00226	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"m6A RIP-seq analysis revealed that FTO-IT1 knockout increased mRNA m6A methylation of a subset of p53 transcriptional target genes (e.g., FAS, TP53INP1, and Sestrin-2 (SESN2)) and induced PCa cell cycle arrest and apoptosis. FTO-IT1 directly binds RBM15 and inhibits RBM15 binding, m6A methylation, and stability of p53 target mRNAs."	.	37478845	.
M6ACROT05206	REG00013	M6ATAR01739	Non-coding RNA	EPIREG00322	EPITAR00028	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"m6A-modified circRNA was found to increase mRNA stability by functioning as a scaffold for the binding of IGF2BP2 and mRNA. This phenomenon was also observed in the present study, and we identified Kremen protein 1 (KRM1) as a target gene of the Circ_HIPK3/IGF2BP2 complex."	M6ADIS0347	38945954	.
M6ACROT05207	REG00005	M6ATAR01740	Non-coding RNA	EPIREG00323	EPITAR00183	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Circ_NRCAM could competitively bind to ALKBH5, which restrained hsa-miR-506-3p expression and promoted NRCAM expression."	M6ADIS0312	38485895	.
M6ACROT05208	REG00005	M6ATAR01741	Non-coding RNA	EPIREG00324	EPITAR00183	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	LINC00659 cooperated with ALKBH5 to accelerate gastric cancer progression by stabilising Tyrosine-protein kinase JAK1 (JAK1) mRNA in an m6 A-YTHDF2-dependent manner	M6ADIS0057	36864711	.
M6ACROT05209	REG00008	M6ATAR01741	Non-coding RNA	EPIREG00324	EPITAR00183	.	Down regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	LINC00659 cooperated with RNA demethylase ALKBH5 (ALKBH5) to accelerate gastric cancer progression by stabilising Tyrosine-protein kinase JAK1 (JAK1) mRNA in an m6 A-YTHDF2-dependent manner	M6ADIS0057	36864711	.
M6ACROT05210	REG00012	M6ATAR01742	Non-coding RNA	EPIREG00325	EPITAR00234	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"SNHG29 competitively binds to IGF2BP1 protein to destabilize E3 ubiquitin-protein ligase synoviolin (SYVN1) mRNA, subsequently suppresses SYVN1-mediated NLRP3 ubiquitination degradation and activates IL1beta/Smad2/3 signaling, thus promoting EMT in cervical cancer. Implication: LRRC75A-AS1 promotes cervical cancer progression, and this study suggests LRRC75A-AS1 as a new therapeutic target for cervical cancer."	M6ADIS0008	38180377	.
M6ACROT05211	REG00008	M6ATAR01743	Non-coding RNA	EPIREG00326	EPITAR00232	.	Down regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Hypoxia-induced HIF-1alpha transcriptionally upregulates the expression of lncRNA STEAP3-AS1, which interacts competitively with YTHDF2, thus upregulating mRNA stability of Metalloreductase STEAP3 (STEAP3) and consequent STEAP3 protein expression."	M6ADIS0059	35986274	.
M6ACROT05212	REG00048	.	Non-coding RNA	EPIREG00238	EPITAR00247	.	.	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"OIP5-AS1 prevented Trim21-mediated ubiquitination and degradation of hnRNPA1, stabilizing hnRNPA1 protein and promoting the malignant progression of GC by regulating PKM2 signaling pathway."	M6ADIS0057	37897508	.
M6ACROT05213	REG00012	.	Non-coding RNA	EPIREG00328	EPITAR00234	.	.	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	hsa-miR-670-3p functions as the regulator of IGF2BP1 expression and plays a crucial role in PA development through m6A modification.	.	32179813	.
M6ACROT05214	REG00007	M6ATAR01744	Non-coding RNA	EPIREG00329	EPITAR00027	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	hsa-miR-33a-3p regulates METTL3-mediated Amphiregulin (AREG) stability and alters EMT to inhibit pancreatic cancer invasion and metastasis	M6ADIS0061	37604948	.
M6ACROT05216	REG00014	M6ATAR00341	Non-coding RNA	EPIREG00330	EPITAR00235	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"The interaction between Myc proto-oncogene protein (MYC) mRNA and LIN28B is speculated to be supported by LOC101929709, which binds to both LIN28B and IGF2BP3. Mechanistically, LOC101929709 enriched in the cytoplasm helps LIN28B stabilize c-MYC mRNA."	M6ADIS0057	36284068	.
M6ACROT05217	REG00055	M6ATAR00341	Non-coding RNA	EPIREG00330	EPITAR00268	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"The interaction between Myc proto-oncogene protein (MYC) mRNA and LIN28B is speculated to be supported by LOC101929709, which binds to both LIN28B and IGF2BP3. Mechanistically, LOC101929709 enriched in the cytoplasm helps LIN28B stabilize c-MYC mRNA."	M6ADIS0057	36284068	.
M6ACROT05218	REG00007	M6ATAR00795	Non-coding RNA	EPIREG00331	EPITAR00027	.	.	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"ADAR1 edits METTL3 mRNA and changes its binding site to hsa-miR-532-5p, leading to increased METTL3 protein, which further targets Rho GTPase activating protein 5 (ARHGAP5), recognized by YTHDF1."	M6ADIS0065	36077054	.
M6ACROT05219	REG00024	M6ATAR00795	Non-coding RNA	EPIREG00331	EPITAR00027	.	.	ncRNA	Indirect	Inhibition	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"ADAR1 edits Methyltransferase-like protein 3 (METTL3) mRNA and changes its binding site to hsa-miR-532-5p, leading to increased METTL3 protein, which further targets Rho GTPase activating protein 5 (ARHGAP5), recognized by YTHDF1."	M6ADIS0065	36077054	.
M6ACROT05220	REG00048	M6ATAR00764	Non-coding RNA	EPIREG00332	EPITAR00247	.	Down regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	LINC01615 promoted Glucose-6-phosphate dehydrogenase (G6PD) expression by competitively binding with hnRNPA1 and facilitating G6PD pre-mRNA splicing.LINC01615 maintains cell survival in adaptation to nutrient starvation through the pentose phosphate pathway and modulates chemosensitivity in colorectal cancer	M6ADIS0059	36576581	M6ADRUG0048
M6ACROT05221	REG00009	M6ATAR00248	Non-coding RNA	EPIREG00333	EPITAR00269	.	Down regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	WTAP may be involved in the methylation process of Protein C-ets-1 (ETS1) in RA. ETS1 m6A methylation levels were altered upon WTAP intervention. The overexpression or interference of Circ_CBLB decreased or increased WTAP expression.	M6ADIS0112	36541909	.
M6ACROT05222	REG00013	M6ATAR00419	Non-coding RNA	EPIREG00334	EPITAR00028	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Circ_ASPH interacted with insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) to stabilize IGF2BP2 protein, therefore enhancing the stability of m6A-modified Stimulator of interferon genes protein (STING1) mRNA."	M6ADIS0059	37624989	.
M6ACROT05223	REG00007	M6ATAR00605	Non-coding RNA	EPIREG00335	EPITAR00027	.	Down regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Mechanistically, gain of H3K4me1 and H3K27Ac led to the activation of MIR570HG expression. LINC00969 interacts with EZH2 and METTL3, transcriptionally regulates the level of H3K27me3 in the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) promoter region, and posttranscriptionally modifies the m6A level of NLRP3 in an m6A-YTHDF2-dependent manner, thus epigenetically repressing NLRP3 expression to suppress the activation of the NLRP3/caspase-1/GSDMD-related classical pyroptosis signalling pathways, thereby endowing an antipyroptotic phenotype and promoting TKI resistance in lung cancer. "	M6ADIS0007	37156816	M6ADRUG0030
M6ACROT05224	REG00008	M6ATAR00605	Non-coding RNA	EPIREG00335	EPITAR00027	.	Down regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"Mechanistically, gain of H3K4me1 and H3K27Ac led to the activation of MIR570HG expression. LINC00969 interacts with EZH2 and Methyltransferase-like protein 3 (METTL3), transcriptionally regulates the level of H3K27me3 in the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) promoter region, and posttranscriptionally modifies the m6A level of NLRP3 in an m6A-YTHDF2-dependent manner, thus epigenetically repressing NLRP3 expression to suppress the activation of the NLRP3/caspase-1/GSDMD-related classical pyroptosis signalling pathways, thereby endowing an antipyroptotic phenotype and promoting TKI resistance in lung cancer. "	M6ADIS0007	37156816	M6ADRUG0030
M6ACROT05225	REG00001	M6ATAR00453	Non-coding RNA	EPIREG00336	EPITAR00179	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"Mechanistically, senescent neutrophils-derived exosomal piR-17560 enhances the expression of fat mass and obesity-associated protein (FTO) in breast cancer cells. The upregulation of FTO further strengthens Zinc finger E-box-binding homeobox 1 (ZEB1) transcripts stability and expression by decreasing N6-methyladenosine (m6A) RNA methylation, leading to chemoresistance and epithelial-mesenchymal transition (EMT) of tumor cells."	M6ADIS0065	36302751	.
M6ACROT05226	REG00001	M6ATAR00457	Non-coding RNA	EPIREG00337	EPITAR00179	.	.	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"CCRR is a protective lncRNA that acts by maintaining the function of FTO, thereby reducing the m6A RNA methylation level of Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2a/ATP2A2), ultimately preserving calcium homeostasis for myocardial contractile function in MI."	M6ADIS0097	38761356	.
M6ACROT05227	REG00007	M6ATAR01747	Non-coding RNA	EPIREG00338	EPITAR00027	.	Down regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"HNF4A-AS1 interacted with METTL3, leading to m6A modification of 2,4-dienoyl-CoA reductase [ (DECR1) mRNA, which subsequently decreased DECR1 expression via YTHDF3-dependent mRNA degradation. Our results indicated the pivotal role of lipid metabolism-related and liver-specific HNF4A-AS1 in inhibiting sorafenib resistance by promoting ferroptosis and suggesting that HNF4A-AS1 might be a potential target for HCC."	M6ADIS0006	39629121	M6ADRUG0032
M6ACROT05228	REG00025	M6ATAR01747	Non-coding RNA	EPIREG00338	EPITAR00027	.	Down regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"HNF4A-AS1 interacted with Methyltransferase-like protein 3 (METTL3), leading to m6A modification of 2,4-dienoyl-CoA reductase [ (DECR1) mRNA, which subsequently decreased DECR1 expression via YTHDF3-dependent mRNA degradation. Our results indicated the pivotal role of lipid metabolism-related and liver-specific HNF4A-AS1 in inhibiting sorafenib resistance by promoting ferroptosis and suggesting that HNF4A-AS1 might be a potential target for HCC."	M6ADIS0006	39629121	M6ADRUG0032
M6ACROT05229	REG00014	M6ATAR01748	Non-coding RNA	EPIREG00339	EPITAR00235	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"HNRNPC mediated Circ_ZBTB44 interaction with IGF2BP3 to up-regulate Hexokinase-3 (HK3), promoting the proliferation and migration of RCC cells in vitro and tumorigenesis in vivo. The results of the study shed new light on the targeted therapy of RCC."	M6ADIS0010	37106446	.
M6ACROT05230	REG00024	M6ATAR00399	Non-coding RNA	EPIREG00340	EPITAR00248	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"PLAGL2 enhances Zinc finger protein SNAI1 (SNAI1) expression and GC progression via the UCA1/hsa-miR-145-5p/YTHDF1 axis, suggesting that PLAGL2 may become a therapeutic target for GC treatment."	M6ADIS0057	36999803	.
M6ACROT05231	REG00005	M6ATAR00334	Non-coding RNA	EPIREG00215	EPITAR00270	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"Silencing MALAT1 led to down-regulation of the N6-methyladenosine (m6A) demethylase ALKBH5 via regulating hsa-miR-141-3p expression, which caused a decrease in the expression levels of 72 kDa type IV collagenase (MMP2) and MMP9 expression, thereby suppressing cell migration and invasion."	M6ADIS0008	37639643	.
M6ACROT05232	REG00005	M6ATAR00334	Non-coding RNA	EPIREG00342	EPITAR00183	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"Silencing MALAT1 led to down-regulation of the N6-methyladenosine (m6A) demethylase ALKBH5 via regulating hsa-miR-141-3p expression, which caused a decrease in the expression levels of 72 kDa type IV collagenase (MMP2) and MMP9 expression, thereby suppressing cell migration and invasion."	M6ADIS0008	37639643	.
M6ACROT05233	REG00005	M6ATAR00335	Non-coding RNA	EPIREG00215	EPITAR00270	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"Silencing MALAT1 led to down-regulation of the N6-methyladenosine (m6A) demethylase ALKBH5 via regulating hsa-miR-141-3p expression, which caused a decrease in the expression levels of MMP2 and Matrix metalloproteinase-9 (MMP9) expression, thereby suppressing cell migration and invasion."	M6ADIS0008	37639643	.
M6ACROT05234	REG00005	M6ATAR00335	Non-coding RNA	EPIREG00342	EPITAR00183	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"Silencing MALAT1 led to down-regulation of the N6-methyladenosine (m6A) demethylase ALKBH5 via regulating hsa-miR-141-3p expression, which caused a decrease in the expression levels of MMP2 and Matrix metalloproteinase-9 (MMP9) expression, thereby suppressing cell migration and invasion."	M6ADIS0008	37639643	.
M6ACROT05235	REG00001	M6ATAR00441	Non-coding RNA	EPIREG00343	EPITAR00179	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hsa_circ_0072309 interacted with hsa-miR-607 via its miRNA response element to upregulate the expression of FTO, an m6A demethylase and downstream target of miR-607, thus promoting tumorigenesis of NSCLC.The m6A demethylase FTO promotes the growth of Non-small cell lung cancer cells by increasing the expression of USP7.Genetic knockdown or pharmacological inhibition (P5091 or P22027) of Ubiquitin carboxyl-terminal hydrolase 7 (USP7) reduced the proliferation rate of lung cancer cells and decreased the capacity of colony formation of lung cancer cells in vitro, whereas lung cancer cells growth inhibition by FTO knockdown is restored by overexertion of USP7."	M6ADIS0007	33879631; 30905413	M6ADRUG0040
M6ACROT05236	REG00001	M6ATAR00441	Non-coding RNA	EPIREG00343	EPITAR00179	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hsa_circ_0072309 interacted with hsa-miR-607 via its miRNA response element to upregulate the expression of FTO, an m6A demethylase and downstream target of miR-607, thus promoting tumorigenesis of NSCLC.The m6A demethylase FTO promotes the growth of Non-small cell lung cancer cells by increasing the expression of USP7.Genetic knockdown or pharmacological inhibition (P5091 or P22027) of Ubiquitin carboxyl-terminal hydrolase 7 (USP7) reduced the proliferation rate of lung cancer cells and decreased the capacity of colony formation of lung cancer cells in vitro, whereas lung cancer cells growth inhibition by FTO knockdown is restored by overexertion of USP7."	M6ADIS0007	33879631; 30905413	.
M6ACROT05237	REG00001	M6ATAR00341	Non-coding RNA	EPIREG00343	EPITAR00179	.	.	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hsa_circ_0072309 interacted with hsa-miR-607 via its miRNA response element to upregulate the expression of FTO, an m6A demethylase and downstream target of miR-607, thus promoting tumorigenesis of NSCLC.This study revealed that m6A methylation is closely related to the poor prognosis of non-small cell lung cancer patients via interference with the TIME, which suggests that m6A plays a role in optimizing individualized immunotherapy management and improving prognosis. The expression levels of METTL3, FTO and YTHDF1 in non-small cell lung cancer were changed. Patients in Cluster 1 had lower immunoscores, higher programmed death-ligand 1 (PD-L1) expression, and shorter overall survival compared to patients in Cluster 2. The Myc proto-oncogene protein (MYC) targets, E2 transcription Factor (E2F) targets were significantly enriched."	M6ADIS0007	33879631; 34734017	.
M6ACROT05238	REG00001	M6ATAR00234	Non-coding RNA	EPIREG00343	EPITAR00179	.	.	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hsa_circ_0072309 interacted with hsa-miR-607 via its miRNA response element to upregulate the expression of FTO, an m6A demethylase and downstream target of miR-607, thus promoting tumorigenesis of NSCLC.This study revealed that m6A methylation is closely related to the poor prognosis of non-small cell lung cancer patients via interference with the TIME, which suggests that m6A plays a role in optimizing individualized immunotherapy management and improving prognosis. The expression levels of METTL3, FTO and YTHDF1 in non-small cell lung cancer were changed. Patients in Cluster 1 had lower immunoscores, higher programmed death-ligand 1 (PD-L1) expression, and shorter overall survival compared to patients in Cluster 2. The hallmarks of the Myelocytomatosis viral oncogene (MYC) targets, Transcription factor E2F1 (E2F1) targets were significantly enriched."	M6ADIS0007	33879631; 34734017	.
M6ACROT05239	REG00001	M6ATAR00360	Non-coding RNA	EPIREG00343	EPITAR00179	.	.	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hsa_circ_0072309 interacted with hsa-miR-607 via its miRNA response element to upregulate the expression of FTO, an m6A demethylase and downstream target of miR-607, thus promoting tumorigenesis of NSCLC.This study revealed that m6A methylation is closely related to the poor prognosis of non-small cell lung cancer patients via interference with the TIME, which suggests that m6A plays a role in optimizing individualized immunotherapy management and improving prognosis. The expression levels of METTL3, FTO and YTHDF1 in non-small cell lung cancer were changed. Patients in Cluster 1 had lower immunoscores, higher Programmed cell death 1 ligand 1 (CD274/PD-L1) expression, and shorter overall survival compared to patients in Cluster 2. The hallmarks of the Myelocytomatosis viral oncogene (MYC) targets, E2 transcription Factor (E2F) targets were significantly enriched."	M6ADIS0007	33879631; 34734017	.
M6ACROT05240	REG00001	M6ATAR00676	Non-coding RNA	EPIREG00343	EPITAR00179	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hsa_circ_0072309 interacted with hsa-miR-607 via its miRNA response element to upregulate the expression of FTO, an m6A demethylase and downstream target of miR-607, thus promoting tumorigenesis of NSCLC.Not only FTO knockdown enhanced the gefitinib sensitivity of GR cells but also FTO reduction in donor exosomes alleviated the acquired resistance of recipient non-small cell lung cancer PC9 cells. FTO/YTHDF2/ATP-binding cassette sub-family C member 10 (ABCC10) axis played a role in intercellular transmission of GR cell-derived exosome-mediated gefitinib resistance."	M6ADIS0007	33879631; 33563765	M6ADRUG0030
M6ACROT05241	REG00001	M6ATAR00720	Non-coding RNA	EPIREG00343	EPITAR00179	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hsa_circ_0072309 interacted with hsa-miR-607 via its miRNA response element to upregulate the expression of FTO, an m6A demethylase and downstream target of miR-607, thus promoting tumorigenesis of NSCLC.FTO upregulated the expression of E2F1 by inhibiting the m6A modification of E2F1. The FTO/E2F1/Protein kinase C-binding protein NELL2 (NELL2) axis modulated NSCLC cell viability, migration, and invasion in vitro as well as affected NSCLC tumor growth and metastasis in vivo."	M6ADIS0007	33879631; 34169146	.
M6ACROT05242	REG00001	M6ATAR00234	Non-coding RNA	EPIREG00343	EPITAR00179	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hsa_circ_0072309 interacted with hsa-miR-607 via its miRNA response element to upregulate the expression of FTO, an m6A demethylase and downstream target of miR-607, thus promoting tumorigenesis of NSCLC.FTO upregulated the expression of Transcription factor E2F1 (E2F1) by inhibiting the m6A modification of E2F1. The FTO/E2F1/NELL2 axis modulated NSCLC cell viability, migration, and invasion in vitro as well as affected NSCLC tumor growth and metastasis in vivo."	M6ADIS0007	33879631; 34169146	.
M6ACROT05243	REG00001	M6ATAR00148	Non-coding RNA	EPIREG00343	EPITAR00179	.	Down regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hsa_circ_0072309 interacted with hsa-miR-607 via its miRNA response element to upregulate the expression of FTO, an m6A demethylase and downstream target of miR-607, thus promoting tumorigenesis of NSCLC.Growth arrest specific 5 (GAS5) suppressed by FTO could promote the autophagic death of NSCLC cells in vitro and inhibit NSCLC tumor growth in vivo."	M6ADIS0007	33879631; 37120495	.
M6ACROT05244	REG00001	M6ATAR00873	Non-coding RNA	EPIREG00343	EPITAR00179	.	.	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hsa_circ_0072309 interacted with hsa-miR-607 via its miRNA response element to upregulate the expression of FTO, an m6A demethylase and downstream target of miR-607, thus promoting tumorigenesis of NSCLC.FTO facilitated NSCLC metastasis by modifying the m6A level of Prolyl endopeptidase FAP (FAP) in a YTHDF2-dependent manner.FTO promoted cell migration and invasion in NSCLC, and the FAK inhibitor defactinib (VS6063) suppressed NSCLC metastasis induced by overexpression of FTO."	M6ADIS0007	33879631; 37919739	M6ADRUG0160
M6ACROT05245	REG00001	M6ATAR00907	Non-coding RNA	EPIREG00343	EPITAR00179	.	.	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hsa_circ_0072309 interacted with hsa-miR-607 via its miRNA response element to upregulate the expression of FTO, an m6A demethylase and downstream target of miR-607, thus promoting tumorigenesis of NSCLC.Phenethyl isothiocyanate inhibits metastasis potential of non-small cell lung cancer cells through FTO mediated Transducin-like enhancer protein 1 (TLE1) m6A modification"	M6ADIS0007	33879631; 37848553	M6ADRUG0125
M6ACROT05246	REG00001	M6ATAR01001	Non-coding RNA	EPIREG00343	EPITAR00179	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hsa_circ_0072309 interacted with hsa-miR-607 via its miRNA response element to upregulate the expression of FTO, an m6A demethylase and downstream target of miR-607, thus promoting tumorigenesis of NSCLC.FTO m6A demethylase promotes gefitinib resistance in NSCLC patients by upregulating downstream Leucine-rich repeat transmembrane protein FLRT3 (FLRT3), PTGIS, and SIRPA expression, with these three downstream genes serving as strong prognostic indicators."	M6ADIS0007	33879631; 37330168	M6ADRUG0030
M6ACROT05247	REG00001	M6ATAR01002	Non-coding RNA	EPIREG00343	EPITAR00179	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hsa_circ_0072309 interacted with hsa-miR-607 via its miRNA response element to upregulate the expression of FTO, an m6A demethylase and downstream target of miR-607, thus promoting tumorigenesis of NSCLC.FTO m6A demethylase promotes gefitinib resistance in NSCLC patients by upregulating downstream FLRT3, Prostacyclin synthase (PTGIS), and SIRPA expression, with these three downstream genes serving as strong prognostic indicators."	M6ADIS0007	33879631; 37330168	M6ADRUG0030
M6ACROT05248	REG00001	M6ATAR01003	Non-coding RNA	EPIREG00343	EPITAR00179	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hsa_circ_0072309 interacted with hsa-miR-607 via its miRNA response element to upregulate the expression of FTO, an m6A demethylase and downstream target of miR-607, thus promoting tumorigenesis of NSCLC.FTO m6A demethylase promotes gefitinib resistance in NSCLC patients by upregulating downstream FLRT3, PTGIS, and Tyrosine-protein phosphatase non-receptor type substrate 1 (SIRPA) expression, with these three downstream genes serving as strong prognostic indicators."	M6ADIS0007	33879631; 37330168	M6ADRUG0030
M6ACROT05249	REG00001	M6ATAR00441	Non-coding RNA	EPIREG00344	EPITAR00271	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"Circ_LIFR interacted with hsa-miR-607 via its miRNA response element to upregulate the expression of FTO, an m6A demethylase and downstream target of miR-607, thus promoting tumorigenesis of NSCLC.The m6A demethylase FTO promotes the growth of Non-small cell lung cancer cells by increasing the expression of USP7.Genetic knockdown or pharmacological inhibition (P5091 or P22027) of Ubiquitin carboxyl-terminal hydrolase 7 (USP7) reduced the proliferation rate of lung cancer cells and decreased the capacity of colony formation of lung cancer cells in vitro, whereas lung cancer cells growth inhibition by FTO knockdown is restored by overexertion of USP7."	M6ADIS0007	33879631; 30905413	M6ADRUG0040
M6ACROT05250	REG00001	M6ATAR00441	Non-coding RNA	EPIREG00344	EPITAR00271	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"Circ_LIFR interacted with hsa-miR-607 via its miRNA response element to upregulate the expression of FTO, an m6A demethylase and downstream target of miR-607, thus promoting tumorigenesis of NSCLC.The m6A demethylase FTO promotes the growth of Non-small cell lung cancer cells by increasing the expression of USP7.Genetic knockdown or pharmacological inhibition (P5091 or P22027) of Ubiquitin carboxyl-terminal hydrolase 7 (USP7) reduced the proliferation rate of lung cancer cells and decreased the capacity of colony formation of lung cancer cells in vitro, whereas lung cancer cells growth inhibition by FTO knockdown is restored by overexertion of USP7."	M6ADIS0007	33879631; 30905413	.
M6ACROT05251	REG00001	M6ATAR00341	Non-coding RNA	EPIREG00344	EPITAR00271	.	.	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"Circ_LIFR interacted with hsa-miR-607 via its miRNA response element to upregulate the expression of FTO, an m6A demethylase and downstream target of miR-607, thus promoting tumorigenesis of NSCLC.This study revealed that m6A methylation is closely related to the poor prognosis of non-small cell lung cancer patients via interference with the TIME, which suggests that m6A plays a role in optimizing individualized immunotherapy management and improving prognosis. The expression levels of METTL3, FTO and YTHDF1 in non-small cell lung cancer were changed. Patients in Cluster 1 had lower immunoscores, higher programmed death-ligand 1 (PD-L1) expression, and shorter overall survival compared to patients in Cluster 2. The Myc proto-oncogene protein (MYC) targets, E2 transcription Factor (E2F) targets were significantly enriched."	M6ADIS0007	33879631; 34734017	.
M6ACROT05252	REG00001	M6ATAR00234	Non-coding RNA	EPIREG00344	EPITAR00271	.	.	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"Circ_LIFR interacted with hsa-miR-607 via its miRNA response element to upregulate the expression of FTO, an m6A demethylase and downstream target of miR-607, thus promoting tumorigenesis of NSCLC.This study revealed that m6A methylation is closely related to the poor prognosis of non-small cell lung cancer patients via interference with the TIME, which suggests that m6A plays a role in optimizing individualized immunotherapy management and improving prognosis. The expression levels of METTL3, FTO and YTHDF1 in non-small cell lung cancer were changed. Patients in Cluster 1 had lower immunoscores, higher programmed death-ligand 1 (PD-L1) expression, and shorter overall survival compared to patients in Cluster 2. The hallmarks of the Myelocytomatosis viral oncogene (MYC) targets, Transcription factor E2F1 (E2F1) targets were significantly enriched."	M6ADIS0007	33879631; 34734017	.
M6ACROT05253	REG00001	M6ATAR00360	Non-coding RNA	EPIREG00344	EPITAR00271	.	.	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"Circ_LIFR interacted with hsa-miR-607 via its miRNA response element to upregulate the expression of FTO, an m6A demethylase and downstream target of miR-607, thus promoting tumorigenesis of NSCLC.This study revealed that m6A methylation is closely related to the poor prognosis of non-small cell lung cancer patients via interference with the TIME, which suggests that m6A plays a role in optimizing individualized immunotherapy management and improving prognosis. The expression levels of METTL3, FTO and YTHDF1 in non-small cell lung cancer were changed. Patients in Cluster 1 had lower immunoscores, higher Programmed cell death 1 ligand 1 (CD274/PD-L1) expression, and shorter overall survival compared to patients in Cluster 2. The hallmarks of the Myelocytomatosis viral oncogene (MYC) targets, E2 transcription Factor (E2F) targets were significantly enriched."	M6ADIS0007	33879631; 34734017	.
M6ACROT05254	REG00001	M6ATAR00676	Non-coding RNA	EPIREG00344	EPITAR00271	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"Circ_LIFR interacted with hsa-miR-607 via its miRNA response element to upregulate the expression of FTO, an m6A demethylase and downstream target of miR-607, thus promoting tumorigenesis of NSCLC.Not only FTO knockdown enhanced the gefitinib sensitivity of GR cells but also FTO reduction in donor exosomes alleviated the acquired resistance of recipient non-small cell lung cancer PC9 cells. FTO/YTHDF2/ATP-binding cassette sub-family C member 10 (ABCC10) axis played a role in intercellular transmission of GR cell-derived exosome-mediated gefitinib resistance."	M6ADIS0007	33879631; 33563765	M6ADRUG0030
M6ACROT05255	REG00001	M6ATAR00720	Non-coding RNA	EPIREG00344	EPITAR00271	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"Circ_LIFR interacted with hsa-miR-607 via its miRNA response element to upregulate the expression of FTO, an m6A demethylase and downstream target of miR-607, thus promoting tumorigenesis of NSCLC.FTO upregulated the expression of E2F1 by inhibiting the m6A modification of E2F1. The FTO/E2F1/Protein kinase C-binding protein NELL2 (NELL2) axis modulated NSCLC cell viability, migration, and invasion in vitro as well as affected NSCLC tumor growth and metastasis in vivo."	M6ADIS0007	33879631; 34169146	.
M6ACROT05256	REG00001	M6ATAR00234	Non-coding RNA	EPIREG00344	EPITAR00271	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"Circ_LIFR interacted with hsa-miR-607 via its miRNA response element to upregulate the expression of FTO, an m6A demethylase and downstream target of miR-607, thus promoting tumorigenesis of NSCLC.FTO upregulated the expression of Transcription factor E2F1 (E2F1) by inhibiting the m6A modification of E2F1. The FTO/E2F1/NELL2 axis modulated NSCLC cell viability, migration, and invasion in vitro as well as affected NSCLC tumor growth and metastasis in vivo."	M6ADIS0007	33879631; 34169146	.
M6ACROT05257	REG00001	M6ATAR00148	Non-coding RNA	EPIREG00344	EPITAR00271	.	Down regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"Circ_LIFR interacted with hsa-miR-607 via its miRNA response element to upregulate the expression of FTO, an m6A demethylase and downstream target of miR-607, thus promoting tumorigenesis of NSCLC.Growth arrest specific 5 (GAS5) suppressed by FTO could promote the autophagic death of NSCLC cells in vitro and inhibit NSCLC tumor growth in vivo."	M6ADIS0007	33879631; 37120495	.
M6ACROT05258	REG00001	M6ATAR00873	Non-coding RNA	EPIREG00344	EPITAR00271	.	.	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"Circ_LIFR interacted with hsa-miR-607 via its miRNA response element to upregulate the expression of FTO, an m6A demethylase and downstream target of miR-607, thus promoting tumorigenesis of NSCLC.FTO facilitated NSCLC metastasis by modifying the m6A level of Prolyl endopeptidase FAP (FAP) in a YTHDF2-dependent manner.FTO promoted cell migration and invasion in NSCLC, and the FAK inhibitor defactinib (VS6063) suppressed NSCLC metastasis induced by overexpression of FTO."	M6ADIS0007	33879631; 37919739	M6ADRUG0160
M6ACROT05259	REG00001	M6ATAR00907	Non-coding RNA	EPIREG00344	EPITAR00271	.	.	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"Circ_LIFR interacted with hsa-miR-607 via its miRNA response element to upregulate the expression of FTO, an m6A demethylase and downstream target of miR-607, thus promoting tumorigenesis of NSCLC.Phenethyl isothiocyanate inhibits metastasis potential of non-small cell lung cancer cells through FTO mediated Transducin-like enhancer protein 1 (TLE1) m6A modification"	M6ADIS0007	33879631; 37848553	M6ADRUG0125
M6ACROT05260	REG00001	M6ATAR01001	Non-coding RNA	EPIREG00344	EPITAR00271	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"Circ_LIFR interacted with hsa-miR-607 via its miRNA response element to upregulate the expression of FTO, an m6A demethylase and downstream target of miR-607, thus promoting tumorigenesis of NSCLC.FTO m6A demethylase promotes gefitinib resistance in NSCLC patients by upregulating downstream Leucine-rich repeat transmembrane protein FLRT3 (FLRT3), PTGIS, and SIRPA expression, with these three downstream genes serving as strong prognostic indicators."	M6ADIS0007	33879631; 37330168	M6ADRUG0030
M6ACROT05261	REG00001	M6ATAR01002	Non-coding RNA	EPIREG00344	EPITAR00271	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"Circ_LIFR interacted with hsa-miR-607 via its miRNA response element to upregulate the expression of FTO, an m6A demethylase and downstream target of miR-607, thus promoting tumorigenesis of NSCLC.FTO m6A demethylase promotes gefitinib resistance in NSCLC patients by upregulating downstream FLRT3, Prostacyclin synthase (PTGIS), and SIRPA expression, with these three downstream genes serving as strong prognostic indicators."	M6ADIS0007	33879631; 37330168	M6ADRUG0030
M6ACROT05262	REG00001	M6ATAR01003	Non-coding RNA	EPIREG00344	EPITAR00271	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"Circ_LIFR interacted with hsa-miR-607 via its miRNA response element to upregulate the expression of FTO, an m6A demethylase and downstream target of miR-607, thus promoting tumorigenesis of NSCLC.FTO m6A demethylase promotes gefitinib resistance in NSCLC patients by upregulating downstream FLRT3, PTGIS, and Tyrosine-protein phosphatase non-receptor type substrate 1 (SIRPA) expression, with these three downstream genes serving as strong prognostic indicators."	M6ADIS0007	33879631; 37330168	M6ADRUG0030
M6ACROT05263	REG00024	M6ATAR00425	Non-coding RNA	EPIREG00345	EPITAR00248	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	hsa-miR-421-3p prevents inflammatory response in cerebral ischemia/reperfusion injury through targeting YTHDF1 to inhibit Transcription factor p65 (RELA) mRNA translation. These findings provide novel insights into understanding the molecular pathogenesis of cerebral I/R injury.	M6ADIS0091	32890792	.
M6ACROT05264	REG00056	M6ATAR00755	Non-coding RNA	EPIREG00346	EPITAR00272	.	Down regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Circ_STX6 acted as a sponge for HNRNPD protein, facilitating its binding to Cyclic-AMP-dependent transcription factor ATF-3 (ATF3) mRNA, consequently promoting ATF3 mRNA decay. Meanwhile, circSTX6-144aa promoted HCC proliferation, migration and invasion independent of circSTX6 itself."	M6ADIS0006	37877357	.
M6ACROT05265	REG00009	M6ATAR00240	Non-coding RNA	EPIREG00347	EPITAR00269	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Circ_PDE5A blocks the WTAP-dependent N6-methyladenisine (m6A) methylation of Eukaryotic translation initiation factor 3 subunit C (EIF3C) mRNA by forming the circPDE5A-WTAP complex, and finally disrupts the translation of EIF3C. Moreover, the circPDE5A-dependent decrease in EIF3C expression inactivates the MAPK pathway and then restrains PCa progression."	M6ADIS0068	35650605	.
M6ACROT05266	REG00014	M6ATAR00277	Non-coding RNA	EPIREG00348	EPITAR00235	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"IGF2BP3 is negatively regulated by promoter methylation and hsa-miR-320a-3p, IGF2BP3 prevent High mobility group protein B1 (HMGB1) mRNA decay in bladder cancer and development"	M6ADIS0070	38504159	M6ADRUG0253
M6ACROT05267	REG00024	M6ATAR00222	Non-coding RNA	EPIREG00349	EPITAR00248	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	hsa-miR-136-5p targeted YTHDF1 to restrain CRC progression and chemoresistance.Silencing YTHDF1 significantly inhibited Wnt/Catenin beta-1 (CTNNB1/Beta-catenin) pathway activity in Colorectal cancer cells. 	M6ADIS0059	37853773; 31131257	.
M6ACROT05268	REG00024	M6ATAR00647	Non-coding RNA	EPIREG00349	EPITAR00248	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hsa-miR-136-5p targeted YTHDF1 to restrain CRC progression and chemoresistance.YTHDF1 promotes cell growth in CRC cell lines and primary organoids and lung and liver metastasis in vivo. YTHDF1 binds to m6A sites of Rho guanine nucleotide exchange factor 2 (ARHGEF2) messenger RNA, resulting in enhanced translation of ARHGEF2."	M6ADIS0059	37853773; 34968454	.
M6ACROT05269	REG00024	M6ATAR01009	Non-coding RNA	EPIREG00349	EPITAR00248	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	hsa-miR-136-5p targeted YTHDF1 to restrain CRC progression and chemoresistance.YTHDF1 recruitment onto m6A-amended Zinc finger protein RFP (TRIM27) was crucial for facilitating the TRIM27 translating process in DDP-resistant CRC cells.	M6ADIS0059	37853773; 38024865	M6ADRUG0047
M6ACROT05270	REG00024	M6ATAR01327	Non-coding RNA	EPIREG00349	EPITAR00248	.	.	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hsa-miR-136-5p targeted YTHDF1 to restrain CRC progression and chemoresistance.Glucose-induced degradation protein 8 homolog (GID8)/Twa1 as a crucial downstream target of YTHDF1. YTHDF1 manipulates GID8 translation efficiency in an m6A-dependent manner, and high expression of GID8 is associated with more aggressive tumor progression and poor overall survival.GID8 is intimately associated with glutamine metabolic demands by maintaining active glutamine uptake and metabolism through the regulation of excitatory amino acid transporter 1 (SLC1A3) and glutaminase (GLS), thereby facilitating the malignant progression of CRC. Inhibition of GID8 attenuated CRC proliferation and metastasis both in vitro and in vivo. "	M6ADIS0059	37853773; 39151722	.
M6ACROT05271	REG00007	M6ATAR00404	Non-coding RNA	EPIREG00350	EPITAR00273	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"Circ_VMP1 acted as microRNA-524-5p (hsa-miR-524-5p) sponge to up-regulate the expression of methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit (METTL3) and Transcription factor SOX-2 (SOX2)."	M6ADIS0007	35467477	M6ADRUG0047
M6ACROT05272	REG00007	M6ATAR00404	Non-coding RNA	EPIREG00351	EPITAR00027	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"CircVMP1 acted as microRNA-524-5p (hsa-miR-524-5p) sponge to up-regulate the expression of methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit (METTL3) and Transcription factor SOX-2 (SOX2)."	M6ADIS0007	35467477	M6ADRUG0047
M6ACROT05273	REG00014	M6ATAR00484	Non-coding RNA	EPIREG00267	EPITAR00235	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"LINC00942 suppresses ferroptosis and induces Treg immunosuppression in HCC by recruiting IGF2BP3 to enhance Cystine/glutamate transporter (SLC7A11) mRNA stability, which may provide novel therapeutic targets for HCC."	M6ADIS0006	38353724	.
M6ACROT05274	REG00013	M6ATAR00476	Non-coding RNA	EPIREG00353	EPITAR00028	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	LINC00460 enhanced the protein expression of High mobility group protein HMG-I/HMG-Y (HMGA1) by directly interacting with IGF2BP2 and DHX9 to bind the 3' untranslated region (UTR) of HMGA1 mRNA and increased the stability of HMGA1 mRNA.	M6ADIS0059	34784937	.
M6ACROT05275	REG00014	M6ATAR00141	Non-coding RNA	EPIREG00354	EPITAR00235	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Mechanistically, hsa_Circ_MALAT1 reduced the stability of its host gene Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) by competitively binding to IGF2BP3 with MALAT1 in an N6-methyladenosine (m6A)-dependent manner."	M6ADIS0137	34953789	.
M6ACROT05276	REG00004	M6ATAR00607	Non-coding RNA	EPIREG00355	EPITAR00212	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"MIR100HG maintained mRNA stability of Transcription factor 7-like 2 (TCF7L2), a major transcriptional coactivator of the Wnt/beta-catenin signaling, by interacting with HNRNPA2B1. hnRNPA2B1 recognized the N6-methyladenosine (m6A) site of TCF7L2 mRNA in the presence of MIR100HG."	M6ADIS0059	35279145	M6ADRUG0101
M6ACROT05277	REG00007	M6ATAR00593	Non-coding RNA	EPIREG00356	EPITAR00027	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	Inhibition of hsa-miR-455-3p rescued beta-catenin depletion-induced reduction of Heat shock factor protein 1 (HSF1) m6A modification and METTL3 interaction.	M6ADIS0059	32838807	.
M6ACROT05278	REG00008	M6ATAR00268	Non-coding RNA	EPIREG00357	EPITAR00232	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hsa-miR-6125 targeted the 3'-UTR of YTHDF2 and downregulated the YTHDF2 protein, thereby increasing the stability of m6A-modified Glycogen synthase kinase-3 beta (GSK3Beta/GSK3B) mRNA."	M6ADIS0059	34709763	.
M6ACROT05279	REG00007	M6ATAR00945	Non-coding RNA	EPIREG00358	EPITAR00027	.	Down regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	hsa-miR-340-3p-modified bone marrow mesenchymal stem cell-derived exosomes inhibit ferroptosis through METTL3-mediated m6A modification of Heme oxygenase 1 (HMOX1) to promote recovery of injured rat uterus.YTHDF2 as a critical m6A reader protein that contributes to HMOX1 mRNA degradation. YTHDF2 facilitates HMOX1 mRNA degradation by identifying the m6A binding site in the 3'-untranslated regions of HMOX1.	M6ADIS0394	39075530	.
M6ACROT05280	REG00008	M6ATAR00945	Non-coding RNA	EPIREG00358	EPITAR00027	.	Down regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	hsa-miR-340-3p-modified bone marrow mesenchymal stem cell-derived exosomes inhibit ferroptosis through Methyltransferase-like protein 3 (METTL3)-mediated m6A modification of Heme oxygenase 1 (HMOX1) to promote recovery of injured rat uterus.YTHDF2 as a critical m6A reader protein that contributes to HMOX1 mRNA degradation. YTHDF2 facilitates HMOX1 mRNA degradation by identifying the m6A binding site in the 3'-untranslated regions of HMOX1.	M6ADIS0394	39075530	.
M6ACROT05281	REG00025	M6ATAR01752	Non-coding RNA	EPIREG00359	EPITAR00249	.	Down regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	A reciprocal feedback between N6-methyladenosine reader YTHDF3 and lncRNA DICER1 antisense RNA 1 (DICER1-AS1) promotes glycolysis of pancreatic cancer through inhibiting maturation of hsa-miR-5586-5p	M6ADIS0061	35183226	.
M6ACROT05282	REG00007	M6ATAR00200	Non-coding RNA	EPIREG00360	EPITAR00027	.	Down regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	piR-36741 regulates Bone morphogenetic protein 2 (BMP2)-mediated osteoblast differentiation via METTL3 controlled m6A modification	M6ADIS0115	34645714	.
M6ACROT05283	REG00004	M6ATAR00150	Non-coding RNA	EPIREG00361	EPITAR00212	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"LINC01833 might form a complex with HNRNPA2B1. In conclusion, m6A transferase METTL3-induced LINC01833 m6A methylation promotes NSCLC progression through modulating HNRNPA2B1 expression. Our findings indicated that LINC01833 might be a therapeutic target for NSCLC.HNRNPA2B1-mediated m6A modification of lncRNA Maternally expressed 3 (MEG3) promotes tumorigenesis and metastasis of NSCLC cells by regulating miR-21-5p/PTEN axis and may provide a therapeutic target for NSCLC. the expression of HNRNPA2B1 was reduced when knocking down LINC01833"	M6ADIS0007	35441574; 37308993	.
M6ACROT05284	REG00009	M6ATAR00122	Non-coding RNA	EPIREG00362	EPITAR00274	.	Up regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	N6-methyladenosine (m6A)-mediated lncRNA DLGAP1 antisense RNA 1 (DLGAP1-AS1)enhances breast canceradriamycin resistance through hsa-miR-299-3p/WTAP feedback loop	M6ADIS0065	34866525	M6ADRUG0034
M6ACROT05285	REG00009	M6ATAR00122	Non-coding RNA	EPIREG00363	EPITAR00269	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	N6-methyladenosine (m6A)-mediated lncRNA DLGAP1 antisense RNA 1 (DLGAP1-AS1)enhances breast canceradriamycin resistance through hsa-miR-299-3p/WTAP feedback loop	M6ADIS0065	34866525	M6ADRUG0034
M6ACROT05286	REG00009	M6ATAR00122	Non-coding RNA	EPIREG00362	EPITAR00274	.	Up regulation	ncRNA	Indirect	Inhibition	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	N6-methyladenosine (m6A)-mediated lncRNA DLGAP1 antisense RNA 1 (DLGAP1-AS1) enhances breast canceradriamycin resistance through hsa-miR-299-3p/WTAP feedback loop	M6ADIS0065	34866525	M6ADRUG0034
M6ACROT05287	REG00007	M6ATAR00375	Non-coding RNA	EPIREG00364	EPITAR00027	.	Down regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"LINC00470-METTL3-mediated Mutated in multiple advanced cancers 1 (PTEN) mRNA degradation relied on the m6A reader protein YTHDF2-dependent pathway. Taken together, LINC00470 might serve as a therapeutic target for GC patients."	M6ADIS0057	31711642	.
M6ACROT05288	REG00008	M6ATAR00375	Non-coding RNA	EPIREG00364	EPITAR00027	.	Down regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"LINC00470-Methyltransferase-like protein 3 (METTL3)-mediated Mutated in multiple advanced cancers 1 (PTEN) mRNA degradation relied on the m6A reader protein YTHDF2-dependent pathway. Taken together, LINC00470 might serve as a therapeutic target for GC patients."	M6ADIS0057	31711642	.
M6ACROT05289	REG00013	M6ATAR00871	Non-coding RNA	EPIREG00365	EPITAR00028	.	.	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	Chidamide inhibited glycolysis in AML by repressing WTAP-mediated GNAS antisense RNA 1 (GNAS-AS1) m6A modification and then regulating the hsa-miR-34a-5p/IGF2BP2 axis.Chidamide inhibits cell glycolysis in acute myeloid leukemia by decreasing N6-methyladenosine-related GNAS-AS1.Chidamide treatment suppressed WT1-associated protein (WTAP)-mediated RNA m6A modification of GNAS-AS1. Chidamide downregulated GNAS-AS1 to inhibit glycolysis in AML cells. GNAS-AS1 targeted miR-34a-5p to promote insulin-like growth factor 2 mRNA-binding protein (IGF2BP2) expression. IGF2BP2 inhibition reversed the promoting effect of miR-34a-5p knockdown on glycolysis and RhoA/ROCK pathway in Chidamide-treated cells. GNAS-AS1 overexpression abolished the inhibitory effect of Chidamide on AML tumorigenesis in vivo by modulating the RhoA/ROCK pathway.	M6ADIS0065	38626369; 31263129	M6ADRUG0039
M6ACROT05290	REG00013	M6ATAR01456	Non-coding RNA	EPIREG00365	EPITAR00028	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"Chidamide inhibited glycolysis in AML by repressing WTAP-mediated GNAS-AS1 m6A modification and then regulating the hsa-miR-34a-5p/IGF2BP2 axis.Chidamide inhibits cell glycolysis in acute myeloid leukemia by decreasing N6-methyladenosine-related GNAS-AS1.Mechanistically, IGF2BP2 stabilizes Protein arginine N-methyltransferase 6 (PRMT6) mRNA via m6A-mediated manner, which catalyzes H3R2me2a and suppresses lipid transporter MFSD2A expression."	M6ADIS0046	37926762; 36574771	.
M6ACROT05291	REG00013	M6ATAR00871	Non-coding RNA	EPIREG00366	EPITAR00275	.	.	ncRNA	Indirect	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	Chidamide inhibited glycolysis in AML by repressing WTAP-mediated GNAS antisense RNA 1 (GNAS-AS1) m6A modification and then regulating the hsa-miR-34a-5p/IGF2BP2 axis.Chidamide inhibits cell glycolysis in acute myeloid leukemia by decreasing N6-methyladenosine-related GNAS-AS1.Chidamide treatment suppressed WT1-associated protein (WTAP)-mediated RNA m6A modification of GNAS-AS1. Chidamide downregulated GNAS-AS1 to inhibit glycolysis in AML cells. GNAS-AS1 targeted miR-34a-5p to promote insulin-like growth factor 2 mRNA-binding protein (IGF2BP2) expression. IGF2BP2 inhibition reversed the promoting effect of miR-34a-5p knockdown on glycolysis and RhoA/ROCK pathway in Chidamide-treated cells. GNAS-AS1 overexpression abolished the inhibitory effect of Chidamide on AML tumorigenesis in vivo by modulating the RhoA/ROCK pathway.	M6ADIS0065	38626369; 31263129	M6ADRUG0039
M6ACROT05292	REG00013	M6ATAR01456	Non-coding RNA	EPIREG00366	EPITAR00275	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"Chidamide inhibited glycolysis in AML by repressing WTAP-mediated GNAS-AS1 m6A modification and then regulating the hsa-miR-34a-5p/IGF2BP2 axis.Chidamide inhibits cell glycolysis in acute myeloid leukemia by decreasing N6-methyladenosine-related GNAS-AS1.Mechanistically, IGF2BP2 stabilizes Protein arginine N-methyltransferase 6 (PRMT6) mRNA via m6A-mediated manner, which catalyzes H3R2me2a and suppresses lipid transporter MFSD2A expression."	M6ADIS0046	37926762; 36574771	.
M6ACROT05293	REG00007	M6ATAR00569	Non-coding RNA	EPIREG00367	EPITAR00027	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	Methylation of hsa-miR-338-5p by EED promotes METTL3-mediated translation of oncogene CUB domain-containing protein 1 (CDCP1) in gastric cancer	M6ADIS0057	33882457	.
M6ACROT05294	REG00013	M6ATAR00497	Non-coding RNA	EPIREG00285	EPITAR00028	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"PCAT6 upregulated Insulin-like growth factor 1 receptor (IGF1R) expression by enhancing IGF1R mRNA stability through the PCAT6/IGF2BP2/IGF1R RNA-protein three-dimensional complex. Importantly, PCAT6 inhibition by ASO in vivo showed therapeutic potential against bone metastasis in PCa. Finally, the clinical correlation of METTL3, IGF2BP2, IGF1R, and PCAT6 was further demonstrated in PCa tissues and cells."	M6ADIS0068	34185427	.
M6ACROT05295	REG00004	M6ATAR00392	Non-coding RNA	EPIREG00368	EPITAR00212	.	Down regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"the RP11/HNRNPA2B1/mRNA complex accelerated the mRNA degradation of two E3 ligases, E3 ubiquitin-protein ligase SIAH1 (SIAH1) and Fbxo45, and subsequently prevented the proteasomal degradation of Zeb1. m6A-induced lncRNA RP11 triggers the dissemination of colorectal cancer cells via upregulation of Zeb1"	M6ADIS0059	30979372	.
M6ACROT05296	REG00004	M6ATAR00251	Non-coding RNA	EPIREG00368	EPITAR00212	.	Down regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"the RP11/HNRNPA2B1/mRNA complex accelerated the mRNA degradation of two E3 ligases, Siah1 and F-box/SPRY domain-containing protein 1 (FBXO45), and subsequently prevented the proteasomal degradation of Zeb1.m6A-induced lncRNA RP11 triggers the dissemination of colorectal cancer cells via upregulation of Zeb1"	M6ADIS0059	30979372	.
M6ACROT05297	REG00008	M6ATAR00336	Non-coding RNA	EPIREG00369	EPITAR00232	.	Down regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"KDM5A was found to downregulate MOB kinase activator 3B (MOB3B) expression, consequently augmenting PCa cell proliferation, migration and invasion in vitro and promoting tumor growth in vivo via the hsa-miR-495/YTHDF2 axis."	M6ADIS0068	33087165	.
M6ACROT05298	REG00014	M6ATAR01753	Non-coding RNA	EPIREG00370	EPITAR00235	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Mechanistically, DMDRMR bound insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) to stabilize target genes, including the cell-cycle kinase CDK4 and three extracellular matrix components (Collagen alpha-1 (COL6A1), LAMA5, and FN1), by specifically enhancing IGF2BP3 activity on them in an m6A-dependent manner. "	M6ADIS0010	33293428	.
M6ACROT05299	REG00014	M6ATAR01754	Non-coding RNA	EPIREG00370	EPITAR00235	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Mechanistically, DMDRMR bound insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) to stabilize target genes, including the cell-cycle kinase CDK4 and three extracellular matrix components (COL6A1, Laminin subunit alpha-5 (LAMA5), and FN1), by specifically enhancing IGF2BP3 activity on them in an m6A-dependent manner. "	M6ADIS0010	33293428	.
M6ACROT05300	REG00014	M6ATAR01530	Non-coding RNA	EPIREG00370	EPITAR00235	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Mechanistically, DMDRMR bound insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) to stabilize target genes, including the cell-cycle kinase CDK4 and three extracellular matrix components (COL6A1, LAMA5, and Fibronectin (FN1)), by specifically enhancing IGF2BP3 activity on them in an m6A-dependent manner. "	M6ADIS0010	33293428	.
M6ACROT05301	REG00007	M6ATAR01486	Non-coding RNA	EPIREG00371	EPITAR00027	.	.	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	METTL3 was confirmed as a direct target gene of hsa-miR-4443. Further mechanistic analysis showed that miR-4443 regulated the expression of Ferroptosis suppressor protein 1 (AIFM2) in an m6A manner via METLL3.	M6ADIS0007	33781830	.
M6ACROT05302	REG00012	M6ATAR01511	Non-coding RNA	EPIREG00324	EPITAR00234	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	Long non-coding RNA LINC00659 promotes tumour progression by regulating Frizzled-6 (FZD6)/Wnt/beta-catenin signalling pathway in colorectal cancer via m6A reader IGF2BP1	M6ADIS0059	38009760	.
M6ACROT05303	REG00048	M6ATAR01095	Non-coding RNA	EPIREG00216	EPITAR00247	.	Down regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"hnRNPA1 bound to CRNDE and remained in the nucleus, which inhibited Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5) expression through the formation of CRNDE-hnRNPA1-mRNA complex."	M6ADIS0093	36648699	.
M6ACROT05304	REG00007	M6ATAR00450	Non-coding RNA	EPIREG00372	EPITAR00027	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hsa-miR-21-5p inhibited the METTL3-mediated m6A modification and mRNA stability of Wnt inhibitory factor 1 (WIF1), thereby facilitating the proliferation, invasion, and migration of Ect-ESCs."	M6ADIS0144	36546578	.
M6ACROT05305	REG00007	M6ATAR00295	Non-coding RNA	EPIREG00373	EPITAR00027	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"ILF3-DT increased Interleukin enhancer-binding factor 3 (ILF3) m6A level via recruiting N6-methyladenosine (m6A) RNA methyltransferase METTL3. Moreover, IFL3-AS1 enhanced the interaction between ILF3 mRNA and m6A reader IGF2BP1"	M6ADIS0006	34491544	.
M6ACROT05306	REG00012	M6ATAR00295	Non-coding RNA	EPIREG00373	EPITAR00027	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"ILF3-DT increased Interleukin enhancer-binding factor 3 (ILF3) m6A level via recruiting N6-methyladenosine (m6A) RNA methyltransferase Methyltransferase-like protein 3 (METTL3). Moreover, IFL3-AS1 enhanced the interaction between ILF3 mRNA and m6A reader IGF2BP1"	M6ADIS0006	34491544	.
M6ACROT05307	REG00013	M6ATAR00323	Non-coding RNA	EPIREG00374	EPITAR00028	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	A1BG-AS1 promotes adriamycin resistance of breast cancer by recruiting IGF2BP2 to upregulate ATP-dependent translocase ABCB1 (ABCB1) in an m6A-dependent manner 	M6ADIS0065	38007504	M6ADRUG0034
M6ACROT05308	REG00008	M6ATAR00556	Non-coding RNA	EPIREG00224	EPITAR00232	.	Down regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"YTHDF2, a protein repressed by MIR145, regulates proliferation, apoptosis, and migration in ovarian cancer cells by targeting Bcl-2-modifying factor (BMF)."	M6ADIS0066	32948220; 33658012	.
M6ACROT05309	REG00004	M6ATAR01090	Non-coding RNA	EPIREG00375	EPITAR00212	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"HNRNPA2B1, which is upregulated by LINC00355, recognizes the N6-methyladenosine (m6A) sites of Cell division control protein 42 homolog (CDC42) and enhances the stability of CDC42 mRNA transcripts."	M6ADIS0057	37983727	.
M6ACROT05310	REG00004	M6ATAR00899	Non-coding RNA	EPIREG00242	EPITAR00212	.	.	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hsa-miR-30c-5p inhibits OvCa progression and reduces the m6A level by inhibiting m6A reader HNRNPA2B1, thus providing new insights into the m6A regulatory mechanism in OvCa. m6A reader HNRNPA2B1 might regulate Cyclin-dependent kinase 19 (CDK19) mRNA stability to alter m6A level.
"	M6ADIS0066	36259156	.
M6ACROT05311	REG00047	M6ATAR00484	Non-coding RNA	EPIREG00376	EPITAR00256	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	SNHG1 contributes to sorafenib resistance of liver cancer cells by promoting SND1-m6A-Cystine/glutamate transporter (SLC7A11)-mediated aerobic glycolysis.	M6ADIS0006	37927237	M6ADRUG0032
M6ACROT05312	REG00007	M6ATAR00389	Non-coding RNA	EPIREG00377	EPITAR00027	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hsa-miR-4429 prevented gastric cancer progression through targeting METTL3 to inhibit m6A-caused stabilization of Translocation protein SEC62 (SEC62), indicating miR-4429 as a promising target for treatment improvement for GC.methyltransferase like 3 (METTL3) interacted with SEC62 to induce the m6A on SEC62 mRNA, therefore facilitated the stabilizing effect of IGF2 binding protein 1 (IGF2BP1) on SEC62 mRNA."	M6ADIS0057	31395342	.
M6ACROT05313	REG00012	M6ATAR00389	Non-coding RNA	EPIREG00377	EPITAR00027	.	Up regulation	ncRNA	Indirect	Inhibition	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"hsa-miR-4429 prevented gastric cancer progression through targeting Methyltransferase-like protein 3 (METTL3) to inhibit m6A-caused stabilization of Translocation protein SEC62 (SEC62), indicating miR-4429 as a promising target for treatment improvement for GC. METTL3 interacted with SEC62 to induce the m6A on SEC62 mRNA, therefore facilitated the stabilizing effect of IGF2 binding protein 1 (IGF2BP1) on SEC62 mRNA."	M6ADIS0057	31395342	.
M6ACROT05314	REG00001	M6ATAR00312	Non-coding RNA	EPIREG00321	EPITAR00179	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	LncRNA FTO-IT1 promotes glycolysis and progression of hepatocellular carcinoma through modulating FTO-mediated N6-methyladenosine modification on GLUT1 and Pyruvate kinase PKM (PKM2/PKM)	M6ADIS0006	37840133	.
M6ACROT05315	REG00001	M6ATAR00269	Non-coding RNA	EPIREG00321	EPITAR00179	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	LncRNA FTO-IT1 promotes glycolysis and progression of hepatocellular carcinoma through modulating FTO-mediated N6-methyladenosine modification on Glucose transporter type 1 (GLUT1) and PKM2	M6ADIS0006	37840133	.
M6ACROT05316	REG00008	M6ATAR00312	Non-coding RNA	EPIREG00321	EPITAR00179	.	Down regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	LncRNA FTO-IT1 promotes glycolysis and progression of hepatocellular carcinoma through modulating FTO alpha-ketoglutarate dependent dioxygenase (FTO)-mediated N6-methyladenosine modification on GLUT1 and Pyruvate kinase PKM (PKM2/PKM) in a YTHDF2 manner.	M6ADIS0006	37840133	.
M6ACROT05317	REG00008	M6ATAR00269	Non-coding RNA	EPIREG00321	EPITAR00179	.	Down regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	LncRNA FTO-IT1 promotes glycolysis and progression of hepatocellular carcinoma through modulating FTO alpha-ketoglutarate dependent dioxygenase (FTO)-mediated N6-methyladenosine modification on Glucose transporter type 1 (GLUT1) and PKM2 in a YTHDF2 manner.	M6ADIS0006	37840133	.
M6ACROT05318	REG00013	M6ATAR00510	Non-coding RNA	EPIREG00378	EPITAR00028	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	LncRNA-PACERR which bound to IGF2BP2 acts as an m6A-dependent manner to enhance the stability of Krueppel-like factor 12 (KLF12) and c-myc in cytoplasm.	M6ADIS0061	35526050	.
M6ACROT05319	REG00013	M6ATAR00341	Non-coding RNA	EPIREG00378	EPITAR00028	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	LncRNA-PACERR which bound to IGF2BP2 acts as an m6A-dependent manner to enhance the stability of KLF12 and Myc proto-oncogene protein (MYC) in cytoplasm.	M6ADIS0061	35526050	.
M6ACROT05320	REG00001	M6ATAR00341	Non-coding RNA	EPIREG00379	EPITAR00276	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	hsa-miR-96 promotes occurrence and progression of colorectal cancer via regulation of the Protein kinase AMP-activated catalytic subunit alpha 2 (PRKAA2)-FTO-m6A/Myc proto-oncogene protein (MYC) axis	M6ADIS0059	33183350	.
M6ACROT05321	REG00009	M6ATAR01576	Non-coding RNA	EPIREG00380	EPITAR00269	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hsa-miR-550-1 might mediate a decrease in m6A levels via targeting WTAP, which led to a further reduction in WW domain-containing transcription regulator protein 1 (WWTR1) stability."	M6ADIS0046	33061801	.
M6ACROT05322	REG00024	M6ATAR00312	Non-coding RNA	EPIREG00381	EPITAR00248	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"tumor hypoxia can transcriptionally induce HIF1alpha and post-transcriptionally inhibit the expression of hsa-miR-16-5p to promote YTHDF1 expression, which could sequentially enhance tumor glycolysis by upregulating Pyruvate kinase PKM (PKM2/PKM) and eventually increase the tumorigenesis and metastasis potential of breast cancer cells."	M6ADIS0065	35319018	.
M6ACROT05323	REG00009	M6ATAR00418	Non-coding RNA	EPIREG00382	EPITAR00269	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	AGAP2-AS1 bound WT1-associated protein (WTAP) to promote the formation of the WTAP/methyltransferase-like 3 (METTL3)/METTL14 m6A methyltransferase complex. AGAP2-AS1 stabilized signal transducer and activator of Signal transducer and activator of transcription 3 (STAT3) mRNA in an m6A-dependent manner	M6ADIS0057	37983949	.
M6ACROT05324	REG00007	M6ATAR00418	Non-coding RNA	EPIREG00382	EPITAR00269	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	AGAP2-AS1 bound WT1-associated protein (Pre-mRNA-splicing regulator WTAP (WTAP)) to promote the formation of the WTAP/methyltransferase-like 3 (METTL3)/METTL14 m6A methyltransferase complex. AGAP2-AS1 stabilized signal transducer and activator of Signal transducer and activator of transcription 3 (STAT3) mRNA in an m6A-dependent manner	M6ADIS0057	37983949	.
M6ACROT05325	REG00006	M6ATAR00418	Non-coding RNA	EPIREG00382	EPITAR00269	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	AGAP2-AS1 bound WT1-associated protein (Pre-mRNA-splicing regulator WTAP (WTAP)) to promote the formation of the WTAP/methyltransferase-like 3 (METTL3)/METTL14 m6A methyltransferase complex. AGAP2-AS1 stabilized signal transducer and activator of Signal transducer and activator of transcription 3 (STAT3) mRNA in an m6A-dependent manner	M6ADIS0057	37983949	.
M6ACROT05326	REG00012	M6ATAR00931	Non-coding RNA	EPIREG00383	EPITAR00234	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"In vitro cell experiments showed that LncRNA CACNA1G-AS1 could up-regulate Ferritin heavy chain (FTH1) expression through IGF2BP1 axis, thus inhibited ferroptosis by regulating ferritinophagy, and finally promoted proliferation and migration in ovarian cancer cells."	M6ADIS0066	37304234	.
M6ACROT05327	REG00007	M6ATAR00341	Non-coding RNA	EPIREG00367	EPITAR00027	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hsa-miR-338-5p inhibited METTL3 expression by qPCR, western blot analysis, and luciferase reporter assay, while upregulation of METTL3 alleviated the role of miR-338-5p in lung cancer cells. We also showed that METTL3 promoted Myc proto-oncogene protein (MYC) expression by increasing the m6A modification of c-Myc, and overexpression of c-Myc restored the inhibition of cell growth and migration of lung cancer cells induced by METTL3 silencing."	M6ADIS0007	33355622	.
M6ACROT05328	REG00009	M6ATAR00283	Non-coding RNA	EPIREG00384	EPITAR00269	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"piR-30473 exerts its oncogenic role through a mechanism involving the upregulation of WTAP, an m6A mRNA methylase, and thus enhances the global m6A level. WTAP increases the expression of its critical target gene, Hexokinase-2 (HK2), by enhancing the HK2 m6A level, thereby promoting the progression of DLBCL."	M6ADIS0177	32967010	.
M6ACROT05329	REG00006	M6ATAR00605	Non-coding RNA	EPIREG00385	EPITAR00195	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"METTL14 was highly present in NP cells from IVDD patients, which stabilize NACHT, LRR and PYD domains-containing protein 3 (NLRP3) mRNA in an IGFBP2-dependent manner. The elevated NLRP3 levels result in the increase of interleukin 1beta (IL-1beta) and IL-18 levels and trigger pyroptotic NP cell death. Such pathogenic axis could be blocked by hucMSC exosomes, which directly degrade METTL14 through exosomal hsa-miR-26a-5p."	M6ADIS0168	34412584	.
M6ACROT05330	REG00034	M6ATAR00605	Non-coding RNA	EPIREG00385	EPITAR00195	.	Up regulation	ncRNA	Indirect	Inhibition	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"Methyltransferase-like protein 14 (METTL14) was highly present in NP cells from IVDD patients, which stabilize NACHT, LRR and PYD domains-containing protein 3 (NLRP3) mRNA in an IGFBP2-dependent manner. The elevated NLRP3 levels result in the increase of interleukin 1beta (IL-1beta) and IL-18 levels and trigger pyroptotic NP cell death. Such pathogenic axis could be blocked by hucMSC exosomes, which directly degrade METTL14 through exosomal hsa-miR-26a-5p."	M6ADIS0168	34412584	.
M6ACROT05331	REG00014	M6ATAR00078	Non-coding RNA	EPIREG00386	EPITAR00277	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"KCNMB2 antisense RNA 1 (KCNMB2-AS1) was predominantly located in the cytoplasm and served as a competing endogenous RNA to abundantly sponge hsa-miR-130b-5p and miR-4294, resulting in the upregulation of IGF2BP3, a well-documented oncogene in CC. Moreover, IGF2BP3 was able to bind KCNMB2-AS1 by three N6-methyladenosine (m6A) modification sites on KCNMB2-AS1, in which IGF2BP3 acted as an m6A ""reader"" and stabilized KCNMB2-AS1."	M6ADIS0008	33028109	.
M6ACROT05332	REG00014	M6ATAR00078	Non-coding RNA	EPIREG00386	EPITAR00278	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"KCNMB2 antisense RNA 1 (KCNMB2-AS1) was predominantly located in the cytoplasm and served as a competing endogenous RNA to abundantly sponge miR-130b-5p and hsa-miR-4294, resulting in the upregulation of IGF2BP3, a well-documented oncogene in CC. Moreover, IGF2BP3 was able to bind KCNMB2-AS1 by three N6-methyladenosine (m6A) modification sites on KCNMB2-AS1, in which IGF2BP3 acted as an m6A ""reader"" and stabilized KCNMB2-AS1."	M6ADIS0008	33028109	.
M6ACROT05333	REG00014	M6ATAR00078	Non-coding RNA	EPIREG00387	EPITAR00235	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"KCNMB2 antisense RNA 1 (KCNMB2-AS1) was predominantly located in the cytoplasm and served as a competing endogenous RNA to abundantly sponge hsa-miR-130b-5p and miR-4294, resulting in the upregulation of IGF2BP3, a well-documented oncogene in CC. Moreover, IGF2BP3 was able to bind KCNMB2-AS1 by three N6-methyladenosine (m6A) modification sites on KCNMB2-AS1, in which IGF2BP3 acted as an m6A ""reader"" and stabilized KCNMB2-AS1."	M6ADIS0008	33028109	.
M6ACROT05334	REG00014	M6ATAR00078	Non-coding RNA	EPIREG00388	EPITAR00235	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"KCNMB2 antisense RNA 1 (KCNMB2-AS1) was predominantly located in the cytoplasm and served as a competing endogenous RNA to abundantly sponge miR-130b-5p and hsa-miR-4294, resulting in the upregulation of IGF2BP3, a well-documented oncogene in CC. Moreover, IGF2BP3 was able to bind KCNMB2-AS1 by three N6-methyladenosine (m6A) modification sites on KCNMB2-AS1, in which IGF2BP3 acted as an m6A ""reader"" and stabilized KCNMB2-AS1."	M6ADIS0008	33028109	.
M6ACROT05335	REG00024	M6ATAR00222	Non-coding RNA	EPIREG00389	EPITAR00248	.	.	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hsa-miR-376c negatively modulated YTHDF1 expression. Under co-culture conditions, ECs transmitted miR-376c into NSCLC cells through Evs, and inhibited the intracellular YTHDF1 expression and the Wnt/Catenin beta-1 (CTNNB1/Beta-catenin) pathway activation."	M6ADIS0007	33280517	.
M6ACROT05336	REG00007	M6ATAR00844	Non-coding RNA	EPIREG00390	EPITAR00027	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"SLERT directly binds to METTL3, increasing the m6A levels of Neurotrophic factor BDNF precursor form (BDNF) mRNA; then, the m6A sites were read by IGF2BP1, enhancing BDNF mRNA stability,"	M6ADIS0067	36721236	.
M6ACROT05337	REG00012	M6ATAR00844	Non-coding RNA	EPIREG00390	EPITAR00027	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"SLERT directly binds to Methyltransferase-like protein 3 (METTL3), increasing the m6A levels of Neurotrophic factor BDNF precursor form (BDNF) mRNA; then, the m6A sites were read by IGF2BP1, enhancing BDNF mRNA stability,"	M6ADIS0067	36721236	.
M6ACROT05338	REG00001	M6ATAR00260	Non-coding RNA	EPIREG00391	EPITAR00179	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"miR-27a-3p inhibits the expression of FTO via direct binding to FTO. FTO overexpression promotes the nuclear translocation of Forkhead box protein O3 (FOXO3) and upregulates the expression levels of the FOXO3a downstream targets BIM, BNIP3, BCL-6, and PUMA, possibly by interacting with FOXO3a."	M6ADIS0245	36718644	.
M6ACROT05339	REG00020	M6ATAR00590	Non-coding RNA	EPIREG00392	EPITAR00226	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"UBA6-AS1 directly associated with Ubiquitin-like modifier-activating enzyme 6 (UBA6) mRNA and inhibited its decay. Further mechanism investigation revealed that UBA6-AS1 increased the m6A methylation of UBA6 mRNA via recruiting RBM15. Insulin like growth factor 2 mRNA binding protein 1 (IGF2BP1) was identified as the m6A reader protein of UBA6-AS1-RBM15-mediated m6A modification of UBA6 mRNA, which enhanced the stability of UBA6 mRNA."	M6ADIS0066	34951345	.
M6ACROT05340	REG00012	M6ATAR00590	Non-coding RNA	EPIREG00392	EPITAR00226	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"UBA6-AS1 directly associated with Ubiquitin-like modifier-activating enzyme 6 (UBA6) mRNA and inhibited its decay. Further mechanism investigation revealed that UBA6-AS1 increased the m6A methylation of UBA6 mRNA via recruiting RNA binding motif protein 15 (RBM15). Insulin like growth factor 2 mRNA binding protein 1 (IGF2BP1) was identified as the m6A reader protein of UBA6-AS1-RBM15-mediated m6A modification of UBA6 mRNA, which enhanced the stability of UBA6 mRNA."	M6ADIS0066	34951345	.
M6ACROT05341	REG00014	M6ATAR00269	Non-coding RNA	EPIREG00393	EPITAR00235	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	Circ_FOXK2 promoted the Glucose transporter type 1 (GLUT1) mRNA stability through cooperating with insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) in a m6A-dependent manner.	M6ADIS0055	36127411	.
M6ACROT05342	REG00007	M6ATAR00801	Non-coding RNA	EPIREG00394	EPITAR00027	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"SNHG4 promotes LPS induced inflammation in human lung fibroblasts and mouse lung tissues in vitro and in vivo by inhibiting METTL3-mediated m6A level of Signal transducer and activator of transcription 2 (STAT2) mRNA, which may provide a potential therapeutic mechanism for NP."	M6ADIS0120	34450538	.
M6ACROT05343	REG00007	M6ATAR00692	Non-coding RNA	EPIREG00395	EPITAR00027	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"METTL3-mediated m6A modification of Kinesin-like protein KIF3C (KIF3C)-mRNA promotes prostate cancer progression and is negatively regulated by hsa-miR-320d. METTL3 induced m6A modification on KIF3C, promoting the stabilization of KIF3C-mRNA by IGF2 binding protein 1 (IGF2BP1)."	M6ADIS0068	34537760	.
M6ACROT05344	REG00012	M6ATAR00692	Non-coding RNA	EPIREG00395	EPITAR00027	.	Up regulation	ncRNA	Indirect	Inhibition	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"Methyltransferase-like protein 3 (METTL3)-mediated m6A modification of Kinesin-like protein KIF3C (KIF3C)-mRNA promotes prostate cancer progression and is negatively regulated by hsa-miR-320d. METTL3 induced m6A modification on KIF3C, promoting the stabilization of KIF3C-mRNA by IGF2 binding protein 1 (IGF2BP1)."	M6ADIS0068	34537760	.
M6ACROT05345	REG00009	M6ATAR00210	Non-coding RNA	EPIREG00396	EPITAR00269	.	.	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	hsa-miR-501-3p inhibits the proliferation of kidney cancer cells by targeting WTAP which increases Cyclin-dependent kinase 2 (CDK2) expression in Kidney cancer.	M6ADIS0069	34595849	.
M6ACROT05346	REG00001	M6ATAR00373	Non-coding RNA	EPIREG00259	EPITAR00179	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"MIR155 regulates m6A level and cell progression by targeting FTO in clear cell renal cell carcinoma.FTO plays a critical anti-tumorigenic role in Clear Cell Renal Cell Carcinoma.Restored expression of FTO, through reducing m6A levels in mRNA transcripts of its critical target gene PPAR-gamma coactivator 1-alpha (PGC-1a/PPARGC1A), increases mitochondrial content, ROS production and oxidative damage, with the most important effect of repressed tumour growth."	M6ADIS0343	34921979; 30648791	.
M6ACROT05347	REG00020	M6ATAR00283	Non-coding RNA	EPIREG00397	EPITAR00226	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Circ-CTNNB1 interacted with RBM15 and subsequently promoted the expression of Hexokinase-2 (HK2), GPI and PGK1 through N6-methyladenosine (m6A) modification to facilitate the glycolysis process and activate OS progression."	M6ADIS0051	36181462	.
M6ACROT05348	REG00020	M6ATAR01512	Non-coding RNA	EPIREG00397	EPITAR00226	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Circ-CTNNB1 interacted with RBM15 and subsequently promoted the expression of HK2, Glucose-6-phosphate isomerase (GPI) and PGK1 through N6-methyladenosine (m6A) modification to facilitate the glycolysis process and activate OS progression."	M6ADIS0051	36181462	.
M6ACROT05349	REG00020	M6ATAR01438	Non-coding RNA	EPIREG00397	EPITAR00226	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Circ-CTNNB1 interacted with RBM15 and subsequently promoted the expression of HK2, GPI and Phosphoglycerate kinase 1 (PGK1) through N6-methyladenosine (m6A) modification to facilitate the glycolysis process and activate OS progression."	M6ADIS0051	36181462	.
M6ACROT05350	REG00008	M6ATAR00748	Non-coding RNA	EPIREG00398	EPITAR00232	.	Down regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	Hypoxia inducible CBSLR modulates ferroptosis through m6A-YTHDF2-dependent modulation of Cystathionine beta-synthase (CBS) in gastric cancer	M6ADIS0057	35499052	.
M6ACROT05351	REG00007	M6ATAR00344	Non-coding RNA	EPIREG00399	EPITAR00279	.	Down regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	dual-luciferase reporter gene assay revealed the presence of direct binding between miR-135 and Zinc finger protein 217 (ZNF217). ZNF217 could upregulate Homeobox protein NANOG (NANOG) by reducing N6-methyladenosine levels via methyltransferase-like 13 (METTL3).	M6ADIS0065	35121826	.
M6ACROT05352	REG00006	M6ATAR00223	Non-coding RNA	EPIREG00267	EPITAR00195	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"LINC00942 directly recruits METTL14 protein by harboring the specific recognize sequence (+176-+265), thereby stabilized the expression of downstream targets of LNC942 including C-X-C chemokine receptor type 4 (CXCR4) and CYP1B1 through posttranscriptional m6A methylation modification in vitro and in vivo."	M6ADIS0065	32576970	.
M6ACROT05353	REG00006	M6ATAR00217	Non-coding RNA	EPIREG00267	EPITAR00195	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"LINC00942 directly recruits METTL14 protein by harboring the specific recognize sequence (+176-+265), thereby stabilized the expression of downstream targets of LNC942 including CXCR4 and Cytochrome P450 1B1 (CYP1B1) through posttranscriptional m6A methylation modification in vitro and in vivo."	M6ADIS0065	32576970	.
M6ACROT05354	REG00007	M6ATAR00659	Non-coding RNA	EPIREG00400	EPITAR00027	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"Long intergenic non-protein coding RNA 1273 (LINC01273) complementarity bound to hsa-miR-600, served as a 'reservoir' increasing miR-600 stability, and facilitating miR-600 targeting methyltransferase 3 (METTL3), a m6A 'writer', resulting in reducing METTL3 level. In addition, LINC01273 was modified with m6A, METTL3 increased LINC01273 m6A modification,"	M6ADIS0006	35037556	M6ADRUG0032
M6ACROT05355	REG00007	M6ATAR00659	Non-coding RNA	EPIREG00401	EPITAR00280	.	Up regulation	ncRNA	Indirect	Inhibition	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"Long intergenic non-protein coding RNA 1273 (LINC01273) complementarity bound to hsa-miR-600, served as a 'reservoir' increasing miR-600 stability, and facilitating miR-600 targeting methyltransferase 3 (METTL3), a m6A 'writer', resulting in reducing METTL3 level. In addition, LINC01273 was modified with m6A, METTL3 increased LINC01273 m6A modification,"	M6ADIS0006	35037556	M6ADRUG0032
M6ACROT05356	REG00007	M6ATAR00729	Non-coding RNA	EPIREG00211	EPITAR00027	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"DARS1-AS1 recruits METTL3/METTL14 to bind and enhance Aspartate--tRNA ligase, cytoplasmic (DARS) mRNA m6A modification and translation for cytoprotective autophagy in cervical cancer"	M6ADIS0008	35638109	.
M6ACROT05357	REG00006	M6ATAR00729	Non-coding RNA	EPIREG00211	EPITAR00195	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"DARS1-AS1 recruits METTL3/METTL14 to bind and enhance Aspartate--tRNA ligase, cytoplasmic (DARS) mRNA m6A modification and translation for cytoprotective autophagy in cervical cancer"	M6ADIS0008	35638109	.
M6ACROT05358	REG00007	M6ATAR01037	Non-coding RNA	EPIREG00402	EPITAR00027	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	Circ_TTLL13 stabilizes Oxidized low-density lipoprotein receptor 1 (OLR1) mRNA via recruiting YTH N6-methyladenosine RNA binding protein 1 (YTHDF1) and promotes m6A methylation of OLR1 pre-mRNA through recruiting methyltransferase-like 3 (METTL3). TOP/FOP-flash reporter assay and western blot verified that circTTLL13 activates Wnt/beta-catenin signaling pathway by regulating OLR1.	M6ADIS0001	37427890	M6ADRUG0010
M6ACROT05359	REG00024	M6ATAR01037	Non-coding RNA	EPIREG00402	EPITAR00248	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	Circ_TTLL13 stabilizes Oxidized low-density lipoprotein receptor 1 (OLR1) mRNA via recruiting YTH N6-methyladenosine RNA binding protein 1 (YTHDF1) and promotes m6A methylation of OLR1 pre-mRNA through recruiting methyltransferase-like 3 (METTL3). TOP/FOP-flash reporter assay and western blot verified that circTTLL13 activates Wnt/beta-catenin signaling pathway by regulating OLR1.	M6ADIS0001	37427890	M6ADRUG0010
M6ACROT05360	REG00007	M6ATAR00401	Non-coding RNA	EPIREG00403	EPITAR00027	.	Down regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hsa-miR-302a was identified to target METTL3, which could inhibit Suppressor of cytokine signaling 2 (SOCS2) expression via m6A modification.Histone demethylase JMJD1C promotes the polarization of M1 macrophages to prevent glioma by upregulating miR-302a"	M6ADIS0001	34586733	.
M6ACROT05361	REG00012	M6ATAR01400	Non-coding RNA	EPIREG00404	EPITAR00234	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Mechanistically, reduced VIM-AS1 expression stabilized Ephrin type-A receptor 3 (EPHA3) mRNA by enhancing the binding of IGF2BP1 to EPHA3 mRNA, leading to increased expression of EPHA3 mRNA and the promotion of HCC progression."	M6ADIS0006	39617786	.
M6ACROT05362	REG00013	M6ATAR01757	Non-coding RNA	EPIREG00405	EPITAR00028	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	Hypoxia induced cellular and exosomal RPPH1 promotes breast cancer angiogenesis and metastasis through stabilizing the IGF2BP2/Fibroblast growth factor receptor 2 (FGFR2) axis	M6ADIS0065	39496940	.
M6ACROT05363	REG00007	M6ATAR00229	Non-coding RNA	EPIREG00406	EPITAR00027	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"Circ_MEG3 inhibits the expression of H/ACA ribonucleoprotein complex subunit DKC1 (DKC1), a component of telomere synthetase H/ACA ribonucleoprotein (RNP; catalyst RNA pseudouracil modification) through METTL3 dependent on HULC."	M6ADIS0006	33425489	.
M6ACROT05364	REG00007	M6ATAR00375	Non-coding RNA	EPIREG00364	EPITAR00027	.	Down regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Our results demonstrated the molecular mechanism underlying the effect of LINC00470 on CML by reducing the Mutated in multiple advanced cancers 1 (PTEN) stability via RNA methyltransferase METTL3, thus leading to the inhibition of cell autophagy while promoting chemoresistance in CML."	M6ADIS0004	33749070	.
M6ACROT05365	REG00003	M6ATAR01412	Non-coding RNA	EPIREG00407	EPITAR00236	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	TGF-beta-induced lncRNA LINC01705 promotes EMT and metastasis in lung adenocarcinoma via HNRNPC-mediated Growth factor receptor-bound protein 2 (GRB2) mRNA stabilization	M6ADIS0007	39102940	.
M6ACROT05366	REG00012	M6ATAR00341	Non-coding RNA	EPIREG00408	EPITAR00234	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	A novel hypoxic long noncoding RNA KB-1980E6.3 maintains breast cancer stem cell stemness via interacting with IGF2BP1 to facilitate Myc proto-oncogene protein (MYC) mRNA stability	M6ADIS0065	33469161	.
M6ACROT05367	REG00013	M6ATAR00308	Non-coding RNA	EPIREG00409	EPITAR00028	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"hsa-miR-320b suppresses lung cancer growth and angiogenesis by inhibiting HNF4G, IGF2BP2 and TK1. In lung cancer, IGF2BP2 modified m6A to increase the expression of Thymidine kinase, cytosolic (TK1), thus promoting angiogenesis."	M6ADIS0007	33758932; 33758932	.
M6ACROT05368	REG00006	M6ATAR01386	Non-coding RNA	EPIREG00410	EPITAR00195	.	Down regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Circ_FTO facilitates the formation of methyltransferases complex to suppress Transcription factor SOX-9 (SOX9) expression with assistance from YTH domain family 2 (YTHDF2) through an m6A-dependent mechanism. Furthermore, inhibition of circFTO improved symptoms of RA in vivo.Remarkably, the biotinylated antisense of circFTO successfully captured METTL14, while the METTL14 antibody also effectively captured circFTO. circFTO also was found to colocalize with METTL14 protein in chondrocytes. These findings strongly support the interaction between circFTO and the WTAP/METTL3/METTL14 complex.Collectively, our findings suggest a potential role for circFTO in facilitating the formation of WTAP/METTL3/METTL14 complex and enhancing overall m6A modification levels within chondrocytes."	M6ADIS0112	38388473	.
M6ACROT05369	REG00009	M6ATAR01386	Non-coding RNA	EPIREG00410	EPITAR00195	.	Down regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Circ_FTO facilitates the formation of methyltransferases complex to suppress Transcription factor SOX-9 (SOX9) expression with assistance from YTH domain family 2 (YTHDF2) through an m6A-dependent mechanism. Furthermore, inhibition of circFTO improved symptoms of RA in vivo.Remarkably, the biotinylated antisense of circFTO successfully captured Methyltransferase-like protein 14 (METTL14), while the METTL14 antibody also effectively captured circFTO. circFTO also was found to colocalize with METTL14 protein in chondrocytes. These findings strongly support the interaction between circFTO and the WTAP/METTL3/METTL14 complex.Collectively, our findings suggest a potential role for circFTO in facilitating the formation of WTAP/METTL3/METTL14 complex and enhancing overall m6A modification levels within chondrocytes."	M6ADIS0112	38388473	.
M6ACROT05370	REG00007	M6ATAR01386	Non-coding RNA	EPIREG00410	EPITAR00195	.	Down regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Circ_FTO facilitates the formation of methyltransferases complex to suppress Transcription factor SOX-9 (SOX9) expression with assistance from YTH domain family 2 (YTHDF2) through an m6A-dependent mechanism. Furthermore, inhibition of circFTO improved symptoms of RA in vivo.Remarkably, the biotinylated antisense of circFTO successfully captured Methyltransferase-like protein 14 (METTL14), while the METTL14 antibody also effectively captured circFTO. circFTO also was found to colocalize with METTL14 protein in chondrocytes. These findings strongly support the interaction between circFTO and the WTAP/METTL3/METTL14 complex.Collectively, our findings suggest a potential role for circFTO in facilitating the formation of WTAP/METTL3/METTL14 complex and enhancing overall m6A modification levels within chondrocytes."	M6ADIS0112	38388473	.
M6ACROT05371	REG00008	M6ATAR01386	Non-coding RNA	EPIREG00410	EPITAR00195	.	Down regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"Circ_FTO facilitates the formation of methyltransferases complex to suppress Transcription factor SOX-9 (SOX9) expression with assistance from YTH domain family 2 (YTHDF2) through an m6A-dependent mechanism. Furthermore, inhibition of circFTO improved symptoms of RA in vivo.Remarkably, the biotinylated antisense of circFTO successfully captured Methyltransferase-like protein 14 (METTL14), while the METTL14 antibody also effectively captured circFTO. circFTO also was found to colocalize with METTL14 protein in chondrocytes. These findings strongly support the interaction between circFTO and the WTAP/METTL3/METTL14 complex.Collectively, our findings suggest a potential role for circFTO in facilitating the formation of WTAP/METTL3/METTL14 complex and enhancing overall m6A modification levels within chondrocytes."	M6ADIS0112	38388473	.
M6ACROT05372	REG00013	M6ATAR00476	Non-coding RNA	EPIREG00353	EPITAR00028	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	LINC00460/DHX9/IGF2BP2 complex promotes colorectal cancer proliferation and metastasis by mediating High mobility group protein HMG-I/HMG-Y (HMGA1) mRNA stability depending on m6A modification	M6ADIS0059	33526059	.
M6ACROT05373	REG00008	M6ATAR01415	Non-coding RNA	EPIREG00411	EPITAR00232	.	Down regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"YTHDF2 function was a downstream of MIAT in cardiac hypertrophy. Finally, we found that MIAT was a necessary regulator of cardiac hypertrophy due to its regulation of the Ythdf2/PPARalpha/Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) axis. This study indicated a new hypertrophic signaling pathway: MIAT/Ythdf2/PPARalpha/CPT-1a. The results provided a new understanding of the MIAT and m6A RNA methylation reading protein, Ythdf2, function and mechanism in cardiac hypertrophy and highlighted the potential therapeutic benefits in the heart."	M6ADIS0243	35383152	.
M6ACROT05374	REG00017	M6ATAR00141	Non-coding RNA	EPIREG00215	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	LncRNAs are involved in a plethora of cellular signaling pathways and actively regulate gene expression via a broad selection of molecular mechanisms. Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) could serve a role as a regulator of RNA processing or modification events through guiding METTL16 onto its RNA targets.	.	29125541	.
M6ACROT05375	REG00007	M6ATAR00319	Non-coding RNA	EPIREG00223	EPITAR00027	.	Up regulation	m6A	Indirect	Inhibition	ncRNA	m6A regulators indirectly modulate the functionality of ncRNAs through downstream signaling pathways	"Ragulator complex protein LAMTOR5 (LAMTOR5/HBXIP) up-regulates METTL3 by suppressing MIRLET7G, in which METTL3 increased HBXIP expression forming a positive feedback loop of HBXIP/let-7g/METTL3/HBXIP, leading to accelerated cell proliferation in breast cancer. "	M6ADIS0065	29174803	.
M6ACROT05376	REG00005	M6ATAR00082	Non-coding RNA	EPIREG00412	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	ALKBH5 inhibits pancreatic cancer motility by demethylating lncRNA KCNK15 and WISP2 antisense RNA 1 (KCNK15-AS1).	M6ADIS0061	30032148	.
M6ACROT05377	REG00004	M6ATAR00107	Non-coding RNA	EPIREG00241	EPITAR00281	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	Urothelial cancer associated 1 (UCA1) increases KRAS phosphorylation by interacting with hnRNPA2B1 and that UCA1 functions as a molecular sponge for hsa-miR-590-3p to promote KRAS expression. the UCA1-KRAS axis plays a crucial role in pancreatic ductal adenocarcinoma progression and that UCA1 serves as a target for new PDAC therapies.	M6ADIS0061	30949406	.
M6ACROT05378	REG00005	M6ATAR00125	Non-coding RNA	EPIREG00413	EPITAR00219	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"ALKBH5 is a tumor-promoting gene in epithelial ovarian cancer, which is involved in the mTOR pathway and microRNA 7-1 (MIR7-1)-Beclin1 complex. ALKBH5 activated Epidermal growth factor receptor (EGFR)-PIK3CA-AKT-mTOR signaling pathway. ALKBH5 inhibited autophagy of epithelial ovarian cancer through microRNA 7-1 (MIR7-1) and BCL-2."	M6ADIS0066	30987661	.
M6ACROT05379	REG00007	M6ATAR00127	Non-coding RNA	EPIREG00414	EPITAR00282	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Cigarette smoke-induced microRNA 25 (MIR25) excessive maturation via m6A modification promotes the development and progression of pancreatic cancer. This modification is catalyzed by overexpressed methyltransferase-like 3 (METTL3) due to hypomethylation of the METTL3 promoter also caused by CSC. Mature miR-25, miR-25-3p, suppresses PH domain leucine-rich repeat protein phosphatase 2 (PHLPP2), resulting in the activation of oncogenic AKT-p70S6K signaling, which provokes malignant phenotypes of pancreatic cancer cells."	M6ADIS0061	31015415	.
M6ACROT05380	REG00007	M6ATAR00009	Non-coding RNA	EPIREG00415	EPITAR00283	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL3 interacts with the microprocessor protein DGCR8 and positively modulates hsa-miR-873-5p mature process in an m6A-dependent manner. METTL3/m6A in colistin-induced nephrotoxicity and provide a new insight on m6A modification in drug induced toxicity. Further experiments show that miR-873-5p could regulate Kelch-like ECH-associated protein 1 (KEAP1)-Nrf2 pathway against colistin-induced oxidative stress and apoptosis.	M6ADIS0119	31156435	.
M6ACROT05381	REG00007	M6ATAR00130	Non-coding RNA	EPIREG00416	EPITAR00151	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3 has an oncogenic role in bladder cancer through interacting with the microprocessor protein DGCR8 and positively modulating the microRNA 221 (MIR221) process in an m6A-dependent manner, resulting in the reduction of Mutated in multiple advanced cancers 1 (PTEN)."	M6ADIS0070	31228940	.
M6ACROT05382	REG00007	M6ATAR00129	Non-coding RNA	EPIREG00417	EPITAR00151	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3 has an oncogenic role in bladder cancer through interacting with the microprocessor protein DGCR8 and positively modulating the microRNA 222 (MIR222) process in an m6A-dependent manner, resulting in the reduction of Mutated in multiple advanced cancers 1 (PTEN)."	M6ADIS0070	31228940	.
M6ACROT05383	REG00004	M6ATAR00010	Non-coding RNA	EPIREG00418	.	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"HNRNPA2B1 is a reader of the N(6)-methyladenosine mark in primary-miRNAs and promotes DROSHA processing to precursor-miRNAs. HNRNPA2B1 downregulated hsa-miR-29a-3p, miR-29b-3p, and miR-222 and upregulated miR-1266-5p, miR-1268a, miR-671-3p. Transient overexpression of HNRNPA2/B1 reduced breast cancer cellMCF-7 sensitivity to 4-hydroxytamoxifen and fulvestrant, suggesting a role for HNRNPA2/B1 in endocrine-resistance."	M6ADIS0065	31263129	M6ADRUG0039
M6ACROT05384	REG00004	M6ATAR00011	Non-coding RNA	EPIREG00419	.	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"HNRNPA2B1 is a reader of the N(6)-methyladenosine mark in primary-miRNAs and promotes DROSHA processing to precursor-miRNAs. HNRNPA2B1 downregulated miR-29a-3p, hsa-miR-29b-3p, and miR-222 and upregulated miR-1266-5p, miR-1268a, miR-671-3p. Transient overexpression of HNRNPA2/B1 reduced breast cancer cellMCF-7 sensitivity to 4-hydroxytamoxifen and fulvestrant, suggesting a role for HNRNPA2/B1 in endocrine-resistance."	M6ADIS0065	31263129	M6ADRUG0039
M6ACROT05385	REG00004	M6ATAR00129	Non-coding RNA	EPIREG00417	.	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"HNRNPA2B1 is a reader of the N(6)-methyladenosine mark in primary-miRNAs and promotes DROSHA processing to precursor-miRNAs. HNRNPA2B1 downregulated miR-29a-3p, miR-29b-3p, and microRNA 222 (MIR222) and upregulated miR-1266-5p, miR-1268a, miR-671-3p. Transient overexpression of HNRNPA2/B1 reduced breast cancer cellMCF-7 sensitivity to 4-hydroxytamoxifen and fulvestrant, suggesting a role for HNRNPA2/B1 in endocrine-resistance."	M6ADIS0065	31263129	M6ADRUG0039
M6ACROT05386	REG00004	M6ATAR00012	Non-coding RNA	EPIREG00421	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"HNRNPA2B1 is a reader of the N(6)-methyladenosine mark in primary-miRNAs and promotes DROSHA processing to precursor-miRNAs. HNRNPA2B1 downregulated miR-29a-3p, miR-29b-3p, and miR-222 and upregulated hsa-miR-1266-5p, miR-1268a, miR-671-3p. Transient overexpression of HNRNPA2/B1 reduced breast cancer cellMCF-7 sensitivity to 4-hydroxytamoxifen and fulvestrant, suggesting a role for HNRNPA2/B1 in endocrine-resistance."	M6ADIS0065	31263129	M6ADRUG0039
M6ACROT05387	REG00004	M6ATAR00013	Non-coding RNA	EPIREG00422	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"HNRNPA2B1 is a reader of the N(6)-methyladenosine mark in primary-miRNAs and promotes DROSHA processing to precursor-miRNAs. HNRNPA2B1 downregulated miR-29a-3p, miR-29b-3p, and miR-222 and upregulated miR-1266-5p, hsa-miR-1268a, miR-671-3p. Transient overexpression of HNRNPA2/B1 reduced breast cancer cellMCF-7 sensitivity to 4-hydroxytamoxifen and fulvestrant, suggesting a role for HNRNPA2/B1 in endocrine-resistance."	M6ADIS0065	31263129	M6ADRUG0039
M6ACROT05388	REG00004	M6ATAR00014	Non-coding RNA	EPIREG00423	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"HNRNPA2B1 is a reader of the N(6)-methyladenosine mark in primary-miRNAs and promotes DROSHA processing to precursor-miRNAs. HNRNPA2B1 downregulated miR-29a-3p, miR-29b-3p, and miR-222 and upregulated miR-1266-5p, miR-1268a, hsa-miR-671-3p. Transient overexpression of HNRNPA2/B1 reduced breast cancer cellMCF-7 sensitivity to 4-hydroxytamoxifen and fulvestrant, suggesting a role for HNRNPA2/B1 in endocrine-resistance."	M6ADIS0065	31263129	M6ADRUG0039
M6ACROT05389	REG00004	M6ATAR00010	Non-coding RNA	EPIREG00418	.	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"HNRNPA2B1 is a reader of the N(6)-methyladenosine mark in primary-miRNAs and promotes DROSHA processing to precursor-miRNAs. HNRNPA2B1 downregulated hsa-miR-29a-3p, miR-29b-3p, and miR-222 and upregulated miR-1266-5p, miR-1268a, miR-671-3p. Transient overexpression of HNRNPA2/B1 reduced breast cancer cellMCF-7 sensitivity to 4-hydroxytamoxifen and fulvestrant, suggesting a role for HNRNPA2/B1 in endocrine-resistance."	M6ADIS0065	31263129	M6ADRUG0028
M6ACROT05390	REG00004	M6ATAR00011	Non-coding RNA	EPIREG00419	.	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"HNRNPA2B1 is a reader of the N(6)-methyladenosine mark in primary-miRNAs and promotes DROSHA processing to precursor-miRNAs. HNRNPA2B1 downregulated miR-29a-3p, hsa-miR-29b-3p, and miR-222 and upregulated miR-1266-5p, miR-1268a, miR-671-3p. Transient overexpression of HNRNPA2/B1 reduced breast cancer cellMCF-7 sensitivity to 4-hydroxytamoxifen and fulvestrant, suggesting a role for HNRNPA2/B1 in endocrine-resistance."	M6ADIS0065	31263129	M6ADRUG0028
M6ACROT05391	REG00004	M6ATAR00129	Non-coding RNA	EPIREG00417	.	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"HNRNPA2B1 is a reader of the N(6)-methyladenosine mark in primary-miRNAs and promotes DROSHA processing to precursor-miRNAs. HNRNPA2B1 downregulated miR-29a-3p, miR-29b-3p, and microRNA 222 (MIR222) and upregulated miR-1266-5p, miR-1268a, miR-671-3p. Transient overexpression of HNRNPA2/B1 reduced breast cancer cellMCF-7 sensitivity to 4-hydroxytamoxifen and fulvestrant, suggesting a role for HNRNPA2/B1 in endocrine-resistance."	M6ADIS0065	31263129	M6ADRUG0028
M6ACROT05392	REG00004	M6ATAR00012	Non-coding RNA	EPIREG00421	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"HNRNPA2B1 is a reader of the N(6)-methyladenosine mark in primary-miRNAs and promotes DROSHA processing to precursor-miRNAs. HNRNPA2B1 downregulated miR-29a-3p, miR-29b-3p, and miR-222 and upregulated hsa-miR-1266-5p, miR-1268a, miR-671-3p. Transient overexpression of HNRNPA2/B1 reduced breast cancer cellMCF-7 sensitivity to 4-hydroxytamoxifen and fulvestrant, suggesting a role for HNRNPA2/B1 in endocrine-resistance."	M6ADIS0065	31263129	M6ADRUG0028
M6ACROT05393	REG00004	M6ATAR00013	Non-coding RNA	EPIREG00422	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"HNRNPA2B1 is a reader of the N(6)-methyladenosine mark in primary-miRNAs and promotes DROSHA processing to precursor-miRNAs. HNRNPA2B1 downregulated miR-29a-3p, miR-29b-3p, and miR-222 and upregulated miR-1266-5p, hsa-miR-1268a, miR-671-3p. Transient overexpression of HNRNPA2/B1 reduced breast cancer cellMCF-7 sensitivity to 4-hydroxytamoxifen and fulvestrant, suggesting a role for HNRNPA2/B1 in endocrine-resistance."	M6ADIS0065	31263129	M6ADRUG0028
M6ACROT05394	REG00004	M6ATAR00014	Non-coding RNA	EPIREG00423	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"HNRNPA2B1 is a reader of the N(6)-methyladenosine mark in primary-miRNAs and promotes DROSHA processing to precursor-miRNAs. HNRNPA2B1 downregulated miR-29a-3p, miR-29b-3p, and miR-222 and upregulated miR-1266-5p, miR-1268a, hsa-miR-671-3p. Transient overexpression of HNRNPA2/B1 reduced breast cancer cellMCF-7 sensitivity to 4-hydroxytamoxifen and fulvestrant, suggesting a role for HNRNPA2/B1 in endocrine-resistance."	M6ADIS0065	31263129	M6ADRUG0028
M6ACROT05395	REG00005	M6ATAR00140	Non-coding RNA	EPIREG00279	EPITAR00437	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	ALKBH5 promotes Gastric cancer invasion and metastasis by demethylating the lncRNA Nuclear paraspeckle assembly transcript 1 (NEAT1). The binding of ALKBH5 and NEAT1 influences the expression of Histone-lysine N-methyltransferase EZH2 (EZH2) and thus affects GC invasion and metastasis.	M6ADIS0057	31290116	.
M6ACROT05396	REG00007	M6ATAR00143	Non-coding RNA	EPIREG00424	EPITAR00284	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Family with sequence similarity 225 member A (FAM225A) functioned as a competing endogenous RNA (ceRNA) for sponging miR-590-3p and miR-1275, leading to the upregulation of their target Integrin subunit beta 3 (ITGB3), and the activation of FAK/PI3K/Akt signaling to promote Nasopharyngeal carcinoma cell proliferation and invasion. FAM225A showed lower RNA stability after silencing of METTL3."	M6ADIS0054	31331909	.
M6ACROT05397	REG00007	M6ATAR00109	Non-coding RNA	EPIREG00425	EPITAR00285	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3/microRNA 1246 (MIR1246)/Sprouty-related, EVH1 domain-containing protein 2 (SPRED2) axis plays an important role in tumor metastasis and provides a new m6A modification pattern in Colorectal cancer development."	M6ADIS0059	31492150	.
M6ACROT05398	REG00008	M6ATAR00148	Non-coding RNA	EPIREG00426	EPITAR00286	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The GAS5 antisense RNA 1 (GAS5-AS1) expression in cervical cancer tissues was markedly decreased when compared with that in the adjacent normal tissues. GAS5-AS1 interacted with the tumor suppressor Growth arrest specific 5 (GAS5), and increased its stability by interacting with RNA demethylase ALKBH5 and decreasing GAS5 N6-methyladenosine (m6A) modification. m6A-mediated GAS5 RNA degradation relied on the m6A reader protein YTHDF2-dependent pathway. "	M6ADIS0008	31497208	.
M6ACROT05399	REG00005	M6ATAR00148	Non-coding RNA	EPIREG00426	EPITAR00286	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The GAS5 antisense RNA 1 (GAS5-AS1) expression in cervical cancer tissues was markedly decreased when compared with that in the adjacent normal tissues. GAS5-AS1 interacted with the tumor suppressor Growth arrest specific 5 (GAS5), and increased its stability by interacting with RNA demethylase ALKBH5 and decreasing GAS5 N6-methyladenosine (m6A) modification. m6A-mediated GAS5 RNA degradation relied on the m6A reader protein YTHDF2-dependent pathway. "	M6ADIS0008	31497208	.
M6ACROT05400	REG00025	M6ATAR00148	Non-coding RNA	EPIREG00426	EPITAR00249	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	A new mechanism for m6A-induced decay of Growth arrest specific 5 (GAS5) on YAP signaling in progression of Colorectal cancer which offers a promising approach for CRC treatment. LncRNA GAS5 expressions is negatively correlated with YAP and YTHDF3 protein levels in tumors from CRC patients.	M6ADIS0059	31619268	.
M6ACROT05401	REG00008	M6ATAR00157	Non-coding RNA	EPIREG00364	EPITAR00151	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	Long intergenic non-protein coding RNA 470 (LINC00470)-METTL3-mediated Mutated in multiple advanced cancers 1 (PTEN) mRNA degradation relied on the m6A reader protein YTHDF2-dependent pathway. LINC00470 served as a therapeutic target for Gastric cancer patients.	M6ADIS0057	31711642	.
M6ACROT05402	REG00007	M6ATAR00157	Non-coding RNA	EPIREG00364	EPITAR00151	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	Long intergenic non-protein coding RNA 470 (LINC00470)-METTL3-mediated Mutated in multiple advanced cancers 1 (PTEN) mRNA degradation relied on the m6A reader protein YTHDF2-dependent pathway.LINC00470 served as a therapeutic target for Gastric cancer patients.	M6ADIS0057	31711642	.
M6ACROT05403	REG00025	M6ATAR00141	Non-coding RNA	EPIREG00215	EPITAR00167	.	Up regulation	m6A	Direct	Enhancement	ncRNA	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"METTL3, YTHDF3, YTHDF1, and eIF3b directly promoted Transcriptional coactivator YAP1 (YAP1) translation through an interaction with the translation initiation machinery. METTL3 knockdown inhibits tumor growth and enhances sensitivity to DDP in vivo.m6A mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the Metastasis associated lung adenocarcinoma transcript 1 (MALAT1)-miR-1914-3p-YAP axis to induce Non-small cell lung cancer drug resistance and metastasis."	M6ADIS0065	38626369; 31263129	M6ADRUG0039
M6ACROT05404	REG00007	M6ATAR00141	Non-coding RNA	EPIREG00215	EPITAR00167	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3, YTHDF3, YTHDF1, and eIF3b directly promoted Transcriptional coactivator YAP1 (YAP1) translation through an interaction with the translation initiation machinery. METTL3 knockdown inhibits tumor growth and enhances sensitivity to DDP in vivo.m6A mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the Metastasis associated lung adenocarcinoma transcript 1 (MALAT1)-miR-1914-3p-YAP axis to induce Non-small cell lung cancer drug resistance and metastasis."	M6ADIS0007	31818312	M6ADRUG0047
M6ACROT05405	REG00024	M6ATAR00141	Non-coding RNA	EPIREG00215	EPITAR00167	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3, YTHDF3, YTHDF1, and eIF3b directly promoted Transcriptional coactivator YAP1 (YAP1) translation through an interaction with the translation initiation machinery. METTL3 knockdown inhibits tumor growth and enhances sensitivity to DDP in vivo.m6A mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the Metastasis associated lung adenocarcinoma transcript 1 (MALAT1)-miR-1914-3p-YAP axis to induce Non-small cell lung cancer drug resistance and metastasis."	M6ADIS0007	31818312	M6ADRUG0047
M6ACROT05406	REG00007	M6ATAR00465	Non-coding RNA	EPIREG00427	EPITAR00167	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3, YTHDF3, YTHDF1, and eIF3b directly promoted Transcriptional coactivator YAP1 (YAP1) translation through an interaction with the translation initiation machinery. METTL3 knockdown inhibits tumor growth and enhances sensitivity to DDP in vivo.m6A mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-hsa-miR-1914-3p-YAP axis to induce Non-small cell lung cancer drug resistance and metastasis."	M6ADIS0007	31818312	M6ADRUG0047
M6ACROT05407	REG00025	M6ATAR00465	Non-coding RNA	EPIREG00427	EPITAR00167	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3, YTHDF3, YTHDF1, and eIF3b directly promoted Transcriptional coactivator YAP1 (YAP1) translation through an interaction with the translation initiation machinery. METTL3 knockdown inhibits tumor growth and enhances sensitivity to DDP in vivo.m6A mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-hsa-miR-1914-3p-YAP axis to induce Non-small cell lung cancer drug resistance and metastasis."	M6ADIS0007	31818312	M6ADRUG0047
M6ACROT05408	REG00024	M6ATAR00465	Non-coding RNA	EPIREG00427	EPITAR00167	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3, YTHDF3, YTHDF1, and eIF3b directly promoted Transcriptional coactivator YAP1 (YAP1) translation through an interaction with the translation initiation machinery. METTL3 knockdown inhibits tumor growth and enhances sensitivity to DDP in vivo.m6A mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-hsa-miR-1914-3p-YAP axis to induce Non-small cell lung cancer drug resistance and metastasis."	M6ADIS0007	31818312	M6ADRUG0047
M6ACROT05409	REG00007	M6ATAR00017	Non-coding RNA	EPIREG00428	EPITAR00287	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	m6A methyltransferase Mettl3 can increase the splicing of precursor hsa-miR-143-3p to facilitate its biogenesis. The miR-143-3p/Vasohibin 1 (VASH1) axis in BM of lung cancers and suggests their critical roles in lung cancer pathogenesis.	M6ADIS0007	31823788	.
M6ACROT05410	REG00006	M6ATAR00118	Non-coding RNA	EPIREG00429	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL14 suppressed Colorectal cancer cell growth, migration, and invasion via the microRNA 375 (MIR375)/YAP1 and miR-375/SP1 pathways."	M6ADIS0059	31839484	.
M6ACROT05411	REG00007	M6ATAR00018	Non-coding RNA	EPIREG00430	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL3 positively modulated the mmu-miR-365-3p processing in a microprocessor protein DiGeorge critical region 8-dependent manner.METTL3-mediated m6A modification in nociceptive sensitization and provide a novel perspective on m6A modification in the development of Inflammatory pain.	M6ADIS0024	31914601	.
M6ACROT05412	REG00007	M6ATAR00088	Non-coding RNA	EPIREG00431	EPITAR00035	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Long intergenic non-protein coding RNA 958 (LINC00958) sponged miR-3619-5p to upregulate Hepatoma-derived growth factor (HDGF) expression, thereby facilitating Hepatocellular carcinoma lipogenesis and progression. METTL3-mediated N6-methyladenosine modification led to LINC00958 upregulation through stabilizing its RNA transcript. "	M6ADIS0006	31915027	.
M6ACROT05413	REG00014	M6ATAR00086	Non-coding RNA	EPIREG00432	EPITAR00235	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"CDR1 antisense RNA (CDR1-AS) a regulator of miR-7, as a hallmark of melanoma progression. CDR1as depletion results from epigenetic silencing of LINC00632, its originating long non-coding RNA (lncRNA) and promotes invasion in vitro and metastasis in vivo through a miR-7-independent, IGF2BP3-mediated mechanism. IGF2BP3 interacts with CDR1as and mediates invasion induced by CDR1as depletion. CDR1asHigh melanoma cell lines were strikingly more sensitive to three different GPX4 inhibitors, which are known to elicit ferroptotic cell death."	M6ADIS0007	31818312	M6ADRUG0047
M6ACROT05414	REG00014	M6ATAR00086	Non-coding RNA	EPIREG00432	EPITAR00235	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"CDR1 antisense RNA (CDR1-AS) a regulator of miR-7, as a hallmark of melanoma progression. CDR1as depletion results from epigenetic silencing of LINC00632, its originating long non-coding RNA (lncRNA) and promotes invasion in vitro and metastasis in vivo through a miR-7-independent, IGF2BP3-mediated mechanism. IGF2BP3 interacts with CDR1as and mediates invasion induced by CDR1as depletion. CDR1asHigh melanoma cell lines were strikingly more sensitive to three different GPX4 inhibitors, which are known to elicit ferroptotic cell death."	M6ADIS0056	33596916	M6ADRUG0047
M6ACROT05415	REG00014	M6ATAR00086	Non-coding RNA	EPIREG00432	EPITAR00235	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"CDR1 antisense RNA (CDR1-AS) a regulator of miR-7, as a hallmark of melanoma progression. CDR1as depletion results from epigenetic silencing of LINC00632, its originating long non-coding RNA (lncRNA) and promotes invasion in vitro and metastasis in vivo through a miR-7-independent, IGF2BP3-mediated mechanism. IGF2BP3 interacts with CDR1as and mediates invasion induced by CDR1as depletion. CDR1asHigh melanoma cell lines were strikingly more sensitive to three different GPX4 inhibitors, which are known to elicit ferroptotic cell death."	M6ADIS0056	33596916	M6ADRUG0047
M6ACROT05416	REG00007	M6ATAR00134	Non-coding RNA	EPIREG00228	EPITAR00027	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	microRNA 186 (MIR186)/METTL3 axis contributed to the progression of Hepatoblastoma via the Wnt/beta-catenin signalling pathway.	M6ADIS0006	31967701	.
M6ACROT05417	REG00005	M6ATAR00153	Non-coding RNA	EPIREG00433	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"ALKBH5 decreased the m6A modification of Pvt1 oncogene (PVT1), thus inhibiting the binding of reader protein YTHDF2 in PVT1. ALKBH5-mediated PVT1 upregulation promoted the osteosarcoma cell proliferation in vitro and tumor growth in vivo."	M6ADIS0051	32021563	.
M6ACROT05418	REG00008	M6ATAR00153	Non-coding RNA	EPIREG00433	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"ALKBH5 decreased the m6A modification of Pvt1 oncogene (PVT1), thus inhibiting the binding of reader protein YTHDF2 in PVT1. ALKBH5-mediated PVT1 upregulation promoted the osteosarcoma cell proliferation in vitro and tumor growth in vivo."	M6ADIS0051	32021563	.
M6ACROT05419	REG00005	M6ATAR00138	Non-coding RNA	EPIREG00434	EPITAR00288	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	m6A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting microRNA 107 (MIR107)/Serine/threonine-protein kinase LATS2 (LATS2)-mediated YAP activity in non-small cell lung cancer. 	M6ADIS0007	32106857	.
M6ACROT05420	REG00008	M6ATAR00152	Non-coding RNA	EPIREG00435	.	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"In colorectal cancer, knockdown of METTL14 substantially abolished m6A level of X inactive specific transcript (XIST) and augmented XIST expression. m6A-methylated XIST was recognized by YTHDF2, a m6A reader protein, to mediate the degradation of XIST. "	M6ADIS0059	32111213	.
M6ACROT05421	REG00006	M6ATAR00152	Non-coding RNA	EPIREG00435	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"In colorectal cancer, knockdown of METTL14 substantially abolished m6A level of X inactive specific transcript (XIST) and augmented XIST expression. m6A-methylated XIST was recognized by YTHDF2, a m6A reader protein, to mediate the degradation of XIST. "	M6ADIS0059	32111213	.
M6ACROT05422	REG00022	M6ATAR00019	Non-coding RNA	EPIREG00436	EPITAR00072	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Knockdown of METTL3 prolonged the half-life of PncRNA-D, and among the known m6A recognition proteins, YTHDC1 was responsible for binding m6A of pncRNA-D Knockdown of METTL3 or YTHDC1 also enhanced the interaction of pncRNA-D with TLS, and results from RNA pulldown assays implicated YTHDC1 in the inhibitory effect on the TLS-pncRNA-D interaction. m6A modification of the long noncoding RNA pncRNA-D plays a role in the regulation of G1/S-specific cyclin-D1 (CCND1) gene expression and cell cycle progression."	M6ADIS0052	32165496	.
M6ACROT05423	REG00007	M6ATAR00019	Non-coding RNA	EPIREG00436	EPITAR00072	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Knockdown of METTL3 prolonged the half-life of PncRNA-D, and among the known m6A recognition proteins, YTHDC1 was responsible for binding m6A of pncRNA-D Knockdown of METTL3 or YTHDC1 also enhanced the interaction of pncRNA-D with TLS, and results from RNA pulldown assays implicated YTHDC1 in the inhibitory effect on the TLS-pncRNA-D interaction. m6A modification of the long noncoding RNA pncRNA-D plays a role in the regulation of G1/S-specific cyclin-D1 (CCND1) gene expression and cell cycle progression."	M6ADIS0052	32165496	.
M6ACROT05424	REG00007	M6ATAR00141	Non-coding RNA	EPIREG00215	EPITAR00289	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	Renal fibrosis is a key factor in chronic kidney disease (CKD). METTL3 upregulates Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) in an m6A-dependent manner and MALAT1/MicroRNA 145 (MIR145)/FAK pathway was involved in the effect of dihydroartemisinin (DHA) on TGF-beta1-induced renal fibrosis in vitro and in vivo. 	M6ADIS0117	32203053	M6ADRUG0041
M6ACROT05425	REG00007	M6ATAR00080	Non-coding RNA	EPIREG00437	EPITAR00290	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	The N6-methyladenosine (m6A) modification mediated by METTL3 and METTL14 enhanced the stability of LncRNA activating regulator of DKK1 (LNCAROD) in head and neck squamous cell carcinoma cells. LNCAROD is stabilized by m6A methylation and promotes cancer progression via forming a ternary complex with HSPA1A and Y-box-binding protein 1 (YBX1) in head and neck squamous cell carcinoma.	M6ADIS0055	32216017	.
M6ACROT05426	REG00006	M6ATAR00080	Non-coding RNA	EPIREG00437	EPITAR00291	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	The N6-methyladenosine (m6A) modification mediated by METTL3 and METTL14 enhanced the stability of LncRNA activating regulator of DKK1 (LNCAROD) in head and neck squamous cell carcinoma cells. LNCAROD is stabilized by m6A methylation and promotes cancer progression via forming a ternary complex with Heat shock 70 kDa protein 1A (HSPA1A) and YBX1 in head and neck squamous cell carcinoma.	M6ADIS0055	32216017	.
M6ACROT05427	REG00015	M6ATAR00092	Non-coding RNA	EPIREG00438	EPITAR00022	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	VIRMA downregulation attenuates the aggressive phenotype of prostate cancer by overall reduction of m6A-levels decreasing stability and abundance of oncogenic lncRNAs. VIRMA depletion and m6A reduction decreased the stability and abundance of Colon cancer associated transcript 1 (CCAT1) transcripts. Stabilization of CCAT1/2 by m6A has an amplifying effect on Myc proto-oncogene protein (MYC) expression levels in cancer cells through both lncRNAs acting as super-enhancers that positively regulate MYC mRNA.	M6ADIS0068	32218194	M6ADRUG0250
M6ACROT05428	REG00015	M6ATAR00091	Non-coding RNA	EPIREG00439	EPITAR00022	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	VIRMA downregulation attenuates the aggressive phenotype of prostate cancer by overall reduction of m6A-levels decreasing stability and abundance of oncogenic lncRNAs. VIRMA depletion and m6A reduction decreased the stability and abundance of Colon cancer associated transcript 2 (CCAT2) transcripts. Stabilization of CCAT1/2 by m6A has an amplifying effect on Myc proto-oncogene protein (MYC) expression levels in cancer cells through both lncRNAs acting as super-enhancers that positively regulate MYC mRNA.	M6ADIS0068	32218194	M6ADRUG0250
M6ACROT05429	REG00012	M6ATAR00076	Non-coding RNA	EPIREG00232	EPITAR00292	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The oncopeptide Septin 14 pseudogene 20 (SEPTIN14P20/LINC00266-1) encoded by Septin 14 pseudogene 20 (SEPTIN14P20/LINC00266-1) is a regulatory subunit of m6A readers and strengthens m6A recognition on the target RNAs by the m6A reader to exert its oncogenic functions. RBRP binds to IGF2BP1 and strengthens m6A recognition by IGF2BP1 on RNAs, such as c-Myc mRNA, to increase the mRNA stability and expression of c-Myc, thereby promoting tumorigenesis."	.	32245947	.
M6ACROT05430	REG00007	M6ATAR00020	Non-coding RNA	EPIREG00440	EPITAR00293	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Down-regulation of METTL3 promotes osteogenic processes both in vitro and in vivo, and this effect is recapitulated by the suppression of mmu-miR-7212-5p maturation. miR-7212-5p inhibits osteoblast differentiation in MC3T3-E1 cells by targeting Fibroblast growth factor receptor 3 (FGFR3). "	M6ADIS0026	32307908	.
M6ACROT05431	REG00006	M6ATAR00063	Non-coding RNA	EPIREG00441	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"In breast cancer, hsa-miR-146a-5p modulated by METTL14 promoted cell migration and invasion."	M6ADIS0065	32323801	.
M6ACROT05432	REG00007	M6ATAR00021	Non-coding RNA	EPIREG00442	EPITAR00151	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3 involves in the pathogenesis of diabetic retinopathy (DR). Both METTL3 mRNA and hsa-miR-25-3p were low-expressed in the peripheral venous blood samples of diabetes mellitus (DM) patients compared to normal volunteers, and high-glucose inhibited METTL3 and miR-25-3p expressions in RPE cells. Overexpression of METTL3 attenuates high-glucose induced RPE cell pyroptosis by regulating miR-25-3p/Mutated in multiple advanced cancers 1 (PTEN)/Akt signaling cascade through DGCR8."	M6ADIS0015	32365051	.
M6ACROT05433	REG00007	M6ATAR00021	Non-coding RNA	EPIREG00442	EPITAR00151	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3 involves in the pathogenesis of diabetic retinopathy (DR). Both METTL3 mRNA and hsa-miR-25-3p were low-expressed in the peripheral venous blood samples of diabetes mellitus (DM) patients compared to normal volunteers, and high-glucose inhibited METTL3 and miR-25-3p expressions in RPE cells. Overexpression of METTL3 attenuates high-glucose induced RPE cell pyroptosis by regulating miR-25-3p/Mutated in multiple advanced cancers 1 (PTEN)/Akt signaling cascade through DGCR8."	M6ADIS0080	32365051	.
M6ACROT05434	REG00007	M6ATAR00121	Non-coding RNA	EPIREG00443	EPITAR00294	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3-mediated m6A methylation increases the maturation of microRNA 335 (MIR335), which promotes SG formation and reduces the apoptosis level of injury neurons and cells, and provides a potential therapeutic strategy for acute ischemic stroke. miR-335 enhanced SG formation through degradation of the mRNA of the ZFP36 ring finger protein like 1 (ZFP36L1)."	M6ADIS0091	32581712	.
M6ACROT05435	REG00006	M6ATAR00024	Non-coding RNA	EPIREG00444	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL14 increased the M6A modification of pri-miR-19a and promoted the processing of mature hsa-miR-19a-3p, thus promoting the proliferation and invasion of atherosclerotic vascular endothelial cells. "	M6ADIS0099	32633395	.
M6ACROT05436	REG00007	M6ATAR00068	Non-coding RNA	EPIREG00445	.	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The relative RNA expression level of hsa_circ_0029589 in macrophages was decreased, whereas the N6-methyladenosine (m6A) level of hsa_circ_0029589 and the expression of m6A methyltransferase METTL3 were validated to be significantly elevated in macrophages in patients with acute coronary syndrome."	M6ADIS0098	32674051	.
M6ACROT05437	REG00001	M6ATAR00341	Non-coding RNA	EPIREG00446	EPITAR00295	.	Up regulation	m6A	Indirect	Enhancement	ncRNA	m6A regulators indirectly modulate the functionality of ncRNAs through downstream signaling pathways	FTO Inhibition Enhances the Antitumor Effect of Temozolomide by Targeting Myc proto-oncogene protein (MYC)-miR-155/MIR23A Cluster-Max-interacting protein 1 (MXI1) Feedback Circuit in Glioma.	M6ADIS0001	32680921	M6ADRUG0010
M6ACROT05438	REG00001	M6ATAR00341	Non-coding RNA	EPIREG00259	EPITAR00295	.	Up regulation	m6A	Indirect	Enhancement	ncRNA	m6A regulators indirectly modulate the functionality of ncRNAs through downstream signaling pathways	FTO Inhibition Enhances the Antitumor Effect of Temozolomide by Targeting Myc proto-oncogene protein (MYC)-MIR155/miR-23a Cluster-Max-interacting protein 1 (MXI1) Feedback Circuit in Glioma.	M6ADIS0001	32680921	M6ADRUG0010
M6ACROT05441	REG00007	M6ATAR00075	Non-coding RNA	EPIREG00447	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	The significantly reduced gene expression of the lncRNA Testis associated oncogenic lncRNA (THORLNC) and the decreased m6A level on the lncRNA THOR in the METTL3stop/stop cells were determined by qRT-PCR and methylated RNA immunoprecipitation (MeRIP) assay. RIP-qRT-PCR and RNA pull-down assay results revealed that the specific m6A readers YTHDF1 and YTHDF2 can read the m6A motifs and regulate the stability of the lncRNA THOR (stabilization and decay).	.	32792482	.
M6ACROT05442	REG00008	M6ATAR00075	Non-coding RNA	EPIREG00447	.	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	The significantly reduced gene expression of the lncRNA Testis associated oncogenic lncRNA (THORLNC) and the decreased m6A level on the lncRNA THOR in the METTL3stop/stop cells were determined by qRT-PCR and methylated RNA immunoprecipitation (MeRIP) assay. RIP-qRT-PCR and RNA pull-down assay results revealed that the specific m6A readers YTHDF1 and YTHDF2 can read the m6A motifs and regulate the stability of the lncRNA THOR (stabilization and decay).	.	32792482	.
M6ACROT05443	REG00024	M6ATAR00075	Non-coding RNA	EPIREG00447	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	The significantly reduced gene expression of the lncRNA Testis associated oncogenic lncRNA (THORLNC) and the decreased m6A level on the lncRNA THOR in the METTL3stop/stop cells were determined by qRT-PCR and methylated RNA immunoprecipitation (MeRIP) assay. RIP-qRT-PCR and RNA pull-down assay results revealed that the specific m6A readers YTHDF1 and YTHDF2 can read the m6A motifs and regulate the stability of the lncRNA THOR (stabilization and decay).	.	32792482	.
M6ACROT05444	REG00005	M6ATAR00140	Non-coding RNA	EPIREG00279	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"ALKBH5 knockdown suppressed malignant behavior of colon cancer partially through Nuclear paraspeckle assembly transcript 1 (NEAT1) by demethylation in vitro and vivo, suggesting that ALKBH5-NEAT1 axis is a potential therapeutic target for colon cancer treatment."	M6ADIS0059	32913527	.
M6ACROT05445	REG00007	M6ATAR00025	Non-coding RNA	EPIREG00448	EPITAR00151	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3 promoted the maturation of hsa-miR-126-5p via the m6A modification of pri-miR-126-5p. Finally, in vitro and in vivo experiments substantiated that silencing of METTL3 impeded the progression and tumorigenesis of ovarian cancer by impairing the miR-126-5p-targeted inhibition of Mutated in multiple advanced cancers 1 (PTEN) and thus blocking the PI3K/Akt/mTOR pathway. "	M6ADIS0066	32939058	.
M6ACROT05446	REG00007	M6ATAR00001	Non-coding RNA	EPIREG00449	EPITAR00331	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	Oxygen glucose deprivation/re-oxygenation (OGD/R) induces neuronal injury via mechanisms that are believed to mimic the pathways associated with brain ischemia. METTL3 shRNA reversed OGD/R-induced Lnc_D63785 m6A methylation to decrease Myocyte enhancer factor 2D (MEF2D) accumulation. The accumulation of the microRNA miR-422a leads to downregulation of miR-422a targets MEF2D and MAPKK6.	M6ADIS0026	32999283	.
M6ACROT05447	REG00007	M6ATAR00001	Non-coding RNA	EPIREG00450	EPITAR00297	.	Down regulation	m6A	Indirect	Enhancement	ncRNA	m6A regulators indirectly modulate the functionality of ncRNAs through downstream signaling pathways	Oxygen glucose deprivation/re-oxygenation (OGD/R) induces neuronal injury via mechanisms that are believed to mimic the pathways associated with brain ischemia. METTL3 shRNA reversed OGD/R-induced Lnc_D63785 m6A methylation to decrease hsa-miR-422a accumulation. The accumulation of the microRNA miR-422a leads to downregulation of miR-422a targets MEF2D and Mitogen-activated protein kinase kinase 6 (MAP2K6).	M6ADIS0026	32999283	.
M6ACROT05448	REG00014	M6ATAR00078	Non-coding RNA	EPIREG00386	EPITAR00277	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"KCNMB2 antisense RNA 1 (KCNMB2-AS1) and IGF2BP3 formed a positive regulatory circuit that enlarged the tumorigenic effect of KCNMB2-AS1 in cervical cancer. KCNMB2-AS1 was predominantly located in the cytoplasm and served as a competing endogenous RNA to abundantly sponge hsa-miR-130b-5p and miR-4294, resulting in the upregulation of IGF2BP3, a well-documented oncogene in CC."	M6ADIS0008	33028109	.
M6ACROT05449	REG00007	M6ATAR00025	Non-coding RNA	EPIREG00448	EPITAR00298	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Interleukin 1-beta (IL-1-beta) is an important inducer of cartilage degeneration that can induce an inflammatory cascade reaction in chondrocytes and inhibit the normal biological function of cells. METTL3 could regulate hsa-miR-126-5p maturation, we first confirmed that METTL3 can bind the key protein underlying pri-miRNA processing, DGCR8. Additionally, when METTL3 expression was inhibited, the miR-126-5p maturation process was blocked. miR-126-5p can inhibit the PI3K/Akt signalling pathway by targeting Phosphatidylinositol 3-kinase regulatory subunit beta (PI3K-p85/PIK3R2) gene, leading to the disorder of cell vitality and functional metabolism."	M6ADIS0114	33098220	.
M6ACROT05450	REG00007	M6ATAR00156	Non-coding RNA	EPIREG00209	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Either knockdown of METTL3 or METTL14 notably reversed the hypoxic preconditioning-induced enhancement of cell viability, anti-apoptosis ability, and H19 imprinted maternally expressed transcript (H19) expression. "	M6ADIS0123	33197240	.
M6ACROT05451	REG00006	M6ATAR00156	Non-coding RNA	EPIREG00209	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Either knockdown of METTL3 or METTL14 notably reversed the hypoxic preconditioning-induced enhancement of cell viability, anti-apoptosis ability, and H19 imprinted maternally expressed transcript (H19) expression. "	M6ADIS0123	33197240	.
M6ACROT05452	REG00007	M6ATAR00112	Non-coding RNA	EPIREG00261	EPITAR00299	.	.	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"ZNFX1 antisense RNA 1 (ZFAS1) sequestered MicroRNA 647 (MIR647), and this RNA-RNA interaction is regulated by METLL3-mediated m6A modification in cervical cancer."	M6ADIS0008	33235466	.
M6ACROT05453	REG00006	M6ATAR00062	Non-coding RNA	EPIREG00451	EPITAR00300	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"GPER promotes non-small-cell lung cancer cell growth by regulating YAP1-TEAD/QKI/circNeurogenic locus notch homolog protein 1 (NOTCH1)/m6A methylated NOTCH1 signalling. Further exploration of the mechanism demonstrated that GPER could up-regulate hsa_circ_0089552 (circNOTCH1), which could compete with NOTCH1 mRNA for METTL14 binding."	M6ADIS0007	33237585	.
M6ACROT05454	REG00014	M6ATAR00027	Non-coding RNA	EPIREG00370	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	DMDRMR is a protumorigenic lncRNA that mediates the stabilization of IGF2BP3 targets in an m6A-dependent manner in clear cell renal cell carcinoma. IGF2BP3 and DMDRMR cooperate to play oncogenic roles. IGF2BP3 cooperates with DMDRMR to regulate CDK4 by enhancing mRNA stability.	M6ADIS0010	33293428	.
M6ACROT05455	REG00006	M6ATAR00112	Non-coding RNA	EPIREG00261	EPITAR00301	.	.	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL14 mediated m6A modification to ZNFX1 antisense RNA 1 (ZFAS1)/Ras-related protein Rab-22A (RAB22A) may play a vital role in atherosclerosis and METTL14/ZFAS1/RAB22A may serve as a potential target for the clinical treatment of atherosclerosis. 	M6ADIS0099	33301833	.
M6ACROT05456	REG00022	M6ATAR00152	Non-coding RNA	EPIREG00435	EPITAR00563	.	.	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RBM15 and WTAP are required for X inactive specific transcript (XIST)-mediated silencing, are co-localized, and potentially interact with XIST RNA. YTHDC1 is the m6A reader of XIST and is required for XIST function. m6A modification is required for XIST-mediated transcriptional repression of X-linked genes, such as Glypican-4 (GPC4) and ATRX."	.	33335959	.
M6ACROT05457	REG00009	M6ATAR00152	Non-coding RNA	EPIREG00435	EPITAR00563	.	.	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RBM15 and WTAP are required for X inactive specific transcript (XIST)-mediated silencing, are co-localized, and potentially interact with XIST RNA. YTHDC1 is the m6A reader of XIST and is required for XIST function. m6A modification is required for XIST-mediated transcriptional repression of X-linked genes, such as Glypican-4 (GPC4) and ATRX."	.	33335959	.
M6ACROT05458	REG00020	M6ATAR00152	Non-coding RNA	EPIREG00435	EPITAR00563	.	.	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RBM15 and WTAP are required for X inactive specific transcript (XIST)-mediated silencing, are co-localized, and potentially interact with XIST RNA. YTHDC1 is the m6A reader of XIST and is required for XIST function. m6A modification is required for XIST-mediated transcriptional repression of X-linked genes, such as Glypican-4 (GPC4) and ATRX."	.	33335959	.
M6ACROT05460	REG00005	M6ATAR00074	Non-coding RNA	EPIREG00452	EPITAR00303	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Overexpression of METTL3 upregulates Long intergenic non-protein coding RNA 2598 (LINC02598/RP11) expression in colorectal cancer cells. Overexpression of ALKBH5 downregulates RP11 expression. RP11 interacts with hnRNPA2B1, downregulating the mRNA expression of E3 ubiquitin-protein ligase SIAH1 (SIAH1) and Fbxo45."	M6ADIS0059	33335959	.
M6ACROT05461	REG00007	M6ATAR00074	Non-coding RNA	EPIREG00452	EPITAR00304	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Overexpression of METTL3 upregulates Long intergenic non-protein coding RNA 2598 (LINC02598/RP11) expression in colorectal cancer cells. Overexpression of ALKBH5 downregulates RP11 expression. RP11 interacts with hnRNPA2B1, downregulating the mRNA expression of Siah1 and F-box/SPRY domain-containing protein 1 (FBXO45)."	M6ADIS0059	33335959	.
M6ACROT05462	REG00022	M6ATAR00072	Non-coding RNA	EPIREG00453	EPITAR00305	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"hsa_circ_0092493 (circ_ARL3) is a critical regulator in HBV-related HCC, targeting the axis of circ-ARL3/MicroRNA 1305 (MIR1305) can be a promising treatment for HBV+ HCC patients. HBx protein upregulated N6 -methyladenosine (m6A) methyltransferases METTL3 expression, increasing the m6A modification of circ-ARL3; then, m6A reader YTHDC1 bound to m6A-modified of circ-ARL3 and favored its reverse splicing and biogenesis. Furthermore, circ-ARL3 was able to sponge miR-1305, antagonizing the inhibitory effects of miR-1305 on a cohort of target oncogenes, thereby promoting HBV+ HCC progression. "	M6ADIS0006	33372396	.
M6ACROT05463	REG00007	M6ATAR00072	Non-coding RNA	EPIREG00453	EPITAR00305	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"hsa_circ_0092493 (circ_ARL3) is a critical regulator in HBV-related HCC, targeting the axis of circ-ARL3/MicroRNA 1305 (MIR1305) can be a promising treatment for HBV+ HCC patients. HBx protein upregulated N6 -methyladenosine (m6A) methyltransferases METTL3 expression, increasing the m6A modification of circ-ARL3; then, m6A reader YTHDC1 bound to m6 A-modified of circ-ARL3 and favored its reverse splicing and biogenesis. Furthermore, circ-ARL3 was able to sponge miR-1305, antagonizing the inhibitory effects of miR-1305 on a cohort of target oncogenes, thereby promoting HBV+ HCC progression. "	M6ADIS0006	33372396	.
M6ACROT05465	REG00007	M6ATAR00028	Non-coding RNA	EPIREG00454	EPITAR00306	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3 promotes adriamycin resistance in MCF-7 breast cancer cells by accelerating hsa-miR-221-3p maturation in a m6A-dependent manner. METTL3 knockdown was shown to reduce the expression of miR-221-3p by reducing pri-miR-221-3p m6A mRNA methylation, reducing the expression of MDR1 and BCRP, and inducing apoptosis. Identified the METTL3/miR-221-3p/Homeodomain-interacting protein kinase 2 (HIPK2)/Che-1 axis as a novel signaling event that will be responsible for resistance of BC cells to ADR."	M6ADIS0029	31935372	M6ADRUG0068
M6ACROT05466	REG00005	M6ATAR00030	Non-coding RNA	EPIREG00455	EPITAR00167	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"ALKBH5 is an anti-tumor factor or a pro-apoptotic factor, acting at least partially by suppressing Transcriptional coactivator YAP1 (YAP1) expression through dual mechanisms with direct m6A methylation of YAP and indirect downregulation of YAP level due to methylation of hsa-mir-181b-1. Further results revealed that m6A methylated pre-miR-181b-1 was subsequently recognized by m6A-binding protein YTHDF2 to mediate RNA degradation. However, methylated YAP transcripts were recognized by YTHDF1 to promote its translation. ALKBH5 overexpression was considered a new approach of replacement therapy for osteosarcoma treatment."	M6ADIS0051	33431791	.
M6ACROT05467	REG00008	M6ATAR00030	Non-coding RNA	EPIREG00455	EPITAR00167	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"ALKBH5 is an anti-tumor factor or a pro-apoptotic factor, acting at least partially by suppressing Transcriptional coactivator YAP1 (YAP1) expression through dual mechanisms with direct m6A methylation of YAP and indirect downregulation of YAP level due to methylation of hsa-mir-181b-1. Further results revealed that m6A methylated pre-miR-181b-1 was subsequently recognized by m6A-binding protein YTHDF2 to mediate RNA degradation. However, methylated YAP transcripts were recognized by YTHDF1 to promote its translation. ALKBH5 overexpression was considered a new approach of replacement therapy for osteosarcoma treatment."	M6ADIS0051	33431791	.
M6ACROT05468	REG00012	M6ATAR00031	Non-coding RNA	EPIREG00408	EPITAR00234	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	Hypoxia-induced lncRNA KB-1980E6.3 is involved in the self-renewal and stemness maintenance of breast cancer stem cells by recruiting IGF2BP1 to regulate c-Myc mRNA stability. 	M6ADIS0065	33469161	.
M6ACROT05469	REG00003	M6ATAR00032	Non-coding RNA	EPIREG00456	EPITAR00236	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"rs7495 in 3'UTR of hnRNPC was associated with pancreatic ductal adenocarcinoma susceptibility in a Chinese population. The rs7495, in the hnRNPC 3'UTR, might disrupt a binding site for hsa-miR-183-3p, thus increasing the expression of hnRNPC and promoting the proliferation of PDAC cells."	M6ADIS0061	33474615	.
M6ACROT05470	REG00007	M6ATAR00100	Non-coding RNA	EPIREG00353	EPITAR00307	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	Long intergenic non-protein coding RNA 460 (LINC00460) is a novel oncogene of colorectal cancer through interacting with IGF2BP2 and ATP-dependent RNA helicase A (DHX9) and bind to the m6A modified HMGA1 mRNA to enhance the HMGA1 mRNA stability. The N6-methyladenosine (m6A) modification of HMGA1 mRNA by METTL3 enhanced HMGA1 expression in CRC.	M6ADIS0059	33526059	.
M6ACROT05471	REG00007	M6ATAR00088	Non-coding RNA	EPIREG00431	EPITAR00308	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	m6A methyltransferase-like 3 (METTL3) gave rise to the upregulation of Long intergenic non-protein coding RNA 958 (LINC00958) by promoting its RNA transcript stability in breast cancer. LINC00958 acted as a competitive endogenous RNA for hsa-miR-378a-3p to promote YY1.	M6ADIS0065	33531456	.
M6ACROT05472	REG00001	M6ATAR00079	Non-coding RNA	EPIREG00457	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	FTO overexpression inhibits H/R-indcued apoptosis in myocardial cells by regulating m6A modification of Myosin heavy chain associated RNA transcript (MHRT). FTO is a target gene for heart failure treatment.	M6ADIS0101	33548009	M6ADRUG0022
M6ACROT05473	REG00007	M6ATAR00033	Non-coding RNA	EPIREG00296	EPITAR00027	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Platinum can increase the overall m6A level of esophageal cancer. SNHG3/hsa-miR-186-5p, induced by platinum, was involved in regulating m6A level by targeting METTL3. miR-186-5p binds to the 3'UTR of METTL3 to inhibit its expression. Our manuscript has provided clues that regulating m6A level was a novel way to enhance the platinum efficacy."	M6ADIS0029	31935372	M6ADRUG0069
M6ACROT05474	REG00007	M6ATAR00477	Non-coding RNA	EPIREG00272	EPITAR00027	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Platinum can increase the overall m6A level of esophageal cancer. Small nucleolar RNA host gene 3 (SNHG3)/miR-186-5p, induced by platinum, was involved in regulating m6A level by targeting METTL3. miR-186-5p binds to the 3'UTR of METTL3 to inhibit its expression. Our manuscript has provided clues that regulating m6A level was a novel way to enhance the platinum efficacy."	M6ADIS0029	31935372	M6ADRUG0072
M6ACROT05477	REG00001	M6ATAR00141	Non-coding RNA	EPIREG00215	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"m6A modification is co-regulated by METTL3 and FTO in cadmium-treated cells. Metastasis associated lung adenocarcinoma transcript 1 (MALAT1), LncRNA-PVT1 and m6A modification could be key nodes for cadmium-induced oxidative damage, and highlight their importance as promising preventive and therapeutic targets in cadmium toxicity."	M6ADIS0118	33639196	.
M6ACROT05478	REG00001	M6ATAR00153	Non-coding RNA	EPIREG00433	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"m6A modification is co-regulated by METTL3 and FTO in cadmium-treated cells. LncRNA-MALAT1, Pvt1 oncogene (PVT1) and m6A modification could be key nodes for cadmium-induced oxidative damage, and highlight their importance as promising preventive and therapeutic targets in cadmium toxicity."	M6ADIS0118	33639196	.
M6ACROT05479	REG00007	M6ATAR00141	Non-coding RNA	EPIREG00215	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"m6A modification is co-regulated by METTL3 and FTO in cadmium-treated cells. Metastasis associated lung adenocarcinoma transcript 1 (MALAT1), LncRNA-PVT1 and m6A modification could be key nodes for cadmium-induced oxidative damage, and highlight their importance as promising preventive and therapeutic targets in cadmium toxicity."	M6ADIS0118	33639196	.
M6ACROT05480	REG00007	M6ATAR00153	Non-coding RNA	EPIREG00433	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"m6A modification is co-regulated by METTL3 and FTO in cadmium-treated cells. LncRNA-MALAT1, Pvt1 oncogene (PVT1) and m6A modification could be key nodes for cadmium-induced oxidative damage, and highlight their importance as promising preventive and therapeutic targets in cadmium toxicity."	M6ADIS0118	33639196	.
M6ACROT05481	REG00007	M6ATAR00124	Non-coding RNA	EPIREG00458	EPITAR00309	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3-mediated formation of EV microRNA 93 (MIR93), facilitated by m6A, is implicated in the aberrant cross-talk of epithelium-macrophages, indicating that this process is involved in the smoking-related emphysema. EV miR-93 was used as a novel risk biomarker for CS-induced emphysema. MiR-93 activated the JNK pathway by targeting Dual specificity protein phosphatase 2 (DUSP2), which elevated the levels of matrix metalloproteinase 9 (MMP9) and matrix metalloproteinase 12 (MMP12) and induced elastin degradation, leading to emphysema."	M6ADIS0105	33660100	.
M6ACROT05483	REG00008	M6ATAR00096	Non-coding RNA	EPIREG00459	EPITAR00310	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	YTHDF2-mediated LncRNA FOXF1 adjacent non-coding developmental regulatory RNA (FENDRR) degradation promotes cell proliferation by elevating Transcription factor SOX-4 (SOX4) expression in endometrioid endometrial carcinoma.	M6ADIS0067	33692441	.
M6ACROT05484	REG00007	M6ATAR00070	Non-coding RNA	EPIREG00460	EPITAR00311	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3-mediated m6A modification plays a key role in stabilizing the expression of hsa_circ_0081609 (circCUX1), thereby inhibiting the expression of Caspase-1 (CASP1) and conferring the radiotherapy resistance of hypopharyngeal squamous cell carcinoma."	M6ADIS0005	33741902	.
M6ACROT05486	REG00007	M6ATAR00152	Non-coding RNA	EPIREG00435	EPITAR00312	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL3 regulates ossification of the posterior longitudinal ligament via the lncRNA X inactive specific transcript (XIST)/hsa-miR-302a-3p/USP8 axis.	M6ADIS0113	33748113	.
M6ACROT05487	REG00007	M6ATAR00157	Non-coding RNA	EPIREG00364	EPITAR00151	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The molecular mechanism underlying the effect of Long intergenic non-protein coding RNA 470 (LINC00470) on chronic myelocytic leukaemia by reducing the Mutated in multiple advanced cancers 1 (PTEN) stability via RNA methyltransferase METTL3, thus leading to the inhibition of cell autophagy while promoting chemoresistance in CML."	M6ADIS0004	33749070	.
M6ACROT05488	REG00007	M6ATAR00036	Non-coding RNA	EPIREG00462	EPITAR00167	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL3-induced Circ_1662 promoted colorectal cancer cell invasion and migration by accelerating Transcriptional coactivator YAP1 (YAP1) nuclear transport. Circ1662 enhanced CRC invasion and migration depending on YAP1 and SMAD3. This result implies that circ1662 is a new prognostic and therapeutic marker for CRC metastasis.	M6ADIS0059	33754062	.
M6ACROT05490	REG00007	M6ATAR00109	Non-coding RNA	EPIREG00425	EPITAR00314	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3 regulates the m6A modification to promote the maturation of microRNA 1246 (MIR1246), which targets Paternally-expressed gene 3 protein (PEG3) to participate in occurrence and development of non-small cell lung cancer."	M6ADIS0007	33898106	.
M6ACROT05491	REG00006	M6ATAR00038	Non-coding RNA	EPIREG00464	EPITAR00315	.	.	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Circ_GFR-Alpha-1 promotes female germline stem cells self-renewal by acting as a ceRNA that sponges MicroRNA 449a (MIR449A), leading to enhanced GFRalpha-1 expression and activation of the GDNF signaling pathway. circGFRalpha-1 acts as a ceRNA based on METTL14-mediated cytoplasmic export through the GGACU motif. "	M6ADIS0128	33928080	.
M6ACROT05492	REG00007	M6ATAR00141	Non-coding RNA	EPIREG00215	EPITAR00316	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL3 promoted the malignant progression of IDH-wildtype gliomas and revealed important insight into the upstream regulatory mechanism of Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) and Transcription factor p65 (RELA) with a primary focus on m6A modification.	M6ADIS0001	33933553	.
M6ACROT05493	REG00005	M6ATAR00345	Non-coding RNA	EPIREG00207	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"ALKBH5 knockdown, was able to inhibit malignant behavior of lung adenocarcinoma by regulating RMRP expression via demethylation. RMRP and ALKBH5 therefore represent promising therapeutic targets for lung adenocarcinoma."	M6ADIS0007	33934179	.
M6ACROT05494	REG00007	M6ATAR00150	Non-coding RNA	EPIREG00249	EPITAR00317	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Maternally expressed 3 (MEG3) regulates the expression of BTG2 through MicroRNA 544b (MIR544B), thus affecting the malignant behavior of hepatocellular carcinoma. METTL3 regulates the m6A modification of MEG3 and its expression."	M6ADIS0006	34163177	.
M6ACROT05495	REG00013	M6ATAR01794	Non-coding RNA	EPIREG00465	EPITAR00318	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	IGF2BP2 physically interacted with Protein argonaute-2 (AGO2) and increased more miR-133a accumulation on its target site.m6A modification promoted the repression of specific miRNA during heart development and hypertrophy.	M6ADIS0100	34226535	.
M6ACROT05496	REG00007	M6ATAR00057	Non-coding RNA	EPIREG00466	EPITAR00319	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3-mediated hsa_circ_0004771 (circNRIP1) exhibits oncogenic roles in osteosarcoma by regulating FOXC2 via sponging hsa-miR-199a-5p, which provides new ideas for the treatment of osteosarcoma."	M6ADIS0051	34245327	.
M6ACROT05497	REG00007	M6ATAR01796	Non-coding RNA	EPIREG00467	EPITAR00320	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3-mediated circNRIP1 exhibits oncogenic roles in osteosarcoma by regulating Forkhead box protein C2 (FOXC2) via sponging miR-199a, which provides new ideas for the treatment of osteosarcoma."	M6ADIS0051	34245327	.
M6ACROT05498	REG00007	M6ATAR00041	Non-coding RNA	EPIREG00468	EPITAR00321	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"LCAT3 upregulation is attributable to N6-methyladenosine (m6A) modification mediated by methyltransferase like 3 (METTL3), leading to LCAT3 stabilization. LCAT3 as a novel oncogenic lncRNA in the lung, and validated the LCAT3-Far upstream element-binding protein 1 (FUBP1)-MYC axis as a potential therapeutic target for lung adenocarcinomas."	M6ADIS0007	34274028	.
M6ACROT05499	REG00006	M6ATAR00081	Non-coding RNA	EPIREG00469	EPITAR00322	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"In gastric cancer, METTL14 was involved in the m6A modification of LINC01320 and induced the up-regulation of Long intergenic non-protein coding RNA 1320 (LINC01320). hsa-miR-495-5p was predicted and demonstrated to target LINC01320 and RAB19."	M6ADIS0057	34288797	.
M6ACROT05500	REG00006	M6ATAR00131	Non-coding RNA	EPIREG00461	EPITAR00323	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"microRNA 211 (MIR211) is a novel tumor suppressor in T-cell lymphoblastic lymphoma,it regulated by METTL14. Targeting of miR-211/Transcription factor 12 (TCF12) axis is a potential treatment for T-cell lymphoblastic lymphoma patients."	M6ADIS0047	34298254	.
M6ACROT05501	REG00013	M6ATAR00097	Non-coding RNA	EPIREG00471	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"IGF2BP2 loss inhibited cell proliferation, migration and invasion, and induced cell apoptosis and cell cycle arrest by down-regulating HOXD antisense growth-associated long non-coding RNA (HAGLR) expression in an m6A-dependent manner in thyroid cancer cells."	M6ADIS0073	34340128	.
M6ACROT05502	REG00007	M6ATAR00140	Non-coding RNA	EPIREG00279	EPITAR00324	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL3-mediated m6A modification induced the aberrant expression of Nuclear paraspeckle assembly transcript 1 (NEAT1) in chronic myelocytic leukemia. Overexpression of NEAT1 inhibited cell viability and promoted the apoptosis of chronic myelocytic leukemia cells. hsa-miR-766-5p was upregulated in CML PBMCs and abrogated the effects of NEAT1 on cell viability and apoptosis of the chronic myelocytic leukemia cells.	M6ADIS0004	34354942	.
M6ACROT05503	REG00007	M6ATAR00043	Non-coding RNA	EPIREG00472	EPITAR00001	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL3-mediated m6A modification induced the aberrant expression of NEAT1 in chronic myelocytic leukemia. Overexpression of NEAT1 inhibited cell viability and promoted the apoptosis of chronic myelocytic leukemia cells. hsa-miR-766-5p was upregulated in CML PBMCs and abrogated the effects of NEAT1 on cell viability and apoptosis of the chronic myelocytic leukemia cells. Cyclin-dependent kinase inhibitor 1 (CDKN1A) was proved to be the target gene of miR-766-5p and was downregulated in the CML PBMCs.	M6ADIS0004	34354942	.
M6ACROT05504	REG00007	M6ATAR00144	Non-coding RNA	EPIREG00473	EPITAR00326	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Identified the lncRNA NIFK antisense RNA 1 (NIFK-AS1) as being highly expressed in hepatocellular carcinoma tissues and cells, promotes disease progression and sorafenib resistance, and showed this up-regulation resulted from METTL3-dependent m6A methylation. NIFK-AS1 positively regulates AKT1 expression in HCC cells through sponging MicroRNA 637 (MIR637) as a ceRNA."	M6ADIS0006	34374933	M6ADRUG0032
M6ACROT05505	REG00013	M6ATAR00064	Non-coding RNA	EPIREG00474	EPITAR00327	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"m6A-modified hsa_circ_0000231 (circARHGAP12) interacts with IGF2BP2 to enhance Forkhead box protein M1 (FOXM1) mRNA stability, forming circARHGAP12/IGF2BP2/FOXM1 complex, thereby promoting the proliferation and migration of cervical cancer cells."	M6ADIS0008	34392306	.
M6ACROT05506	REG00003	M6ATAR00134	Non-coding RNA	EPIREG00228	EPITAR00236	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"HNRNPC, YTHDF, ZC3H13, YTHDC2, and METTL14 were dysregulated in esophageal cancer tissues. miR-186 interacted with HNRNPC and suppressed the expression of HNRNPC. Four miRNAs (microRNA 186 (MIR186), miR-320c, miR-320d, and miR-320b) were used to construct a prognostic signature, which could serve as a prognostic predictor independent from routine clinicopathological features."	M6ADIS0056	34395102	.
M6ACROT05507	REG00003	M6ATAR00045	Non-coding RNA	EPIREG00475	EPITAR00236	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"HNRNPC, YTHDF, ZC3H13, YTHDC2, and METTL14 were dysregulated in esophageal cancer tissues. miR-186 interacted with HNRNPC and suppressed the expression of HNRNPC. Four miRNAs (miR-186, hsa-miR-320c, miR-320d, and miR-320b) were used to construct a prognostic signature, which could serve as a prognostic predictor independent from routine clinicopathological features."	M6ADIS0056	34395102	.
M6ACROT05508	REG00003	M6ATAR00046	Non-coding RNA	EPIREG00395	EPITAR00236	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"HNRNPC, YTHDF, ZC3H13, YTHDC2, and METTL14 were dysregulated in esophageal cancer tissues. miR-186 interacted with HNRNPC and suppressed the expression of HNRNPC. Four miRNAs (miR-186, miR-320c, hsa-miR-320d, and miR-320b) were used to construct a prognostic signature, which could serve as a prognostic predictor independent from routine clinicopathological features."	M6ADIS0056	34395102	.
M6ACROT05509	REG00003	M6ATAR00047	Non-coding RNA	EPIREG00409	EPITAR00236	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"HNRNPC, YTHDF, ZC3H13, YTHDC2, and METTL14 were dysregulated in esophageal cancer tissues. miR-186 interacted with HNRNPC and suppressed the expression of HNRNPC. Four miRNAs (miR-186, miR-320c, miR-320d, and hsa-miR-320b) were used to construct a prognostic signature, which could serve as a prognostic predictor independent from routine clinicopathological features."	M6ADIS0056	34395102	.
M6ACROT05510	REG00007	M6ATAR00141	Non-coding RNA	EPIREG00215	EPITAR00328	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Silencing METTL3 down-regulate Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) and HMGA2 by sponging hsa-miR-26b, and finally inhibit EMT, migration and invasion in breast cancer, providing a theoretical basis for clinical treatment of breast cancer."	M6ADIS0065	34419065	.
M6ACROT05511	REG00005	M6ATAR00049	Non-coding RNA	EPIREG00372	.	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"In non-small cell lung cancer, m6A marks in mature hsa-miR-21-5p could directly affect its silencing potency towards target genes, which finally impaired its promotion to proliferation and motility. Depletion of the demethylase ALKBH5 altered the m6A abundance of miR-21-5p, thereby changing the expression levels of its target gene. "	M6ADIS0007	34480914	.
M6ACROT05512	REG00015	M6ATAR00017	Non-coding RNA	EPIREG00525	EPITAR00329	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"KIAA1429 is downregulated while ALKBH5 is upregulated in aortic tissues from aortic dissection patients. KIAA1429/ALKBH5-mediated m6A modifications can regulate the processing of hsa-miR-143-3p through interacting with the microprocessor protein DGCR8. KIAA1429 and ALKBH5 can oppositely regulate HASMC proliferation, HAEC apoptosis, and AD progression in AngII-infused mice via the miR-143-3p/DEAD-box helicase 6 (DDX6) pathway."	M6ADIS0102	34490238	.
M6ACROT05513	REG00005	M6ATAR00017	Non-coding RNA	EPIREG00525	EPITAR00329	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"KIAA1429 is downregulated while ALKBH5 is upregulated in aortic tissues from aortic dissection patients. KIAA1429/ALKBH5-mediated m6A modifications can regulate the processing of hsa-miR-143-3p through interacting with the microprocessor protein DGCR8. KIAA1429 and ALKBH5 can oppositely regulate HASMC proliferation, HAEC apoptosis, and AD progression in AngII-infused mice via the miR-143-3p/DEAD-box helicase 6 (DDX6) pathway."	M6ADIS0102	34490238	.
M6ACROT05514	REG00001	M6ATAR00141	Non-coding RNA	EPIREG00215	.	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"In bladder cancer, the changes in m6A methylation level mainly appeared at 5' untranslated region (5' UTR) of Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) and NOTCH1 transcripts, and at 3' UTR of CSNK2A2 and ITGA6 transcripts, responding to the overexpression of FTO. SFPQ could influence the FTO-mediated m6A RNA demethylation, eventually affecting the gene expression."	M6ADIS0070	34499008	.
M6ACROT05515	REG00007	M6ATAR00141	Non-coding RNA	EPIREG00215	EPITAR00022	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"This study highlighted METTL3 as a tumor promoter in Thymic tumors and Myc proto-oncogene protein (MYC) as a promising target to be exploited for the treatment of TET. High expression of c-MYC protein is enabled by lncRNA Metastasis associated lung adenocarcinoma transcript 1 (MALAT1), which is methylated and delocalized by METTL3. Silencing of METTL3 combined with cisplatin or c-MYC inhibitor induces cell death in TET cells. Blocking of c-MYC by using JQ1 inhibitor cooperates with METTL3 depletion in the inhibition of proliferation and induction of cell death."	M6ADIS0028	34530916	M6ADRUG0056
M6ACROT05516	REG00007	M6ATAR00141	Non-coding RNA	EPIREG00215	EPITAR00022	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"This study highlighted METTL3 as a tumor promoter in Thymic tumors and Myc proto-oncogene protein (MYC) as a promising target to be exploited for the treatment of TET. High expression of c-MYC protein is enabled by lncRNA Metastasis associated lung adenocarcinoma transcript 1 (MALAT1), which is methylated and delocalized by METTL3. Silencing of METTL3 combined with cisplatin or c-MYC inhibitor induces cell death in TET cells. Blocking of c-MYC by using JQ1 inhibitor cooperates with METTL3 depletion in the inhibition of proliferation and induction of cell death."	M6ADIS0028	34530916	M6ADRUG0047
M6ACROT05517	REG00007	M6ATAR00146	Non-coding RNA	EPIREG00477	EPITAR00331	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The increased LBX2 antisense RNA 1 (LBX2-AS1) in CRC was mediated by METTL3-dependent m6A methylation. LBX2-AS1 serves as a therapeutic target and predictor of 5-FU benefit in colorectal cancer patients. knockdown of LBX2-AS1 inhibited CRC proliferation, migration and invasion with this phenotype linked to LBX2-AS1-mediated regulation of AKT1, acting as a ceRNA to sponge hsa-miR-422a."	M6ADIS0059	34535128	M6ADRUG0005
M6ACROT05518	REG00008	M6ATAR00151	Non-coding RNA	EPIREG00478	EPITAR00001	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The elevated FTO in esophageal squamous cell carcinoma decreased m6A methylation of LINC00022 transcript, leading to the inhibition of Deleted in lymphocytic leukemia 2 (DLEU2/LINC00022) decay via the m6A reader YTHDF2. LINC00022 directly binds to Cyclin-dependent kinase inhibitor 1 (CDKN1A) protein and promotes its ubiquitination-mediated degradation, thereby facilitating cell-cycle progression and proliferation."	M6ADIS0056	34544449	.
M6ACROT05519	REG00001	M6ATAR00151	Non-coding RNA	EPIREG00478	EPITAR00001	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The elevated FTO in esophageal squamous cell carcinoma decreased m6A methylation of Deleted in lymphocytic leukemia 2 (DLEU2/LINC00022) transcript, leading to the inhibition of LINC00022 decay via the m6A reader YTHDF2. LINC00022 directly binds to Cyclin-dependent kinase inhibitor 1 (CDKN1A) protein and promotes its ubiquitination-mediated degradation, thereby facilitating cell-cycle progression and proliferation."	M6ADIS0056	34544449	.
M6ACROT05520	REG00001	M6ATAR00098	Non-coding RNA	EPIREG00479	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"FTO-stabilized HOXC13 antisense RNA (HOXC13-AS) epigenetically up-regulated FZD6 and activated Wnt/beta-catenin signaling to drive cervical cancer proliferation, invasion, and EMT, suggesting HOXC13-AS as a potential target for cervical cancer treatment."	M6ADIS0008	34564982	.
M6ACROT05521	REG00007	M6ATAR00094	Non-coding RNA	EPIREG00480	EPITAR00001	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3/FOXD2 adjacent opposite strand RNA 1 (FOXD2-AS1) accelerates cervical cancer progression via a m6A-dependent modality, which serves as a potential therapeutic target for cervical cancer. FOXD2-AS1 recruited lysine-specific demethylase 1 (LSD1) to the promoter region of Cyclin-dependent kinase inhibitor 1 (CDKN1A) to silence its transcription abundance."	M6ADIS0008	34589576	.
M6ACROT05522	REG00007	M6ATAR00102	Non-coding RNA	EPIREG00481	EPITAR00332	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"LV-sh-THAP7 antisense RNA 1 (THAP7-AS1) treatment could suppress gastric cancer growth. THAP7-AS1, transcriptionally activated by SP1 and then modified by METTL3-mediated m6A, exerts oncogenic functions, by promoting interaction between NLS and importin alpha-1 and then improving the Cullin 4B (CUL4B) protein entry into the nucleus to repress the transcription of miR-22-3p and miR-320a. "	M6ADIS0057	34608273	.
M6ACROT05523	REG00006	M6ATAR00147	Non-coding RNA	EPIREG00482	EPITAR00333	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"HLA complex group 11 (HCG11) mediated by METTL14 inhibited the growth of lung adenocarcinoma via IGF2BP2/Serine/threonine-protein kinase LATS1 (LATS1). The m6A modification of HCG11 promoted its nuclear exportation and binding by Insulin Like Growth Factor 2 MRNA Binding Protein 2 (IGF2BP2), resulting in increased stability."	M6ADIS0007	34624573	.
M6ACROT05524	REG00013	M6ATAR00147	Non-coding RNA	EPIREG00482	EPITAR00333	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"HLA complex group 11 (HCG11) mediated by METTL14 inhibited the growth of lung adenocarcinoma via IGF2BP2/Serine/threonine-protein kinase LATS1 (LATS1). The m6A modification of HCG11 promoted its nuclear exportation and binding by Insulin Like Growth Factor 2 MRNA Binding Protein 2 (IGF2BP2), resulting in increased stability."	M6ADIS0007	34624573	.
M6ACROT05525	REG00013	M6ATAR00087	Non-coding RNA	EPIREG00483	EPITAR00334	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	Cancer susceptibility 9 (CASC9)/IGF2BP2/Hexokinase-2 (HK2) axis promotes the aerobic glycolysis of glioblastoma multiforme.	M6ADIS0001	34645788	.
M6ACROT05526	REG00007	M6ATAR00099	Non-coding RNA	EPIREG00484	EPITAR00335	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3 induced m6A hyper-methylation on the 3' UTR of LIFR antisense RNA 1 (LIFR-AS1) to enhance its mRNA stability and LIFR-AS1 could directly interact with hsa-miR-150-5p, thereby indirectly up-regulating VEGFA expressions within cells. A noval m6A-LIFR-AS1 axis promotes pancreatic cancer progression at least in part via regulation of the miR-150-5p/VEGFA axis, indicating that this regulatory axis can be a viable clinical target for the treatment of pancreatic cancer."	M6ADIS0061	34658294	.
M6ACROT05527	REG00023	M6ATAR00053	Non-coding RNA	EPIREG00485	EPITAR00336	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	YTHDC2/Circ_YTHDC2/Tet methylcytosine dioxygenase 2 (TET2) pathway is an important target of metformin in preventing the progression of VSMCs dysfunction under high glucose.	M6ADIS0077	34660707	.
M6ACROT05528	REG00005	M6ATAR00140	Non-coding RNA	EPIREG00279	.	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Hypoxia-induced ALKBH5 erased m6A deposition from the lncRNA NEAT1, stabilizing the transcript and facilitating Nuclear paraspeckle assembly transcript 1 (NEAT1)-mediated paraspeckle assembly. Ectopic expression of CXCL8 in ALKBH5-deficient glioblastoma multiforme cells partially restored TAM recruitment and tumor progression. "	M6ADIS0001	34670781	.
M6ACROT05529	REG00009	M6ATAR00067	Non-coding RNA	EPIREG00486	EPITAR00269	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Circ0008399 bound WTAP to promote formation of the WTAP/METTL3/METTL14 m6A methyltransferase complex, reduce cisplatin sensitivity in bladder cancer, implicating the potential therapeutic value of targeting this axis."	M6ADIS0070	34702726	M6ADRUG0047
M6ACROT05530	REG00007	M6ATAR00067	Non-coding RNA	EPIREG00486	EPITAR00269	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Circ0008399 bound Pre-mRNA-splicing regulator WTAP (WTAP) to promote formation of the WTAP/METTL3/METTL14 m6A methyltransferase complex, reduce cisplatin sensitivity in bladder cancer, implicating the potential therapeutic value of targeting this axis."	M6ADIS0070	34702726	M6ADRUG0047
M6ACROT05531	REG00006	M6ATAR00067	Non-coding RNA	EPIREG00486	EPITAR00269	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Circ0008399 bound Pre-mRNA-splicing regulator WTAP (WTAP) to promote formation of the WTAP/METTL3/METTL14 m6A methyltransferase complex, reduce cisplatin sensitivity in bladder cancer, implicating the potential therapeutic value of targeting this axis."	M6ADIS0070	34702726	M6ADRUG0047
M6ACROT05532	REG00007	M6ATAR00058	Non-coding RNA	EPIREG00487	EPITAR00337	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"In hepatocellular carcinoma, METTL3 could direct the formation of hsa_circ_0021427 (circHPS5), and specific m6A controlled the accumulation of circHPS5. YTHDC1 facilitated the cytoplasmic output of circHPS5 under m6A modification. CircHPS5 can act as a hsa-miR-370-3p sponge to regulate the expression of HMGA2 and further accelerate hepatocellular carcinoma cell tumorigenesis."	M6ADIS0006	34703649	.
M6ACROT05533	REG00022	M6ATAR00058	Non-coding RNA	EPIREG00487	EPITAR00337	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"In hepatocellular carcinoma, METTL3 could direct the formation of circHPS5, and specific m6A controlled the accumulation of circHPS5. YTHDC1 facilitated the cytoplasmic output of hsa_circ_0021427 (circHPS5) under m6A modification. CircHPS5 can act as a hsa-miR-370-3p sponge to regulate the expression of HMGA2 and further accelerate hepatocellular carcinoma cell tumorigenesis."	M6ADIS0006	34703649	.
M6ACROT05534	REG00007	M6ATAR00119	Non-coding RNA	EPIREG00488	EPITAR00168	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"In hepatocellular carcinoma, METTL3 could direct the formation of circHPS5, and specific m6A controlled the accumulation of circHPS5. YTHDC1 facilitated the cytoplasmic output of circHPS5 under m6A modification. CircHPS5 can act as a microRNA 370 (MIR370) sponge to regulate the expression of High mobility group protein HMGI-C (HMGA2) and further accelerate hepatocellular carcinoma cell tumorigenesis."	M6ADIS0006	34703649	.
M6ACROT05535	REG00022	M6ATAR00119	Non-coding RNA	EPIREG00488	EPITAR00168	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"In hepatocellular carcinoma, METTL3 could direct the formation of circHPS5, and specific m6A controlled the accumulation of circHPS5. YTHDC1 facilitated the cytoplasmic output of circHPS5 under m6A modification. CircHPS5 can act as a microRNA 370 (MIR370) sponge to regulate the expression of High mobility group protein HMGI-C (HMGA2) and further accelerate hepatocellular carcinoma cell tumorigenesis."	M6ADIS0006	34703649	.
M6ACROT05536	REG00001	M6ATAR00115	Non-coding RNA	EPIREG00489	EPITAR00122	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"FTO promoted bladder cancer cell proliferation, migration and invasion via the FTO/microRNA 576 (MIR576)/Cyclin-dependent kinase 6 (CDK6) pathways in an m6A-dependent manner."	M6ADIS0070	34725345	.
M6ACROT05537	REG00013	M6ATAR00112	Non-coding RNA	EPIREG00261	EPITAR00338	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The critical modulation network underlying m6A readers stabilizes lncRNAs, and they jointly promote mitochondrial energy metabolism in the pathogenesis of colorectal cancer. N6-methyladenosine reader stabilizes the ZNFX1 antisense RNA 1 (ZFAS1)/Obg-like ATPase 1 (OLA1) axis. Thus, direct interaction between the KH3-4 domain of IMP2 and ZFAS1 where IMP2 serves as a reader for m6A-modified ZFAS1 and promotes the RNA stability of ZFAS1 is critical for CRC development."	M6ADIS0059	34743750	.
M6ACROT05538	REG00005	M6ATAR00132	Non-coding RNA	EPIREG00490	EPITAR00078	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"ALKBH5 plays an antitumor role in colorectal cancer by modulating the FOXO3/microRNA 21 (MIR21)/Protein sprouty homolog 2 (SPRY2) axis, which not only suggests a regulatory effect between ALKBH5 and FOXO3, but also provides a new therapeutic direction for colorectal cancer."	M6ADIS0059	34786052	.
M6ACROT05539	REG00008	M6ATAR00140	Non-coding RNA	EPIREG00279	.	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"In renal cell carcinoma, YTHDF2 accelerated the degradation of Nuclear paraspeckle assembly transcript 1 (NEAT1)_1 by selectively recognizing METTL14-mediated m6A marks on Nuclear paraspeckle assembly transcript 1 (NEAT1)_1."	M6ADIS0010	34813676	.
M6ACROT05540	REG00006	M6ATAR00140	Non-coding RNA	EPIREG00279	.	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"In renal cell carcinoma, YTHDF2 accelerated the degradation of Nuclear paraspeckle assembly transcript 1 (NEAT1)_1 by selectively recognizing METTL14-mediated m6A marks on Nuclear paraspeckle assembly transcript 1 (NEAT1)_1."	M6ADIS0010	34813676	.
M6ACROT05541	REG00008	M6ATAR00154	Non-coding RNA	EPIREG00491	EPITAR00339	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"ALKBH5 mediates KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1) expression via an m6A-YTHDF2-dependent manner and KCNQ1OT1 could directly bind to Homeobox A9 (HOXA9) to further regulate the proliferation, invasion and metastasis of laryngeal squamous cell carcinoma cells."	M6ADIS0027	34850551	.
M6ACROT05542	REG00005	M6ATAR00154	Non-coding RNA	EPIREG00491	EPITAR00339	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"ALKBH5 mediates KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1) expression via an m6A-YTHDF2-dependent manner and KCNQ1OT1 could directly bind to Homeobox A9 (HOXA9) to further regulate the proliferation, invasion and metastasis of laryngeal squamous cell carcinoma cells."	M6ADIS0027	34850551	.
M6ACROT05543	REG00005	M6ATAR00082	Non-coding RNA	EPIREG00412	EPITAR00340	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"ALKBH5-mediated m6A demethylation enhanced the stability of KCNK15-AS1. In pancreatic cancer, KCNK15 and WISP2 antisense RNA 1 (KCNK15-AS1) bound to Potassium two pore domain channel subfamily K member 15 (KCNK15) to inhibit its translation, and interacted with MDM2 to induce REST ubiquitination, which eventually facilitated PTEN transcription to inactivate AKT pathway. "	M6ADIS0061	34853296	.
M6ACROT05544	REG00007	M6ATAR00056	Non-coding RNA	EPIREG00492	EPITAR00341	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL3/SNHG1/hsa-miR-140-3p/Ubiquitin-conjugating enzyme E2 C (UBE2C) axis plays a crucial role in cancer progression and the immune response in non-small cell lung cancer.	M6ADIS0007	34858987	.
M6ACROT05545	REG00007	M6ATAR00117	Non-coding RNA	EPIREG00376	EPITAR00342	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL3/Small nucleolar RNA host gene 1 (SNHG1)/hsa-miR-140-3p/UBE2C axis plays a crucial role in cancer progression and the immune response in non-small cell lung cancer.	M6ADIS0007	34858987	.
M6ACROT05546	REG00009	M6ATAR00122	Non-coding RNA	EPIREG00362	EPITAR00274	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	LncRNA DLGAP1-AS1 promotes BC ADR-resistance through WTAP/DLGAP1 antisense RNA 1 (DLGAP1-AS1)/hsa-miR-299-3p feedback loop in breast cancer.	M6ADIS0065	34866525	M6ADRUG0022
M6ACROT05547	REG00007	M6ATAR00069	Non-coding RNA	EPIREG00493	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"In hepatocellular carcinoma, hsa_circ_0058493 contained m6A methylation sites and that METTL3 mediated the degree of methylation modification of hsa_circ_0058493. YTHDC1 could bind to hsa_circ_0058493 and promote its intracellular localization from the nucleus to the cytoplasm."	M6ADIS0006	34888309	.
M6ACROT05548	REG00022	M6ATAR00069	Non-coding RNA	EPIREG00493	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"In hepatocellular carcinoma, hsa_circ_0058493 contained m6A methylation sites and that METTL3 mediated the degree of methylation modification of hsa_circ_0058493. YTHDC1 could bind to hsa_circ_0058493 and promote its intracellular localization from the nucleus to the cytoplasm."	M6ADIS0006	34888309	.
M6ACROT05549	REG00007	M6ATAR00485	Non-coding RNA	EPIREG00494	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The participation of Metformin decreased the bindings of DNMT3A/b to the METTL3 promoter with the help of the readers of NKAP and HNRNPA2B1.the mediation of m6A formation on pri-Let-7b processing increased the mature microRNA let-7b (MIRLET7B), whose key role is to suppress the Notch signaling and to re-captivate the Osimertinib treatment.The findings open up future drug development, targeting this pathway for lung cancer patients."	M6ADIS0007	35070958	M6ADRUG0090
M6ACROT05550	REG00019	M6ATAR00485	Non-coding RNA	EPIREG00494	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The participation of Metformin decreased the bindings of DNMT3A/b to the METTL3 promoter with the help of the readers of NKAP and HNRNPA2B1.the mediation of m6A formation on pri-Let-7b processing increased the mature microRNA let-7b (MIRLET7B), whose key role is to suppress the Notch signaling and to re-captivate the Osimertinib treatment.The findings open up future drug development, targeting this pathway for lung cancer patients."	M6ADIS0007	35070958	M6ADRUG0007
M6ACROT05551	REG00004	M6ATAR00485	Non-coding RNA	EPIREG00494	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The participation of Metformin decreased the bindings of DNMT3A/b to the METTL3 promoter with the help of the readers of NKAP and HNRNPA2B1.the mediation of m6A formation on pri-Let-7b processing increased the mature microRNA let-7b (MIRLET7B), whose key role is to suppress the Notch signaling and to re-captivate the Osimertinib treatment.The findings open up future drug development, targeting this pathway for lung cancer patients."	M6ADIS0007	35070958	M6ADRUG0007
M6ACROT05552	REG00005	M6ATAR00141	Non-coding RNA	EPIREG00215	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"ALKBH5 could up-regulate Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) expression by demethylation. Furthermore, dexmedetomidine inhibited the expression of ALKBH5 in LPS-treated HK-2 cells. Dexmedetomidine suppressed the biological behavior of HK-2 cells treated with LPS by inhibiting the expression of ALKBH5 in vitro, which provides potential targets for the prevention and treatment of sepsis-induced kidney injury. Dexmedetomidine suppressed the biological behavior of HK-2 cells treated with LPS by inhibiting the expression of ALKBH5 in vitro, which provides potential targets for the prevention and treatment of sepsis-induced kidney injury."	M6ADIS0025	32656611	M6ADRUG0206
M6ACROT05553	REG00022	M6ATAR00048	Non-coding RNA	EPIREG00495	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Direct suppression of m6A modification of S-mu-GLT (SugLT) or of m6A reader YTHDC1 reduces CSR. METTL3 enzyme-catalyzed N6-methyladenosine (m6A) RNA modification drives recognition and 3' end processing of S-mu-GLT by the RNA exosome, promoting class switch recombination and suppressing chromosomal translocations. Tamoxifen affects the role of METTL3 in B cell development."	.	34450044	M6ADRUG0039
M6ACROT05554	REG00007	M6ATAR00017	Non-coding RNA	EPIREG00428	EPITAR00343	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3 promoted DGCR8 binding to pri-miR-143-3p through m6A modification, thus enhancing hsa-miR-143-3p expression to inhibit Protein kinase C epsilon (PRKCE) transcription and further aggravating cardiomyocyte pyroptosis and MI/R injury."	M6ADIS0096	35066738	.
M6ACROT05555	REG00007	M6ATAR00049	Non-coding RNA	EPIREG00372	EPITAR00344	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL3-m6A-miR-21-5p-Sprouty RTK signaling antagonist 1 (SPRY1)/ERK/NF-kB axis in obstructive renal fibrosis and provides a deeper understanding of renal fibrosis.	M6ADIS0170	34164910	.
M6ACROT05556	REG00007	M6ATAR00783	Non-coding RNA	EPIREG00496	EPITAR00345	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	Silencing METTL3 inhibited m6A level and decreased the binding of DGCR8 to pri-miR-375 and further limited hsa-miR-375-3p expression. METTL3-mediated m6A modification promoted VSMC phenotype transformation and made Atherosclerosis (AS) plaques more vulnerable via the miR-375-3p/PDH kinase 1 (PDK1) axis.	M6ADIS0099	35704246	.
M6ACROT05557	REG00009	M6ATAR00784	Non-coding RNA	EPIREG00497	EPITAR00536	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Subsequent loss- and gain-of-function experiments reveal WTAP is increased in senescent nucleus pulposus cells, and significantly promotes Long intergenic non-protein coding RNA 657 (NORAD) m6A modification. YTHDF2-mediated decay of NORAD is enhanced in senescent NPCs, and then deficiency of NORAD results in less sequestraion of PUMILIO proteins, contributing to the augmented activity of Pumilio homolog 1 (PUM1) and PUM2, thus repressing the expression of target E2F3 mRNAs and promoting the cellular senescence. This study shows interruption of NORAD m6A modification or the NORAD/PUMILIO/E2F3 axis could serve as a potential therapeutic target to inhibit the senescence of NPCs and development of intervertebral disc degeneration(IVDD)."	M6ADIS0168	35304463	.
M6ACROT05558	REG00007	M6ATAR00785	Non-coding RNA	EPIREG00498	EPITAR00118	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Enhanced METTL3 promoted the m6A methylation in total RNAs and inhibited neuropathic pain (NP) progression. Mechanistically, METTL3 accelerated microRNA 150 (MIR150) maturation via mediating m6A methylation of primiR-150 at locus 498, cooperating with the ""m6A reader"" YTHDF2. Therefore, the METTL3/miR-150/Neurotrophic factor BDNF precursor form (BDNF) pathway is a promising therapeutic target for NP patients."	M6ADIS0161	35210391	.
M6ACROT05559	REG00005	M6ATAR00787	Non-coding RNA	EPIREG00499	EPITAR00347	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"circCPSF6 was dominated by ALKBH5-mediated demethylation, followed by the recognization and destabilization by YTHDF2. Meanwhile, circCPSF6 was upregulated in HCC specimens, and elevated hsa_circ_0000417 (circCPSF6) expression served as an independent prognostic factor for worse survival of patients with HCC. circCPSF6 competitively bound Poly(rC)-binding protein 2, blunting its binding to YAP1 mRNA, thereby sustaining the stability of YAP1. "	M6ADIS0006	34916222	.
M6ACROT05560	REG00007	M6ATAR00788	Non-coding RNA	EPIREG00382	EPITAR00348	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3 resulted in the upregulation of AGAP2-AS1 in psoriasis. LOC10013.776 (AGAP2-AS1) is upregulated in the skin tissue of psoriasis patients and m6A methylation was involved in its upregulation. AGAP2-AS1 functioned as a competitive endogenous RNA by sponging hsa-miR-424-5p to upregulate AKT3, activate AKT/mTOR pathway, as well as promote cell proliferation in keratinocytes."	M6ADIS0172	34930676	.
M6ACROT05561	REG00007	M6ATAR00130	Non-coding RNA	EPIREG00416	EPITAR00349	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3 positively modulates the pri-miR-221/222 maturation process in an m6A-dependent manner and subsequently activates Wnt/Beta-catenin signaling by inhibiting Dickkopf-related protein 2 (DKK2), thus promoting Ang-II-induced cardiac hypertrophy."	M6ADIS0100	35836108	.
M6ACROT05562	REG00007	M6ATAR00129	Non-coding RNA	EPIREG00417	EPITAR00349	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3 positively modulates the pri-miR221/pri-miR-222 maturation process in an m6A-dependent manner and subsequently activates Wnt/Beta-catenin signaling by inhibiting Dickkopf-related protein 2 (DKK2), thus promoting Ang-II-induced cardiac hypertrophy."	M6ADIS0100	35836108	.
M6ACROT05563	REG00007	M6ATAR00791	Non-coding RNA	EPIREG00502	EPITAR00151	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"hsa-miR-380-3p was enriched with m6A modifications, and elimination of m6A modifications by deleting METTL3 and METTL14 synergistically suppressed miR-380-3p expressions in pancreatic cancer cells. miR-380-3p targeted the 3' untranslated regions (3'UTRs) of Mutated in multiple advanced cancers 1 (PTEN) for its inhibition and degradation, resulting in the activation of the downstream Akt signal pathway."	M6ADIS0061	35758158	.
M6ACROT05564	REG00006	M6ATAR00791	Non-coding RNA	EPIREG00502	EPITAR00151	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"hsa-miR-380-3p was enriched with m6A modifications, and elimination of m6A modifications by deleting METTL3 and METTL14 synergistically suppressed miR-380-3p expressions in pancreatic cancer cells. miR-380-3p targeted the 3' untranslated regions (3'UTRs) of Mutated in multiple advanced cancers 1 (PTEN) for its inhibition and degradation, resulting in the activation of the downstream Akt signal pathway."	M6ADIS0061	35758158	.
M6ACROT05565	REG00007	M6ATAR00792	Non-coding RNA	EPIREG00503	EPITAR00350	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Specifically, increased METTL3 methylated Keratin, type II cytoskeletal 7 (KRT7)-AS at A877 to increase the stability of a KRT7-AS/KRT7 mRNA duplex via IGF2BP1/HuR complexes. m6A promotes breast cancer lung metastasis by increasing the stability of a KRT7-AS/KRT7 mRNA duplex and translation of KRT7. "	M6ADIS0065	33795252	.
M6ACROT05566	REG00007	M6ATAR00793	Non-coding RNA	EPIREG00504	EPITAR00351	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"hsa_circ_0000677 and its downstream target ATP binding cassette subfamily C member 1 (ABCC1 blood group) (ABCC1) were upregulated in CRC cells, induced by the METTL3-mediated m6 A modification of circ_0000677 and SUMO1-mediated SUMOylation of METTL3. This work provided a new strategy for the therapeutic treatment of CRC."	M6ADIS0059	35030640	.
M6ACROT05567	REG00001	M6ATAR00141	Non-coding RNA	EPIREG00215	EPITAR00352	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"FTO facilitates the tumorigenesis of bladder cancer through regulating the Metastasis associated lung adenocarcinoma transcript 1 (MALAT1)/MicroRNA 384 (MIR384)/MAL2 axis in m6A RNA modification manner, which ensures the potential of FTO for serving as a diagnostic or prognostic biomarker in bladder cancer."	M6ADIS0070	33634966	.
M6ACROT05568	REG00007	M6ATAR00493	Non-coding RNA	EPIREG00505	EPITAR00167	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"NKILA physically interacted with and suppressed hsa-miR-582-3p, which was regulated by METTL3-mediated N6 -methyladenosine (m6A) modification. Transcriptional coactivator YAP1 (YAP1) was a target of NKILA via miR-582-3p and NKILA functioned partially via YAP1 in CCA."	M6ADIS0006	35274813	.
M6ACROT05569	REG00007	M6ATAR00495	Non-coding RNA	EPIREG00506	EPITAR00353	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL3 acts on the m6A functional site of 1956 bp in hsa_circ_0008542. RNA demethylase ALKBH5 inhibits the binding of circ_0008542 with hsa-miR-185-5p to correct the bone resorption process.	M6ADIS0138	34145224	.
M6ACROT05570	REG00005	M6ATAR00495	Non-coding RNA	EPIREG00506	EPITAR00353	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL3 acts on the m6A functional site of 1956 bp in hsa_circ_0008542. RNA demethylase ALKBH5 inhibits the binding of circ_0008542 with hsa-miR-185-5p to correct the bone resorption process.	M6ADIS0138	34145224	.
M6ACROT05571	REG00007	M6ATAR00496	Non-coding RNA	EPIREG00285	EPITAR00028	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3-mediated m6A modification contributed to Prostate cancer associated transcript 6 (PCAT6) upregulation in an Insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2)-dependent manner. Furthermore, PCAT6 upregulated IGF1R expression by enhancing IGF1R mRNA stability through the PCAT6/IGF2BP2/IGF1R RNA-protein three-dimensional complex. The m6 A-induced PCAT6/IGF2BP2/IGF1R axis promotes PCa bone metastasis and tumor growth, suggesting that PCAT6 serves as a promising prognostic marker and therapeutic target against bone-metastatic PCa."	M6ADIS0068	34185427	.
M6ACROT05572	REG00013	M6ATAR00496	Non-coding RNA	EPIREG00285	EPITAR00028	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3-mediated m6A modification contributed to Prostate cancer associated transcript 6 (PCAT6) upregulation in an IGF2BP2-dependent manner. Furthermore, PCAT6 upregulated IGF1R expression by enhancing IGF1R mRNA stability through the PCAT6/IGF2BP2/IGF1R RNA-protein three-dimensional complex. The m6 A-induced PCAT6/IGF2BP2/IGF1R axis promotes PCa bone metastasis and tumor growth, suggesting that PCAT6 serves as a promising prognostic marker and therapeutic target against bone-metastatic PCa."	M6ADIS0068	34185427	.
M6ACROT05573	REG00006	M6ATAR00507	Non-coding RNA	EPIREG00507	EPITAR00354	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL14, an m6A RNA methyltransferase downregulated in ESCC, suppresses Tribbles homolog 2 (TRIB2) expression via hsa-miR-99a-5p-mediated degradation of TRIB2 mRNA by targeting its 3' untranslated region, whereas TRIB2 induces ubiquitin-mediated proteasomal degradation of METTL14 in a COP1-dependent manner. "	M6ADIS0056	34586732	.
M6ACROT05574	REG00013	M6ATAR00509	Non-coding RNA	EPIREG00378	EPITAR00355	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"IGF2BP2 stabilizes PTGS2 antisense RNA 1 (PACERR) in an m6A-dependent manner. Meanwhile the Krueppel-like factor 12 (KLF12)-transcribed LncRNA-PACERR interacts directly with KLF12 and the KLF12/PACERR complex activates LncRNA-PACERR transcription by recruiting EP300, thereby promoting M2 polarization and pro-tumour function in TAMs."	M6ADIS0061	35526050	.
M6ACROT05575	REG00015	M6ATAR00517	Non-coding RNA	EPIREG00508	EPITAR00233	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Circ_DLC1, a downstream target of KIAA1429, is a promising prognostic marker for HCC patients, and the circDLC1-ELAV-like protein 1 (HuR/ELAVL1)-MMP1 axis serve as a potential therapeutic target for HCC treatment."	M6ADIS0006	33391541	.
M6ACROT05576	REG00007	M6ATAR00528	Non-coding RNA	EPIREG00509	EPITAR00357	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"In non-small-cell lung carcinoma, METTL3 mediates the N6-methyladenosine (m6A) modification of Circ_IGF2BP3 and promotes its circularization in a manner dependent on the m6A reader protein YTHDC1. circIGF2BP3 competitively upregulates PKP3 expression by sponging hsa-miR-328-3p and miR-3173-5p to compromise the cancer immune response."	M6ADIS0007	34416901	.
M6ACROT05577	REG00022	M6ATAR00528	Non-coding RNA	EPIREG00509	EPITAR00358	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"In non-small-cell lung carcinoma, METTL3 mediates the N6-methyladenosine (m6A) modification of Circ_IGF2BP3 and promotes its circularization in a manner dependent on the m6A reader protein YTHDC1. circIGF2BP3 competitively upregulates PKP3 expression by sponging miR-328-3p and hsa-miR-3173-5p to compromise the cancer immune response."	M6ADIS0007	34416901	.
M6ACROT05578	REG00006	M6ATAR00534	Non-coding RNA	EPIREG00510	EPITAR00359	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL14 was remarkably downregulated in LC tissues and cell lines. METTL14 promoted the maturation of hsa-miR-30c-1-3p and mediated MARCKS-related protein (MARCKSL1) expression to inhibit the progression of LC.	M6ADIS0007	34586620	.
M6ACROT05579	REG00001	M6ATAR00540	Non-coding RNA	EPIREG00511	EPITAR00360	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	FTO up-regulated ADP-ribosylation factor-like protein 5B (ARL5B) by inhibiting hsa-miR-181b-3p. The carcinogenic activity of FTO in promoting the invasion and migration of breast cancer cells via the FTO/miR-181b-3p/ARL5B signaling pathway.	M6ADIS0065	32805088	.
M6ACROT05580	REG00007	M6ATAR00010	Non-coding RNA	EPIREG00418	EPITAR00361	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	The knockout of methyltransferase 3 (N6-adenosine-methyltransferase complex catalytic subunit) removed the m6A modification of hsa-miR-29a-3p and reduced miR-29a-3p expression. These findings suggest that miR-29a-3p is a potential target that can be manipulated for ALI/ARDS. miR-29a-3p targets Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) to inhibit PANoptosis in alveolar epithelial cells	M6ADIS0134	35656115	.
M6ACROT05581	REG00012	M6ATAR00548	Non-coding RNA	EPIREG00512	EPITAR00234	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	IGF2BP1 was predominantly binded with Circ_PTPRA in the cytoplasm in BC cells.	M6ADIS0070	33853613	.
M6ACROT05582	REG00007	M6ATAR00552	Non-coding RNA	EPIREG00513	EPITAR00151	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"In gastric cancer, m6A facilitated processing of pri-miR-17-92 into the miR-17-92 cluster through an m6A/DGCR8-dependent mechanism. METTL3-high tumors showed preferred sensitivity to an mTOR inhibitor, everolimus. The miR-17-92 cluster activated the AKT/mTOR pathway by targeting Mutated in multiple advanced cancers 1 (PTEN) or TMEM127."	M6ADIS0057	33037176	M6ADRUG0105
M6ACROT05583	REG00007	M6ATAR00063	Non-coding RNA	EPIREG00441	EPITAR00362	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3 acts as a fate determinant that controls the sensitivity of bladder cancer cells to melittin treatment. Moreover, METTL3/hsa-miR-146a-5p/Protein numb homolog (NUMB)/NOTCH2 axis plays an oncogenic role in bladder cancer pathogenesis and could be a potential therapeutic target for recurrent bladder cancer treatment."	M6ADIS0070	35278613	M6ADRUG0098
M6ACROT05584	REG00007	M6ATAR00568	Non-coding RNA	EPIREG00515	EPITAR00159	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"m6A-mediated Long intergenic non-protein coding RNA 680 (LINC00680) regulates the proliferation and ECM degradation of chondrocytes through LINC00680/m6A/NAD-dependent protein deacetylase sirtuin-1 (SIRT1) mRNA axis. METTL3-mediated LINC00680 accelerates osteoarthritis(OA) progression, which provides novel understanding of the role of m6A and lncRNA in OA."	M6ADIS0110	35501316	.
M6ACROT05585	REG00008	M6ATAR00575	Non-coding RNA	EPIREG00516	EPITAR00363	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	Increased YTHDF2-mediated endoribonucleolytic cleavage of m6A-modified Circ_Mitogen-activated protein kinase kinase kinase 5 (MAP3K5) accounts for its downregulation in gefitinib-resistant cells. Either METTL3 silencing or YTHDF2 silencing suppressed the decay of circASK1 in HCC827-GR cells. This study provides a novel therapeutic target to overcome gefitinib resistance in LUAD patients. A novel protein encoded by circASK1 ameliorates gefitinib resistance in lung adenocarcinoma by competitively activating ASK1-dependent apoptosis.	M6ADIS0007	34389432	M6ADRUG0030
M6ACROT05586	REG00007	M6ATAR00575	Non-coding RNA	EPIREG00516	EPITAR00363	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	Increased YTHDF2-mediated endoribonucleolytic cleavage of m6A-modified Circ_Mitogen-activated protein kinase kinase kinase 5 (MAP3K5) accounts for its downregulation in gefitinib-resistant cells. Either METTL3 silencing or YTHDF2 silencing suppressed the decay of circASK1 in HCC827-GR cells. This study provides a novel therapeutic target to overcome gefitinib resistance in LUAD patients. A novel protein encoded by circASK1 ameliorates gefitinib resistance in lung adenocarcinoma by competitively activating ASK1-dependent apoptosis.	M6ADIS0007	34389432	M6ADRUG0030
M6ACROT05587	REG00007	M6ATAR00585	Non-coding RNA	EPIREG00517	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3 promoted cell proliferation, migration, invasion and tumorigenesis in PCa. METTL3 upregulating the level of m6A, and interacted with DGCR8 to recognize the m6A modification of pre-miR-182 to regulate its splicing and maturation and promote the high expression of miRNA. "	M6ADIS0068	35413135	.
M6ACROT05588	REG00012	M6ATAR00586	Non-coding RNA	EPIREG00518	EPITAR00364	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Driven by m6A modification, Circ_MAP3K4 encoded circMAP3K4-455aa, protected HCC cells from cisplatin exposure, and predicted worse prognosis of HCC patients. IGF2BP1 facilitates circMAP3K4 peptide translation, then the circMAP3K4 peptide inhibits Apoptosis inducing factor mitochondria associated 1 (AIFM1) cleavage and nuclear distribution"	M6ADIS0006	35366894	M6ADRUG0047
M6ACROT05589	REG00009	M6ATAR00094	Non-coding RNA	EPIREG00480	EPITAR00327	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"A remarkable m6A-modified site was found on the 3'-UTR of FOXD2 adjacent opposite strand RNA 1 (FOXD2-AS1), and m6A methyltransferase WTAP promoted the methylation modification, thus enhancing the stability of FOXD2-AS1 transcripts. m6A-modified FOXD2-AS1 accelerates the osteosarcoma progression through m6A manner, which provides new concepts for osteosarcoma tumorigenesis. FOXD2-AS1 interacted with downstream target Forkhead box protein M1 (FOXM1) mRNA through m6A sites, forming a FOXD2-AS1/m6A/FOXM1 complex to heighten FOXM1 mRNA stability."	M6ADIS0051	35356854	.
M6ACROT05590	REG00006	M6ATAR00588	Non-coding RNA	EPIREG00519	EPITAR00365	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The expression of METTL14 was negatively correlated to the prognosis, stage, and ccRCC tumor grade. Lnc-LSG1 could be regulated by METTL14. Lnc_LSG1 can directly bind to Epithelial splicing regulatory protein 2 (ESRP2) protein and promote ESRP2 degradation via facilitating ESRP2 ubiquitination."	M6ADIS0010	35036065	.
M6ACROT05591	REG00020	M6ATAR00084	Non-coding RNA	EPIREG00392	EPITAR00366	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"IGF2BP1 was identified as the m6A reader protein of UBA6 divergent transcript (UBA6-DT/UBA6-AS1)-RBM15-mediated m6A modification of UBA6 mRNA, which enhanced the stability of Ubiquitin-like modifier-activating enzyme 6 (UBA6) mRNA. UBA6-AS1 suppressed the proliferation, migration and invasion of OC cells via UBA6."	M6ADIS0066	34951345	.
M6ACROT05592	REG00012	M6ATAR00084	Non-coding RNA	EPIREG00392	EPITAR00366	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"IGF2BP1 was identified as the m6A reader protein of UBA6 divergent transcript (UBA6-DT/UBA6-AS1)-RBM15-mediated m6A modification of UBA6 mRNA, which enhanced the stability of Ubiquitin-like modifier-activating enzyme 6 (UBA6) mRNA. UBA6-AS1 suppressed the proliferation, migration and invasion of OC cells via UBA6."	M6ADIS0066	34951345	.
M6ACROT05593	REG00007	M6ATAR00599	Non-coding RNA	EPIREG00520	EPITAR00072	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL3 modulates miR-193b mature process in an m6A-dependent manner. Reintroduction of hsa-miR-193b profoundly inhibits tumorigenesis of cervical cancer cells both in vivo and in vitro through G1/S-specific cyclin-D1 (CCND1) targeting.	M6ADIS0008	34178650	.
M6ACROT05595	REG00007	M6ATAR00137	Non-coding RNA	EPIREG00521	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The METTL3/m6A/microRNA 126 (MIR126) pathway, whose inhibition contributes to endometriosis development by enhancing cellular migration and invasion."	M6ADIS0144	34382070	.
M6ACROT05596	REG00007	M6ATAR00517	Non-coding RNA	EPIREG00508	EPITAR00368	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3-mediated m6A modification upregulated Circ_DLC1 expression, and circDLC1 promoted CTNNBIP1 transcription by sponging hsa-miR-671-5p, thus repressing the malignant proliferation of glioma."	M6ADIS0001	35474040	.
M6ACROT05597	REG00007	M6ATAR00613	Non-coding RNA	EPIREG00522	EPITAR00369	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3-mediated m6A modification upregulated circDLC1 expression, and circDLC1 promoted Beta-catenin-interacting protein 1 (CTNNBIP1) transcription by sponging hsa-miR-671-5p, thus repressing the malignant proliferation of glioma."	M6ADIS0001	35474040	.
M6ACROT05598	REG00006	M6ATAR00616	Non-coding RNA	EPIREG00523	EPITAR00370	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL14-mediated m6A modification of Circ_ORC5 suppresses gastric cancer progression by regulating hsa-miR-30c-2-3p/AKT1S1 axis. METTL14 was downregulated in GC tissue samples and its low expression acted as a prognostic factor of poor survival in patients with GC.	M6ADIS0057	35164771	.
M6ACROT05599	REG00006	M6ATAR00617	Non-coding RNA	EPIREG00524	EPITAR00371	.	Up regulation	m6A	Indirect	Enhancement	ncRNA	m6A regulators indirectly modulate the functionality of ncRNAs through downstream signaling pathways	METTL14-mediated m6A modification of circORC5 suppresses gastric cancer progression by regulating hsa-miR-30c-2-3p/Proline-rich AKT1 substrate 1 (AKT1S1) axis.METTL14 was downregulated in GC tissue samples and its low expression acted as a prognostic factor of poor survival in patients with GC.	M6ADIS0057	35164771	.
M6ACROT05600	REG00007	M6ATAR00623	Non-coding RNA	EPIREG00525	EPITAR00538	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL3 deficiency contributes to heart regeneration after MI via METTL3-pri-miR-143-(miR-143)-YY1-associated protein 1 (YY1AP1)/Ctnnd1 axis.	M6ADIS0097	34428587	.
M6ACROT05601	REG00009	M6ATAR00627	Non-coding RNA	EPIREG00526	EPITAR00373	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"WTAP-mediated m6A modification of DIAPH1 antisense RNA 1 (DIAPH1-AS1) enhanced its stability relying on the m6A reader IGF2BP2-dependent pathway. Furthermore, DIAPH1-AS1 acted as a molecular adaptor that promoted MTDH-LIM and SH3 domain protein 1 (LASP1) complex formation and upregulated LASP1 expression, ultimately facilitating NPC growth and metastasis."	M6ADIS0054	34999731	.
M6ACROT05602	REG00013	M6ATAR00627	Non-coding RNA	EPIREG00526	EPITAR00373	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"WTAP-mediated m6A modification of DIAPH1 antisense RNA 1 (DIAPH1-AS1) enhanced its stability relying on the m6A reader IGF2BP2-dependent pathway. Furthermore, DIAPH1-AS1 acted as a molecular adaptor that promoted MTDH-LIM and SH3 domain protein 1 (LASP1) complex formation and upregulated LASP1 expression, ultimately facilitating NPC growth and metastasis."	M6ADIS0054	34999731	.
M6ACROT05603	REG00001	M6ATAR00632	Non-coding RNA	EPIREG00527	EPITAR00374	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"FTO inhibited growth, migration and invasion of GBM cells in vitro and in vivo.decreased FTO expression could induce the downregulation of Myotubularin related protein 3 (MTMR3) expression by modulating the processing of pri-miR-10a in an m6A/HNRNPA2B1-dependent manner in GBM cells. Furthermore, the transcriptional activity of FTO was inhibited by the transcription factor SPI1."	M6ADIS0001	35317283	.
M6ACROT05604	REG00007	M6ATAR00636	Non-coding RNA	EPIREG00528	.	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3 affected the growth, apoptosis, and stemness of MM cells through accelerating the stability of YY1 mRNA and the maturation of pri-miR-27 in vitro and in vivo."	M6ADIS0048	35038059	.
M6ACROT05605	REG00007	M6ATAR00641	Non-coding RNA	EPIREG00529	EPITAR00376	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	hsa-miR-1915-3p expression was regulated by METTL3/YTHDF2 m6A axis through transcription factor KLF4. miR-1915-3p function as a tumor suppressor by targeting Protein SET (SET) and has an anti-metastatic therapeutic potential for lung cancer treatment.	M6ADIS0007	34774019	.
M6ACROT05606	REG00006	M6ATAR00118	Non-coding RNA	EPIREG00429	EPITAR00377	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	Mettl14-mediated m6A modification inhibited Dexamethasone-induced Ras-related protein 1 (RASD1) and induced the apoptosis of spinal cord neurons in SCI by promoting the transformation of pri-miR-375 to mature microRNA 375 (MIR375).	M6ADIS0166	33706799	.
M6ACROT05607	REG00007	M6ATAR00651	Non-coding RNA	EPIREG00530	EPITAR00159	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL3/m6A-mediated hsa-miR-34a maturation in AAA formation and provide a novel therapeutic target and diagnostic biomarker for AAA treatment. miR-34a overexpression significantly decreased NAD-dependent protein deacetylase sirtuin-1 (SIRT1) expression.	M6ADIS0102	32650237	.
M6ACROT05608	REG00007	M6ATAR00141	Non-coding RNA	EPIREG00215	EPITAR00328	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Silencing METTL3 down-regulate Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) and HMGA2 by sponging hsa-miR-26b, and finally inhibit EMT, migration and invasion in BC, providing a theoretical basis for clinical treatment of BC."	M6ADIS0065	34419065	.
M6ACROT05609	REG00008	M6ATAR00641	Non-coding RNA	EPIREG00529	EPITAR00376	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	hsa-miR-1915-3p expression was regulated by METTL3/YTHDF2 m6A axis through transcription factor KLF4. miR-1915-3p function as a tumor suppressor by targeting Protein SET (SET) and has an anti-metastatic therapeutic potential for lung cancer treatment.	M6ADIS0007	34774019	.
M6ACROT05610	REG00007	M6ATAR00653	Non-coding RNA	EPIREG00531	EPITAR00168	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Silencing METTL3 down-regulate MALAT1 and High mobility group protein HMGI-C (HMGA2) by sponging hsa-miR-26b, and finally inhibit EMT, migration and invasion in BC, providing a theoretical basis for clinical treatment of BC."	M6ADIS0065	34419065	.
M6ACROT05611	REG00007	M6ATAR00659	Non-coding RNA	EPIREG00401	EPITAR00280	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Long intergenic non-protein coding RNA 1273 (LINC01273) was modified with m6A, METTL3 increased LINC01273 m6A modification, followed by LINC01273 decay in the presence of YTHDF2, a m6A 'reader'. And LINC01273 plays a key role in sorafenib resistant HCC cells. LINC01273 complementarity bound to hsa-miR-600, served as a 'reservoir' increasing miR-600 stability, and facilitating miR-600 targeting methyltransferase 3 (METTL3), a m6A 'writer', resulting in reducing METTL3 level."	M6ADIS0006	35037556	M6ADRUG0032
M6ACROT05612	REG00008	M6ATAR00659	Non-coding RNA	EPIREG00401	EPITAR00280	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Long intergenic non-protein coding RNA 1273 (LINC01273) was modified with m6A, METTL3 increased LINC01273 m6A modification, followed by LINC01273 decay in the presence of YTHDF2, a m6A 'reader'. And LINC01273 plays a key role in sorafenib resistant HCC cells. LINC01273 complementarity bound to hsa-miR-600, served as a 'reservoir' increasing miR-600 stability, and facilitating miR-600 targeting methyltransferase 3 (METTL3), a m6A 'writer', resulting in reducing METTL3 level."	M6ADIS0006	35037556	M6ADRUG0032
M6ACROT05613	REG00007	M6ATAR00141	Non-coding RNA	EPIREG00215	EPITAR00153	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3 can regulate the expression of Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) through m6A, mediate the Transcription factor E2F1 (E2F1)/AGR2 axis, and promote the adriamycin resistance of breast cancer. "	M6ADIS0065	34964205	M6ADRUG0034
M6ACROT05614	REG00015	M6ATAR00088	Non-coding RNA	EPIREG00431	EPITAR00378	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Long intergenic non-protein coding RNA 958 (LINC00958) accelerated the aerobic glycolysis of GC cells. Mechanistically, KIAA1429 interacted with the m6A modification site and promoted the enrichment of LINC00958, and LINC00958 subsequently cooperated with Solute carrier family 2 member 1 (SLC2A1) mRNA to enhance its mRNA stability."	M6ADIS0057	34409730	.
M6ACROT05615	REG00007	M6ATAR00666	Non-coding RNA	EPIREG00532	EPITAR00379	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3-dependent m6A methylation was upregulated in CRC to promote the processing of miR-181d-5p by DGCR8. This led to increased hsa-miR-181d-5p expression, which inhibited the 5-FU sensitivity of CRC cells by targeting Neurocalcin-delta (NCALD)."	M6ADIS0059	35014676	M6ADRUG0005
M6ACROT05616	REG00005	M6ATAR00672	Non-coding RNA	EPIREG00348	EPITAR00327	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	ALKBH5 promotes silica-induced lung fibrosis via the hsa-miR-320a-3p/Forkhead box protein M1 (FOXM1) axis or targeting FOXM1 directly.	M6ADIS0016	35279083	.
M6ACROT05617	REG00007	M6ATAR00673	Non-coding RNA	EPIREG00533	EPITAR00153	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The reduction in cell proliferation induced by SVIL antisense RNA 1 (SVIL-AS1) overexpression could be rescued by Transcription factor E2F1 (E2F1) overexpression or METTL3 knockdown. In conclusion, METTL3-induced SVIL-AS1 in LUAD, which connects m6A and lncRNA in lung cancer carcinogenesis."	M6ADIS0007	35068325	.
M6ACROT05618	REG00007	M6ATAR00675	Non-coding RNA	EPIREG00217	EPITAR00173	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	LINC00035 (ABHD11-AS1) was upregulated in NSCLC tissue specimens and cells and the ectopic overexpression was closely correlated with unfavorable prognosis of NSCLC patients.METTL3 installed the m6A modification and enhanced ABHD11-AS1 transcript stability to increase its expression. ABHD11-AS1 epigenetically repressed Krueppel-like factor 4 (KLF4) in NSCLC	M6ADIS0007	32892348	.
M6ACROT05619	REG00001	M6ATAR00685	Non-coding RNA	EPIREG00534	EPITAR00357	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"FTO-mediated N6-methyladenosine demethylation downregulated AC008440.5 (AC008) transcription, while lower FTO expression led to upregulation of AC008 transcription in OA. AC008 functioned as a competing endogenous RNA (ceRNA) to regulate hsa-miR-328-3p."	M6ADIS0110	34737423	.
M6ACROT05620	REG00007	M6ATAR00691	Non-coding RNA	EPIREG00361	EPITAR00212	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	m6A transferase METTL3-induced Long intergenic non-protein coding RNA 1833 (LINC01833) m6A methylation promotes NSCLC progression through modulating Heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1) expression.	M6ADIS0007	35441574	.
M6ACROT05621	REG00005	M6ATAR00140	Non-coding RNA	EPIREG00279	EPITAR00380	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"ALKBH5 knockdown suppressed cell proliferation, migration and invasion of infantile hemangioma cells, while promoting cell apoptosis. ALKBH5 promoted lncRNA Nuclear paraspeckle assembly transcript 1 (NEAT1) expression by reducing the m6A modification of lncRNA NEAT1. In addition, MicroRNA 378b (MIR378B) was the target of lncRNA NEAT1, and its overexpression reversed the promotion effect of lncRNA NEAT1 overexpression on IH cell tumor-like behaviors."	M6ADIS0154	35182329	.
M6ACROT05622	REG00005	M6ATAR00697	Non-coding RNA	EPIREG00535	EPITAR00381	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	ALKBH5 demethylated pri-miR-194-2 and inhibited miR-194-2 biogenesis through an m6A/DGCR8-dependent manner. ALKBH5/miR-194-2/Retinoic acid-induced protein 1 (RAI1) axis was also validated in clinical samples. This study revealed ALKBH5 in miRNAs biogenesis and provide novel insight for developing treatment strategies in esophageal cancer.	M6ADIS0056	34312488	M6ADRUG0260
M6ACROT05623	REG00007	M6ATAR00704	Non-coding RNA	EPIREG00275	EPITAR00022	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL3-stabilized lncRNA Small nucleolar RNA host gene (SNHG7) accelerates glycolysis in PCa via SRSF1/Myc proto-oncogene protein (MYC) axis and inspires the understanding of m6A roles in lncRNA metabolism and tumor progression.	M6ADIS0068	35405116	.
M6ACROT05624	REG00006	M6ATAR00141	Non-coding RNA	EPIREG00215	EPITAR00382	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL14 and lncRNA Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) were upregulated, and hsa-miR-224-5p was downregulated in OSCC tissues and cells. METTL14 induced m6A modification of MALAT1 to upregulate MALAT1."	M6ADIS0055	35467063	.
M6ACROT05625	REG00007	M6ATAR00711	Non-coding RNA	EPIREG00536	EPITAR00383	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"DBH antisense RNA 1 (Lnc_DBH-AS1) expression in pancreatic cancer(PC) was found to be linked to the METTL3-dependent m6A methylation of the lncRNA. Mechanistically, DBH-AS1 was able to increase PC cell sensitivity to gemcitabine by sequestering MicroRNA 3163 (MIR3163) and thus upregulating USP44 in these tumor cells."	M6ADIS0061	35433957	M6ADRUG0024
M6ACROT05626	REG00007	M6ATAR00717	Non-coding RNA	EPIREG00537	EPITAR00384	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Hypoxia induced rapid H3K4 methylation of the promoter of the methyltransferase-like 3 gene (METTL3) and resulted in its overexpression. METTL3 overexpression evokes N6-methyladenosine (m6A)-dependent miR-503 biogenesis in endothelial cells. miR-503 promoted cardiomyocyte death by directly binding to PPARG coactivator 1 beta (PPARGC1B) and SIRT3, thereby triggering mitochondrial metabolic dysfunction and cardiomyocyte death. In summary, this study highlights a novel endogenous mechanism wherein EVs aggravate myocardial injury during the onset of AMI via endothelial cell-secreted miR-503 shuttling."	M6ADIS0159	35452193	.
M6ACROT05627	REG00007	M6ATAR00112	Non-coding RNA	EPIREG00261	EPITAR00385	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Knockout of METTL3 can reduce the total expression of ZNFX1 antisense RNA 1 (ZFAS1). ZFAS1 is used as an oncogenic lncRNA, which can promote NPCcell proliferation, migration and tumor growth. ZFAS1 up-regulates the expression of ATG10 by competitively adsorbing hsa-miR-100-3p and regulates the level of autophagy by inhibiting the PI3K/Akt signaling pathway to promote the proliferation and migration of NPC cells."	M6ADIS0054	34980191	.
M6ACROT05629	REG00007	M6ATAR00733	Non-coding RNA	EPIREG00538	EPITAR00386	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Silencing METTL3 suppresses hsa-miR-222-3p expression and thus stimulates Serine/threonine-protein kinase 4 (STK4) expression, thereby repressing the malignancy and metastasis of Thyroid Carcinoma."	M6ADIS0073	34562008	.
M6ACROT05630	REG00007	M6ATAR00735	Non-coding RNA	EPIREG00539	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3 up-regulated the expression of hsa-miR-589-5p and promoted the maturation of miR-589-5p. Overexpressed miR-589-5p and METTL3 promoted the viability, migration and invasion of liver cancer cells."	M6ADIS0006	35348293	.
M6ACROT05631	REG00013	M6ATAR00141	Non-coding RNA	EPIREG00215	EPITAR00387	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"IGF2BP2 promotes Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) stability in an m6A-dependent mechanism, thus promoting its downstream target Ubiquitin-like protein ATG12 (ATG12) expression and NSCLC proliferation."	M6ADIS0007	35111811	.
M6ACROT05633	REG00008	M6ATAR00742	Non-coding RNA	EPIREG00540	.	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"In lung adenocarcinoma, The miR-146a/Notch signaling was sustained highly activated in a m6A dependent manner, and the m6A regulator of YTHDF2 suppressed LINC00902 (TUSC7), both of which contributed to the resistant features. Functionally, the sponge type of TUSC7 regulation of miR-146a inhibited Notch signaling functions, and affected the cancer progression and stem cells' renewal in Erlotinib resistant PC9 cells (PC9ER) and Erlotinib resistant HCC827 cells (HCC827ER) cells."	M6ADIS0007	34656164	M6ADRUG0100
M6ACROT05634	REG00022	M6ATAR00743	Non-coding RNA	EPIREG00541	EPITAR00388	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"MiR-30d is a novel target for YTHDC1 through m6A modification, and hsa-miR-30d represses pancreatic ductal adenocarcinoma tumorigenesis via suppressing aerobic glycolysis. miR-30d inhibited aerobic glycolysis through regulating SLC2A1 and HK1 expression by directly targeting the transcription factor Runt-related transcription factor 1 (RUNX1), which bound to the promoters of the SLC2A1 and HK1 genes."	M6ADIS0061	34021267	.
M6ACROT05635	REG00007	M6ATAR00047	Non-coding RNA	EPIREG00409	EPITAR00389	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3 could interact with DGCR8 protein and positively modulate pri-miR-320b maturation process in an N6-methyladenosine (m6A)-dependent manner. Therefore, our findings uncover a VEGF-C-independent mechanism of exosomal and intracellular hsa-miR-320b-mediated LN metastasis and identify miR-320b as a novel predictive marker and therapeutic target for LN metastasis in ESCC. Programmed cell death 4 (PDCD4) as a direct target of miR-320b through bioinformatic prediction and luciferase reporter assay."	M6ADIS0056	34729394	.
M6ACROT05637	REG00014	M6ATAR00751	Non-coding RNA	EPIREG00354	EPITAR00154	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	hsa_circ_0004287 was upregulated in peripheral blood mononuclear cells of both AD and psoriasis patients. hsa_circ_0004287 reduced the stability of its host gene Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) by competitively binding to IGF2BP3 with MALAT1 in an N6-methyladenosine (m6A)-dependent manner.	M6ADIS0137	34953789	.
M6ACROT05638	REG00014	M6ATAR00141	Non-coding RNA	EPIREG00215	EPITAR00539	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"circRNA hsa_circ_0004287 was upregulated in peripheral blood mononuclear cells of both AD and psoriasis patients. hsa_circ_0004287 reduced the stability of its host gene Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) by competitively binding to IGF2BP3 with MALAT1 in an N6-methyladenosine (m6A)-dependent manner. Lower levels of MALAT1 promoted the ubiquitination degradation of Protein S100-A8 (S100A8)/S100A9, thereby impeding p38/mitogen-activated protein kinase phosphorylation and macrophage-mediated inflammation."	M6ADIS0137	34953789	.
M6ACROT05639	REG00005	M6ATAR00140	Non-coding RNA	EPIREG00279	EPITAR00052	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"ALKBH5 could up-regulate Nuclear paraspeckle assembly transcript 1 (NEAT1) expression by inhibiting m6A enrichment. ALKBH5-induced NEAT1 promoted cell proliferation and migration of HCC by sponging MicroRNA 214 (MIR214) in vitro, which provided a potential therapeutic target for HCC."	M6ADIS0006	35357550	.
M6ACROT05640	REG00007	M6ATAR00493	Non-coding RNA	EPIREG00505	EPITAR00167	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"NKILA physically interacted with and suppressed hsa-miR-582-3p, which was regulated by METTL3-mediated N6 -methyladenosine (m6A) modification. Transcriptional coactivator YAP1 (YAP1) was a target of NKILA via miR-582-3p and NKILA functioned partially via YAP1 in CCA."	M6ADIS0006	35274813	.
M6ACROT05641	REG00013	M6ATAR00806	Non-coding RNA	EPIREG00543	EPITAR00392	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	BACE1 antisense RNA (BACE1-AS) as a novel target of IGF2BP2 through m6A modification. m6A modified BACE1-AS promotes CRC liver metastasis through TUFT1 dependent activation of Wnt signaling pathway by hsa-miR-214-3p.	M6ADIS0059	37986103	.
M6ACROT05642	REG00008	M6ATAR00813	Non-coding RNA	EPIREG00544	EPITAR00393	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Circ_RERE expression is downregulated in human osteoarthritis (OA) cartilage and chondrocytes, and circRERE downregulation is likely attributed to its increased m6A modification prone to endoribonucleolytic cleavage by YTHDF2-HRSP12-RNase P/MRP. Mechanistically, circRERE downregulation leads to aberrant beta-catenin ubiquitin and degradation by targeting hsa-miR-195-5p/IRF2BPL during OA pathogenesis."	M6ADIS0110	35733354	M6ADRUG0142
M6ACROT05643	REG00022	M6ATAR00815	Non-coding RNA	EPIREG00545	.	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"the m6A ""reader"" protein YTHDC1 was found to reduce Circ_MPP1 expression via m6A modification. In conclusion, this study demonstrates that YTHDC1 maintains trophoblasts function by promoting degradation of m6A-mediated circMPP1."	M6ADIS0373	36780989	.
M6ACROT05644	REG00007	M6ATAR00141	Non-coding RNA	EPIREG00215	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"in osteosarcoma cells, METTL3, acting as an oncogene, promoted m6A modification of Metastasis associated lung adenocarcinoma transcript 1 (MALAT1), increased the stability of MALAT, and enhanced MALAT1-mediated oncogenic function."	M6ADIS0051	37897586	.
M6ACROT05645	REG00009	M6ATAR00827	Non-coding RNA	EPIREG00546	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	WTAP-mediated IQ motif and ankyrin repeat containing 1 (IQANK1) promotes GC development via m6A modification.	M6ADIS0057	37477820	.
M6ACROT05646	REG00001	M6ATAR00148	Non-coding RNA	EPIREG00426	EPITAR00394	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	LncRNA Growth arrest specific 5 (GAS5) regulated by FTO-mediated m6A demethylation promotes autophagic cell death in NSCLC by targeting UPF1/Bromodomain-containing protein 4 (BRD4) axis.	M6ADIS0007	37120495	.
M6ACROT05647	REG00022	M6ATAR00153	Non-coding RNA	EPIREG00433	EPITAR00395	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Pvt1 oncogene (PVT1) positively regulated Interleukin-33 (IL33) expression by recruiting YTHDC1 to mediate m6A modification of IL-33. In conclusion, silencing PVT1 demonstrated beneficial effects in alleviating BPD by facilitating YTHDC1-mediated m6A modification of IL-33."	M6ADIS0383	37917328	.
M6ACROT05648	REG00007	M6ATAR00856	Non-coding RNA	EPIREG00547	EPITAR00396	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3 potentially methylates RNA component of 7SK nuclear ribonucleoprotein (RN7SK) to aberrantly activate RNA Pol II transcription in cancer cells, our study provides the molecular basis for potential therapeutics that modulate m6A-7SK for NSCLC treatment. Removal of m6A leads to 7SK structural rearrangements that facilitate sequestration of The positive transcription elongation factor b complex (P-TEFb)."	M6ADIS0007	37820733	.
M6ACROT05649	REG00005	M6ATAR00856	Non-coding RNA	EPIREG00547	EPITAR00396	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"ALKBH5 potentially demethylates RNA component of 7SK nuclear ribonucleoprotein (RN7SK) to aberrantly inhibit RNA Pol II transcription in cancer cells, our study provides the molecular basis for potential therapeutics that modulate m6A-7SK for NSCLC treatment. Removal of m6A leads to 7SK structural rearrangements that facilitate sequestration of The positive transcription elongation factor b complex (P-TEFb)."	M6ADIS0007	37820733	.
M6ACROT05650	REG00008	M6ATAR00834	Non-coding RNA	EPIREG00548	EPITAR00397	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"YTHDF2 recognized m6A-modified Circ_IRF2 and diminished circIRF2 stability, partly accounting for the decreased circIRF2 in liver fibrosis. Cytoplasmic circIRF2 may directly harbor hsa-miR-29b-1-5p and competitively relieve its inhibitory effect on FOXO3, inducing FOXO3 nuclear translocation and accumulation."	M6ADIS0017	37467831	.
M6ACROT05651	REG00001	M6ATAR00135	Non-coding RNA	EPIREG00259	.	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	Downregulation of FTO expression contributes to increased m6A RNA modification of microRNA 155 (MIR155) in cerebral I/R injury.	M6ADIS0185	37437797	.
M6ACROT05652	REG00036	M6ATAR00141	Non-coding RNA	EPIREG00215	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RNA immunoprecipitation and mass spectrometry revealed 12 new synapse-specific learning-induced m6A readers in the mPFC of male C57/BL6 mice, with m6A-modified Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) binding to a subset of these, including CYFIP2 and DPYSL2. In addition, a cell type- and synapse-specific, and state-dependent, reduction of m6A on Malat1 impairs fear-extinction memory; an effect that likely occurs through a disruption in the interaction between Malat1 and DPYSL2 and an associated decrease in dendritic spine formation."	.	37669863	.
M6ACROT05653	REG00037	M6ATAR00141	Non-coding RNA	EPIREG00215	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RNA immunoprecipitation and mass spectrometry revealed 12 new synapse-specific learning-induced m6A readers in the mPFC of male C57/BL6 mice, with m6A-modified Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) binding to a subset of these, including CYFIP2 and DPYSL2. In addition, a cell type- and synapse-specific, and state-dependent, reduction of m6A on Malat1 impairs fear-extinction memory; an effect that likely occurs through a disruption in the interaction between Malat1 and DPYSL2 and an associated decrease in dendritic spine formation."	.	37669863	.
M6ACROT05654	REG00007	M6ATAR00846	Non-coding RNA	EPIREG00550	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Overexpression of methyltransferase like 3 (METTL3) promoted the osteogenic differentiation of PPDLSCs, while knocking down METTL3 showed an inhibitory effect. Furthermore, METTL3 overexpression promotes the stability of Long intergenic non-protein coding RNA 1638 (LINC01638) to upregulate the expression level. Moreover, lncRNA4114 overexpression promoted the osteogenic differentiation of PPDLSCs."	M6ADIS0210	36516331	.
M6ACROT05655	REG00009	M6ATAR00848	Non-coding RNA	EPIREG00551	EPITAR00398	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Enhanced expression of WTAP or METTL16 upregulated m6A modification level of AC026356.1 in HCC cells. The interaction between m6A-modified AC026356.1 and IGF2BP1 promoted the binding of Interleukin-11 (IL11) mRNA to IGF2BP1, leading to increased IL11 mRNA stability and IL11 secretion."	M6ADIS0006	37926706	.
M6ACROT05656	REG00007	M6ATAR00848	Non-coding RNA	EPIREG00551	EPITAR00398	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Enhanced expression of WTAP or METTL3 upregulated m6A modification level of AC026356.1 in HCC cells. The interaction between m6A-modified AC026356.1 and IGF2BP1 promoted the binding of Interleukin-11 (IL11) mRNA to IGF2BP1, leading to increased IL11 mRNA stability and IL11 secretion."	M6ADIS0006	37926706	.
M6ACROT05657	REG00007	M6ATAR00850	Non-coding RNA	EPIREG00552	EPITAR00399	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3 overexpression increased total m6A, Circ_SETD2 m6A, and circSETD2 levels. m6A modification mediated circSETD2 upregulation. circSETD2 was a sponge of hsa-miR-181a-5p to elevate MCL1 transcription. miR-181a-5p overexpression or MCL1 silencing annulled the role of m6A-modified circSETD2. circSETD2 inhibition negated suppression of METTL3 overexpression on chorionic trophoblast apoptosis in vivo. Collectively, m6A modification of circSETD2 suppressed miR-181a-5p and increased MCL1 transcription, thus regulating trophoblasts."	M6ADIS0162	36260529	.
M6ACROT05658	REG00001	M6ATAR00850	Non-coding RNA	EPIREG00552	EPITAR00399	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Knockdown of FTO increased total m6A, Circ_SETD2 m6A, and circSETD2 levels. m6A modification mediated circSETD2 upregulation. circSETD2 was a sponge of hsa-miR-181a-5p to elevate MCL1 transcription. miR-181a-5p overexpression or MCL1 silencing annulled the role of m6A-modified circSETD2. circSETD2 inhibition negated suppression of METTL3 overexpression on chorionic trophoblast apoptosis in vivo. Collectively, m6A modification of circSETD2 suppressed miR-181a-5p and increased MCL1 transcription, thus regulating trophoblasts."	M6ADIS0162	36260529	.
M6ACROT05659	REG00014	M6ATAR00856	Non-coding RNA	EPIREG00547	EPITAR00400	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RNA component of 7SK nuclear ribonucleoprotein (RN7SK) was identified as a small nuclear RNA that interacts with m6A readers. m6A readers recognized and facilitated secondary structure formation of m6A-modified RN7SK, which in turn prevented m6A reader mRNA degradation from exonucleases. Thus, a positive feedback circuit between RN7SK and m6A readers is established in tumor cells. From findings on the interaction with RN7SK, m6A readers, such as EWS RNA binding protein 1 (EWSR1), KH RNA binding domain containing, signal transduction-associated 1 (KHDRBS1) and IGF2BP3, were identified and shown to boost Wnt/beta-catenin signaling and tumorigenesis by suppressing translation of Cullin1 (Cullin 1 (CUL1)) which is regulated by METTL3 and YTHDC2."	.	36566349	M6ADRUG0132
M6ACROT05660	REG00007	M6ATAR00856	Non-coding RNA	EPIREG00547	EPITAR00400	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RNA component of 7SK nuclear ribonucleoprotein (RN7SK) was identified as a small nuclear RNA that interacts with m6A readers. m6A readers recognized and facilitated secondary structure formation of m6A-modified RN7SK, which in turn prevented m6A reader mRNA degradation from exonucleases. Thus, a positive feedback circuit between RN7SK and m6A readers is established in tumor cells. From findings on the interaction with RN7SK, m6A readers, such as EWS RNA binding protein 1 (EWSR1), KH RNA binding domain containing, signal transduction-associated 1 (KHDRBS1) and IGF2BP3, were identified and shown to boost Wnt/beta-catenin signaling and tumorigenesis by suppressing translation of Cullin1 (Cullin 1 (CUL1)) which is regulated by METTL3 and YTHDC2."	.	36566349	M6ADRUG0132
M6ACROT05661	REG00023	M6ATAR00856	Non-coding RNA	EPIREG00547	EPITAR00400	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RNA component of 7SK nuclear ribonucleoprotein (RN7SK) was identified as a small nuclear RNA that interacts with m6A readers. m6A readers recognized and facilitated secondary structure formation of m6A-modified RN7SK, which in turn prevented m6A reader mRNA degradation from exonucleases. Thus, a positive feedback circuit between RN7SK and m6A readers is established in tumor cells. From findings on the interaction with RN7SK, m6A readers, such as EWS RNA binding protein 1 (EWSR1), KH RNA binding domain containing, signal transduction-associated 1 (KHDRBS1) and IGF2BP3, were identified and shown to boost Wnt/beta-catenin signaling and tumorigenesis by suppressing translation of Cullin1 (Cullin 1 (CUL1)) which is regulated by METTL3 and YTHDC2."	.	36566349	M6ADRUG0132
M6ACROT05662	REG00007	M6ATAR00477	Non-coding RNA	EPIREG00272	EPITAR00264	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL3-mediated m6A modification of lncRNA Small nucleolar RNA host gene 3 (SNHG3) accelerates GC progression by modulating hsa-miR-186-5p/cyclinD2 axis	M6ADIS0057	37823387	.
M6ACROT05663	REG00022	M6ATAR00860	Non-coding RNA	EPIREG00553	EPITAR00022	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"m6A-modified ATP8B1 antisense RNA 1 (ATP8B1-AS1) interacts with and recruits m6A reader YTHDC1 and histone demethylase KDM3B to Myc proto-oncogene protein (MYC) promoter region, leading to the reduction of H3K9me2 level at MYC promoter region and activation of MYC transcription. Functional rescue assays showed that depletion of MYC largely abolished the oncogenic roles of ATP8B1-AS1."	M6ADIS0006	37701563	.
M6ACROT05664	REG00005	M6ATAR00865	Non-coding RNA	EPIREG00554	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	Benzo[a]pyrene-induced up-regulation of hsa_circ_0003552 (Circ_MOCOS) via ALKBH5-mediated m6A modification promotes DNA damage in human bronchial epithelial cells.	.	37573961	M6ADRUG0182
M6ACROT05665	REG00007	M6ATAR00866	Non-coding RNA	EPIREG00555	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL3 could upregulate FGD5 antisense RNA 1 (FGD5-AS1) expression via N6-methyladenosine (m6A) modification.research has shed light on the involvement of the METTL3/FGD5-AS1 axis in the development of PTX resistance in EC	M6ADIS0067	37755125	M6ADRUG0089
M6ACROT05666	REG00006	M6ATAR00867	Non-coding RNA	EPIREG00556	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL14 mediates m6A modification on osteogenic proliferation and differentiation of bone marrow mesenchymal stem cells by regulating the processing of pri-miR-873.	.	37449516	.
M6ACROT05667	REG00008	M6ATAR00870	Non-coding RNA	EPIREG00557	EPITAR00401	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"m6A reader YTHDF2 could recognize m6A-modified Cardiac mesoderm enhancer-associated non-coding RNA (CARMN) and promote its degradation in CC cells, thereby affecting the expression of its downstream target hsa-miR-21-5p."	M6ADIS0008	37273106	.
M6ACROT05668	REG00009	M6ATAR00871	Non-coding RNA	EPIREG00366	EPITAR00275	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	Chidamide treatment suppressed WT1-associated protein (WTAP)-mediated RNA m6A modification of GNAS antisense RNA 1 (GNAS-AS1). Chidamide downregulated GNAS-AS1 to inhibit glycolysis in AML cells. GNAS-AS1 targeted hsa-miR-34a-5p to promote insulin-like growth factor 2 mRNA-binding protein (IGF2BP2) expression. IGF2BP2 inhibition reversed the promoting effect of miR-34a-5p knockdown on glycolysis and RhoA/ROCK pathway in Chidamide-treated cells. GNAS-AS1 overexpression abolished the inhibitory effect of Chidamide on AML tumorigenesis in vivo by modulating the RhoA/ROCK pathway.	M6ADIS0046	37926762	M6ADRUG0174
M6ACROT05670	REG00015	M6ATAR00872	Non-coding RNA	EPIREG00558	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	VIRMA promoted lncRNA POU6F2 antisense RNA 1 (POU6F2-AS1) expression via m6A modification.lncRNA POU6F2-AS1 was modulated by KIAA1429 in the form of m6A modification to regulate the malignant phenotype of CRC	M6ADIS0059	38103097	.
M6ACROT05671	REG00009	M6ATAR00011	Non-coding RNA	EPIREG00419	EPITAR00402	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	WTAP-mediated m6A modification promoted osteogenic differentiation and inhibited adipogenic differentiation of BMMSCs through the hsa-miR-29b-3p/Histone deacetylase 4 (HDAC4) axis.	M6ADIS0115	37010483	.
M6ACROT05672	REG00024	M6ATAR00874	Non-coding RNA	EPIREG00559	EPITAR00028	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"YTHDF1 serves as a reader for the m6A modified Long intergenic non-protein coding RNA 901 (LINC00901) and downregulates the LINC00901 level. LINC00901 positively regulates MYC through upregulation of Insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2), a known RNA binding protein that can enhance MYC mRNA stability."	M6ADIS0061	37223505	.
M6ACROT05673	REG00022	M6ATAR00875	Non-coding RNA	EPIREG00560	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The m6A reader YTHDC1-mediated lncRNA RNA, U1 small nuclear 8, pseudogene (RNU1-8P) m6A modification accelerates cholangiocarcinoma progression."	M6ADIS0006	37809459	.
M6ACROT05674	REG00004	M6ATAR00877	Non-coding RNA	EPIREG00561	EPITAR00403	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	Activation of the HNRNPA2B1/ hsa-miR-93-5p/FERM domain containing 6 (FRMD6) axis facilitates prostate cancer progression in an m6A-dependent manner	M6ADIS0068	37215455	.
M6ACROT05675	REG00007	M6ATAR00885	Non-coding RNA	EPIREG00562	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL3-mediated lncRNA EN_42575 exerted a regulatory effect on IPEC-J2 cells exposed to CPB2 toxins.	M6ADIS0379	36982798	.
M6ACROT05676	REG00004	M6ATAR00150	Non-coding RNA	EPIREG00249	EPITAR00401	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	HNRNPA2B1-mediated m6A modification of lncRNA Maternally expressed 3 (MEG3) promotes tumorigenesis and metastasis of NSCLC cells by regulating hsa-miR-21-5p/PTEN axis and may provide a therapeutic target for NSCLC.	M6ADIS0007	37308993	.
M6ACROT05677	REG00005	M6ATAR00345	Non-coding RNA	EPIREG00207	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	Hypoxia-induced m6A demethylase ALKBH5 promotes ovarian cancer tumorigenicity by decreasing methylation of the lncRNA RMRP.	M6ADIS0066	37818080	.
M6ACROT05678	REG00007	M6ATAR00898	Non-coding RNA	EPIREG00563	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"the m6A modification of chromosome 2 open reading frame 92 (C2orf92) was mediated by METTL3 and LINC01125 inhibited cell invasion, migration and proliferation, thereby suppressing the development of PTC."	M6ADIS0073	37824376	.
M6ACROT05679	REG00015	M6ATAR00140	Non-coding RNA	EPIREG00279	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Mechanistically, we reveal that VIRMA overexpression upregulates the m6A-modified long non-coding RNA, Nuclear paraspeckle assembly transcript 1 (NEAT1), which contributes to breast cancer cell growth. "	M6ADIS0065	37208522	.
M6ACROT05680	REG00007	M6ATAR00905	Non-coding RNA	EPIREG00346	EPITAR00404	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL3-mediated m6A modification of hsa_circ_0007905 (Circ_STX6) promotes age-related cataract progression through hsa-miR-6749-3p/EIF4EBP1	M6ADIS0014	36908822	.
M6ACROT05681	REG00007	M6ATAR00137	Non-coding RNA	EPIREG00651	EPITAR00405	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RNA m6A reader YTHDF2 facilitates precursor microRNA 126 (MIR126) maturation to promote acute myeloid leukemia progression.methyltransferase-like 3 (METTL3) adds m6A in primary microRNAs (pri-miRNAs) and facilitates its processing into precursor miRNAs (pre-miRNAs). Expression levels of multiple downstream targets (CDK3, ADAM metallopeptidase domain 9 (ADAM9), ILK, TOM1, FCGR1A, FCN1, and LRCH4) were significantly decreased by miR-126"	M6ADIS0046	37588203	.
M6ACROT05682	REG00008	M6ATAR00137	Non-coding RNA	EPIREG00651	EPITAR00405	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RNA m6A reader YTHDF2 facilitates precursor microRNA 126 (MIR126) maturation to promote acute myeloid leukemia progression.methyltransferase-like 3 (METTL3) adds m6A in primary microRNAs (pri-miRNAs) and facilitates its processing into precursor miRNAs (pre-miRNAs). Expression levels of multiple downstream targets (CDK3, ADAM metallopeptidase domain 9 (ADAM9), ILK, TOM1, FCGR1A, FCN1, and LRCH4) were significantly decreased by miR-126"	M6ADIS0046	37588203	.
M6ACROT05683	REG00008	M6ATAR00909	Non-coding RNA	EPIREG00566	EPITAR00406	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	ALKBH5/YTHDF2-mediated m6A modification of Circ_AFF2 enhances radiosensitivity of colorectal cancer by inhibiting Cullin associated and neddylation dissociated 1 (CAND1).	M6ADIS0059	37381158	.
M6ACROT05684	REG00005	M6ATAR00909	Non-coding RNA	EPIREG00566	EPITAR00406	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	ALKBH5/YTHDF2-mediated m6A modification of Circ_AFF2 enhances radiosensitivity of colorectal cancer by inhibiting Cullin associated and neddylation dissociated 1 (CAND1).	M6ADIS0059	37381158	.
M6ACROT05685	REG00001	M6ATAR00910	Non-coding RNA	EPIREG00567	EPITAR00276	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"FTO-mediated m6A demethylation of pri-miR-3591 leaded to a maturation block of miR-3591-5p, which relieved the inhibitory effect of miR-3591-5p on Protein kinase AMP-activated catalytic subunit alpha 2 (PRKAA2) and then promoted the increase of PRKAA2, thereby alleviating OA cartilage damage."	M6ADIS0110	37005694	.
M6ACROT05686	REG00007	M6ATAR00911	Non-coding RNA	EPIREG00568	EPITAR00408	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Mechanistically, Circ_MYO1C cyclization was mediated by m6A methyltransferase METTL3. Moreover, methylated RNA immunoprecipitation sequencing (MeRIP-seq) unveiled the remarkable m6A modification on CD274 molecule (CD274) mRNA. Moreover, circMYO1C targeted the m6A site of PD-L1 mRNA to enhance its stability by cooperating with IGF2BP2, thereby accelerating PDAC immune escape."	M6ADIS0061	36781839	.
M6ACROT05687	REG00007	M6ATAR00914	Non-coding RNA	EPIREG00569	EPITAR00409	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3 was able to promote the maturation of hsa-miR-181a-5p that targets NFKB activating protein (NKAP), and then inhibited the expression of NF-kappaB and IL-1alpha."	M6ADIS0094	36608773	.
M6ACROT05688	REG00007	M6ATAR00477	Non-coding RNA	EPIREG00272	EPITAR00410	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL3-mediated m6A modification of lncRNA Small nucleolar RNA host gene 3 (SNHG3) promoted the growth and invasion of melanoma cells by regulating the hsa-miR-330-5p/CNBP axis.	M6ADIS0029	37606168	.
M6ACROT05689	REG00007	M6ATAR00919	Non-coding RNA	EPIREG00570	.	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	This study demonstrates the promise of BRAF-activated non-protein coding RNA (BANCR) as a new diagnostic and therapeutic target for pancreatic cancer and reveals the therapeutic effect that STM2457(METTL3) exerts on pancreatic cancer by down-regulating BANCR m6A modifications.	M6ADIS0061	37998732	.
M6ACROT05690	REG00007	M6ATAR00675	Non-coding RNA	EPIREG00217	EPITAR00411	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Mechanical experiments confirmed that METTL3 m6A dependently increased stability and expression levels of LINC00035 (ABHD11-AS1), and elevated ABHD11-AS1 sponged hsa-miR-1301-3p to upregulate HIF1AN, resulting in the downregulation of HIF-1alpha. this study firstly reported a novel METTL3/m6A/ ABHD11-AS1/miR-1301-3p/HIF1AN/HIF-1alpha signaling cascade in regulating the progression of cerebral I/R injury, and future work will focus on investigating whether the above genes can be used as biomarkers for the treatment of cerebral I/R injury by performing clinical studies."	M6ADIS0091	37610605	.
M6ACROT05691	REG00009	M6ATAR00921	Non-coding RNA	EPIREG00571	EPITAR00412	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"m6A modification mediated by WTAP promotes the maturation of pri-miR-92b to hsa-miR-92b-5p, thereby enhancing the targeted inhibitory function of miR-92b-5p on Metalloproteinase inhibitor 4 (TIMP4). Furthermore, we have discovered that WTAP can directly facilitate the degradation of TIMP4 mRNAs in a YTHDF2-dependent manner."	M6ADIS0110	37563688	.
M6ACROT05692	REG00008	M6ATAR00922	Non-coding RNA	EPIREG00572	EPITAR00413	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"These findings identified a novel m6A-modified Circ_FUT8 recognized and destabilized by YTHDF2, which competitively interacted with YTHDF2 and miR-186-5p to stabilize Fucosyltransferase 8 (FUT8) mRNA to promote malignant progression in LUAD."	M6ADIS0007	37669906	.
M6ACROT05693	REG00007	M6ATAR00923	Non-coding RNA	EPIREG00573	EPITAR00414	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL3-mediated m6A modification of pri-hsa-miR-148a-3p affects prostate cancer progression by regulating Thioredoxin-interacting protein (TXNIP)	M6ADIS0068	37449729	.
M6ACROT05694	REG00007	M6ATAR00141	Non-coding RNA	EPIREG00215	EPITAR00254	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"ES samples expressed low hsa-miR-124-3p and high METTL3, Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) and CDK4. METTL3 elevated MALAT1 expression by m6A modification. MALAT1 enhanced CDK4 expression by competing with miR-124-3p. In ES cells, METTL3 silencing repressed cell migration and invasion by inhibiting MALAT1. In conclusion, METTL3 promotes tumorigenesis of ES through the MALAT1/miR-124-3p/CDK4 axis."	M6ADIS0250	37605570	.
M6ACROT05695	REG00018	M6ATAR01463	Non-coding RNA	EPIREG00574	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL5-mediated 18S rRNA m6A modification promotes oncogenic mRNA translation and intrahepatic cholangiocarcinoma progression.	M6ADIS0006	37735874	.
M6ACROT05698	REG00007	M6ATAR00704	Non-coding RNA	EPIREG00275	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	Depicting the Profile of METTL3-Mediated lncRNA m6A Modification Variants and Identified Small nucleolar RNA host gene (SNHG7) as a Prognostic Indicator of MNNG-Induced Gastric Cancer.	M6ADIS0057	37999596	.
M6ACROT05699	REG00007	M6ATAR00944	Non-coding RNA	EPIREG00210	EPITAR00415	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Long intergenic non-protein coding RNA 662 (LINC00662), which is methylated by METTL3, recruites Integrin subunit alpha 1 (ITGA1) to activate the transcription of ITGA1 in a m6A-dependent manner and initiates the formation of focal adhesions through the ITGA1-FAK-Erk pathway, thereby promoting malignant behavior in PC cells."	M6ADIS0061	37293163	.
M6ACROT05700	REG00014	M6ATAR00944	Non-coding RNA	EPIREG00210	EPITAR00415	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Long intergenic non-protein coding RNA 662 (LINC00662), which is methylated by METTL3 and recognized by IGF2BP3, recruites Integrin subunit alpha 1 (ITGA1) to activate the transcription of ITGA1 in a m6A-dependent manner and initiates the formation of focal adhesions through the ITGA1-FAK-Erk pathway, thereby promoting malignant behavior in PC cells. "	M6ADIS0061	37293163	.
M6ACROT05701	REG00007	M6ATAR00117	Non-coding RNA	EPIREG00376	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL3 promotes proliferation and migration of colorectal cancer cells by increasing Small nucleolar RNA host gene 1 (SNHG1) stability.	M6ADIS0059	37772373	.
M6ACROT05702	REG00007	M6ATAR00154	Non-coding RNA	EPIREG00491	EPITAR00416	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"in BC cells and DOX-resistant BC cells, lnc KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1) could be mediated by METTL3 through m6A modification to elevate and stabilize its expression, further inhibiting hsa-miR-103a-3p/MDR1 axis to promote DOX resistance, which might provide novel thought to overcome DOX resistance in BC."	M6ADIS0065	37243702	M6ADRUG0022
M6ACROT05703	REG00007	M6ATAR00950	Non-coding RNA	EPIREG00575	EPITAR00417	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL3-mediated m6A modification of hsa-miR-1908-5p contributes to nasopharyngeal carcinoma progression by targeting HOP homeobox (HOPX).	M6ADIS0054	38018881	.
M6ACROT05706	REG00007	M6ATAR00966	Non-coding RNA	EPIREG00576	EPITAR00418	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3/YTHDF2 promoted the degradation of Circ_RNF13 and subsequently affected the stability of C-X-C motif chemokine ligand 1 (CXCL1), ultimately enhancing the radiosensitivity of CC cells."	M6ADIS0008	37468464	.
M6ACROT05707	REG00008	M6ATAR00966	Non-coding RNA	EPIREG00576	EPITAR00418	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3/YTHDF2 promoted the degradation of Circ_RNF13 and subsequently affected the stability of C-X-C motif chemokine ligand 1 (CXCL1), ultimately enhancing the radiosensitivity of CC cells."	M6ADIS0008	37468464	.
M6ACROT05708	REG00007	M6ATAR00974	Non-coding RNA	EPIREG00577	EPITAR00028	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Methyltransferase METTL3 upregulated m6A modification of Circ_EPHB4, and YTHDC1 promoted cytoplasmic localization of m6A-modified CircEPHB4. Overexpression of wild-type CircEPHB4 enhanced glioma cells' stemness, metastasis, and proliferation. Cytoplasmic CircEPHB4 increased SOX2 mRNA stability by binding to Insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2), and the effects observed by SOX2 knockdown were reversed by CircEPHB4 in glioma cells."	M6ADIS0001	37614011	.
M6ACROT05709	REG00022	M6ATAR00974	Non-coding RNA	EPIREG00577	EPITAR00028	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Methyltransferase MELLT3 upregulated m6A modification of Circ_EPHB4, and YTHDC1 promoted cytoplasmic localization of m6A-modified CircEPHB4. Overexpression of wild-type CircEPHB4 enhanced glioma cells' stemness, metastasis, and proliferation. Cytoplasmic CircEPHB4 increased SOX2 mRNA stability by binding to Insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2), and the effects observed by SOX2 knockdown were reversed by CircEPHB4 in glioma cells."	M6ADIS0001	37614011	.
M6ACROT05710	REG00008	M6ATAR00977	Non-coding RNA	EPIREG00578	EPITAR00419	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"m6A-methylated Circ_GPATCH2L is recognised and endoribonucleolytically cleaved by a YTHDF2-RPL10-RNase P/MRP complex to maintain the physiological state of nucleus pulposus cells, and then regulates DNA damage and apoptosis through Tripartite motif containing 28 (TRIM28) in intervertebral disc degeneration."	M6ADIS0371	37438603	.
M6ACROT05711	REG00022	M6ATAR00979	Non-coding RNA	EPIREG00579	EPITAR00238	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The expression of FAM111A was positively correlated with the m6A level of FAM111A divergent transcript (FAM111A-DT), and the expression of methyltransferase complex, YTHDC1, and KDM3B in HCC tissues. Depletion of FAM111A largely attenuated the roles of m6A-modified FAM111A-DT in HCC. In summary, the m6A-modified FAM111A-DT/YTHDC1/KDM3B/FAM111A regulatory axis promoted HCC growth and represented a candidate therapeutic target for HCC."	M6ADIS0006	37400994	.
M6ACROT05712	REG00007	M6ATAR00140	Non-coding RNA	EPIREG00279	EPITAR00420	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL3-mediated m6A modification of lncRNA Nuclear paraspeckle assembly transcript 1 (NEAT1) plays an oncogenic role in non-small cell lung cancer by upregulating the HMGA1 expression through binding hsa-miR-361-3p.	M6ADIS0007	37688756	.
M6ACROT05713	REG00007	M6ATAR00980	Non-coding RNA	EPIREG00580	EPITAR00421	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3 is believed to enhance the expression of Long intergenic non-protein coding RNA 426 (LINC00426) through m6A methylation modification.The LINC00426/hsa-miR-200a-3p/ZEB1 axis plays a crucial role in regulating E-cadherin, N-cadherin and vimentin during EMT in CC.Overexpression of LINC00426 in CC cells caused resistance to Cisplatin and Bleomycin, but sensitivity to imatinib."	M6ADIS0008	37392859	M6ADRUG0047
M6ACROT05714	REG00007	M6ATAR00980	Non-coding RNA	EPIREG00580	EPITAR00421	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3 is believed to enhance the expression of Long intergenic non-protein coding RNA 426 (LINC00426) through m6A methylation modification.The LINC00426/hsa-miR-200a-3p/ZEB1 axis plays a crucial role in regulating E-cadherin, N-cadherin and vimentin during EMT in CC.Overexpression of LINC00426 in CC cells caused resistance to Cisplatin and Bleomycin, but sensitivity to imatinib."	M6ADIS0008	37392859	M6ADRUG0180
M6ACROT05715	REG00007	M6ATAR00980	Non-coding RNA	EPIREG00580	EPITAR00421	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3 is believed to enhance the expression of Long intergenic non-protein coding RNA 426 (LINC00426) through m6A methylation modification.The LINC00426/hsa-miR-200a-3p/ZEB1 axis plays a crucial role in regulating E-cadherin, N-cadherin and vimentin during EMT in CC.Overexpression of LINC00426 in CC cells caused resistance to Cisplatin and Bleomycin, but sensitivity to imatinib."	M6ADIS0008	37392859	M6ADRUG0107
M6ACROT05716	REG00007	M6ATAR00981	Non-coding RNA	EPIREG00581	EPITAR00234	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL3-Modulated Circ_UHRF2 Promotes Colorectal Cancer Stemness and Metastasis through Increasing DDX27 mRNA Stability by Recruiting Insulin like growth factor 2 mRNA binding protein 1 (IGF2BP1)	M6ADIS0059	37370759	.
M6ACROT05717	REG00007	M6ATAR00148	Non-coding RNA	EPIREG00426	EPITAR00177	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3 mediated m6A methylation of LncRNA-Growth arrest specific 5 (GAS5) via an YTHDF2-dependent manner. METTL3 boosts mitochondrial fission and induces cardiac fibrosis by enhancing LncRNA GAS5 methylation. Overexpression of GAS5 suppressed Dynamin-1-like protein (DRP1)-mediated mitochondrial fission, inhibiting cardiac fibroblast proliferation and migration."	M6ADIS0375	37379961	.
M6ACROT05718	REG00008	M6ATAR00148	Non-coding RNA	EPIREG00426	EPITAR00177	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3 mediated m6A methylation of LncRNA-Growth arrest specific 5 (GAS5) via an YTHDF2-dependent manner. METTL3 boosts mitochondrial fission and induces cardiac fibrosis by enhancing LncRNA GAS5 methylation. Overexpression of GAS5 suppressed Dynamin-1-like protein (DRP1)-mediated mitochondrial fission, inhibiting cardiac fibroblast proliferation and migration."	M6ADIS0375	37379961	.
M6ACROT05719	REG00022	M6ATAR00985	Non-coding RNA	EPIREG00582	EPITAR00236	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The mTOR inhibitor dactolisib and FAO inhibitor perhexiline exert a synergistic effect on CLL cells. In addition, the biogenesis of Circ_TET2 can be affected by the splicing process and the RBPs RBMX and YTHDC1. CP028, a splicing inhibitor, modulates the expression of circTET2 and shows pronounced inhibitory effects. m6A-Modified circTET2 Interacting with Heterogeneous nuclear ribonucleoprotein C (HNRNPC) Regulates Fatty Acid Oxidation to Promote the Proliferation of Chronic Lymphocytic Leukemia."	M6ADIS0228	37821382	M6ADRUG0169
M6ACROT05720	REG00022	M6ATAR00985	Non-coding RNA	EPIREG00582	EPITAR00236	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The mTOR inhibitor dactolisib and FAO inhibitor perhexiline exert a synergistic effect on CLL cells. In addition, the biogenesis of Circ_TET2 can be affected by the splicing process and the RBPs RBMX and YTHDC1. CP028, a splicing inhibitor, modulates the expression of circTET2 and shows pronounced inhibitory effects. m6A-Modified circTET2 Interacting with Heterogeneous nuclear ribonucleoprotein C (HNRNPC) Regulates Fatty Acid Oxidation to Promote the Proliferation of Chronic Lymphocytic Leukemia."	M6ADIS0228	37821382	M6ADRUG0162
M6ACROT05721	REG00022	M6ATAR00985	Non-coding RNA	EPIREG00582	EPITAR00236	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The mTOR inhibitor dactolisib and FAO inhibitor perhexiline exert a synergistic effect on CLL cells. In addition, the biogenesis of Circ_TET2 can be affected by the splicing process and the RBPs RBMX and YTHDC1. CP028, a splicing inhibitor, modulates the expression of circTET2 and shows pronounced inhibitory effects. m6A-Modified circTET2 Interacting with Heterogeneous nuclear ribonucleoprotein C (HNRNPC) Regulates Fatty Acid Oxidation to Promote the Proliferation of Chronic Lymphocytic Leukemia."	M6ADIS0228	37821382	M6ADRUG0126
M6ACROT05722	REG00027	M6ATAR00985	Non-coding RNA	EPIREG00582	EPITAR00236	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The mTOR inhibitor dactolisib and FAO inhibitor perhexiline exert a synergistic effect on CLL cells. In addition, the biogenesis of Circ_TET2 can be affected by the splicing process and the RBPs RBMX and YTHDC1. CP028, a splicing inhibitor, modulates the expression of circTET2 and shows pronounced inhibitory effects. m6A-Modified circTET2 Interacting with Heterogeneous nuclear ribonucleoprotein C (HNRNPC) Regulates Fatty Acid Oxidation to Promote the Proliferation of Chronic Lymphocytic Leukemia."	M6ADIS0228	37821382	M6ADRUG0169
M6ACROT05723	REG00027	M6ATAR00985	Non-coding RNA	EPIREG00582	EPITAR00236	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The mTOR inhibitor dactolisib and FAO inhibitor perhexiline exert a synergistic effect on CLL cells. In addition, the biogenesis of Circ_TET2 can be affected by the splicing process and the RBPs RBMX and YTHDC1. CP028, a splicing inhibitor, modulates the expression of circTET2 and shows pronounced inhibitory effects. m6A-Modified circTET2 Interacting with Heterogeneous nuclear ribonucleoprotein C (HNRNPC) Regulates Fatty Acid Oxidation to Promote the Proliferation of Chronic Lymphocytic Leukemia."	M6ADIS0228	37821382	M6ADRUG0162
M6ACROT05724	REG00027	M6ATAR00985	Non-coding RNA	EPIREG00582	EPITAR00236	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The mTOR inhibitor dactolisib and FAO inhibitor perhexiline exert a synergistic effect on CLL cells. In addition, the biogenesis of Circ_TET2 can be affected by the splicing process and the RBPs RBMX and YTHDC1. CP028, a splicing inhibitor, modulates the expression of circTET2 and shows pronounced inhibitory effects. m6A-Modified circTET2 Interacting with Heterogeneous nuclear ribonucleoprotein C (HNRNPC) Regulates Fatty Acid Oxidation to Promote the Proliferation of Chronic Lymphocytic Leukemia."	M6ADIS0228	37821382	M6ADRUG0126
M6ACROT05725	REG00006	M6ATAR00989	Non-coding RNA	EPIREG00583	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"LncRNA TNF and HNRNPL related immunoregulatory long non-coding RNA (THRIL), transcriptionally activated by AP-1 and stabilized by METTL14-mediated m6A modification, accelerates LPS-evoked acute injury in alveolar epithelial cells."	M6ADIS0391	37543013	M6ADRUG0135
M6ACROT05726	REG00017	M6ATAR00991	Non-coding RNA	EPIREG00584	EPITAR00424	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Mechanistically, Transcript inducer of Aurora kinase A (AURKA) lysosomal degradation (TIALD) directly interacts with AURKA and facilitate its degradation through the lysosomal pathway to inhibited EMT and metastasis of HCC. AURKA's specific inhibitor alisertib exerts effective therapeutic effect on liver cancer with low TIALD expression, which might provide a new insight into HCC therapy. Our study uncovers a negative functional loop of METTL16-TIALD-AURKA axis, and identifies a new mechanism for METTL16 mediated m6A-induced decay of TIALD on AURKA signaling in HCC progression, which may provide potential prognostic and therapeutic targets for HCC."	M6ADIS0006	37773181	M6ADRUG0186
M6ACROT05727	REG00001	M6ATAR00150	Non-coding RNA	EPIREG00249	.	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	Demethylase FTO-Mediated m6A Modification of lncRNA Maternally expressed 3 (MEG3) Activates Neuronal Pyroptosis via NLRP3 Signaling in Cerebral Ischemic Stroke.	M6ADIS0091	37676392	.
M6ACROT05728	REG00007	M6ATAR00141	Non-coding RNA	EPIREG00215	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RBM10 recruits METTL3 to induce N6-methyladenosine-Metastasis associated lung adenocarcinoma transcript 1 (MALAT1)-dependent modification, inhibiting the invasion and migration of NSCLC."	M6ADIS0007	36608868	.
M6ACROT05729	REG00006	M6ATAR00140	Non-coding RNA	EPIREG00279	EPITAR00173	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Exercise Mitigates Endothelial Pyroptosis and Atherosclerosis by Downregulating Nuclear paraspeckle assembly transcript 1 (NEAT1) Through N6-Methyladenosine Modifications. Exercise induced a significant downregulation of m6A modification and METTL14, which binds to the m6A sites of NEAT1 and promotes NEAT1 expression through subsequent YTHDC1 (YTH domain-containing 1) recognition to promote endothelial pyroptosis. NEAT1 induces endothelial pyroptosis by binding Krueppel-like factor 4 (KLF4) to promote the transcriptional activation of the key pyroptotic protein NLRP3."	M6ADIS0386	37078289	.
M6ACROT05730	REG00022	M6ATAR00140	Non-coding RNA	EPIREG00279	EPITAR00173	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Exercise Mitigates Endothelial Pyroptosis and Atherosclerosis by Downregulating Nuclear paraspeckle assembly transcript 1 (NEAT1) Through N6-Methyladenosine Modifications. Exercise induced a significant downregulation of m6A modification and METTL14, which binds to the m6A sites of NEAT1 and promotes NEAT1 expression through subsequent YTHDC1 (YTH domain-containing 1) recognition to promote endothelial pyroptosis. NEAT1 induces endothelial pyroptosis by binding Krueppel-like factor 4 (KLF4) to promote the transcriptional activation of the key pyroptotic protein NLRP3."	M6ADIS0386	37078289	.
M6ACROT05731	REG00007	M6ATAR01005	Non-coding RNA	EPIREG00585	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL3 regulates miR-196b expression via an N6-methyladenosine (m6A)-pri-miR-196b-dependent mechanism and thereby promotes CRC metastasis.	M6ADIS0059	36348020	.
M6ACROT05732	REG00007	M6ATAR00111	Non-coding RNA	EPIREG00586	EPITAR00426	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3-mediated m6A modifications were essential for sustaining the stability of microRNA 675 (MIR675), and silencing of METTL3 restrained tumorigenesis of GISTs cells by regulating the microRNA-675/myosin phosphatase targeting protein 1 (MYPT1) axis."	M6ADIS0174	37678441	.
M6ACROT05733	REG00005	M6ATAR01013	Non-coding RNA	EPIREG00587	EPITAR00427	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	ALKBH5-demethylated lncRNA small nucleolar RNA host gene 15 (SNHG15) promotes myeloma tumorigenicity by increasing chromatin accessibility and recruiting H3K36me3 modifier Histone-lysine N-methyltransferase SETD2 (SETD2).	M6ADIS0048	38145297	.
M6ACROT05734	REG00006	M6ATAR01014	Non-coding RNA	EPIREG00588	EPITAR00428	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL14-upregulated miR-6858 triggers cell apoptosis in keratinocytes of oral lichen planus through decreasing Gasdermin C (GSDMC)	M6ADIS0367	37741915	.
M6ACROT05735	REG00006	M6ATAR01018	Non-coding RNA	EPIREG00589	EPITAR00028	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL14 Facilitates the Metastasis of Pancreatic Carcinoma by Stabilizing Long intergenic non-protein coding RNA 941 (LINC00941) in an m6A-Insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2)-Dependent Manner	M6ADIS0061	37215454	.
M6ACROT05736	REG00013	M6ATAR01018	Non-coding RNA	EPIREG00589	EPITAR00028	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL14 Facilitates the Metastasis of Pancreatic Carcinoma by Stabilizing Long intergenic non-protein coding RNA 941 (LINC00941) in an m6A-IGF2BP2-Dependent Manner	M6ADIS0061	37215454	.
M6ACROT05737	REG00007	M6ATAR00507	Non-coding RNA	EPIREG00507	EPITAR00429	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL3-Mediated Maturation of hsa-miR-99a-5p Promotes Cell Migration and Invasion in Oral Squamous Cell Carcinoma by Targeting Beta-transducin repeat containing E3 ubiquitin protein ligase pseudogene 1 (BTRCP1).	M6ADIS0055	37498409	.
M6ACROT05738	REG00007	M6ATAR00097	Non-coding RNA	EPIREG00471	EPITAR00430	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Preeclampsia (PE) is a serious pregnancy-specific syndrome. METTL3-mediated lncRNA HOXD antisense growth-associated long non-coding RNA (HAGLR) stability regulates inflammation, and the migration and invasion of trophoblast cells via the MicroRNA 135a-1 (MIR135A1)/ beta-TRCP axis."	M6ADIS0162	38075198	.
M6ACROT05739	REG00007	M6ATAR01020	Non-coding RNA	EPIREG00591	EPITAR00234	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Mechanistically, methyltransferase-like 3 (METTL3) enhanced Circ_MIRLET7BHG expression via m6A methylation, which enhanced ADAM10 mRNA stability via interaction with Insulin like growth factor 2 mRNA binding protein 1 (IGF2BP1),thereby promoting AR by inducing epithelial barrier dysfunction."	M6ADIS0349	37976602	.
M6ACROT05740	REG00015	M6ATAR01023	Non-coding RNA	EPIREG00592	EPITAR00431	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Silencing vir-like m6A methyltransferase-associated (VIRMA) and insulin-like growth factor 2 mRNA-binding proteins 1 (IGF2BP1) attenuated the expression level and RNA stability of Long intergenic non-protein coding RNA 839 (LINC00839) in an m6A-dependent manner. Taken together, our study unveils a novel oncogenic VIRMA/IGF2BP1-LINC00839-TATA-box binding protein associated factor 15 (TAF15)-AOC1 axis and highlights the significance and prognostic value of LINC00839 expression in NPC carcinogenesis."	M6ADIS0054	37257820	.
M6ACROT05741	REG00012	M6ATAR01023	Non-coding RNA	EPIREG00592	EPITAR00431	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Silencing vir-like m6A methyltransferase-associated (VIRMA) and insulin-like growth factor 2 mRNA-binding proteins 1 (IGF2BP1) attenuated the expression level and RNA stability of Long intergenic non-protein coding RNA 839 (LINC00839) in an m6A-dependent manner. Taken together, our study unveils a novel oncogenic VIRMA/IGF2BP1-LINC00839-TATA-box binding protein associated factor 15 (TAF15)-AOC1 axis and highlights the significance and prognostic value of LINC00839 expression in NPC carcinogenesis."	M6ADIS0054	37257820	.
M6ACROT05742	REG00005	M6ATAR01025	Non-coding RNA	EPIREG00593	EPITAR00432	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	ALKBH5-mediated m6A demethylation of Heparan Sulfate-Glucosamine 3-Sulfotransferase 3B1 Intronic Transcript 1 (Heparan sulfate-glucosamine 3-sulfotransferase 3B1 (HS3ST3B1)-IT1) prevents osteoarthritis progression	M6ADIS0110	37752950	.
M6ACROT05743	REG00007	M6ATAR01031	Non-coding RNA	EPIREG00594	EPITAR00433	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"miR-935 targeted Gap junction alpha-1 protein (GJA1) and mediated CCA cell tumor properties by negatively regulating GJA1 expression. METTL3 promoted miR-935 maturation by inducing m6A methylation of pri-miR-935, and its overexpression contributed to CCA cell tumor properties through the regulation of miR-935. METTL3 promoted choriocarcinoma progression by m6A-dependently activating the miR-935/GJA1 pathway."	M6ADIS0006	37881126	.
M6ACROT05744	REG00007	M6ATAR01033	Non-coding RNA	EPIREG00595	EPITAR00028	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3 overexpression increased Circ_ABCC4 expression via m6A modification in PCa cells. circABCC4 recruited Insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2) protein to CCAR1 mRNA, thereby enhancing CCAR1 mRNA stability and subsequent activation of the Wnt/beta-catenin pathway."	M6ADIS0068	37563361	.
M6ACROT05745	REG00007	M6ATAR01034	Non-coding RNA	EPIREG00391	EPITAR00434	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"OMT exhibited a dose-dependent inhibitory effect on the volume of IH PPNL-resistant tumors, which was partially dependent on the regulation of m6A methylation transfer enzyme METTL3 and the hsa-miR-27a-3p/Peroxisome proliferator-activated receptor gamma (PPARG) axis, thereby inducing apoptosis."	M6ADIS0154	37958388	M6ADRUG0127
M6ACROT05746	REG00007	M6ATAR01034	Non-coding RNA	EPIREG00391	EPITAR00434	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"OMT exhibited a dose-dependent inhibitory effect on the volume of IH PPNL-resistant tumors, which was partially dependent on the regulation of m6A methylation transfer enzyme METTL3 and the hsa-miR-27a-3p/Peroxisome proliferator-activated receptor gamma (PPARG) axis, thereby inducing apoptosis."	M6ADIS0154	37958388	M6ADRUG0124
M6ACROT05747	REG00017	M6ATAR01035	Non-coding RNA	EPIREG00596	EPITAR00435	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	Hypoxia induces hepatocellular carcinoma metastasis via the HIF-1alpha/METTL16/Lnc-CSMD1-7/RNA binding fox-1 homolog 2 (RBFOX2) axis	M6ADIS0006	38089592	.
M6ACROT05748	REG00001	M6ATAR01036	Non-coding RNA	EPIREG00597	EPITAR00436	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	These results elucidate the mechanism by which FTO-stabilized Long intergenic non-protein coding RNA 1139 (LINC01139) plays oncogenic roles and identify the FTO/LINK-A/Minichromosome maintenance complex component 3 (MCM3)/HIF-1alpha axis as a promising therapeutic target for ESCC.	M6ADIS0056	37858471	.
M6ACROT05750	REG00007	M6ATAR01041	Non-coding RNA	EPIREG00598	EPITAR00518	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The expression of RNF32 divergent transcript (RNF32-DT) was increased by METTL3 via m6A modification. c-MYC directly induced METTL3. Both c-MYC and LINC01006 were commonly targeted by miR-34a/b/c and MicroRNA 2682 (MIR2682), and thereby c-MYC/METTL3/LINC01006 formed a positive feedback loop through miRNA targets in NSCLC. LINC01006 is an oncogenic lncRNA, which induces migration, invasion and proliferation of NSCLC. METTL3 increases LINC01006 expression through stabilizing LINC01006 mRNA. c-MYC, as a transcription factor, activates METTL3, which results in an elevated level of LINC01006. c-MYC, METTL3 and LINC01006 form a positive feedback loop through multiple miRNA targets in NSCLC."	M6ADIS0007	37774794	.
M6ACROT05751	REG00007	M6ATAR01042	Non-coding RNA	EPIREG00599	.	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL3 Promotes Osteo/Odontogenic Differentiation of Stem Cells by Inhibiting hsa-miR-196b-5p Maturation.	M6ADIS0359	37323630	.
M6ACROT05752	REG00009	M6ATAR01043	Non-coding RNA	EPIREG00600	EPITAR00013	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The WTAP/YTHDC1/miR-181a and miR-181c/Secreted frizzled related protein 1 (SFRP1) axis regulated the differentiation fate of BMSCs, suggesting that it might be a potential therapeutic target for osteoporosis."	M6ADIS0115	36650131	.
M6ACROT05753	REG00009	M6ATAR01044	Non-coding RNA	EPIREG00601	EPITAR00013	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The WTAP/YTHDC1/miR-181a and miR-181c/Secreted frizzled related protein 1 (SFRP1) axis regulated the differentiation fate of BMSCs, suggesting that it might be a potential therapeutic target for osteoporosis."	M6ADIS0115	36650131	.
M6ACROT05754	REG00022	M6ATAR01043	Non-coding RNA	EPIREG00600	EPITAR00013	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The WTAP/YTHDC1/miR-181a and miR-181c/Secreted frizzled related protein 1 (SFRP1) axis regulated the differentiation fate of BMSCs, suggesting that it might be a potential therapeutic target for osteoporosis."	M6ADIS0115	36650131	.
M6ACROT05755	REG00022	M6ATAR01044	Non-coding RNA	EPIREG00601	EPITAR00013	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The WTAP/YTHDC1/miR-181a and miR-181c/Secreted frizzled related protein 1 (SFRP1) axis regulated the differentiation fate of BMSCs, suggesting that it might be a potential therapeutic target for osteoporosis."	M6ADIS0115	36650131	.
M6ACROT05756	REG00007	M6ATAR01050	Non-coding RNA	EPIREG00602	EPITAR00238	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL3/YTH N6-methyladenosine RNA binding protein C1 (YTHDC1)-mediated upregulation of Long intergenic non-protein coding RNA 294 (LINC00294) promotes hepatocellular carcinoma progression.LINC00294 promoted the interaction between YTHDC1 and HK2 and GLUT1 mRNA.	M6ADIS0006	38125436	.
M6ACROT05757	REG00022	M6ATAR01050	Non-coding RNA	EPIREG00602	EPITAR00238	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL3/YTHDC1-mediated upregulation of Long intergenic non-protein coding RNA 294 (LINC00294) promotes hepatocellular carcinoma progression.LINC00294 promoted the interaction between YTHDC1 and HK2 and GLUT1 mRNA.	M6ADIS0006	38125436	.
M6ACROT05758	REG00005	M6ATAR01051	Non-coding RNA	EPIREG00603	EPITAR00437	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"AlkB homolog 5 (ALKBH5) enhanced CALML3 antisense RNA 1 (CALML3-AS1) stability via N6-methyladenosine (m6A) demethylation, whereas m6A reader YTH domain-containing 2 (YTHDC2) destabilized CALML3-AS1. LncRNA CALML3-AS1 modulated by m6A modification induces BTNL9 methylation to drive non-small-cell lung cancer progression through the recruitment of Zeste Histone-lysine N-methyltransferase EZH2 (EZH2)."	M6ADIS0007	37884580	.
M6ACROT05759	REG00023	M6ATAR01051	Non-coding RNA	EPIREG00603	EPITAR00437	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"AlkB homolog 5 (ALKBH5) enhanced CALML3 antisense RNA 1 (CALML3-AS1) stability via N6-methyladenosine (m6A) demethylation, whereas m6A reader YTH domain-containing 2 (YTHDC2) destabilized CALML3-AS1. LncRNA CALML3-AS1 modulated by m6A modification induces BTNL9 methylation to drive non-small-cell lung cancer progression through the recruitment of Zeste Histone-lysine N-methyltransferase EZH2 (EZH2)."	M6ADIS0007	37884580	.
M6ACROT05760	REG00007	M6ATAR00017	Non-coding RNA	EPIREG00428	EPITAR00438	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	m6A-modified hsa-miR-143-3p in a METTL3 manner inhibits epithelial mesenchymal transition in bronchial epithelial cells and extracellular matrix production in lung fibroblasts by targeting Mothers against decapentaplegic homolog 3 (SMAD3).	M6ADIS0164	37666296	.
M6ACROT05761	REG00007	M6ATAR01055	Non-coding RNA	EPIREG00604	EPITAR00439	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL3 mediated m6A modification of SLC7A11 antisense RNA 1 (SLC7A11-AS1) to elevate its expression. SLC7A11-AS1 downregulated KLF9 expression by affecting E3 ubiquitin-protein ligase CHIP (STUB1)-mediated ubiquitination degradation and KLF9 enhanced PHLPP2 expression to inactivate the AKT pathway.	M6ADIS0006	37498069	.
M6ACROT05762	REG00009	M6ATAR01056	Non-coding RNA	EPIREG00605	EPITAR00234	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	WTAP-mediated m6A modification on Circ_CMTM3 inhibits hepatocellular carcinoma ferroptosis by recruiting Insulin like growth factor 2 mRNA binding protein 1 (IGF2BP1) to increase PARK7 stability	M6ADIS0006	36586770	.
M6ACROT05763	REG00007	M6ATAR01058	Non-coding RNA	EPIREG00606	EPITAR00440	.	Down regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL3 mediated m6A methylation of hsa_circ_0124554.m6A-modified circ_0124554 promoted CRC progression and radioresistance by inducing LASP1 expression through interaction with MicroRNA 1184-1 (MIR1184-1).	M6ADIS0059	38091882	.
M6ACROT05764	REG00007	M6ATAR01063	Non-coding RNA	EPIREG00607	EPITAR00441	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3/IGF2BP1-mediated m6A modification maintained Circ_ASXL1 stability and upregulated its expression. CircASXL1 was a ceRNA that sequestrated hsa-miR-320d from RACGAP1, leading to increased RACGAP1 expression. CircASXL1 promoted OC cell proliferation, migration and invasion via the miR-320d/RACGAP1 axis. "	M6ADIS0066	37738681	.
M6ACROT05765	REG00012	M6ATAR01063	Non-coding RNA	EPIREG00607	EPITAR00441	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3/IGF2BP1-mediated m6A modification maintained Circ_ASXL1 stability and upregulated its expression. CircASXL1 was a ceRNA that sequestrated hsa-miR-320d from RACGAP1, leading to increased RACGAP1 expression. CircASXL1 promoted OC cell proliferation, migration and invasion via the miR-320d/RACGAP1 axis. "	M6ADIS0066	37738681	.
M6ACROT05766	REG00004	M6ATAR01072	Non-coding RNA	EPIREG00608	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	HNRNPA2B1-Mediated microRNA-92a Upregulation and Section Acts as a Promising Noninvasive Diagnostic Biomarker in Colorectal Cancer.	M6ADIS0059	36831695	.
M6ACROT05767	REG00022	M6ATAR01075	Non-coding RNA	EPIREG00609	EPITAR00233	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The nuclear m6A reader YTHDC1 regulated Long intergenic non-protein coding RNA 641 (LINC00641) expression by affecting its stability. LINC00641 binds to ELAV-like protein 1 (HuR/ELAVL1) and inhibits the accumulation of HuR in cytoplasm. Downregulation of N6-methyladenosine-modified LINC00641 promotes EMT, but provides a ferroptotic vulnerability in lung cancer"	M6ADIS0007	37311754	.
M6ACROT05768	REG00013	M6ATAR00097	Non-coding RNA	EPIREG00471	EPITAR00442	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"PTEN overexpression abolished the inhibition of silenced HOXD antisense growth-associated long non-coding RNA (HAGLR) on pyroptosis in HRPE cells. HAGLR, epigenetically modified by IGF2BP2 in an m6A-dependent manner, functioned as a sponge for Has-miR-106b-5p, thereby activating PTEN/Akt signaling cascade to accelerate DR pathology."	M6ADIS0015	38088496	.
M6ACROT05769	REG00007	M6ATAR01081	Non-coding RNA	EPIREG00610	EPITAR00443	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3-mediated m6 A modification of Circ_PRKAR1B promotes Crohn's colitis by by interacting with Spectrin beta, non-erythrocytic 1 (SPTBN1)."	M6ADIS0381	37679886	.
M6ACROT05770	REG00006	M6ATAR00124	Non-coding RNA	EPIREG00458	EPITAR00414	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL14 drives growth and metastasis of non-small cell lung cancer by regulating microRNA 93 (MIR93) maturation and Thioredoxin-interacting protein (TXNIP) expression	M6ADIS0007	37594665	.
M6ACROT05771	REG00005	M6ATAR01089	Non-coding RNA	EPIREG00612	EPITAR00444	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	ALKBH5 induced the upregulation of Circ_PUM1 to accelerate the development of NB through regulating hsa-miR-423-5p/PA2G4 axis.	M6ADIS0001	37421841	.
M6ACROT05772	REG00001	M6ATAR01092	Non-coding RNA	EPIREG00613	EPITAR00445	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	Overexpression of FTO alleviates osteoarthritis by regulating the processing of hsa-miR-515-5p and the Toll-like receptor 4 (TLR4)/MyD88/NF-kappaB axis	M6ADIS0110	36538851	.
M6ACROT05773	REG00006	M6ATAR00848	Non-coding RNA	EPIREG00551	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	Silencing AC026356.1 significantly inhibited proliferation and migration but increased apoptosis in A549-cisplatin (DDP) cells.METTL14/IGF2BP2-mediated m6A modification and stabilization of the AC026356.1 RNA.	M6ADIS0007	37142269	.
M6ACROT05774	REG00013	M6ATAR00848	Non-coding RNA	EPIREG00551	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	Silencing AC026356.1 significantly inhibited proliferation and migration but increased apoptosis in A549-cisplatin (DDP) cells.METTL14/IGF2BP2-mediated m6A modification and stabilization of the AC026356.1 RNA.	M6ADIS0007	37142269	.
M6ACROT05775	REG00001	M6ATAR01093	Non-coding RNA	EPIREG00614	EPITAR00446	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	FTO Knockdown-Mediated Maturation of hsa-miR-383-5p Inhibits Malignant Advancement of Pancreatic Cancer by Targeting Integrin subunit alpha 3 (ITGA3).m6A-modified miRNA processing was recognized by IGF2BP1	M6ADIS0061	38001392	.
M6ACROT05776	REG00012	M6ATAR01093	Non-coding RNA	EPIREG00614	EPITAR00446	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	FTO Knockdown-Mediated Maturation of hsa-miR-383-5p Inhibits Malignant Advancement of Pancreatic Cancer by Targeting Integrin subunit alpha 3 (ITGA3). m6A-modified miRNA processing was recognized by IGF2BP1	M6ADIS0061	38001392	.
M6ACROT05777	REG00003	M6ATAR00132	Non-coding RNA	EPIREG00490	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The levels of pri-miR-21, pre-miR-21, and mature microRNA 21 (MIR21) decreased after hnRNPC silencing. HNRNPC interacts with the MIR21."	.	22907752	.
M6ACROT05778	REG00012	M6ATAR01141	Non-coding RNA	EPIREG00616	EPITAR00389	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Posttranscriptional destabilization of the liver-specific long noncoding RNA hepatocellular carcinoma up-regulated long non-coding RNA (HULC), which affects Programmed cell death 4 (PDCD4) expression, by the IGF2 mRNA-binding protein 1 (IGF2BP1)."	.	23728852	.
M6ACROT05779	REG00001	M6ATAR01150	Non-coding RNA	EPIREG00617	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	Knockdown of FTO reduced levels of hsa-mir-22 miRNAs	.	25723394	.
M6ACROT05780	REG00001	M6ATAR00125	Non-coding RNA	EPIREG00413	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	Knockdown of FTO reduced levels of microRNA 7-1 (MIR7-1) miRNAs	.	25723394	.
M6ACROT05781	REG00001	M6ATAR01151	Non-coding RNA	EPIREG00619	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	Knockdown of FTO reduced levels of MIRLET7E miRNAs	.	25723394	.
M6ACROT05782	REG00017	M6ATAR01177	Non-coding RNA	EPIREG00620	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Inhibition of METTL16 activity significantly reduces the m6A modification levels of RNA, U6 small nuclear 1 (RNU6-1)"	.	28525753	.
M6ACROT05783	REG00017	M6ATAR01177	Non-coding RNA	EPIREG00620	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Inhibition of METTL16 activity significantly reduces the m6A modification levels of RNA, U6 small nuclear 1 (RNU6-1)"	.	29051200	.
M6ACROT05785	REG00002	M6ATAR01216	Non-coding RNA	EPIREG00621	EPITAR00447	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"ELAVL1 increased Long intergenic non-protein coding RNA 336 (LINC00336) expression by stabilizing its posttranscriptional level, whereas LSH (lymphoid-specific helicase) increased ELAVL1 expression through the p53 signaling pathway, further supporting the hypothesis that LSH promotes LINC00336 expression. LINC00336 served as an endogenous sponge of microRNA 6852 (MicroRNA 6852 (MIR6852)) to regulate the expression of cystathionine-beta-synthase (CBS), a surrogate marker of ferroptosis. "	M6ADIS0007	30787392	.
M6ACROT05788	REG00007	M6ATAR01230	Non-coding RNA	EPIREG00622	EPITAR00448	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3 enhanced, whereas METTL3 silence or knockout suppressed, the m6A methylations of Runt-related transcription factor 2 (Runx2) and hsa-mir-320a."	.	31896070	.
M6ACROT05790	REG00017	M6ATAR01177	Non-coding RNA	EPIREG00620	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL16 is the conserved RNA, U6 small nuclear 1 (RNU6-1) methyltransferase"	.	31940410	.
M6ACROT05791	REG00017	M6ATAR01233	Non-coding RNA	EPIREG00623	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL16 could bind with RNA, 18S ribosomal 1 (RNA18S1) and stabilize it."	.	31940410	.
M6ACROT05792	REG00017	M6ATAR01234	Non-coding RNA	EPIREG00624	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL16 could bind with RNA28S1 and stabilize it.	.	31940410	.
M6ACROT05793	REG00017	M6ATAR01235	Non-coding RNA	EPIREG00625	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL16 could bind with RNA5S1 and stabilize it.	.	31940410	.
M6ACROT05794	REG00017	M6ATAR00141	Non-coding RNA	EPIREG00215	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL16 could bind with Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) and stabilize it.	.	31940410	.
M6ACROT05795	REG00004	M6ATAR01247	Non-coding RNA	EPIREG00626	EPITAR00449	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	Integrative Analysis of NSCLC Identifies Long intergenic non-protein coding RNA 1234 (LINC01234) as an Oncogenic lncRNA that Interacts with HNRNPA2B1 and Regulates hsa-mir-106b Biogenesis	M6ADIS0007	32246902	.
M6ACROT05796	REG00004	M6ATAR01248	Non-coding RNA	EPIREG00627	EPITAR00237	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Depletion of either LINC01234 or HNRNPA2B1 reduced the processing of several miRNA precursors, including primary microRNA (pri-miR)-106b. hsa-mir-106b enhanced NSCLC cell growth by downregulating Cryptochrome circadian regulator 2 (CRY2)"	M6ADIS0007	32246902	.
M6ACROT05797	REG00004	M6ATAR01247	Non-coding RNA	EPIREG00626	EPITAR00451	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The Long intergenic non-protein coding RNA 1234 (LINC01234)-HNRNPA2B1 complex recruits DGCR8 to promote processing of pri-miRNAs, such as miR-106b-5p, MIR17, MIR374A, hsa-mir-425, and MIR362, to their mature forms. "	M6ADIS0007	32246902	.
M6ACROT05798	REG00004	M6ATAR01247	Non-coding RNA	EPIREG00626	EPITAR00452	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The Long intergenic non-protein coding RNA 1234 (LINC01234)-HNRNPA2B1 complex recruits DGCR8 to promote processing of pri-miRNAs, such as miR-106b-5p, MIR17, MIR374A, hsa-mir-425, and MIR362, to their mature forms. "	M6ADIS0007	32246902	.
M6ACROT05799	REG00004	M6ATAR01247	Non-coding RNA	EPIREG00626	EPITAR00453	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The Long intergenic non-protein coding RNA 1234 (LINC01234)-HNRNPA2B1 complex recruits DGCR8 to promote processing of pri-miRNAs, such as miR-106b-5p, MIR17, MIR374A, hsa-mir-425, and MIR362, to their mature forms. "	M6ADIS0007	32246902	.
M6ACROT05800	REG00004	M6ATAR01247	Non-coding RNA	EPIREG00626	EPITAR00454	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The Long intergenic non-protein coding RNA 1234 (LINC01234)-HNRNPA2B1 complex recruits DGCR8 to promote processing of pri-miRNAs, such as miR-106b-5p, MIR17, MIR374A, hsa-mir-425, and MIR362, to their mature forms. "	M6ADIS0007	32246902	.
M6ACROT05802	REG00013	M6ATAR01260	Non-coding RNA	EPIREG00628	EPITAR00455	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Knockdown of IGF2BP2 decreased the expression of lncRNA FBXL19 antisense RNA 1 (FBXL19-AS1) and FBXL19-AS1 could bind to 3'-UTR of Zinc finger protein 765 (ZNF765) mRNA and down-regulate ZNF765 mRNA expression through STAU1-mediated mRNA decay (SMD). ZNF765 also inhibited the transcriptional activity of IGF2BP2, thereby forming a feedback loop in regulating the BTB permeability. Single or combined application of silenced IGF2BP2 and FBXL19-AS1 improved the delivery and antitumor efficiency of doxorubicin (DOX). In general, our study revealed the regulation mechanism of IGF2BP2/FBXL19-AS1/ZNF765 axis on BTB permeability, which may provide valuable insight into treatment strategy for glioma."	M6ADIS0001	32713259	M6ADRUG0022
M6ACROT05803	REG00012	M6ATAR00496	Non-coding RNA	EPIREG00285	EPITAR00456	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"MiR-513 family was a target of Prostate cancer associated transcript 6 (PCAT6) and Insulin like growth factor 2 mRNA binding protein 1 (IGF2BP1) was a target of miR-513. Hence, PCAT6 upregulated IGF2BP1 expression via miR-513 in a competing endogenous RNAs manner. PCAT6 and IGF2BP1 functioned as oncogenes while miR-513 acted as a tumor suppressor gene in glioblastoma. PCAT6 and miR-513 modulated the proliferation and survival of glioblastoma cells via AKT signaling by mediating IGF2BP1. IGF2BP1 raised the expression of PCAT6 by increasing its stability. In conclusion, our results indicate that PCAT6/miR-513/IGF2BP1 positive feedback loop plays a crucial role in facilitating glioblastoma progression."	M6ADIS0001	32990800	.
M6ACROT05804	REG00006	M6ATAR00651	Non-coding RNA	EPIREG00654	EPITAR00159	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL14 regulated the m6A modification of miR-34a-5p and interacted with DGCR8 to process hsa-miR-34a. The miR-34a-5p inhibitor inhibited the cell cycle senescence of HNPCs. miR-34a-5p was predicted to interact with the NAD-dependent protein deacetylase sirtuin-1 (SIRT1) mRNA.	.	33763423	.
M6ACROT05805	REG00007	M6ATAR01151	Non-coding RNA	EPIREG00619	EPITAR00457	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	The overexpression of METTL3 increased the levels of both MIRLET7E and individual miRNAs of the miR-17-92 cluster while reducing the expression of Thrombospondin 1 (THBS1).	.	33910374	.
M6ACROT05806	REG00006	M6ATAR01287	Non-coding RNA	EPIREG00238	EPITAR00458	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL14 promotes tumorigenesis by regulating lncRNA OIP5 antisense RNA 1 (OIP5-AS1)/MicroRNA 98 (MIR98)/ADAMTS8 signaling in papillary thyroid cancer.	M6ADIS0073	34131102	.
M6ACROT05807	REG00004	M6ATAR01248	Non-coding RNA	EPIREG00627	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Knockdown of HNRNPA2B1 significantly decreased the expression of MIR17, MIR18A, MIR20A, MIR93, and hsa-mir-106b and inhibited the proliferation of ESCA cells.."	.	34277606	.
M6ACROT05808	REG00004	M6ATAR00993	Non-coding RNA	EPIREG00630	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Knockdown of HNRNPA2B1 significantly decreased the expression of pri-miR-17, MIR18A, MIR20A, MIR93, and MIR106B and inhibited the proliferation of ESCA cells.."	.	34277606	.
M6ACROT05809	REG00004	M6ATAR01292	Non-coding RNA	EPIREG00631	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Knockdown of HNRNPA2B1 significantly decreased the expression of MIR17, hsa-mir-18a, MIR20A, MIR93, and MIR106B and inhibited the proliferation of ESCA cells.."	.	34277606	.
M6ACROT05810	REG00004	M6ATAR01293	Non-coding RNA	EPIREG00632	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Knockdown of HNRNPA2B1 significantly decreased the expression of MIR17, MIR18A, hsa-mir-20a, MIR93, and MIR106B and inhibited the proliferation of ESCA cells.."	.	34277606	.
M6ACROT05811	REG00004	M6ATAR00124	Non-coding RNA	EPIREG00458	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Knockdown of HNRNPA2B1 significantly decreased the expression of MIR17, MIR18A, MIR20A, microRNA 93 (MIR93), and MIR106B and inhibited the proliferation of ESCA cells.."	.	34277606	.
M6ACROT05812	REG00013	M6ATAR01287	Non-coding RNA	EPIREG00238	EPITAR00459	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"IGF2BP2 enhances the stability of OIP5 antisense RNA 1 (OIP5-AS1), thereby increasing the binding of OIP5-AS1 to hsa-miR-495-3p, weakening the binding of miR-495-3p to the 3'UTR of HIF1A and MMP14 mRNA, and ultimately promoting the formation of VM in glioma."	M6ADIS0001	34345216	.
M6ACROT05813	REG00006	M6ATAR00154	Non-coding RNA	EPIREG00491	EPITAR00460	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL14 promotes doxorubicin-induced cardiomyocyte ferroptosis by regulating the KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1)-hsa-miR-7-5p-TFRC axis.	.	34648132	M6ADRUG0022
M6ACROT05814	REG00007	M6ATAR01839	Non-coding RNA	EPIREG00634	EPITAR00461	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3 promoted m6A modification and the binding of DGCR8 to hsa-miR-20a-5p to further elevate the miR-20a-5p expression and inhibit Nuclear factor 1 C-type (NFIC) transcription, thus promoting EMT, invasion and migration."	.	34666602	.
M6ACROT05815	REG00007	M6ATAR00107	Non-coding RNA	EPIREG00241	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"m6A writers, METTL3 and WTAP positively regulate Urothelial cancer associated 1 (UCA1) expression in an IGF2BP2 dependent manner."	.	34809621	.
M6ACROT05816	REG00009	M6ATAR00107	Non-coding RNA	EPIREG00241	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"m6A writers, METTL3 and WTAP positively regulate Urothelial cancer associated 1 (UCA1) expression in an IGF2BP2 dependent manner."	.	34809621	.
M6ACROT05817	REG00013	M6ATAR00107	Non-coding RNA	EPIREG00241	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"m6A writers, METTL3 and WTAP positively regulate Urothelial cancer associated 1 (UCA1) expression in an IGF2BP2 dependent manner."	.	34809621	.
M6ACROT05818	REG00008	M6ATAR00153	Non-coding RNA	EPIREG00433	.	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"YTHDF2 plays a key role in maintaining the stability of Pvt1 oncogene (PVT1), mediated by ALKBH5, while PVT1-induced autophagy protects hippocampal neurons against synaptic plasticity loss and apoptosis, ultimately reducing cognitive deficits associated with diabetes.YTHDF2 may influence cognitive dysfunction in diabetes through several pathways, including the modulation of the PI3K/Akt pathway"	M6ADIS0258	39424201	.
M6ACROT05819	REG00008	M6ATAR00136	Non-coding RNA	EPIREG00224	.	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"YTHDF2 has been identified as a direct target of microRNA 145 (MIR145), and downregulation of miR-145 has been shown to decrease Caspase-9 expression in the hippocampus. This reduction in Caspase-9 levels leads to decreased hippocampal neuronal apoptosis, which positively impacts memory and learning in epileptic rats "	M6ADIS0378	39424201	.
M6ACROT05820	REG00007	M6ATAR01324	Non-coding RNA	EPIREG00635	.	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"knocking down METTL3 significantly reduced m6A modification of hsa_circ_0072380 (Circ_ZNF131), indicating that METTL3 regulated changes in m6A modification of hsa_circ_0072380. Our study revealed the important regulatory role of METTL3 and m6A modification of hsa_circ_0072380 in GDM."	M6ADIS0148	39191355	.
M6ACROT05821	REG00005	M6ATAR00477	Non-coding RNA	EPIREG00272	EPITAR00233	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"ALKBH5 induced m6A-demethylation in Small nucleolar RNA host gene 3 (SNHG3), leading to its degradation. Low expression of SNHG3, on the other hand, prevented the formation of the SNHG3-ELAV-like protein 1 (HuR/ELAVL1)-ZBP1/AIM2 complex, which in turn destabilized ZBP1 and AIM2 mRNA, resulting in the downregulation of these PANoptosis-related genes. ALKBH5 protected against PANoptosis in cerebral I/R injury models through the inhibition of SNHG3.This study sheds light on the intricate molecular mechanisms involved in the pathogenesis of cerebral I/R injury and highlights the potential of m6A-related genes as therapeutic targets in this condition."	M6ADIS0091	38996894	.
M6ACROT05822	REG00007	M6ATAR00141	Non-coding RNA	EPIREG00215	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3 was upregulated in osteosarcoma tissues and cell lines. Functionally, METTL3 promoted the proliferation and migration of osteosarcoma cells. Moreover, a clear positive correlation was found between METTL3 and Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) expression, and MALAT1 was upregulated in osteosarcoma tissues and cells. Mechanistically, the presence of m6A modification sites in MALAT1 and METTL3-mediated m6A modification increased the stability of MALAT1 in osteosarcoma cells and promoted their proliferation and migration."	M6ADIS0051	37897586	.
M6ACROT05823	REG00006	M6ATAR00049	Non-coding RNA	EPIREG00372	EPITAR00438	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL14 can regulate the Mothers against decapentaplegic homolog 3 (SMAD3) pathway by modulating hsa-miR-21-5p. METTL14 depletion induces trophoblast cell dysfunction by inhibiting miR-21-5p processing in an m6A-dependent manner.	M6ADIS0361	39332090	.
M6ACROT05824	REG00007	M6ATAR01350	Non-coding RNA	EPIREG00636	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL3 was notably reduced in PTC samples and was positively correlated with hsa_circ_0136959. Mechanistically, METTL3 enhanced hsa_circ_0136959 expression through m6A modification. Our results demonstrate that METTL3-mediated m6A modification elevated hsa_circ_0136959 expression and subsequently restricted the tumor characteristics of PTC by accelerating ferroptosis."	M6ADIS0073	39623910	.
M6ACROT05825	REG00009	M6ATAR00827	Non-coding RNA	EPIREG00546	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"WTAP silencing reversed the cancer-promoting role of IQ motif and ankyrin repeat containing 1 (IQANK1) overexpression in GC cell migration, proliferation, and invasion. Our results suggest that WTAP-mediated FAM83H-AS1 promotes GC development via m6A modification. Our findings provide new biomarkers for GC diagnosis and targeted therapy."	M6ADIS0057	37477820	.
M6ACROT05826	REG00015	M6ATAR01355	Non-coding RNA	EPIREG00637	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	This study showed that VIRMA enhanced Long intergenic non-protein coding RNA 1106 (LINC01106) m6A modification to promote LUAD development. These results may lead to a better understanding of the mechanism of KIAA1429 m6A LINC01106 in LUAD and offer a valuable therapeutic target for LUAD.	M6ADIS0007	38848293	.
M6ACROT05827	REG00026	M6ATAR01357	Non-coding RNA	EPIREG00638	.	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	ZC3H13-mediated m6A modification of hsa_circ_0081723 (Circ_POLR2J2) promotes CC progression by modulating AMPK/p53 pathway. Our findings may contribute to the understanding of the molecular mechanisms underlying CC and offer potential therapeutic targets for clinical treatment.	M6ADIS0008	39476847	.
M6ACROT05828	REG00007	M6ATAR01361	Non-coding RNA	EPIREG00639	EPITAR00463	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The targeting of Homeobox protein DLX-3 (DLX3) by hsa-miR-665 and the potential direct regulation of DLX3 expression by METTL3, mediated by the ""reader"" protein YTHDF1, were demonstrated. Overall, the METTL3/pre-miR-665/DLX3 pathway might provide a new target for SCAP-based tooth root/maxillofacial bone tissue regeneration."	M6ADIS0359	38825638	.
M6ACROT05829	REG00024	M6ATAR01361	Non-coding RNA	EPIREG00639	EPITAR00463	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The targeting of Homeobox protein DLX-3 (DLX3) by hsa-miR-665 and the potential direct regulation of DLX3 expression by METTL3, mediated by the ""reader"" protein YTHDF1, were demonstrated. Overall, the METTL3/pre-miR-665/DLX3 pathway might provide a new target for SCAP-based tooth root/maxillofacial bone tissue regeneration."	M6ADIS0359	38825638	.
M6ACROT05830	REG00001	M6ATAR00150	Non-coding RNA	EPIREG00249	EPITAR00437	EPITAR00500	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"FTO regulates the Maternally expressed 3 (MEG3)-TGFB1 signalling pathway in a YTHDC1 dependent manner by binding simultaneously with the Histone-lysine N-methyltransferase EZH2 (EZH2), thereby suppressing trophoblast invasion and proliferation in URSA trophoblast cells. These findings provide new insights for the treatment of URSA."	M6ADIS0361	38245815	.
M6ACROT05831	REG00022	M6ATAR00150	Non-coding RNA	EPIREG00249	EPITAR00437	EPITAR00500	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"FTO protein regulates the Maternally expressed 3 (MEG3)-TGFB1 signalling pathway in a YTHDC1 dependent manner by binding simultaneously with the Histone-lysine N-methyltransferase EZH2 (EZH2), thereby suppressing trophoblast invasion and proliferation in URSA trophoblast cells. These findings provide new insights for the treatment of URSA."	M6ADIS0361	38245815	.
M6ACROT05832	REG00006	M6ATAR01379	Non-coding RNA	EPIREG00640	.	.	.	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL14 was upstream of TRHDE antisense RNA 1 (TRHDE-AS1) to induce m6A modification of TRHDE-AS1 in PC cells. Collectively, our results show that propofol prevents PC progression by upregulating TRHDE-AS1 expression and METTL14 is involved in the m6A modification of TRHDE-AS1. These findings suggest that TRHDE-AS1 may be a potential therapeutic target for the improvement of propofol's therapeutic effect."	M6ADIS0068	39322401	M6ADRUG0255
M6ACROT05833	REG00007	M6ATAR01381	Non-coding RNA	EPIREG00641	EPITAR00464	.	Up regulation	m6A	Direct	Enhancement	ncRNA	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"METTL3 and METTL14-induced m6A modification upregulated SREBF2 antisense RNA 1 (SREBF2-AS1) expression through increasing SREBF2-AS1 transcript stability. m6A-modified SREBF2-AS1 bound and recruited m6A reader FMR1 autosomal homolog 1 (FXR1) and DNA 5-methylcytosine dioxygenase TET1 to SREBF2 promoter, leading to DNA demethylation at SREBF2 promoter and the upregulation of SREBF2 transcription."	M6ADIS0046	37926762; 37926762	M6ADRUG0174
M6ACROT05834	REG00006	M6ATAR01381	Non-coding RNA	EPIREG00641	EPITAR00464	.	Up regulation	m6A	Direct	Enhancement	ncRNA	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"METTL3 and METTL14-induced m6A modification upregulated SREBF2 antisense RNA 1 (SREBF2-AS1) expression through increasing SREBF2-AS1 transcript stability. m6A-modified SREBF2-AS1 bound and recruited m6A reader FMR1 autosomal homolog 1 (FXR1) and DNA 5-methylcytosine dioxygenase TET1 to SREBF2 promoter, leading to DNA demethylation at SREBF2 promoter and the upregulation of SREBF2 transcription."	M6ADIS0046	37926762; 37926762	M6ADRUG0174
M6ACROT05836	REG00006	M6ATAR00152	Non-coding RNA	EPIREG00435	.	.	.	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Because methylation regulates X inactive specific transcript (XIST) expression, the differences in m6A-related genes expressed between the high and low XIST expression groups were analyzed. The expression of METTL14 in the low XIST expression group was notably increased compared with that in the high XIST expression group (P = 0.03276), which indicated that METTL14 participated in XIST m6A-methylation."	M6ADIS0177	38426786	.
M6ACROT05867	REG00012	M6ATAR00341	Non-coding RNA	EPIREG00204	EPITAR00234	.	Up regulation	m6A	Indirect	Inhibition	ncRNA	m6A regulators indirectly modulate the functionality of ncRNAs through downstream signaling pathways	"LINC00261 decreased Myc proto-oncogene protein (MYC) mRNA stability by sequestering IGF2BP1. However, The phosphorylation of c-myc suppresses the expression of LINC00261, thereby inhibiting the recruitment of IGF2BP1 by LINC00261."	M6ADIS0061	33122827	.
M6ACROT05869	REG00014	.	Non-coding RNA	EPIREG00530	EPITAR00235	.	.	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"IGF2BP3 is a direct target of hsa-miR-34a in GC. The expression of miR-34a showed negative correlation with IGF2BP3 mRNA expression in primary GC samples and more importantly, re-overexpression of IGF2BP3 rescued the inhibitory effect of miR-34a."	M6ADIS0057	28399871	.
M6ACROT05870	REG00007	M6ATAR01644	Non-coding RNA	EPIREG00649	EPITAR00526	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	The m6A reader YTHDC1 recognized m6A-modified Lnc668 and elevated the METTL3-mediated lnc668 modification. lnc668 enhanced Phosphatidylinositol-binding clathrin assembly protein (PICALM) mRNA stability to promote pulmonary fibrogenesis depending on YTHDC1 phase separation	M6ADIS0310	40221424	.
M6ACROT05871	REG00022	M6ATAR01644	Non-coding RNA	EPIREG00649	EPITAR00526	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	The m6A reader YTHDC1 recognized m6A-modified Lnc668 and elevated the METTL3-mediated lnc668 modification. lnc668 enhanced Phosphatidylinositol-binding clathrin assembly protein (PICALM) mRNA stability to promote pulmonary fibrogenesis depending on YTHDC1 phase separation	M6ADIS0310	40221424	.
M6ACROT05872	REG00001	M6ATAR00189	Non-coding RNA	EPIREG00642	EPITAR00179	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"Circ_RAB11FIP1 directly bound to the mRNA of FTO and promoted its expression. Then, CircRAB11FIP1 mediated mRNA expression levels of Autophagy protein 5 (ATG5) and ATG7 depending on m6A."	M6ADIS0066	33637694	.
M6ACROT05873	REG00001	M6ATAR00190	Non-coding RNA	EPIREG00642	EPITAR00179	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"Circ_RAB11FIP1 directly bound to the mRNA of FTO and promoted its expression. Then, CircRAB11FIP1 mediated mRNA expression levels of ATG5 and Ubiquitin-like modifier-activating enzyme ATG7 (ATG7) depending on m6A."	M6ADIS0066	33637694	.
M6ACROT05874	REG00001	M6ATAR01837	Non-coding RNA	EPIREG00224	EPITAR00179	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	MIR145 induces binding of FTO to CAP-Gly domain-containing linker protein 3 (CLIP3) mRNA and increases cellular m6A demethylase activity. miRNA-mediated loss of m6A increases nascent translation in glioblastoma	M6ADIS0001	33684100	.
M6ACROT05875	REG00013	M6ATAR01287	Non-coding RNA	EPIREG00658	EPITAR00148	.	Up regulation	m6A	Indirect	Inhibition	ncRNA	m6A regulators indirectly modulate the functionality of ncRNAs through downstream signaling pathways	"IGF2BP2 enhances the stability of OIP5 antisense RNA 1 (OIP5-AS1), thereby increasing the binding of OIP5-AS1 to hsa-miR-495-3p, weakening the binding of miR-495-3p to the 3'UTR of Hypoxia-inducible factor 1-alpha (HIF-1-Alpha/HIF1A) and MMP14 mRNA, and ultimately promoting the formation of VM in glioma."	M6ADIS0001	34345216	.
M6ACROT05876	REG00013	M6ATAR01287	Non-coding RNA	EPIREG00658	EPITAR00522	.	Up regulation	m6A	Indirect	Inhibition	ncRNA	m6A regulators indirectly modulate the functionality of ncRNAs through downstream signaling pathways	"IGF2BP2 enhances the stability of OIP5 antisense RNA 1 (OIP5-AS1), thereby increasing the binding of OIP5-AS1 to hsa-miR-495-3p, weakening the binding of miR-495-3p to the 3'UTR of HIF1A and Matrix metalloproteinase-14 (MMP14) mRNA, and ultimately promoting the formation of VM in glioma."	M6ADIS0001	34345216	.
M6ACROT05877	REG00048	M6ATAR01407	Non-coding RNA	EPIREG00405	EPITAR00028	.	Up regulation	m6A	Indirect	Enhancement	ncRNA	m6A regulators indirectly modulate the functionality of ncRNAs through downstream signaling pathways	Hypoxia-induced transcription factor HIF1A facilitates the expression and functions of ribonuclease P RNA component H1 (RPPH1) in breast cancer cells and its packaging into exosomes via hnRNPA1. Exosomal RPPH1 promotes breast cancer angiogenesis and metastasis through stabilizing the Insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2)/FGFR2 axis	M6ADIS0065	40263423	.
M6ACROT05878	REG00007	M6ATAR00797	Non-coding RNA	EPIREG00215	EPITAR00027	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"MALAT1 hijacks both the chimeric mRNAs and fusion proteins in nuclear speckles during chromosomal translocations and mediates the colocalization of oncogenic fusion proteins with METTL14. MALAT1 and fusion protein complexes serve as a functional loading bridge for the interaction of Retinoic Acid Receptor Alpha-Retinoic Acid Receptor Alpha (PML-RARalpha) mRNA, METTL14, METTL3 and WTAP. MALAT1 regulates chimeric mRNA export in a manner dependent on the YTHDC1 and SRSF3"	M6ADIS0004	32703936	.
M6ACROT05879	REG00006	M6ATAR00797	Non-coding RNA	EPIREG00215	EPITAR00195	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"MALAT1 hijacks both the chimeric mRNAs and fusion proteins in nuclear speckles during chromosomal translocations and mediates the colocalization of oncogenic fusion proteins with METTL14. MALAT1 and fusion protein complexes serve as a functional loading bridge for the interaction of Retinoic Acid Receptor Alpha-Retinoic Acid Receptor Alpha (PML-RARalpha) mRNA, METTL14, METTL3 and WTAP. MALAT1 regulates chimeric mRNA export in a manner dependent on the YTHDC1 and SRSF3"	M6ADIS0004	32703936	.
M6ACROT05880	REG00009	M6ATAR00797	Non-coding RNA	EPIREG00215	EPITAR00269	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"MALAT1 hijacks both the chimeric mRNAs and fusion proteins in nuclear speckles during chromosomal translocations and mediates the colocalization of oncogenic fusion proteins with METTL14. MALAT1 and fusion protein complexes serve as a functional loading bridge for the interaction of Retinoic Acid Receptor Alpha-Retinoic Acid Receptor Alpha (PML-RARalpha) mRNA, METTL14, METTL3 and WTAP. MALAT1 regulates chimeric mRNA export in a manner dependent on the YTHDC1 and SRSF3"	M6ADIS0004	32703936	.
M6ACROT05881	REG00022	M6ATAR00797	Non-coding RNA	EPIREG00215	EPITAR00238	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"MALAT1 hijacks both the chimeric mRNAs and fusion proteins in nuclear speckles during chromosomal translocations and mediates the colocalization of oncogenic fusion proteins with METTL14. MALAT1 and fusion protein complexes serve as a functional loading bridge for the interaction of Retinoic Acid Receptor Alpha-Retinoic Acid Receptor Alpha (PML-RARalpha) mRNA, METTL14, METTL3 and WTAP. MALAT1 regulates chimeric mRNA export in a manner dependent on the YTHDC1 and SRSF3"	M6ADIS0001	32703936	.
M6ACROT05882	REG00012	M6ATAR00496	Non-coding RNA	EPIREG00659	EPITAR00234	.	Up regulation	m6A	Indirect	Inhibition	ncRNA	m6A regulators indirectly modulate the functionality of ncRNAs through downstream signaling pathways	"MIR513A1 was a target of Prostate cancer associated transcript 6 (PCAT6) and Insulin like IGF2BP1 was a target of miR-513. Hence, PCAT6 upregulated IGF2BP1 expression via miR-513 in a competing endogenous RNAs manner. PCAT6 and IGF2BP1 functioned as oncogenes while miR-513 acted as a tumor suppressor gene in glioblastoma. PCAT6 and miR-513 modulated the proliferation and survival of glioblastoma cells via AKT signaling by mediating IGF2BP1. IGF2BP1 raised the expression of PCAT6 by increasing its stability. In conclusion, our results indicate that PCAT6/miR-513/IGF2BP1 positive feedback loop plays a crucial role in facilitating glioblastoma progression."	M6ADIS0001	32990800	.
M6ACROT05883	REG00012	M6ATAR00496	Non-coding RNA	EPIREG00285	EPITAR00456	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"MiR-513 family was a target of Prostate cancer associated transcript 6 (PCAT6) and Insulin like growth factor 2 mRNA binding protein 1 (IGF2BP1) was a target of miR-513. Hence, PCAT6 upregulated IGF2BP1 expression via miR-513 in a competing endogenous RNAs manner. PCAT6 and IGF2BP1 functioned as oncogenes while miR-513 acted as a tumor suppressor gene in glioblastoma. PCAT6 and miR-513 modulated the proliferation and survival of glioblastoma cells via AKT signaling by mediating IGF2BP1. IGF2BP1 raised the expression of PCAT6 by increasing its stability. In conclusion, our results indicate that PCAT6/miR-513/IGF2BP1 positive feedback loop plays a crucial role in facilitating glioblastoma progression."	M6ADIS0001	32990800	.
M6ACROT05884	REG00012	M6ATAR00496	Non-coding RNA	EPIREG00659	EPITAR00234	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"MIR513A1 was a target of Prostate cancer associated transcript 6 (PCAT6) and IGF2BP1 was a target of miR-513. Hence, PCAT6 upregulated IGF2BP1 expression via miR-513 in a competing endogenous RNAs manner. PCAT6 and IGF2BP1 functioned as oncogenes while miR-513 acted as a tumor suppressor gene in glioblastoma. PCAT6 and miR-513 modulated the proliferation and survival of glioblastoma cells via AKT signaling by mediating IGF2BP1. IGF2BP1 raised the expression of PCAT6 by increasing its stability. In conclusion, our results indicate that PCAT6/miR-513/IGF2BP1 positive feedback loop plays a crucial role in facilitating glioblastoma progression."	M6ADIS0001	32990800	.
M6ACROT05885	REG00013	M6ATAR01260	Non-coding RNA	EPIREG00628	EPITAR00455	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"Knockdown of IGF2BP2 decreased the expression of lncRNA FBXL19 antisense RNA 1 (FBXL19-AS1) and FBXL19-AS1 could bind to 3'-UTR of Zinc finger protein 765 (ZNF765) mRNA and down-regulate ZNF765 mRNA expression through STAU1-mediated mRNA decay (SMD). ZNF765 also inhibited the transcriptional activity of IGF2BP2, thereby forming a feedback loop in regulating the BTB permeability. Single or combined application of silenced IGF2BP2 and FBXL19-AS1 improved the delivery and antitumor efficiency of doxorubicin (DOX). In general, our study revealed the regulation mechanism of IGF2BP2/FBXL19-AS1/ZNF765 axis on BTB permeability, which may provide valuable insight into treatment strategy for glioma."	M6ADIS0001	32713259	M6ADRUG0022
M6ACROT05886	REG00005	M6ATAR00404	Non-coding RNA	EPIREG00665	EPITAR00183	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"LncRNA Transcription factor SOX-2 (SOX2)OT promotes temozolomide resistance by elevating SOX2 expression via ALKBH5-mediated epigenetic regulation in glioblastoma. SOX2OT recruited ALKBH5, which binds with SOX2, demethylating the SOX2 transcript, leading to enhanced SOX2 expression. LncRNA SOX2OT inhibited cell apoptosis, promoted cell proliferation, and TMZ resistance by upregulating SOX2 expression, which activated the Wnt5a/beta-catenin signaling pathway."	M6ADIS0001	32439916	M6ADRUG0010
M6ACROT05887	REG00002	M6ATAR00453	Non-coding RNA	EPIREG00214	EPITAR00233	.	Up regulation	m6A	Indirect	Enhancement	ncRNA	m6A regulators indirectly modulate the functionality of ncRNAs through downstream signaling pathways	"Zinc finger E-box-binding homeobox 1 (ZEB1) induced-upregulation of ZEB1-AS1 maintained the stability of ZEB1 mRNA by binding with ELAVL1, which formed a feedback loop to facilitate TNBC progression. These findings might provide a new target for TNBC treatment."	M6ADIS0184	31922280	.
M6ACROT05888	REG00002	M6ATAR01229	Non-coding RNA	EPIREG00644	EPITAR00233	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"HOXB-AS1 obstruction suppressed MM cell proliferation, and stimulated cell apoptosis. In addition, HOXB-AS1 could modulate Alpha-(1,3)-fucosyltransferase 4 (FUT4) and FUT4-mediated Wnt/beta-catenin pathway. HOXB-AS1 enhanced the interaction between ELAVL1 and FUT4 so as to stabilize FUT4 messenger RNA. "	M6ADIS0048	31886581	.
M6ACROT05889	REG00012	M6ATAR00267	Non-coding RNA	EPIREG00647	EPITAR00234	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"A novel, liver-specific long noncoding RNA LINC01093 suppresses HCC progression by interaction with IGF2BP1 to facilitate decay of Zinc finger protein GLI1 (GLI1) mRNA. Mechanistic analyses indicate that LINC01093 directly binds insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1), interfering with interaction between IGF2BP1 and GLI1 mRNA."	M6ADIS0006	30790682	.
M6ACROT05890	REG00002	M6ATAR01216	Non-coding RNA	EPIREG00662	EPITAR00505	.	Up regulation	m6A	Indirect	Inhibition	ncRNA	m6A regulators indirectly modulate the functionality of ncRNAs through downstream signaling pathways	"ELAVL1 increased Long intergenic non-protein coding RNA 336 (LINC00336) expression by stabilizing its posttranscriptional level, whereas LSH (lymphoid-specific helicase) increased ELAVL1 expression through the p53 signaling pathway, further supporting the hypothesis that LSH promotes LINC00336 expression. LINC00336 served as an endogenous sponge of microRNA 6852 (MIR6852) to regulate the expression of Cystathionine beta-synthase (CBS), a surrogate marker of ferroptosis. "	M6ADIS0007	30787392	.
M6ACROT05891	REG00012	M6ATAR00341	Non-coding RNA	EPIREG00447	EPITAR00234	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"TN treatment in NPC cells disrupted LncRNA THOR (""THORLNC"")-IGF2BP1 association, causing depletion of Lnc-THOR and downregulation of IGF2BP1 mRNA targets (Myc proto-oncogene protein (MYC), IGF2 and Gli1)."	M6ADIS0054	30503558	M6ADRUG0259
M6ACROT05892	REG00012	M6ATAR01124	Non-coding RNA	EPIREG00447	EPITAR00234	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"TN treatment in NPC cells disrupted LncRNA THOR (""THORLNC"")-Insulin-like growth factor 2 (IGF2)BP1 association, causing depletion of Lnc-THOR and downregulation of IGF2BP1 mRNA targets (Myc, IGF2 and Gli1)."	M6ADIS0054	30503558	M6ADRUG0259
M6ACROT05893	REG00012	M6ATAR00267	Non-coding RNA	EPIREG00447	EPITAR00234	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"TN treatment in NPC cells disrupted LncRNA THOR (""THORLNC"")-IGF2BP1 association, causing depletion of Lnc-THOR and downregulation of IGF2BP1 mRNA targets (Myc, IGF2 and Zinc finger protein GLI1 (GLI1))."	M6ADIS0054	30503558	M6ADRUG0259
M6ACROT05894	REG00005	M6ATAR01089	Non-coding RNA	EPIREG00657	EPITAR00525	.	Up regulation	m6A	Indirect	Inhibition	ncRNA	m6A regulators indirectly modulate the functionality of ncRNAs through downstream signaling pathways	ALKBH5-induced Circ_PUM1 upregulation facilitated the progression of neuroblastoma via hsa-miR-423-5p/Proliferation-associated protein 2G4 (PA2G4) axis.	M6ADIS0001	37421841	.
M6ACROT05895	REG00013	M6ATAR00097	Non-coding RNA	EPIREG00212	EPITAR00151	.	Up regulation	m6A	Indirect	Inhibition	ncRNA	m6A regulators indirectly modulate the functionality of ncRNAs through downstream signaling pathways	"HOXD antisense growth-associated long non-coding RNA (HAGLR), epigenetically modified by IGF2BP2 in an m6A-dependent manner, functioned as a sponge for hsa-miR-106b-5p, thereby activating Mutated in multiple advanced cancers 1 (PTEN)/Akt signaling cascade to accelerate DR pathology."	M6ADIS0015	38088496	.
M6ACROT05896	REG00007	M6ATAR01063	Non-coding RNA	EPIREG00395	EPITAR00528	.	Up regulation	m6A	Indirect	Inhibition	ncRNA	m6A regulators indirectly modulate the functionality of ncRNAs through downstream signaling pathways	"METTL3/IGF2BP1-mediated m6A modification maintained Circ_ASXL1 stability and upregulated its expression. CircASXL1 was a ceRNA that sequestrated hsa-miR-320d from Rac GTPase-activating protein 1 (RACGAP1), leading to increased RACGAP1 expression. CircASXL1 promoted OC cell proliferation, migration and invasion via the miR-320d/RACGAP1 axis. "	M6ADIS0066	37738681	.
M6ACROT05897	REG00012	M6ATAR01063	Non-coding RNA	EPIREG00395	EPITAR00528	.	Up regulation	m6A	Indirect	Inhibition	ncRNA	m6A regulators indirectly modulate the functionality of ncRNAs through downstream signaling pathways	"METTL3/IGF2BP1-mediated m6A modification maintained Circ_ASXL1 stability and upregulated its expression. CircASXL1 was a ceRNA that sequestrated hsa-miR-320d from Rac GTPase-activating protein 1 (RACGAP1), leading to increased RACGAP1 expression. CircASXL1 promoted OC cell proliferation, migration and invasion via the miR-320d/RACGAP1 axis. "	M6ADIS0066	37738681	.
M6ACROT05898	REG00007	M6ATAR01058	Non-coding RNA	EPIREG00650	EPITAR00373	.	Down regulation	m6A	Indirect	Inhibition	ncRNA	m6A regulators indirectly modulate the functionality of ncRNAs through downstream signaling pathways	METTL3 mediated m6A methylation of hsa_circ_0124554. m6A-modified circ_0124554 promoted CRC progression and radioresistance by inducing LIM and SH3 protein 1 (LASP1) expression through interaction with miR-1184.	M6ADIS0059	38091882	.
M6ACROT05899	REG00012	M6ATAR01506	Non-coding RNA	EPIREG00605	EPITAR00234	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Circ_CMTM3 promoted the carcinogenesis through inhibiting ferroptosis by recruiting IGF2BP1 to increase Parkinson disease protein 7 (PARK7) stability in HCC, suggesting that cicrCMTM3 may be an important marker for HCC treatment."	M6ADIS0006	36586770	.
M6ACROT05900	REG00022	M6ATAR00283	Non-coding RNA	EPIREG00602	EPITAR00238	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	METTL3/YTHDC1-mediated upregulation of LINC00294 promotes hepatocellular carcinoma progression. LINC00294 promoted the interaction between YTHDC1 and Hexokinase-2 (HK2) and GLUT1 mRNA.	M6ADIS0006	38125436	.
M6ACROT05901	REG00022	M6ATAR00269	Non-coding RNA	EPIREG00602	EPITAR00238	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	METTL3/YTHDC1-mediated upregulation of LINC00294 promotes hepatocellular carcinoma progression. LINC00294 promoted the interaction between YTHDC1 and HK2 and Glucose transporter type 1 (GLUT1) mRNA.	M6ADIS0006	38125436	.
M6ACROT05902	REG00007	M6ATAR01041	Non-coding RNA	EPIREG00598	EPITAR00519	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The expression of RNF32 divergent transcript (RNF32-DT) was increased by METTL3 via m6A modification. c-MYC directly induced METTL3. Both c-MYC and LINC01006 were commonly targeted by MicroRNA 34a (MIR34A)/b/c and miR-2682, and thereby c-MYC/METTL3/LINC01006 formed a positive feedback loop through miRNA targets in NSCLC. LINC01006 is an oncogenic lncRNA, which induces migration, invasion and proliferation of NSCLC. METTL3 increases LINC01006 expression through stabilizing LINC01006 mRNA. c-MYC, as a transcription factor, activates METTL3, which results in an elevated level of LINC01006. c-MYC, METTL3 and LINC01006 form a positive feedback loop through multiple miRNA targets in NSCLC."	M6ADIS0007	37774794	.
M6ACROT05903	REG00007	M6ATAR01041	Non-coding RNA	EPIREG00598	EPITAR00520	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The expression of RNF32 divergent transcript (RNF32-DT) was increased by METTL3 via m6A modification. c-MYC directly induced METTL3. Both c-MYC and LINC01006 were commonly targeted by miR-34a/MicroRNA 34b (MIR34B)/miR-34c and miR-2682, and thereby c-MYC/METTL3/LINC01006 formed a positive feedback loop through miRNA targets in NSCLC. LINC01006 is an oncogenic lncRNA, which induces migration, invasion and proliferation of NSCLC. METTL3 increases LINC01006 expression through stabilizing LINC01006 mRNA. c-MYC, as a transcription factor, activates METTL3, which results in an elevated level of LINC01006. c-MYC, METTL3 and LINC01006 form a positive feedback loop through multiple miRNA targets in NSCLC."	M6ADIS0007	37774794	.
M6ACROT05904	REG00007	M6ATAR01041	Non-coding RNA	EPIREG00598	EPITAR00521	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"The expression of RNF32 divergent transcript (RNF32-DT) was increased by METTL3 via m6A modification. c-MYC directly induced METTL3. Both c-MYC and LINC01006 were commonly targeted by miR-34a/miR-34b/MicroRNA 34c (MIR34C) and miR-2682, and thereby c-MYC/METTL3/LINC01006 formed a positive feedback loop through miRNA targets in NSCLC. LINC01006 is an oncogenic lncRNA, which induces migration, invasion and proliferation of NSCLC. METTL3 increases LINC01006 expression through stabilizing LINC01006 mRNA. c-MYC, as a transcription factor, activates METTL3, which results in an elevated level of LINC01006. c-MYC, METTL3 and LINC01006 form a positive feedback loop through multiple miRNA targets in NSCLC."	M6ADIS0007	37774794	.
M6ACROT05905	REG00007	M6ATAR01041	Non-coding RNA	EPIREG00653	EPITAR00022	.	Up regulation	m6A	Indirect	Inhibition	ncRNA	m6A regulators indirectly modulate the functionality of ncRNAs through downstream signaling pathways	"The expression of RNF32 divergent transcript (RNF32-DT) was increased by METTL3 via m6A modification. Myc proto-oncogene protein (MYC) directly induced METTL3. Both c-MYC and LINC01006 were commonly targeted by miR-34a/b/c and MIR2682, and thereby c-MYC/METTL3/LINC01006 formed a positive feedback loop through miRNA targets in NSCLC. LINC01006 is an oncogenic lncRNA, which induces migration, invasion and proliferation of NSCLC. METTL3 increases LINC01006 expression through stabilizing LINC01006 mRNA. c-MYC, as a transcription factor, activates METTL3, which results in an elevated level of LINC01006. c-MYC, METTL3 and LINC01006 form a positive feedback loop through multiple miRNA targets in NSCLC."	M6ADIS0007	37774794	.
M6ACROT05906	REG00007	M6ATAR01041	Non-coding RNA	EPIREG00530	EPITAR00022	.	Up regulation	m6A	Indirect	Inhibition	ncRNA	m6A regulators indirectly modulate the functionality of ncRNAs through downstream signaling pathways	"The expression of RNF32 divergent transcript (RNF32-DT) was increased by METTL3 via m6A modification. Myc proto-oncogene protein (MYC) directly induced METTL3. Both c-MYC and LINC01006 were commonly targeted by hsa-miR-34a/b/c and miR-2682, and thereby c-MYC/METTL3/LINC01006 formed a positive feedback loop through miRNA targets in NSCLC. LINC01006 is an oncogenic lncRNA, which induces migration, invasion and proliferation of NSCLC. METTL3 increases LINC01006 expression through stabilizing LINC01006 mRNA. c-MYC, as a transcription factor, activates METTL3, which results in an elevated level of LINC01006. c-MYC, METTL3 and LINC01006 form a positive feedback loop through multiple miRNA targets in NSCLC."	M6ADIS0007	37774794	.
M6ACROT05907	REG00007	M6ATAR01041	Non-coding RNA	EPIREG00655	EPITAR00022	.	Up regulation	m6A	Indirect	Inhibition	ncRNA	m6A regulators indirectly modulate the functionality of ncRNAs through downstream signaling pathways	"The expression of RNF32 divergent transcript (RNF32-DT) was increased by METTL3 via m6A modification. Myc proto-oncogene protein (MYC) directly induced METTL3. Both c-MYC and LINC01006 were commonly targeted by miR-34a/MIR34B/miR-34c and miR-2682, and thereby c-MYC/METTL3/LINC01006 formed a positive feedback loop through miRNA targets in NSCLC. LINC01006 is an oncogenic lncRNA, which induces migration, invasion and proliferation of NSCLC. METTL3 increases LINC01006 expression through stabilizing LINC01006 mRNA. c-MYC, as a transcription factor, activates METTL3, which results in an elevated level of LINC01006. c-MYC, METTL3 and LINC01006 form a positive feedback loop through multiple miRNA targets in NSCLC."	M6ADIS0007	37774794	.
M6ACROT05908	REG00007	M6ATAR01041	Non-coding RNA	EPIREG00656	EPITAR00022	.	Up regulation	m6A	Indirect	Inhibition	ncRNA	m6A regulators indirectly modulate the functionality of ncRNAs through downstream signaling pathways	"The expression of RNF32 divergent transcript (RNF32-DT) was increased by METTL3 via m6A modification. Myc proto-oncogene protein (MYC) directly induced METTL3. Both c-MYC and LINC01006 were commonly targeted by miR-34a/miR-34b/MIR34C and miR-2682, and thereby c-MYC/METTL3/LINC01006 formed a positive feedback loop through miRNA targets in NSCLC. LINC01006 is an oncogenic lncRNA, which induces migration, invasion and proliferation of NSCLC. METTL3 increases LINC01006 expression through stabilizing LINC01006 mRNA. c-MYC, as a transcription factor, activates METTL3, which results in an elevated level of LINC01006. c-MYC, METTL3 and LINC01006 form a positive feedback loop through multiple miRNA targets in NSCLC."	M6ADIS0007	37774794	.
M6ACROT05909	REG00007	M6ATAR01041	Non-coding RNA	EPIREG00598	EPITAR00518	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"The expression of RNF32 divergent transcript (RNF32-DT) was increased by METTL3 via m6A modification. c-MYC directly induced METTL3. Both c-MYC and LINC01006 were commonly targeted by miR-34a/b/c and MicroRNA 2682 (MIR2682), and thereby c-MYC/METTL3/LINC01006 formed a positive feedback loop through miRNA targets in NSCLC. LINC01006 is an oncogenic lncRNA, which induces migration, invasion and proliferation of NSCLC. METTL3 increases LINC01006 expression through stabilizing LINC01006 mRNA. c-MYC, as a transcription factor, activates METTL3, which results in an elevated level of LINC01006. c-MYC, METTL3 and LINC01006 form a positive feedback loop through multiple miRNA targets in NSCLC."	M6ADIS0007	37774794	.
M6ACROT05910	REG00007	M6ATAR01041	Non-coding RNA	EPIREG00598	EPITAR00519	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"The expression of RNF32 divergent transcript (RNF32-DT) was increased by METTL3 via m6A modification. c-MYC directly induced METTL3. Both c-MYC and LINC01006 were commonly targeted by MicroRNA 34a (MIR34A)/b/c and miR-2682, and thereby c-MYC/METTL3/LINC01006 formed a positive feedback loop through miRNA targets in NSCLC. LINC01006 is an oncogenic lncRNA, which induces migration, invasion and proliferation of NSCLC. METTL3 increases LINC01006 expression through stabilizing LINC01006 mRNA. c-MYC, as a transcription factor, activates METTL3, which results in an elevated level of LINC01006. c-MYC, METTL3 and LINC01006 form a positive feedback loop through multiple miRNA targets in NSCLC."	M6ADIS0007	37774794	.
M6ACROT05911	REG00007	M6ATAR01041	Non-coding RNA	EPIREG00598	EPITAR00520	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"The expression of RNF32 divergent transcript (RNF32-DT) was increased by METTL3 via m6A modification. c-MYC directly induced METTL3. Both c-MYC and LINC01006 were commonly targeted by miR-34a/MicroRNA 34b (MIR34B)/miR-34c and miR-2682, and thereby c-MYC/METTL3/LINC01006 formed a positive feedback loop through miRNA targets in NSCLC. LINC01006 is an oncogenic lncRNA, which induces migration, invasion and proliferation of NSCLC. METTL3 increases LINC01006 expression through stabilizing LINC01006 mRNA. c-MYC, as a transcription factor, activates METTL3, which results in an elevated level of LINC01006. c-MYC, METTL3 and LINC01006 form a positive feedback loop through multiple miRNA targets in NSCLC."	M6ADIS0007	37774794	.
M6ACROT05912	REG00007	M6ATAR01041	Non-coding RNA	EPIREG00598	EPITAR00521	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"The expression of RNF32 divergent transcript (RNF32-DT) was increased by METTL3 via m6A modification. c-MYC directly induced METTL3. Both c-MYC and LINC01006 were commonly targeted by miR-34a/miR-34b/MicroRNA 34c (MIR34C) and miR-2682, and thereby c-MYC/METTL3/LINC01006 formed a positive feedback loop through miRNA targets in NSCLC. LINC01006 is an oncogenic lncRNA, which induces migration, invasion and proliferation of NSCLC. METTL3 increases LINC01006 expression through stabilizing LINC01006 mRNA. c-MYC, as a transcription factor, activates METTL3, which results in an elevated level of LINC01006. c-MYC, METTL3 and LINC01006 form a positive feedback loop through multiple miRNA targets in NSCLC."	M6ADIS0007	37774794	.
M6ACROT05913	REG00007	M6ATAR01041	Non-coding RNA	EPIREG00653	EPITAR00022	.	Up regulation	ncRNA	Indirect	Inhibition	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"The expression of RNF32 divergent transcript (RNF32-DT) was increased by METTL3 via m6A modification. Myc proto-oncogene protein (MYC) directly induced METTL3. Both c-MYC and LINC01006 were commonly targeted by miR-34a/b/c and MIR2682, and thereby c-MYC/METTL3/LINC01006 formed a positive feedback loop through miRNA targets in NSCLC. LINC01006 is an oncogenic lncRNA, which induces migration, invasion and proliferation of NSCLC. METTL3 increases LINC01006 expression through stabilizing LINC01006 mRNA. c-MYC, as a transcription factor, activates METTL3, which results in an elevated level of LINC01006. c-MYC, METTL3 and LINC01006 form a positive feedback loop through multiple miRNA targets in NSCLC."	M6ADIS0007	37774794	.
M6ACROT05914	REG00007	M6ATAR01041	Non-coding RNA	EPIREG00530	EPITAR00022	.	Up regulation	ncRNA	Indirect	Inhibition	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"The expression of RNF32 divergent transcript (RNF32-DT) was increased by METTL3 via m6A modification. Myc proto-oncogene protein (MYC) directly induced METTL3. Both c-MYC and LINC01006 were commonly targeted by hsa-miR-34a/b/c and miR-2682, and thereby c-MYC/METTL3/LINC01006 formed a positive feedback loop through miRNA targets in NSCLC. LINC01006 is an oncogenic lncRNA, which induces migration, invasion and proliferation of NSCLC. METTL3 increases LINC01006 expression through stabilizing LINC01006 mRNA. c-MYC, as a transcription factor, activates METTL3, which results in an elevated level of LINC01006. c-MYC, METTL3 and LINC01006 form a positive feedback loop through multiple miRNA targets in NSCLC."	M6ADIS0007	37774794	.
M6ACROT05915	REG00007	M6ATAR01041	Non-coding RNA	EPIREG00655	EPITAR00022	.	Up regulation	ncRNA	Indirect	Inhibition	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"The expression of RNF32 divergent transcript (RNF32-DT) was increased by METTL3 via m6A modification. Myc proto-oncogene protein (MYC) directly induced METTL3. Both c-MYC and LINC01006 were commonly targeted by miR-34a/MIR34B/miR-34c and miR-2682, and thereby c-MYC/METTL3/LINC01006 formed a positive feedback loop through miRNA targets in NSCLC. LINC01006 is an oncogenic lncRNA, which induces migration, invasion and proliferation of NSCLC. METTL3 increases LINC01006 expression through stabilizing LINC01006 mRNA. c-MYC, as a transcription factor, activates METTL3, which results in an elevated level of LINC01006. c-MYC, METTL3 and LINC01006 form a positive feedback loop through multiple miRNA targets in NSCLC."	M6ADIS0007	37774794	.
M6ACROT05916	REG00007	M6ATAR01041	Non-coding RNA	EPIREG00656	EPITAR00022	.	Up regulation	ncRNA	Indirect	Inhibition	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"The expression of RNF32 divergent transcript (RNF32-DT) was increased by METTL3 via m6A modification. Myc proto-oncogene protein (MYC) directly induced METTL3. Both c-MYC and LINC01006 were commonly targeted by miR-34a/miR-34b/MIR34C and miR-2682, and thereby c-MYC/METTL3/LINC01006 formed a positive feedback loop through miRNA targets in NSCLC. LINC01006 is an oncogenic lncRNA, which induces migration, invasion and proliferation of NSCLC. METTL3 increases LINC01006 expression through stabilizing LINC01006 mRNA. c-MYC, as a transcription factor, activates METTL3, which results in an elevated level of LINC01006. c-MYC, METTL3 and LINC01006 form a positive feedback loop through multiple miRNA targets in NSCLC."	M6ADIS0007	37774794	.
M6ACROT05917	REG00009	.	Non-coding RNA	EPIREG00664	EPITAR00269	.	.	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	piR-17458 promotes tumorigenesis of CC in a WTAP-mediated m6A methylation manner.	M6ADIS0008	37325054	.
M6ACROT05918	REG00013	M6ATAR01495	Non-coding RNA	EPIREG00595	EPITAR00028	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"METTL3 overexpression increased Circ_ABCC4 expression via m6A modification in PCa cells. circABCC4 recruited IGF2BP2 protein to Cell division cycle and apoptosis regulator protein 1 (CCAR1) mRNA, thereby enhancing CCAR1 mRNA stability and subsequent activation of the Wnt/beta-catenin pathway."	M6ADIS0068	37563361	.
M6ACROT05919	REG00012	M6ATAR01021	Non-coding RNA	EPIREG00591	EPITAR00234	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Mechanistically, methyltransferase-like 3 (METTL3) enhanced Circ_MIRLET7BHG expression via m6A methylation, which enhanced Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) mRNA stability via interaction with IGF2BP1, thereby promoting AR by inducing epithelial barrier dysfunction."	M6ADIS0349	37976602	.
M6ACROT05920	REG00012	M6ATAR01481	Non-coding RNA	EPIREG00581	EPITAR00234	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	METTL3-Modulated Circ_UHRF2 Promotes Colorectal Cancer Stemness and Metastasis through Increasing Probable ATP-dependent RNA helicase DDX27 (DDX27) mRNA Stability by Recruiting IGF2BP1	M6ADIS0059	37370759	.
M6ACROT05921	REG00013	M6ATAR00404	Non-coding RNA	EPIREG00577	EPITAR00028	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Methyltransferase MELLT3 upregulated m6A modification of Circ_EPHB4, and YTHDC1 promoted cytoplasmic localization of m6A-modified CircEPHB4. Overexpression of wild-type CircEPHB4 enhanced glioma cells' stemness, metastasis, and proliferation. Cytoplasmic CircEPHB4 increased Transcription factor SOX-2 (SOX2) mRNA stability by binding to IGF2BP2, and the effects observed by SOX2 knockdown were reversed by CircEPHB4 in glioma cells."	M6ADIS0001	37614011	.
M6ACROT05922	REG00001	.	Non-coding RNA	EPIREG00660	EPITAR00179	.	.	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	SMAD3 and FTO are involved in hsa-miR-5581-3p-mediated inhibition of cell migration and proliferation in bladder cancer.	M6ADIS0070	35418191	.
M6ACROT05923	REG00013	M6ATAR00360	Non-coding RNA	EPIREG00493	EPITAR00028	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"Circ_RHBDD1 binds to IGF2BP2, disrupting the interaction between E3 ligase TRIM25 and IGF2BP2, and ultimately inhibiting IGF2BP2 ubiquitination and degradation. Intriguingly, IGF2BP2 enhances Programmed cell death 1 ligand 1 (CD274/PD-L1) mRNA stability through m6A modification."	M6ADIS0057	39080693	.
M6ACROT05924	REG00007	M6ATAR00137	Non-coding RNA	EPIREG00651	EPITAR00512	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RNA m6A reader YTHDF2 facilitates precursor microRNA 126 (MIR126) maturation to promote acute myeloid leukemia progression.methyltransferase-like 3 (METTL3) adds m6A in primary microRNAs (pri-miRNAs) and facilitates its processing into precursor miRNAs (pre-miRNAs). Expression levels of multiple downstream targets (CDK3, ADAM9, Scaffold protein ILK (ILK), TOM1, FCGR1A, FCN1, and LRCH4) were significantly decreased by miR-126"	M6ADIS0046	37588203	.
M6ACROT05925	REG00008	M6ATAR00137	Non-coding RNA	EPIREG00651	EPITAR00512	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RNA m6A reader YTHDF2 facilitates precursor microRNA 126 (MIR126) maturation to promote acute myeloid leukemia progression.methyltransferase-like 3 (METTL3) adds m6A in primary microRNAs (pri-miRNAs) and facilitates its processing into precursor miRNAs (pre-miRNAs). Expression levels of multiple downstream targets (CDK3, ADAM9, Scaffold protein ILK (ILK), TOM1, FCGR1A, FCN1, and LRCH4) were significantly decreased by miR-126"	M6ADIS0046	37588203	.
M6ACROT05926	REG00007	M6ATAR00137	Non-coding RNA	EPIREG00651	EPITAR00504	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RNA m6A reader YTHDF2 facilitates precursor microRNA 126 (MIR126) maturation to promote acute myeloid leukemia progression.methyltransferase-like 3 (METTL3) adds m6A in primary microRNAs (pri-miRNAs) and facilitates its processing into precursor miRNAs (pre-miRNAs). Expression levels of multiple downstream targets (Cyclin-dependent kinase 3 (CDK3), ADAM9, ILK, TOM1, FCGR1A, FCN1, and LRCH4) were significantly decreased by miR-126"	M6ADIS0046	37588203	.
M6ACROT05927	REG00008	M6ATAR00137	Non-coding RNA	EPIREG00651	EPITAR00504	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RNA m6A reader YTHDF2 facilitates precursor microRNA 126 (MIR126) maturation to promote acute myeloid leukemia progression.methyltransferase-like 3 (METTL3) adds m6A in primary microRNAs (pri-miRNAs) and facilitates its processing into precursor miRNAs (pre-miRNAs). Expression levels of multiple downstream targets (Cyclin-dependent kinase 3 (CDK3), ADAM9, ILK, TOM1, FCGR1A, FCN1, and LRCH4) were significantly decreased by miR-126"	M6ADIS0046	37588203	.
M6ACROT05928	REG00009	M6ATAR00871	Non-coding RNA	EPIREG00365	EPITAR00028	.	Down regulation	m6A	Indirect	Enhancement	ncRNA	m6A regulators indirectly modulate the functionality of ncRNAs through downstream signaling pathways	Chidamide treatment suppressed WT1-associated protein (WTAP)-mediated RNA m6A modification of GNAS antisense RNA 1 (GNAS-AS1). Chidamide downregulated GNAS-AS1 to inhibit glycolysis in AML cells. GNAS-AS1 targeted hsa-miR-34a-5p to promote Insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2) expression. IGF2BP2 inhibition reversed the promoting effect of miR-34a-5p knockdown on glycolysis and RhoA/ROCK pathway in Chidamide-treated cells. GNAS-AS1 overexpression abolished the inhibitory effect of Chidamide on AML tumorigenesis in vivo by modulating the RhoA/ROCK pathway.	M6ADIS0046	37926762	M6ADRUG0174
M6ACROT05929	REG00007	M6ATAR00802	Non-coding RNA	EPIREG00648	EPITAR00027	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"LINC01605 was regulated by SMYD2-EP300-mediated modifications of histone H3K4me3 as well as H3K27ac. LINC01605 was found to bind to METTL3 and promote the m6A modification of Spectrin beta, non-erythrocytic 2 (SPTBN2) mRNA, thereby facilitating the translation of SPTBN2."	M6ADIS0059	34544413	.
M6ACROT05930	REG00007	M6ATAR00141	Non-coding RNA	EPIREG00224	EPITAR00507	.	Up regulation	m6A	Indirect	Inhibition	ncRNA	m6A regulators indirectly modulate the functionality of ncRNAs through downstream signaling pathways	m6A methyltransferase methyltransferase-like 3 (METTL3) was shown to be the main methyltransferase of m6A modification on Metastasis associated lung adenocarcinoma transcript 1 (MALAT1). MALAT1/MIR145/Focal adhesion kinase 1 (FAK) pathway was involved in the effect of dihydroartemisinin (DHA) on TGF-beta1-induced renal fibrosis in vitro and in vivo. 	M6ADIS0117	32203053	M6ADRUG0041
M6ACROT05931	REG00006	M6ATAR00118	Non-coding RNA	EPIREG00429	EPITAR00532	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"METTL14 was observed to mediate the low microRNA 375 (MIR375) expression through m6A modification, leading to increased Transcription factor SOX-12 (SOX12) expression levels in breast cancer."	M6ADIS0065	35022519	.
M6ACROT05932	REG00007	M6ATAR00137	Non-coding RNA	EPIREG00651	EPITAR00534	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RNA m6A reader YTHDF2 facilitates precursor microRNA 126 (MIR126) maturation to promote acute myeloid leukemia progression.methyltransferase-like 3 (METTL3) adds m6A in primary microRNAs (pri-miRNAs) and facilitates its processing into precursor miRNAs (pre-miRNAs). Expression levels of multiple downstream targets (CDK3, ADAM9, ILK, Target of Myb1 membrane trafficking protein (TOM1), FCGR1A, FCN1, and LRCH4) were significantly decreased by miR-126"	M6ADIS0046	37588203	.
M6ACROT05933	REG00008	M6ATAR00137	Non-coding RNA	EPIREG00651	EPITAR00534	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RNA m6A reader YTHDF2 facilitates precursor microRNA 126 (MIR126) maturation to promote acute myeloid leukemia progression.methyltransferase-like 3 (METTL3) adds m6A in primary microRNAs (pri-miRNAs) and facilitates its processing into precursor miRNAs (pre-miRNAs). Expression levels of multiple downstream targets (CDK3, ADAM9, ILK, Target of Myb1 membrane trafficking protein (TOM1), FCGR1A, FCN1, and LRCH4) were significantly decreased by miR-126"	M6ADIS0046	37588203	.
M6ACROT05934	REG00007	M6ATAR00137	Non-coding RNA	EPIREG00651	EPITAR00509	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RNA m6A reader YTHDF2 facilitates precursor microRNA 126 (MIR126) maturation to promote acute myeloid leukemia progression.methyltransferase-like 3 (METTL3) adds m6A in primary microRNAs (pri-miRNAs) and facilitates its processing into precursor miRNAs (pre-miRNAs). Expression levels of multiple downstream targets (CDK3, ADAM9, ILK, TOM1, High affinity immunoglobulin gamma Fc receptor I (FCGR1A), FCN1, and LRCH4) were significantly decreased by miR-126"	M6ADIS0046	37588203	.
M6ACROT05935	REG00008	M6ATAR00137	Non-coding RNA	EPIREG00651	EPITAR00509	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RNA m6A reader YTHDF2 facilitates precursor microRNA 126 (MIR126) maturation to promote acute myeloid leukemia progression.methyltransferase-like 3 (METTL3) adds m6A in primary microRNAs (pri-miRNAs) and facilitates its processing into precursor miRNAs (pre-miRNAs). Expression levels of multiple downstream targets (CDK3, ADAM9, ILK, TOM1, High affinity immunoglobulin gamma Fc receptor I (FCGR1A), FCN1, and LRCH4) were significantly decreased by miR-126"	M6ADIS0046	37588203	.
M6ACROT05936	REG00007	M6ATAR00137	Non-coding RNA	EPIREG00651	EPITAR00510	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RNA m6A reader YTHDF2 facilitates precursor microRNA 126 (MIR126) maturation to promote acute myeloid leukemia progression.methyltransferase-like 3 (METTL3) adds m6A in primary microRNAs (pri-miRNAs) and facilitates its processing into precursor miRNAs (pre-miRNAs). Expression levels of multiple downstream targets (CDK3, ADAM9, ILK, TOM1, FCGR1A, Ficolin-1 (FCN1), and LRCH4) were significantly decreased by miR-126"	M6ADIS0046	37588203	.
M6ACROT05937	REG00008	M6ATAR00137	Non-coding RNA	EPIREG00651	EPITAR00510	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RNA m6A reader YTHDF2 facilitates precursor microRNA 126 (MIR126) maturation to promote acute myeloid leukemia progression.methyltransferase-like 3 (METTL3) adds m6A in primary microRNAs (pri-miRNAs) and facilitates its processing into precursor miRNAs (pre-miRNAs). Expression levels of multiple downstream targets (CDK3, ADAM9, ILK, TOM1, FCGR1A, Ficolin-1 (FCN1), and LRCH4) were significantly decreased by miR-126"	M6ADIS0046	37588203	.
M6ACROT05938	REG00007	M6ATAR00137	Non-coding RNA	EPIREG00651	EPITAR00516	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RNA m6A reader YTHDF2 facilitates precursor microRNA 126 (MIR126) maturation to promote acute myeloid leukemia progression.methyltransferase-like 3 (METTL3) adds m6A in primary microRNAs (pri-miRNAs) and facilitates its processing into precursor miRNAs (pre-miRNAs). Expression levels of multiple downstream targets (CDK3, ADAM9, ILK, TOM1, FCGR1A, FCN1, and Leucine-rich repeat and calponin homology domain-containing protein 4 (LRCH4)) were significantly decreased by miR-126"	M6ADIS0046	37588203	.
M6ACROT05939	REG00008	M6ATAR00137	Non-coding RNA	EPIREG00651	EPITAR00516	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RNA m6A reader YTHDF2 facilitates precursor microRNA 126 (MIR126) maturation to promote acute myeloid leukemia progression.methyltransferase-like 3 (METTL3) adds m6A in primary microRNAs (pri-miRNAs) and facilitates its processing into precursor miRNAs (pre-miRNAs). Expression levels of multiple downstream targets (CDK3, ADAM9, ILK, TOM1, FCGR1A, FCN1, and Leucine-rich repeat and calponin homology domain-containing protein 4 (LRCH4)) were significantly decreased by miR-126"	M6ADIS0046	37588203	.
M6ACROT05940	REG00007	M6ATAR00001	Non-coding RNA	EPIREG00450	EPITAR00296	.	Down regulation	m6A	Indirect	Enhancement	ncRNA	m6A regulators indirectly modulate the functionality of ncRNAs through downstream signaling pathways	Oxygen glucose deprivation/re-oxygenation (OGD/R) induces neuronal injury via mechanisms that are believed to mimic the pathways associated with brain ischemia. METTL3 shRNA reversed OGD/R-induced Lnc_D63785 m6A methylation to decrease hsa-miR-422a accumulation. The accumulation of the microRNA miR-422a leads to downregulation of miR-422a targets Myocyte enhancer factor 2D (MEF2D) and MAPKK6.	M6ADIS0026	32999283	.
M6ACROT05941	REG00007	M6ATAR00552	Non-coding RNA	EPIREG00513	EPITAR00533	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"miR-17-92 into the miR-17-92 cluster through an m6A/DGCR8-dependent mechanism. METTL3-high tumors showed preferred sensitivity to an mTOR inhibitor, everolimus. The miR-17-92 cluster activated the AKT/mTOR pathway by targeting PTEN or Transmembrane protein 127 (TMEM127)."	M6ADIS0057	33037176	M6ADRUG0105
M6ACROT05942	REG00007	M6ATAR00143	Non-coding RNA	EPIREG00424	EPITAR00281	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Silencing METTL3 decreases Family with sequence similarity 225 member A (FAM225A) RNA stability, which serves as the ceRNA for sponging both hsa-miR-590-3p and miR-1275, increasing the levels of their target integrin beta3 (ITGB3), finally stimulating FAK/PI3K/Akt signaling. miR-590-3p has been reported as a tumor suppressor in cholangiocarcinoma and hepatocellular carcinoma and miR-1275 can inhibit NPC cell growth and suppress hepatocellular carcinoma cell proliferation."	M6ADIS0346	33335959	.
M6ACROT05943	REG00007	M6ATAR00143	Non-coding RNA	EPIREG00424	EPITAR00517	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Silencing METTL3 decreases Family with sequence similarity 225 member A (FAM225A) RNA stability, which serves as the ceRNA for sponging both miR-590-3p and MicroRNA 1275 (MIR1275), increasing the levels of their target integrin beta3 (ITGB3), finally stimulating FAK/PI3K/Akt signaling. miR-590-3p has been reported as a tumor suppressor in cholangiocarcinoma and hepatocellular carcinoma and miR-1275 can inhibit NPC cell growth and suppress hepatocellular carcinoma cell proliferation."	M6ADIS0054	33335959	.
M6ACROT05944	REG00007	M6ATAR00143	Non-coding RNA	EPIREG00424	EPITAR00281	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Silencing METTL3 decreases Family with sequence similarity 225 member A (FAM225A) RNA stability, which serves as the ceRNA for sponging both hsa-miR-590-3p and miR-1275, increasing the levels of their target integrin beta3 (ITGB3), finally stimulating FAK/PI3K/Akt signaling. miR-590-3p has been reported as a tumor suppressor in cholangiocarcinoma and hepatocellular carcinoma and miR-1275 can inhibit NPC cell growth and suppress hepatocellular carcinoma cell proliferation."	M6ADIS0006	33335959	.
M6ACROT05945	REG00007	M6ATAR00143	Non-coding RNA	EPIREG00424	EPITAR00517	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Silencing METTL3 decreases Family with sequence similarity 225 member A (FAM225A) RNA stability, which serves as the ceRNA for sponging both miR-590-3p and MicroRNA 1275 (MIR1275), increasing the levels of their target integrin beta3 (ITGB3), finally stimulating FAK/PI3K/Akt signaling. miR-590-3p has been reported as a tumor suppressor in cholangiocarcinoma and hepatocellular carcinoma and miR-1275 can inhibit NPC cell growth and suppress hepatocellular carcinoma cell proliferation."	M6ADIS0006	33335959	.
M6ACROT05946	REG00007	M6ATAR00143	Non-coding RNA	EPIREG00661	EPITAR00284	.	Up regulation	m6A	Indirect	Inhibition	ncRNA	m6A regulators indirectly modulate the functionality of ncRNAs through downstream signaling pathways	"Silencing METTL3 decreases Family with sequence similarity 225 member A (FAM225A) RNA stability, which serves as the ceRNA for sponging both hsa-miR-590-3p and miR-1275, increasing the levels of their target integrin beta3 (Integrin subunit beta 3 (ITGB3)), finally stimulating FAK/PI3K/Akt signaling. miR-590-3p has been reported as a tumor suppressor in cholangiocarcinoma and hepatocellular carcinoma and miR-1275 can inhibit NPC cell growth and suppress hepatocellular carcinoma cell proliferation."	M6ADIS0346	33335959	.
M6ACROT05947	REG00007	M6ATAR00143	Non-coding RNA	EPIREG00652	EPITAR00284	.	Up regulation	m6A	Indirect	Inhibition	ncRNA	m6A regulators indirectly modulate the functionality of ncRNAs through downstream signaling pathways	"Silencing METTL3 decreases Family with sequence similarity 225 member A (FAM225A) RNA stability, which serves as the ceRNA for sponging both miR-590-3p and MIR1275, increasing the levels of their target integrin beta3 (Integrin subunit beta 3 (ITGB3)), finally stimulating FAK/PI3K/Akt signaling. miR-590-3p has been reported as a tumor suppressor in cholangiocarcinoma and hepatocellular carcinoma and miR-1275 can inhibit NPC cell growth and suppress hepatocellular carcinoma cell proliferation."	M6ADIS0054	33335959	.
M6ACROT05948	REG00007	M6ATAR00143	Non-coding RNA	EPIREG00661	EPITAR00284	.	Up regulation	m6A	Indirect	Inhibition	ncRNA	m6A regulators indirectly modulate the functionality of ncRNAs through downstream signaling pathways	"Silencing METTL3 decreases Family with sequence similarity 225 member A (FAM225A) RNA stability, which serves as the ceRNA for sponging both hsa-miR-590-3p and miR-1275, increasing the levels of their target integrin beta3 (Integrin subunit beta 3 (ITGB3)), finally stimulating FAK/PI3K/Akt signaling. miR-590-3p has been reported as a tumor suppressor in cholangiocarcinoma and hepatocellular carcinoma and miR-1275 can inhibit NPC cell growth and suppress hepatocellular carcinoma cell proliferation."	M6ADIS0006	33335959	.
M6ACROT05949	REG00007	M6ATAR00143	Non-coding RNA	EPIREG00652	EPITAR00284	.	Up regulation	m6A	Indirect	Inhibition	ncRNA	m6A regulators indirectly modulate the functionality of ncRNAs through downstream signaling pathways	"Silencing METTL3 decreases Family with sequence similarity 225 member A (FAM225A) RNA stability, which serves as the ceRNA for sponging both miR-590-3p and MIR1275, increasing the levels of their target integrin beta3 (Integrin subunit beta 3 (ITGB3)), finally stimulating FAK/PI3K/Akt signaling. miR-590-3p has been reported as a tumor suppressor in cholangiocarcinoma and hepatocellular carcinoma and miR-1275 can inhibit NPC cell growth and suppress hepatocellular carcinoma cell proliferation."	M6ADIS0006	33335959	.
M6ACROT05950	REG00013	M6ATAR00341	Non-coding RNA	EPIREG00559	EPITAR00028	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"YTHDF1 serves as a reader for the m6A modified LINC00901 and downregulates the LINC00901 level. LINC00901 positively regulates Myc proto-oncogene protein (MYC) through upregulation of IGF2BP2, a known RNA binding protein that can enhance MYC mRNA stability."	M6ADIS0061	37223505	.
M6ACROT05958	REG00044	M6ATAR00224	Non-coding RNA	EPIREG00643	EPITAR00511	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	Differentiation antagonizing non-protein coding RNA (DANCR) activated Interleukin-11 (IL11)-STAT3 signaling and increased CCND1 and PLAU expression via guiding leucine-rich pentatricopeptide repeat containing (LRPPRC) to stabilize mRNA.	M6ADIS0070	30660488	M6ADRUG0256
M6ACROT05959	REG00044	M6ATAR00224	Non-coding RNA	EPIREG00643	EPITAR00072	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	Differentiation antagonizing non-protein coding RNA (DANCR) activated IL-11-STAT3 signaling and increased G1/S-specific cyclin-D1 (CCND1) and PLAU expression via guiding leucine-rich pentatricopeptide repeat containing (LRPPRC) to stabilize mRNA.	M6ADIS0070	30660488	M6ADRUG0256
M6ACROT05960	REG00044	M6ATAR00224	Non-coding RNA	EPIREG00643	EPITAR00527	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	Differentiation antagonizing non-protein coding RNA (DANCR) activated IL-11-STAT3 signaling and increased CCND1 and Urokinase-type plasminogen activator (PLAU) expression via guiding leucine-rich pentatricopeptide repeat containing (LRPPRC) to stabilize mRNA.	M6ADIS0070	30660488	M6ADRUG0256
M6ACROT05961	REG00007	M6ATAR01491	Non-coding RNA	EPIREG00267	EPITAR00027	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"LINC00942 recruits RNA methyltransferase METTL3 to stimulate N6-methyladenosine (m6A) deposit on Cysteine methyltransferase DNMT3A (DNMT3A) transcripts, triggering IGF2BP3/HuR to recognize modified mRNA for reinforced stability. SQSTM1/p62 recruits Linc00942 for autophagic degradation which can be abrogated after autophagy inhibition by p62 knockdown or chloroquine treatment."	M6ADIS0057	37477089	M6ADRUG0252
M6ACROT05962	REG00014	M6ATAR01491	Non-coding RNA	EPIREG00267	EPITAR00027	.	Up regulation	ncRNA	Indirect	Enhancement	m6A	ncRNAs indirectly impacts m6A modification through downstream signaling pathways	"LINC00942 recruits RNA methyltransferase Methyltransferase-like protein 3 (METTL3) to stimulate N6-methyladenosine (m6A) deposit on Cysteine methyltransferase DNMT3A (DNMT3A) transcripts, triggering IGF2BP3/HuR to recognize modified mRNA for reinforced stability. SQSTM1/p62 recruits Linc00942 for autophagic degradation which can be abrogated after autophagy inhibition by p62 knockdown or chloroquine treatment."	M6ADIS0057	37477089	M6ADRUG0252
M6ACROT05963	REG00006	M6ATAR01287	Non-coding RNA	EPIREG00663	EPITAR00501	.	Down regulation	m6A	Indirect	Enhancement	ncRNA	m6A regulators indirectly modulate the functionality of ncRNAs through downstream signaling pathways	"Overexpression of METTL14 suppresses PTC cell proliferation and migration/invasion through inhibiting OIP5 antisense RNA 1 (OIP5-AS1) expression. OIP5-AS1 acts as a target of MIR98, which activates A disintegrin and metalloproteinase with thrombospondin motifs 8 (ADAMTS8). OIP5-AS1 promotes PTC cell progression through miR-98/ADAMTS8 and EGFR, MEK/ERK pathways."	M6ADIS0073	34131102	.
M6ACROT05964	REG00015	M6ATAR00092	Non-coding RNA	EPIREG00438	EPITAR00514	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"In prostate cancer, VIRMA-mediated m6A modification of Colon cancer associated transcript 1 (CCAT1) can upregulate CCAT1, which act as a sponge for MicroRNA let-7a-1 (Let-7A) to upregulate the expression of MYC."	M6ADIS0068	32218194	M6ADRUG0250
M6ACROT05965	REG00015	M6ATAR00092	Non-coding RNA	EPIREG00646	EPITAR00022	.	Up regulation	m6A	Indirect	Inhibition	ncRNA	m6A regulators indirectly modulate the functionality of ncRNAs through downstream signaling pathways	"In prostate cancer, VIRMA-mediated m6A modification of Colon cancer associated transcript 1 (CCAT1) can upregulate CCAT1, which act as a sponge for Let-7A to upregulate the expression of Myc proto-oncogene protein (MYC)."	M6ADIS0068	32218194	M6ADRUG0250
M6ACROT05966	REG00015	M6ATAR00091	Non-coding RNA	EPIREG00439	EPITAR00289	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"In prostate cancer, VIRMA-mediated m6A modification of Colon cancer associated transcript 2 (CCAT2) can upregulate CCAT2, which act as a sponge for MicroRNA 145 (MIR145) to upregulate the expression of MYC."	M6ADIS0068	32218194	M6ADRUG0250
M6ACROT05967	REG00015	M6ATAR00091	Non-coding RNA	EPIREG00224	EPITAR00022	.	Up regulation	m6A	Indirect	Inhibition	ncRNA	m6A regulators indirectly modulate the functionality of ncRNAs through downstream signaling pathways	"In prostate cancer, VIRMA-mediated m6A modification of Colon cancer associated transcript 2 (CCAT2) can upregulate CCAT2, which act as a sponge for MIR145 to upregulate the expression of Myc proto-oncogene protein (MYC)."	M6ADIS0068	32218194	M6ADRUG0250
M6ACROT05968	REG00001	M6ATAR00362	Non-coding RNA	EPIREG00645	EPITAR00179	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	JPX interacted with N6-methyladenosine (m6A) demethylase FTO and enhanced FTO-mediated PDH kinase 1 (PDK1) mRNA demethylation. JPX exerted its GBM-promotion effects through the FTO/PDK1 axis. These findings reveal the key role of JPX in promoting GBM aerobic glycolysis and temozolomide (TMZ) chemoresistance in an m6A-dependent manner.	M6ADIS0245	34390075	M6ADRUG0010
M6ACROT05969	REG00012	M6ATAR01532	Non-coding RNA	EPIREG00666	EPITAR00523	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"IGF2BP1 upregulated MIR4435-2 host gene (MIR4435-2HG) expression in HCC through N6-methyladenosine (m6A) modification. Moreover, MIR4435-2HG protected Nucleolar protein 58 (NOP58) from degradation, which raised rRNA 2'-O-Me levels and promoted internal ribosome entry site (IRES)-dependent translation of oncogenes."	M6ADIS0006	37891494	.
M6ACROT05970	REG00008	M6ATAR00784	Non-coding RNA	EPIREG00497	EPITAR00536	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Subsequent loss- and gain-of-function experiments reveal WTAP is increased in senescent nucleus pulposus cells, and significantly promotes Long intergenic non-protein coding RNA 657 (NORAD) m6A modification. YTHDF2-mediated decay of NORAD is enhanced in senescent NPCs, and then deficiency of NORAD results in less sequestraion of PUMILIO proteins, contributing to the augmented activity of Pumilio homolog 1 (PUM1) and PUM2, thus repressing the expression of target E2F3 mRNAs and promoting the cellular senescence. This study shows interruption of NORAD m6A modification or the NORAD/PUMILIO/E2F3 axis could serve as a potential therapeutic target to inhibit the senescence of NPCs and development of intervertebral disc degeneration(IVDD)."	M6ADIS0168	35304463	.
M6ACROT05971	REG00009	M6ATAR00784	Non-coding RNA	EPIREG00497	EPITAR00537	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Subsequent loss- and gain-of-function experiments reveal WTAP is increased in senescent nucleus pulposus cells, and significantly promotes Long intergenic non-protein coding RNA 657 (NORAD) m6A modification. YTHDF2-mediated decay of NORAD is enhanced in senescent NPCs, and then deficiency of NORAD results in less sequestraion of PUMILIO proteins, contributing to the augmented activity of PUM1 and Pumilio homolog 2 (PUM2), thus repressing the expression of target E2F3 mRNAs and promoting the cellular senescence. This study shows interruption of NORAD m6A modification or the NORAD/PUMILIO/E2F3 axis could serve as a potential therapeutic target to inhibit the senescence of NPCs and development of intervertebral disc degeneration(IVDD)."	M6ADIS0168	35304463	.
M6ACROT05972	REG00008	M6ATAR00784	Non-coding RNA	EPIREG00497	EPITAR00537	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"Subsequent loss- and gain-of-function experiments reveal WTAP is increased in senescent nucleus pulposus cells, and significantly promotes Long intergenic non-protein coding RNA 657 (NORAD) m6A modification. YTHDF2-mediated decay of NORAD is enhanced in senescent NPCs, and then deficiency of NORAD results in less sequestraion of PUMILIO proteins, contributing to the augmented activity of PUM1 and Pumilio homolog 2 (PUM2), thus repressing the expression of target E2F3 mRNAs and promoting the cellular senescence. This study shows interruption of NORAD m6A modification or the NORAD/PUMILIO/E2F3 axis could serve as a potential therapeutic target to inhibit the senescence of NPCs and development of intervertebral disc degeneration(IVDD)."	M6ADIS0168	35304463	.
M6ACROT05982	REG00007	M6ATAR00795	Non-coding RNA	EPIREG00227	EPITAR00027	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"In summary, impaired autophagic degradation of lncRNA ARHGAP5-AS1 in chemoresistant cancer cells promoted chemoresistance. It can activate the transcription of ARHGAP5 in the nucleus and stimulate m6A modification of Rho GTPase activating protein 5 (ARHGAP5) mRNA to stabilize ARHGAP5 mRNA in the cytoplasm by recruiting METTL3."	M6ADIS0057	31097692	M6ADRUG0034
M6ACROT05983	REG00007	M6ATAR00795	Non-coding RNA	EPIREG00227	EPITAR00027	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"In summary, impaired autophagic degradation of lncRNA ARHGAP5-AS1 in chemoresistant cancer cells promoted chemoresistance. It can activate the transcription of ARHGAP5 in the nucleus and stimulate m6A modification of Rho GTPase activating protein 5 (ARHGAP5) mRNA to stabilize ARHGAP5 mRNA in the cytoplasm by recruiting METTL3."	M6ADIS0057	31097692	M6ADRUG0005
M6ACROT05984	REG00006	M6ATAR00547	Non-coding RNA	EPIREG00313	EPITAR00195	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"MiR-200 family (miR-200b/miR-200c) and hsa-miR-141 reduced Pancreas/duodenum homeobox protein 1 (Pdx1) via targeting METTL14, which should also be a crucial contributor to beta-cell dysfunction and apoptosis in the pancreas of BPF-exposed mice."	.	36924560	M6ADRUG0200
M6ACROT05985	REG00006	M6ATAR00547	Non-coding RNA	EPIREG00314	EPITAR00195	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"MiR-200 family (hsa-miR-200b/miR-200c) and miR-141 reduced Pancreas/duodenum homeobox protein 1 (Pdx1) via targeting METTL14, which should also be a crucial contributor to beta-cell dysfunction and apoptosis in the pancreas of BPF-exposed mice."	.	36924560	M6ADRUG0200
M6ACROT05986	REG00006	M6ATAR00547	Non-coding RNA	EPIREG00315	EPITAR00195	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"MiR-200 family (miR-200b/hsa-miR-200c) and miR-141 reduced Pancreas/duodenum homeobox protein 1 (Pdx1) via targeting METTL14, which should also be a crucial contributor to beta-cell dysfunction and apoptosis in the pancreas of BPF-exposed mice."	.	36924560	M6ADRUG0200
M6ACROT05987	REG00006	M6ATAR00547	Non-coding RNA	EPIREG00313	EPITAR00195	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"MiR-200 family (miR-200b/miR-200c) and hsa-miR-141 reduced Pancreas/duodenum homeobox protein 1 (Pdx1) via targeting METTL14, which should also be a crucial contributor to beta-cell dysfunction and apoptosis in the pancreas of BPF-exposed mice."	.	36924560	M6ADRUG0201
M6ACROT05988	REG00006	M6ATAR00547	Non-coding RNA	EPIREG00314	EPITAR00195	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"MiR-200 family (hsa-miR-200b/miR-200c) and miR-141 reduced Pancreas/duodenum homeobox protein 1 (Pdx1) via targeting METTL14, which should also be a crucial contributor to beta-cell dysfunction and apoptosis in the pancreas of BPF-exposed mice."	.	36924560	M6ADRUG0201
M6ACROT05989	REG00006	M6ATAR00547	Non-coding RNA	EPIREG00315	EPITAR00195	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"MiR-200 family (miR-200b/hsa-miR-200c) and miR-141 reduced Pancreas/duodenum homeobox protein 1 (Pdx1) via targeting METTL14, which should also be a crucial contributor to beta-cell dysfunction and apoptosis in the pancreas of BPF-exposed mice."	.	36924560	M6ADRUG0201
M6ACROT05990	REG00006	M6ATAR00547	Non-coding RNA	EPIREG00313	EPITAR00195	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"MiR-200 family (miR-200b/miR-200c) and hsa-miR-141 reduced Pancreas/duodenum homeobox protein 1 (Pdx1) via targeting METTL14, which should also be a crucial contributor to beta-cell dysfunction and apoptosis in the pancreas of BPF-exposed mice."	.	36924560	M6ADRUG0181
M6ACROT05991	REG00006	M6ATAR00547	Non-coding RNA	EPIREG00314	EPITAR00195	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"MiR-200 family (hsa-miR-200b/miR-200c) and miR-141 reduced Pancreas/duodenum homeobox protein 1 (Pdx1) via targeting METTL14, which should also be a crucial contributor to beta-cell dysfunction and apoptosis in the pancreas of BPF-exposed mice."	.	36924560	M6ADRUG0181
M6ACROT05992	REG00006	M6ATAR00547	Non-coding RNA	EPIREG00315	EPITAR00195	.	Up regulation	ncRNA	Direct	Inhibition	m6A	ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator 	"MiR-200 family (miR-200b/hsa-miR-200c) and miR-141 reduced Pancreas/duodenum homeobox protein 1 (Pdx1) via targeting METTL14, which should also be a crucial contributor to beta-cell dysfunction and apoptosis in the pancreas of BPF-exposed mice."	.	36924560	M6ADRUG0181
M6ACROT05993	REG00013	M6ATAR01736	Non-coding RNA	EPIREG00316	EPITAR00028	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"SNHG5 enhanced Zinc finger protein 281 (ZNF281) mRNA stability by binding with the m6A reader IGF2BP2. Enhanced ZNF281 transcriptionally regulated CCL2 and CCL5 expression to activate P38 MAPK signaling in endothelial cells. High CCL2 and CCL5 expression was associated with tumor metastasis and poor prognosis in BC patients. The inhibitors RS102895, marasviroc and cenicriviroc inhibited angiogenesis and vascular permeability in the PMN by blocking the binding of CCL2/CCR2 and CCL5/CCR5. The lncSNHG5-ZNF281-CCL2/CCL5 signaling axis plays an essential role in inducing premetastatic niche formation to promote BC metastasis."	M6ADIS0065	36438499	M6ADRUG0203
M6ACROT05994	REG00013	M6ATAR01736	Non-coding RNA	EPIREG00316	EPITAR00028	.	Up regulation	ncRNA	Direct	Enhancement	m6A	ncRNAs directly impacts m6A modification through recruiting m6A regulator	"SNHG5 enhanced Zinc finger protein 281 (ZNF281) mRNA stability by binding with the m6A reader IGF2BP2. Enhanced ZNF281 transcriptionally regulated CCL2 and CCL5 expression to activate P38 MAPK signaling in endothelial cells. High CCL2 and CCL5 expression was associated with tumor metastasis and poor prognosis in BC patients. The inhibitors RS102895, marasviroc and cenicriviroc inhibited angiogenesis and vascular permeability in the PMN by blocking the binding of CCL2/CCR2 and CCL5/CCR5. The lncSNHG5-ZNF281-CCL2/CCL5 signaling axis plays an essential role in inducing premetastatic niche formation to promote BC metastasis."	M6ADIS0065	36438499	M6ADRUG0204
M6ACROT06024	REG00022	M6ATAR00152	Non-coding RNA	EPIREG00435	EPITAR00542	.	.	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RBM15 and WTAP are required for X inactive specific transcript (XIST)-mediated silencing, are co-localized, and potentially interact with XIST RNA. YTHDC1 is the m6A reader of XIST and is required for XIST function. m6A modification is required for XIST-mediated transcriptional repression of X-linked genes, such as GPC4 and Transcriptional regulator ATRX (ATRX)."	.	33335959	.
M6ACROT06025	REG00009	M6ATAR00152	Non-coding RNA	EPIREG00435	EPITAR00542	.	.	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RBM15 and WTAP are required for X inactive specific transcript (XIST)-mediated silencing, are co-localized, and potentially interact with XIST RNA. YTHDC1 is the m6A reader of XIST and is required for XIST function. m6A modification is required for XIST-mediated transcriptional repression of X-linked genes, such as GPC4 and Transcriptional regulator ATRX (ATRX)."	.	33335959	.
M6ACROT06026	REG00020	M6ATAR00152	Non-coding RNA	EPIREG00435	EPITAR00542	.	.	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RBM15 and WTAP are required for X inactive specific transcript (XIST)-mediated silencing, are co-localized, and potentially interact with XIST RNA. YTHDC1 is the m6A reader of XIST and is required for XIST function. m6A modification is required for XIST-mediated transcriptional repression of X-linked genes, such as GPC4 and Transcriptional regulator ATRX (ATRX)."	.	33335959	.
M6ACROT06027	REG00007	M6ATAR00623	Non-coding RNA	EPIREG00525	EPITAR00541	.	Down regulation	m6A	Direct	Inhibition	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	METTL3 deficiency contributes to heart regeneration after MI via METTL3-pri-miR-143-(miR-143)-Yap/Catenin delta-1 (CTNND1) axis.	M6ADIS0097	34428587	.
M6ACROT06028	REG00014	M6ATAR00141	Non-coding RNA	EPIREG00215	EPITAR00540	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"circRNA hsa_circ_0004287 was upregulated in peripheral blood mononuclear cells of both AD and psoriasis patients. hsa_circ_0004287 reduced the stability of its host gene Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) by competitively binding to IGF2BP3 with MALAT1 in an N6-methyladenosine (m6A)-dependent manner. Lower levels of MALAT1 promoted the ubiquitination degradation of S100A8/Protein S100-A9 (S100A9), thereby impeding p38/mitogen-activated protein kinase phosphorylation and macrophage-mediated inflammation."	M6ADIS0137	34953789	.
M6ACROT06029	REG00014	M6ATAR00856	Non-coding RNA	EPIREG00547	EPITAR00400	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RNA component of 7SK nuclear ribonucleoprotein (RN7SK) was identified as a small nuclear RNA that interacts with m6A readers. m6A readers recognized and facilitated secondary structure formation of m6A-modified RN7SK, which in turn prevented m6A reader mRNA degradation from exonucleases. Thus, a positive feedback circuit between RN7SK and m6A readers is established in tumor cells. From findings on the interaction with RN7SK, m6A readers, such as EWS RNA binding protein 1 (EWSR1), KH RNA binding domain containing, signal transduction-associated 1 (KHDRBS1) and IGF2BP3, were identified and shown to boost Wnt/beta-catenin signaling and tumorigenesis by suppressing translation of Cullin 1 (CUL1) which is regulated by METTL3 and YTHDC2."	.	36566349	M6ADRUG0144
M6ACROT06030	REG00007	M6ATAR00856	Non-coding RNA	EPIREG00547	EPITAR00400	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RNA component of 7SK nuclear ribonucleoprotein (RN7SK) was identified as a small nuclear RNA that interacts with m6A readers. m6A readers recognized and facilitated secondary structure formation of m6A-modified RN7SK, which in turn prevented m6A reader mRNA degradation from exonucleases. Thus, a positive feedback circuit between RN7SK and m6A readers is established in tumor cells. From findings on the interaction with RN7SK, m6A readers, such as EWS RNA binding protein 1 (EWSR1), KH RNA binding domain containing, signal transduction-associated 1 (KHDRBS1) and IGF2BP3, were identified and shown to boost Wnt/beta-catenin signaling and tumorigenesis by suppressing translation of Cullin 1 (CUL1) which is regulated by METTL3 and YTHDC2."	.	36566349	M6ADRUG0144
M6ACROT06031	REG00023	M6ATAR00856	Non-coding RNA	EPIREG00547	EPITAR00400	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RNA component of 7SK nuclear ribonucleoprotein (RN7SK) was identified as a small nuclear RNA that interacts with m6A readers. m6A readers recognized and facilitated secondary structure formation of m6A-modified RN7SK, which in turn prevented m6A reader mRNA degradation from exonucleases. Thus, a positive feedback circuit between RN7SK and m6A readers is established in tumor cells. From findings on the interaction with RN7SK, m6A readers, such as EWS RNA binding protein 1 (EWSR1), KH RNA binding domain containing, signal transduction-associated 1 (KHDRBS1) and IGF2BP3, were identified and shown to boost Wnt/beta-catenin signaling and tumorigenesis by suppressing translation of Cullin 1 (CUL1) which is regulated by METTL3 and YTHDC2."	.	36566349	M6ADRUG0144
M6ACROT06032	REG00014	M6ATAR00856	Non-coding RNA	EPIREG00547	EPITAR00400	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RNA component of 7SK nuclear ribonucleoprotein (RN7SK) was identified as a small nuclear RNA that interacts with m6A readers. m6A readers recognized and facilitated secondary structure formation of m6A-modified RN7SK, which in turn prevented m6A reader mRNA degradation from exonucleases. Thus, a positive feedback circuit between RN7SK and m6A readers is established in tumor cells. From findings on the interaction with RN7SK, m6A readers, such as EWS RNA binding protein 1 (EWSR1), KH RNA binding domain containing, signal transduction-associated 1 (KHDRBS1) and IGF2BP3, were identified and shown to boost Wnt/beta-catenin signaling and tumorigenesis by suppressing translation of Cullin 1 (CUL1) which is regulated by METTL3 and YTHDC2."	.	36566349	M6ADRUG0123
M6ACROT06033	REG00007	M6ATAR00856	Non-coding RNA	EPIREG00547	EPITAR00400	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RNA component of 7SK nuclear ribonucleoprotein (RN7SK) was identified as a small nuclear RNA that interacts with m6A readers. m6A readers recognized and facilitated secondary structure formation of m6A-modified RN7SK, which in turn prevented m6A reader mRNA degradation from exonucleases. Thus, a positive feedback circuit between RN7SK and m6A readers is established in tumor cells. From findings on the interaction with RN7SK, m6A readers, such as EWS RNA binding protein 1 (EWSR1), KH RNA binding domain containing, signal transduction-associated 1 (KHDRBS1) and IGF2BP3, were identified and shown to boost Wnt/beta-catenin signaling and tumorigenesis by suppressing translation of Cullin 1 (CUL1) which is regulated by METTL3 and YTHDC2."	.	36566349	M6ADRUG0123
M6ACROT06034	REG00023	M6ATAR00856	Non-coding RNA	EPIREG00547	EPITAR00400	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RNA component of 7SK nuclear ribonucleoprotein (RN7SK) was identified as a small nuclear RNA that interacts with m6A readers. m6A readers recognized and facilitated secondary structure formation of m6A-modified RN7SK, which in turn prevented m6A reader mRNA degradation from exonucleases. Thus, a positive feedback circuit between RN7SK and m6A readers is established in tumor cells. From findings on the interaction with RN7SK, m6A readers, such as EWS RNA binding protein 1 (EWSR1), KH RNA binding domain containing, signal transduction-associated 1 (KHDRBS1) and IGF2BP3, were identified and shown to boost Wnt/beta-catenin signaling and tumorigenesis by suppressing translation of Cullin 1 (CUL1) which is regulated by METTL3 and YTHDC2."	.	36566349	M6ADRUG0123
M6ACROT06035	REG00014	M6ATAR00856	Non-coding RNA	EPIREG00547	EPITAR00400	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RNA component of 7SK nuclear ribonucleoprotein (RN7SK) was identified as a small nuclear RNA that interacts with m6A readers. m6A readers recognized and facilitated secondary structure formation of m6A-modified RN7SK, which in turn prevented m6A reader mRNA degradation from exonucleases. Thus, a positive feedback circuit between RN7SK and m6A readers is established in tumor cells. From findings on the interaction with RN7SK, m6A readers, such as EWS RNA binding protein 1 (EWSR1), KH RNA binding domain containing, signal transduction-associated 1 (KHDRBS1) and IGF2BP3, were identified and shown to boost Wnt/beta-catenin signaling and tumorigenesis by suppressing translation of Cullin 1 (CUL1) which is regulated by METTL3 and YTHDC2."	.	36566349	M6ADRUG0048
M6ACROT06036	REG00007	M6ATAR00856	Non-coding RNA	EPIREG00547	EPITAR00400	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RNA component of 7SK nuclear ribonucleoprotein (RN7SK) was identified as a small nuclear RNA that interacts with m6A readers. m6A readers recognized and facilitated secondary structure formation of m6A-modified RN7SK, which in turn prevented m6A reader mRNA degradation from exonucleases. Thus, a positive feedback circuit between RN7SK and m6A readers is established in tumor cells. From findings on the interaction with RN7SK, m6A readers, such as EWS RNA binding protein 1 (EWSR1), KH RNA binding domain containing, signal transduction-associated 1 (KHDRBS1) and IGF2BP3, were identified and shown to boost Wnt/beta-catenin signaling and tumorigenesis by suppressing translation of Cullin 1 (CUL1) which is regulated by METTL3 and YTHDC2."	.	36566349	M6ADRUG0048
M6ACROT06037	REG00023	M6ATAR00856	Non-coding RNA	EPIREG00547	EPITAR00400	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RNA component of 7SK nuclear ribonucleoprotein (RN7SK) was identified as a small nuclear RNA that interacts with m6A readers. m6A readers recognized and facilitated secondary structure formation of m6A-modified RN7SK, which in turn prevented m6A reader mRNA degradation from exonucleases. Thus, a positive feedback circuit between RN7SK and m6A readers is established in tumor cells. From findings on the interaction with RN7SK, m6A readers, such as EWS RNA binding protein 1 (EWSR1), KH RNA binding domain containing, signal transduction-associated 1 (KHDRBS1) and IGF2BP3, were identified and shown to boost Wnt/beta-catenin signaling and tumorigenesis by suppressing translation of Cullin 1 (CUL1) which is regulated by METTL3 and YTHDC2."	.	36566349	M6ADRUG0048
M6ACROT06038	REG00014	M6ATAR00856	Non-coding RNA	EPIREG00547	EPITAR00400	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RNA component of 7SK nuclear ribonucleoprotein (RN7SK) was identified as a small nuclear RNA that interacts with m6A readers. m6A readers recognized and facilitated secondary structure formation of m6A-modified RN7SK, which in turn prevented m6A reader mRNA degradation from exonucleases. Thus, a positive feedback circuit between RN7SK and m6A readers is established in tumor cells. From findings on the interaction with RN7SK, m6A readers, such as EWS RNA binding protein 1 (EWSR1), KH RNA binding domain containing, signal transduction-associated 1 (KHDRBS1) and IGF2BP3, were identified and shown to boost Wnt/beta-catenin signaling and tumorigenesis by suppressing translation of Cullin 1 (CUL1) which is regulated by METTL3 and YTHDC2."	.	36566349	M6ADRUG0154
M6ACROT06039	REG00007	M6ATAR00856	Non-coding RNA	EPIREG00547	EPITAR00400	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RNA component of 7SK nuclear ribonucleoprotein (RN7SK) was identified as a small nuclear RNA that interacts with m6A readers. m6A readers recognized and facilitated secondary structure formation of m6A-modified RN7SK, which in turn prevented m6A reader mRNA degradation from exonucleases. Thus, a positive feedback circuit between RN7SK and m6A readers is established in tumor cells. From findings on the interaction with RN7SK, m6A readers, such as EWS RNA binding protein 1 (EWSR1), KH RNA binding domain containing, signal transduction-associated 1 (KHDRBS1) and IGF2BP3, were identified and shown to boost Wnt/beta-catenin signaling and tumorigenesis by suppressing translation of Cullin 1 (CUL1) which is regulated by METTL3 and YTHDC2."	.	36566349	M6ADRUG0154
M6ACROT06040	REG00023	M6ATAR00856	Non-coding RNA	EPIREG00547	EPITAR00400	.	Up regulation	m6A	Direct	Enhancement	ncRNA	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA	"RNA component of 7SK nuclear ribonucleoprotein (RN7SK) was identified as a small nuclear RNA that interacts with m6A readers. m6A readers recognized and facilitated secondary structure formation of m6A-modified RN7SK, which in turn prevented m6A reader mRNA degradation from exonucleases. Thus, a positive feedback circuit between RN7SK and m6A readers is established in tumor cells. From findings on the interaction with RN7SK, m6A readers, such as EWS RNA binding protein 1 (EWSR1), KH RNA binding domain containing, signal transduction-associated 1 (KHDRBS1) and IGF2BP3, were identified and shown to boost Wnt/beta-catenin signaling and tumorigenesis by suppressing translation of Cullin 1 (CUL1) which is regulated by METTL3 and YTHDC2."	.	36566349	M6ADRUG0154